Glucose depletion rapidly inhibits translation initiation in yeast

Molecular Biology of the Cell

Volumn 11, Issue 3, 2000, Pages 833-848

  Ashe, Mark P ^a   De Long, Susan K ^a   Sachs, Alan B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ARTICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0034100041     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.3.833     Document Type: Article

References (69)

1. Alms, G.R., Sanz, P., Carlson, M., and Haystead, T.A.J. (1999). Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome. EMBO J. 25, 4157-4168.
2. Baker, S.H., Frederick, D.L., Bloecher, A., and Tatchell, K. (1997). Alanine-scanning mutagenesis of protein phosphatase type 1 in the yeast Saccharomyces cerevisiae. Genetics 145, 615-626.
3. Barbet, N.C., Schneider, U., Helliwell, S.B., Stansfield, I., Tuite, M.F., and Hall, M.N. (1996). TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell 7, 25-42.
4. Beelman, C.A., and Parker, R. (1994). Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J. Biol. Chem. 269, 9687-9692.
5. Berset, C., Trachsel, H., and Altmann, M. (1998). The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 95, 4264-4269.
6. Boeck, R., Lapeyre, B., Brown, C.E., and Sachs, A.B. (1998). Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant. Mol. Cell. Biol. 18, 5062-5072.
7. Cameron, S., Levin L., Zoller, M., and Wigler, M. (1988). cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell 53, 555-556.
8. Celenza, J.L., and Carlson, M. (1986). A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science 233, 1175-1180.
9. Celenza, J.L., Eng, F.J., and Carlson, M. (1989). Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase. Mol. Cell. Biol. 9, 5045-5054.
10. Crauwels, M., Donaton, M.C.V., Pernambuco, M.B., Winderickx, J., de Winde, J.H., and Thevelein, J.M. (1997). The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology 143, 2627-2637.
11. Dever, T.E., Feng, L., Wek, R.C., Cigan, A.M., Donahue, T.F., and Hinnebusch, A.G. (1992). Phosphorylation of initiator factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 68, 585-596.
12. Devit, M.J., Waddle, J.A., and Johnston, M. (1997). Regulated nuclear translocation of the Mig1 glucose repressor. Mol. Biol. Cell 8, 1603-1618.
13. Di Como, C.J., and Arndt, K.T. (1996). Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 10, 1904-1916.
14. Ditzelmüller, G., Wöhrer, W., Kubicek, C.P., and Röhr, M. (1983). Nucleotide pools of growing, synchronized and stressed cultures of Saccharomyces cerevisiae. Arch. Microbiol. 135, 63-67.
15. Entian, K.-D. (1980). Genetic and biochemical evidence for hexokinase PII as a key enzyme involved in carbon catabolite repression in yeast. Mol. Gen. Genet. 178, 633-637.
16. Flick, J.S., and Johnston, M. (1991). GKR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Mol. Cell. Biol. 11, 5101-5112.
17. Gancedo, J.M. (1998). Yeast carbon catabolite repression. Microbiol. Mol. Biol. Rev. 62, 334-361.
18. 2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 12, 586-597.
19. Guthrie, C., and Fink, G.R. (eds.) (1991). Guide to Yeast Genetics and Molecular Biology, San Diego, CA: Academic Press.
20. Hartwell, L.H., and McLaughlin, C.S. (1969). A mutant of yeast apparently defective in the initiation of protein synthesis. Proc. Natl. Acad. Sci. USA 62, 468-474.
21. Herrick, D., Parker, R., and Jacobson, A. (1990). Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae. Mol. Cell. Biol. 10, 2269-2284.
22. Hinnebusch, A.G. (1984). Evidence for translational regulation of the activator of general amino acid control in yeast. Proc. Natl. Acad. Sci. USA 81, 6442-6446.
23. Hinnebusch, A.G. (1996). Translational control of GCN4: gene-specific regulation by phosphorylation of eIF2. In: Translational Control, ed. J.W.B. Hershey, M.B. Mathews, and N. Sonenberg, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 199-244.
24. Hubbard, E.J.A., Yang, X., and Carlson, M. (1992). Relationship of the cAMP-dependent protein kinase pathway to the SNF1 protein kinase and invertase expression in Saccharomyces cerevisiae. Genetics 130, 71-80.
25. Jiang, R., and Carlson, M. (1996). Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. Genes Dev. 10, 3105-3115.
26. Jiang, Y., and Broach, J.R. (1999). Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 18, 2782-2792.
27. Jiang, Y., Davis, C., and Broach, J.R. (1998). Efficient transition to growth on fermentable carbon sources in Saccharomyces cerevisiae requires signaling through the Ras pathway. EMBO J. 17, 6942-6951.
28. Li, F.N., and Johnston, M. (1997). Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. EMBO J. 16, 5629-5638.
29. Ludin, K., Jiang, R., and Carlson, M. (1998). Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 95, 6245-6250.
30. Luthe, D.S. (1983). A simple technique for the preparation and storage of sucrose gradients. Anal. Biochem. 135, 230-232.
31. Martinez-Pastor, M.T., and Estruch, F. (1996). Sudden depletion of carbon source blocks translation, but not transcription, in the yeast Saccharomyces cerevisiae. FEBS Lett. 390, 319-322.
32. Mathews, M.B., Sonenberg, N., and Hershey, J.W.B. (1996). Origins and targets of translational control. In: Translational Control, ed. J.W.B. Hershey, M.B. Mathews, and N. Sonenberg, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1-30.
