Rac2 expression and mutation in human brain tumors

Acta Neurochirurgica

Volumn 147, Issue 5, 2005, Pages 551-554

  Hwang, S L ^a   Lieu, A S ^a   Chang, J H ^b   Cheng, T S ^b   Cheng, C Y ^a   Lee, K S ^a   Lin, C L ^a   Howng, S L ^a   Hong, Y R ^b,c  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c University of Kaohsiung   (Taiwan)

Author keywords

Brain tumors; Rac2

Indexed keywords

PROTEIN; RAC2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTOMA; BRAIN TUMOR; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; MENINGIOMA; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

ASTROCYTOMA; BRAIN NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; DNA MUTATIONAL ANALYSIS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MENINGIOMA; MUTATION; PITUITARY NEOPLASMS; RAC GTP-BINDING PROTEINS; RNA;

EID: 18044380087     PISSN: 00016268     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00701-005-0515-5     Document Type: Article

References (27)

1. Abraham MT, Kuriakose MA, Sacks PG, Yee H, Chiriboga L, Bearer EL, Delacure MD (2001) Motility-related proteins as markers for head and neck squamous cell cancer. Laryngoscope 111: 1285-1289
2. 21 rac1. Nature 353: 668-670
3. 21 rac1, and cytochrome b-245. J Biol Chem 267: 16767-16770
4. Ambruso DR, Knall C, Abell AN, Panepinto J, Kurkchubasche A, Thurman G, Gonzalez-Aller C, Hiester A, deBoer M, Harbeck RJ, Oyer R, Johnson GL, Roos D (2000) Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc Natl Acad Sci USA 97: 4654-4659
5. Barbacid M (1987) Ras genes. Annu Rev Biochem 56: 779-827
6. Bar-Sagi D, Hall A (2000) Ras and Rho GTPases: a family reunion. Cell 103: 227-238
7. Freeman JL, Kreck ML, Uhlinger DJ, Lambeth JD (1994) Rac effector-homologue region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex. Biochemistry 33: 13431-13435
8. 47 phox in vitro. J Biol Chem 271: 22578-22582
9. Fritz G, Just I, Kaina B (1999) Rho GTPases are over-expressed in human tumors. Int J Cancer 81: 682-687
10. Grill B, Schrader JW (2002) Activation of Rac1, Rac2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen. Blood 100: 3183-3192
11. Haataja L, Groffen J, Heisterkamp N (1997) Characterization of RAC3, a novel member of the Rho family. J Biol Chem 272: 20384-20388
12. Heyworth PG, Bohl BP, Bokoch GM, Curnutte JT (1994) Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. J Biol Chem 269: 30749-30752
13. Hwang SL, Hong YR, Sy WD, Lieu AS, Lin CL, Lee KS, Howng SL (2004) Rac1 gene mutations in human brain tumors. Eur J Surg Oncol 30: 68-72
14. Kaziro Y, Itoh H, Kozasa T, Nakafuku M, Satoh T (1991) Structure and function of signal-transducing GTP-binding proteins. Annu Rev Biochem 60: 349-400
15. Kjoller L, Hall A (1999) Signaling to Rho GTPases. Exp Cell Res 253: 166-179
16. Kleihues P, Burger PC, Scheithauer W (1993) The new WHO classification of brain tumors. Brain Pathol 3: 255-268
17. Lozano E, Betson M, Braga VMM (2003) Tumor progression: small GTPases and loss of cell-cell adhesion. BioEssays 25: 452-463
18. Mackay DJ, Hall A (1998) Rho GTPases. J Biol Chem 273: 20685-20688
19. Marshall C (1984) Functions of ras oncogenes. Nature (Lond.) 310: 448
20. 21-activated kinase-dependent pathway. Proc Natl Acad Sci USA 97: 185-189
21. Pan Y, Bi F, Liu N, Xue Y, Yao X, Zheng Y, Fan D (2004) Expression of seven main Rho family members in gastric carcinoma. BBRC 315: 686-691
22. Perona R, Montaner S, Saniger L, Sanchez-Perez I, Bravo R, Lacal JC (1997) Activation of the nuclear factor-κB by Rho, CDC42, and Rac1 proteins. Genes Dev 11: 463-475
23. Quinn MT, Evans T, Loetterle LR, Jesaitis AJ, Bokoch GM (1993) Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J Biol Chem 268: 20983-20987
24. Roberts AW, Kim C, Zhen JB, Lowe JB, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA (1999) Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 10: 183-196
25. Van Aelst L, D'Souza-Schorey C (1997) Rho GTPases and signaling networks. Genes Dev 11: 2295-2322
26. Yang FC, Kapur R, King AJ, Tao W, Kim C, Borneo J, Breese R, Marshall M, Dinauer MC, Williams DA (2000) Rac2 stimulates AKT activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity 12: 557-568
27. Zigmond SH, Joyce M, Borleis J, Bokoch GM, Devreotes PN (1997) Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. J Cell Boil 138: 363-374