Expression of Fas and Fas ligand after experimental traumatic brain injury in the rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 4, 2000, Pages 669-677

  Beer, Ronny ^a   Franz, Gerhard ^a   Schöpf, Marion ^a   Reindl, Markus ^a   Zelger, Bernhard ^b   Schmutzhard, Erich ^a   Poewe, Werner ^a   Kampfl, Andreas ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b Universitatsklinik fuer Dermatologie und Venerologie Innsbruck   (Austria)

Author keywords

Apoptosis; Fas; Fas ligand; Traumatic brain injury; TUNEL

Indexed keywords

FAS ANTIGEN; LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOHISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0034051781     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200004000-00004     Document Type: Article

References (18)

1. Aihara N, Hall JJ, Pitts LH, Fukuda K, Noble LJ (1995) Altered immunoexpression of microglia and macrophages after mild head injury. J Neurotrauma 12:53-63
2. Austrian Department of Health and Science. Guide for the Care and Use of Laboratory Animals. Federal Law Gazette 501/1989.
3. Becher B, Parker PA, Owens T, Antel JP (1998) CD95-CD95L: can the brain learn from the immune system? Trends Neurosci 21:114-117
4. Bernassola F, Scheuerpflug C, Herr I, Krammer PH, Debatin K-H, Melino G (1999) Induction of apoptosis by INFγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit. Cell Death Differ 6:652-660
5. Bonetti B, Raine CS (1997) Multiple sclerosis: oligodendrocytes display cell death related molecules in situ but do not undergo apoptosis. Ann Neurol 42:74-84
6. Bredesen DE (1995) Neural apoptosis. Ann Neurol 38:839-851
7. Bryan RM, Cherian L, Robertson C (1995) Regional cerebral blood flow after controlled cortical impact in rats. Anaesth Analg 80:87-695
8. Cheema ZF, Wade SB, Sata M, Walsh K, Sohrabji F, Miranda RC (1999) Fas/Apo (apoptosis)-1 and associated proteins in the differentiating cortex: induction of caspase dependent cell death and induction of NF-kappa B. J Neurosci 19:1745-1770
9. Cheng J, Zhou T, Liu C, et al. (1994) Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263: 1759-1762
10. Clark RS, Chen J, Watkins SC, et al. (1997) Apoptosis suppressor gene bcl-2 expression after traumatic brain injury in rats. J Neurosci 17:9172-9182
11. Colicos MA, Dash PK (1996) Apoptotic morphology of the dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits. Brain Res 739: 120-131
12. Colicos MA, Dixon CE, Dash PK (1996) Delayed, selective neuronal death following experimental cortical impact injury in rats: possible role in spatial memory deficits. Brain Res 739:111-119
13. Conti AC, Raghupathi R, Trojanowski JQ, McIntosh TK (1998) Experimental brain injury induces regionally distinct apoptosis in the acute and delayed post-traumatic period. J Neurosci 18:5663-5672
14. Debus E, Weber K, Osborn M (1983) Monoclonal antibodies specific for glal fibrillary acidic (GFA) protein and for each of the neurofilament triplet polypeptides. Differentiation 25:193-203
15. Dietrich WD, Alonso O, Halley M (1994) Early microvascular and neuronal consequences of traumatic brain injury: a light and electronic microscopy study in rats. J Neurotrauma 11:289-301
16. Dixon CE, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL (1991) A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Methods 39:253-262
17. Dowling P, Shang J, Raval S, Menonna J, Cook S, Husar W (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain. J Exp Med 184:1513-1518
18. D'Souza SD, Bonetti B, Balasingam V, et al. (1996) Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J Exp Med 181:393-398