Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 1, 2007, Pages 451-457

  Kim, Jin Sung ^a   Rhee, Hee Kyung ^a   Park, Hyen Joo ^a   Lee, In Kyoung ^a   Lee, Sang Kook ^a   Suh, Myung Eun ^a   Lee, Hwa Jeong ^a   Ryu, Chung Kyu ^a   Choo, Hea Young Park ^a  

^a Ewha Womans University   (South Korea)

Author keywords

6 Chloroisoquinoline 5,8 diones; Cytotoxicity; DNA topoisomerase inhibitory activity; Permeability; Pyrido 3,4 b phenazine 5,12 diones

Indexed keywords

4 (6 CHLORO 5,8 DIOXOISOQUINOLIN 7 YL)BENZAMIDE; 6 CHLORO 7 [N (3 FLUOROPHENYL)AMINO]ISOQUINOLINE 5,8 DIONE; 6 CHLORO 7 [N (3 HYDROXYPHENYL)AMINO]ISOQUINOLINE 5,8 DIONE; 6 CHLORO 7 [N (4 ISOPROPYLPHENYL)AMINO]ISOQUINOLINE 5,8 DIONE; 8 (2 HYDROXYETHYL)PYRIDO[3,4 B]PHENAZINE 5,12 DIONE; 8 (TRIFLUOROMETHOXY)PYRIDO[3,4 B]PHENAZINE 5,12 DIONE; 8 ISOPROPYLPYRIDO[3,4 B]PHENAZINE 5,12 DIONE; 8 METHOXYPYRIDO[3,4 B]PHENAZINE 5,12 DIONE; ETHYL 5,12 DIHYDRO 1,12 DIOXOPYRIDO[3,4 B]PHENAZINE 8 CARBOXYLATE; GYRASE INHIBITOR; ISOQUINOLINE DERIVATIVE; N,N DIMETHYLFORMAMIDE; PHENAZINE DERIVATIVE; SODIUM AZIDE; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; COLON CANCER; CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; EVALUATION; FIBROSARCOMA; HUMAN; HUMAN CELL; IC 50; LEUKEMIA; LUNG CANCER; PLASMID; STOMACH CANCER;

CACO-2 CELLS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; MOLECULAR STRUCTURE; PERMEABILITY; PHENAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750953284     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.040     Document Type: Article

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