Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Krajewska, Maryla ^a   You, Zerong ^b,f   Rong, Juan ^a   Kress, Christina ^a   Huang, Xianshu ^a   Yang, Jinsheng ^b   Kyoda, Tiffany ^a   Leyva, Ricardo ^a   Banares, Steven ^a   Hu, Yue ^c,d   Sze, Chia Hung ^a   Whalen, Michael J ^b   Salemena, Leonardo ^e,g   Hakem, Razqallah ^e   Head, Brian P ^c   Reed, John C ^a   Krajewski, Stan ^a  

^a BURNHAM INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^e PRINCESS MARGARET HOSPITAL   (Canada)

^f TUFTS UNIVERSITY   (United States)

^g BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; CASPASE 3; CASPASE 8; CRE RECOMBINASE; CYCLOHEXIMIDE; GENE PRODUCT; GLIAL FIBRILLARY ACIDIC PROTEIN; IBA1 PROTEIN; KAINIC ACID; MICROTUBULE ASSOCIATED PROTEIN 2; NEURON SPECIFIC NUCLEAR PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN S 100; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; NEUROTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL GANGLION; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN INJURY; BRAIN PROTECTION; BRAIN REGION; BRAIN SLICE; CASPASE 8 GENE; CAUDATE PUTAMEN; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; ENTORHINAL CORTEX; EXCITOTOXICITY; GENE; GENE DELETION; HEMISPHERE; HIPPOCAMPUS; HISTOPATHOLOGY; HOMOZYGOSITY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KNOCKOUT MOUSE; LEARNING; MICROGLIA; MORPHOMETRICS; MOTOR CORTEX; MOTOR PERFORMANCE; MOUSE; NEOCORTEX; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; SEIZURE INDUCED BRAIN INJURY; SENSORIMOTOR FUNCTION; SUPERIOR LEARNING; SURVIVAL; THALAMUS NUCLEUS; TRAUMATIC BRAIN INJURY; WORKING MEMORY; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; CELL DEATH; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; GENETICS; GLIOSIS; INFLAMMATION; MEMORY; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEIZURE;

MURINAE; MUS;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; CASPASE 8; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYO, MAMMALIAN; GENE DELETION; GLIOSIS; INFLAMMATION; KAINIC ACID; MEMORY; MICE; NEURONS; NEUROTOXINS; SEIZURES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052837010     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024341     Document Type: Article

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