New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3887-3899

  Font, María ^a   González, Álvaro ^a   Palop, Juan Antonio ^a   Sanmartín, Carmen ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Apoptosis; Cytotoxicity; Pyrido 2,3 d pyrimidin 2,4 diamine; Pyrimidin 2,4 diamine; Quinazolin 2,4 diamine; Structure activity relationships

Indexed keywords

2 (ALKYLSULFANYL)N ALKYLPYRIDO[2,3 D]D]PYRIMIDIN 4 AMINE DERIVATIVE; ANTINEOPLASTIC AGENT; DIAMINE DERIVATIVE; N,N' BIS(2 PHENYLETHYL)PYRIMIDIN 2,4 DIAMINE; N,N' BIS(3 HYDROXYPROPYL)PYRIDO[2,3 D] PYRIMIDIN 2,4 DIAMINE; N,N' BIS(3 PHENYLPROPYL)PYRIMIDIN 2,4 DIAMINE; N,N' BIS(4 CHLOROPHENYL)METHYLPYRIMIDIN 2,4 DIAMINE; N,N' BIS(4 HYDROXYBUTYL)PYRIDO[2,3 D] PYRIMIDIN 2,4 DIAMINE; N,N' BIS(4 METHOXYPHENYL)METHYLPYRIMIDIN 2,4 DIAMINE; N,N' BIS(4 METHYLPHENYL)METHYLPYRIMIDIN 2,4 DIAMINE; N,N' BIS(4 PHENYLBUTYL)PYRIMIDIN 2,4 DIAMINE; N,N' DIBENZYLAMINOPYRIMIDIN 2,4 DIAMINE; N,N' DIHEXYLAMINOPYRIDO[2,3 D]PYRIMIDIN 2,4 DIAMINE; NITROGEN; PYRIDO[2,3 D]PYRIMIDIN 2,4 DIAMINE DERIVATIVE; PYRIMIDIN 2,4 DIAMINE DERIVATIVE; QUINAZOLIN 2,4 DIAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; PYRIMIDINES; QUINAZOLINES;

EID: 80052939634     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.060     Document Type: Article

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