Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3909-3916

  Zhang, Zhichao ^a   Yang, Hongna ^a   Wu, Guiye ^a   Li, Zhiqiang ^a   Song, Ting ^a   Li, Xiang Qian ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Apoptosis; Bcl 2; Dual inhibitor; Mcl 1; p2 pocket

Indexed keywords

3 (2 METHOXYPHENOXY) 8 OXO 8H ACENAPHTHO[1,2 B]PYRROLE 9 CARBONITRILE; 3 (4 BUTYLPHENOXY) 8 OXO 8H ACENAPHTHO[1,2 B]PYRROLE 9 CARBONITRILE; 3 (TOLYLOXY) 8 OXO 8H ACENAPHTHO[1,2 B]PYRROLE 9 CARBONITRILE; 8 OXO 8H ACENAPHTHO[1,2 B]PYRROLE 9 CARBONITRILE DERIVATIVE; CYANIDE; PROTEIN BCL 2; PROTEIN MCL 1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENCE POLARIZATION; HUMANS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR PROBES; MORPHOLINES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052920610     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.062     Document Type: Article

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