Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 4, 2007, Pages 1651-1658

  Rhee, Hee Kyung ^a   Park, Hyen Joo ^a   Lee, Sang Kook ^a   Lee, Chong Ock ^b   Choo, Hea Young Park ^a  

^a Ewha Womans University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Benzofuroquinolinediones; Cytotoxicity; Human cancer cell lines; Topoisomerase II

Indexed keywords

2 CHLORO 3 [2 (DIETHYLAMINO)ETHOXY]BENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 2 CHLORO 3 [2 (DIMETHYLAMINO)ISOPROPOXY]BENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 2 CHLORO 3 [2 (DIMETHYLAMINO)PROPOXY]BENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 2 CHLORO 3 [2 [BIS(1 METHYLETHYLAMINO)]ETHOXY]BENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 3 [2 (DIETHYLAMINO)ETHOXY]BENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 3 [2 (DIMETHYLAMINO)ISOPROPOXY]BENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 3 [2 (DIMETHYLAMINO)PROPOXY]BENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 3 [2 [BIS(1 METHYLETHYLAMINO)]ETHOXY]BENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 7 CHLORO 8 HYDROXYBENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 [1 (DIMETHYLAMINO)PROPAN 2 YLOXY] 7 CHLOROBENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 [1 (DIMETHYLAMINO)PROPAN 2 YLOXY]BENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 [2 (DIETHYLAMINO)ETHOXY] 7 CHLOROBENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 [2 (DIETHYLAMINO)ETHOXY]BENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 [2 (DIISOPROPYLAMINO)ETHOXY] 7 CHLOROBENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 [2 (DIISOPROPYLAMINO)ETHOXY]BENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 [2 (DIMETHYLAMINO)PROPOXY] 7 CHLOROBENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 [2 (DIMETHYLAMINO)PROPOXY]BENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; 8 HYDROXYBENZOFURO[3,2 G]QUINOLINE 5,11 DIONE; CAMPTOTHECIN; DNA TOPOISOMERASE; DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; POLYMERIZATION;

CELL DEATH; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE II; DOXORUBICIN; HUMANS; INHIBITORY CONCENTRATION 50; QUINOLONES;

EID: 33847771813     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.012     Document Type: Article

References (19)

1. Tomas C.J., Rahier N.J., and Hecht S.M. Bioorg. Med. Chem. 12 (2004) 1585
2. Perchellet E.M., Sperfslage B.J., Qabaja G., Jones G.B., and Perchellet J.-P. AntiCancer Drugs 12 (2001) 401
3. Garbett N.C., and Graves D.E. Curr. Med. Chem: Anti-Cancer Agents 4 (2004) 149
4. Cheng C.-C., Dong Q., Liu D.-F., Luo Y.-l., Liu L.F., Chen A.Y., Yu C., Savaraj N., and Chou T.-C. J. Med. Chem. 36 (1993) 4108
5. Pindur U., Haber M., and Sattler K. J. Chem. Educ. 70 (1993) 263
6. Baldwin E.L., and Osheroff N. Curr. Med. Chem: Anti-Cancer Agents 5 (2005) 363
7. Ji Z., Wang H.-K., Bastow K.-H., Zhu X.-K., Cho S.J., Cheng Y.-C., and Lee K.-H. Bioorg. Med. Chem. Lett. 7 (1997) 607
8. Kim M.-Y., Na Y., Vankayalapati H., Gleason-Guzman M., and Hurley L.H. J. Med. Chem. 46 (2003) 2958
9. Ma Z., Hano Y., Nomura T., and Chen Y. Bioorg. Med. Chem. Lett. 14 (2004) 1193
10. Temiz-Arpaci O., Tekiner-Gulbas B., Yldiz I., Aki-Sener E., and Yalcin I. Bioorg. Med. Chem. 13 (2005) 6354
11. Hejaz H.A.M., Woo L.W.L., Purohit A., Reed M.J., and Potter B.V.L. Bioorg. Med. Chem. 12 (2004) 2759
12. Shaikh I.A., Johnson F., and Grollman A.P. J. Med. Chem. 29 (1986) 1329
13. Barnett C.J., and Smirz J.C. J. Org. Chem. 41 (1976) 710
14. Lee S.K., Cui B., Mehta R.R., Kinghorn A.D., and Pezzuto J.M. Chem. Biol. Interact 115 (1998) 215
15. Liu L.F. Annu. Rev. Biochem. 58 (1989) 351
16. Asche C. Mini-Rev. Med. Chem. 5 (2005) 449
17. Park H.J., Lee H.-J., Lee E.-J., Hwang H.J., Shin S.-H., Suh M.-E., Kim C., Kim H.J., Seo E.-K., and Lee S.K. Biosci. Biotechnol. Biochem. 67 (2003) 1944
18. Park H.J., Kim Y.-S., Kim J.S., Lee E.-J., Lee Y.-J., Hwang H.J., Suh M.-E., Ryu C.-K., and Lee S.K. Bioorg. Med. Chem. Lett. 14 (2004) 3385
19. Giles G.I., and Sharma R.P. Med. Chem. 1 (2005) 383