Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 21, 2009, Pages 7537-7541

  Rhee, Hee Kyung ^a   Lim, So Yun ^b   Jung, Mi Ja ^b   Kwon, Youngjoo ^b   Kim, Myung Hwa ^c   Choo, Hea Young Park ^b  

^a Sookmyung Women's University   (South Korea)

^b Ewha Womans University   (South Korea)

^c AmorePacific Corporation   (South Korea)

Author keywords

Cytotoxic potentiation; Isoquinolinone; PARP 1

Indexed keywords

10 CHLORO 6H PYRIDO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 10 METHOXY 6H PYRIMIDO[3',4':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 10 METHYL 6H PYRIDO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 10 METHYL PYRIMIDO[1',2':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 11 METHYL 6H PYRIDO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 6H NAPHTO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 6H PYRIMIDO[1',2':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 6H PYRIMIDO[4',3':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 8 METHYL 6H PYRIDO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 8,10 DIMETHYL 6H PYRIDO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 9 BROMO 6H PYRIDO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 9 CHLORO 6H PYRIDO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; 9 METHYL 6H PYRIDO[2',1':1,2]IMIDAZO[5,4 C]ISOQUINOLIN 5 ONE; ADENOSINE DIPHOSPHATE RIBOSE; ANTINEOPLASTIC AGENT; ETOPOSIDE; ISOQUINOLINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5 (6H) ONE; TEMOZOLOMIDE; TETRACYCLINE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; METHYL 6H PYRIDO(2',1' 1,2)IMIDAZO(5,4 C)ISOQUINOLIN 5 ONE; METHYL-6H-PYRIDO(2',1'-1,2)IMIDAZO(5,4-C)ISOQUINOLIN-5-ONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; QUINOLONE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; CHEMISTRY; DNA DAMAGE; DRUG ANTAGONISM; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA DAMAGE; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; ISOQUINOLINES; POLY(ADP-RIBOSE) POLYMERASES; QUINOLONES;

EID: 73949157710     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.014     Document Type: Article

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