33. Merrick, W.C., and Hershey, J.W.B. (1996). The pathway and mechanism of eukaryotic protein synthesis. In: Translational Control, ed. J.W.B. Hershey, M.B. Mathews, and N. Sonenberg, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 31-70.
34. Niederacher, D., and Entian, K.-D. (1987). Isolation and characterization of the regulatory HEX2 gene necessary for glucose repression in yeast. Mol. Gen. Genet. 206, 505-509.
35. Nikawa, J.-I., Cameron, S., Toda, T., Ferguson, K.M., and Wigler, M. (1987). Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev. 1, 931-937.
36. Nonet, M., Scafe, C., Sexton, J., and Young, R. (1987). Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis. Mol. Cell. Biol. 7, 1602-1611.
37. Özcan, S., Dover, J., and Johnston, M. (1998). Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae. EMBO J. 17, 2566-2573.
38. Özcan, S., Dover, J., Rosenwald, A.G., Wölfl, S., and Johnston, M. (1996a). Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc. Natl. Acad. Sci. USA 93, 12428-12432.
39. Özcan, S., and Johnston, M. (1996). Two different repressors collaborate to restrict expression of the yeast glucose transporter genes HXT2 and HXT4 to low levels of glucose. Mol. Cell. Biol. 16, 5536-5545.
40. Özcan, S., Leong, T., and Johnston, M. (1996b). Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Mol. Cell. Biol. 16, 6419-6426.
41. Pan, X., and Heitman, J. (1999). Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 4874-4887.
42. Parks, R.E., Jr., and Argawal, R.P. (1973). Nucleoside diphosphokinases. In: The Enzymes, 3rd ed., vol. 8, ed. P.D. Boyer, New York: Academic Press, 307-333.
43. Peltz, S.W., Donahue, J.L., and Jacobson, A. (1992). A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae. Mol. Cell. Biol. 22, 5778-5784.
44. Powers, T., and Walter, P. (1999). Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol. Biol. Cell 10, 987-1000.
45. Ramaswamy, N.T., Li, L., Kahlil, M., and Cannon, J.F. (1998). Regulation of yeast glycogen metabolism and sporulation by Glc7p protein phosphatase. Genetics 149, 57-72.
46. Ramirez, M., Wek, R.C., Vazquez de Alana, C.R., Jackson, B.M., Freeman, B., and Hinnebusch, A.G. (1992). Mutations activating the yeast eIF2α kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol. Cell. Biol. 12, 5801-5815.
47. Randez-Gil, F., Sanz, P., Entian, K.-D., and Prieto, J.A. (1998). Carbon source-dependent phosphorylation of hexokinase PII and its role in the glucose-signaling response in yeast. Mol. Cell. Biol. 18, 2940-2948.
48. Rolfes, R.J., and Hinnebusch, A.C. (1993). Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Mol. Cell. Biol. 13, 5099-5111.
49. Sachs, A.B., and Deardorff, J.A. (1992). Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast. Cell 70, 961-973.
50. Schmidt, A., Beck, T., Koller, A., Kunz, J., and Hall, M.N. (1998). The TOR nutrient signaling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 17, 6924-6931.
51. Schmidt, M.C., McCartney, R.R., Zhang, X., Tillman, T.S., Solimeo, H., Wölfl, S., Almonte, C., and Watkins, S.C. (1999). Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 4561-4571.
52. Schüller, H.J., and Entian, K.-D. (1987). Isolation and expression analysis of two yeast regulatory genes involved in the derepression of glucose-repressible enzymes. Mol. Gen. Genet. 209, 366-373.
53. Sherwood, P.W., and Carlson, M. (1997). Mutations in GSF1 and GSF2 alter glucose signaling in Saccharomyces cerevisiae. Genetics 147, 557-566.
54. Simpson, W.J., and Hammond, J.R.M. (1989). Cold ATP extractants compatible with constant light signal firefly luciferase reagents. In: ATP Luminescence: Rapid Methods in Microbiology, ed. P.E. Stanley, B.J. McCarthy, and R. Smither, Oxford, UK: Blackwell Scientific, 45-52.
55. Smith, A., Ward, M.P., and Garrett, S. (1998). Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation. EMBO J. 17, 3556-3564.
56. Tarun, S.Z., Jr., and Sachs, A.B. (1996). Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G. EMBO J. 15, 7168-7177.
57. Thevelein, J.M. (1991). Fermentable sugars and intracellular acidification as specific activators of the Ras-adenylate cyclase signaling pathway in yeast: the relationship to nutrient-induced cell cycle control. Mol. Microbiol. 5, 1301-1307.
58. Thevelein, J.M. (1994). Signal transduction in yeast. Yeast 10, 1753-1790.
59. Thompson-Jaeger, S., François, J., Gaughran, J.P., and Tatchell, K. (1991). Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway. Genetics 129, 697-706.
60. Trachsel, H. (1996). Binding of initiator methionyl-tRNA to ribosomes. In: Translational Control, ed. J.W.B. Hershey, M.B. Mathews, and N. Sonenberg, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 113-138.
61. Tu, J., and Carlson, M. (1994). The GLC7 type 1 protein phosphatase is required for glucose repression in Saccharomyces cerevisiae. Mol. Cell. Biol. 14, 6789-6796.
62. Tu, J., and Carlson, M. (1995). REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J. 14, 5939-5946.
63. Tung, K.-S., and Hopper, A.K. (1995). The glucose repression and RAS-cAMP signal transduction pathways of Saccharomyces cerevisiae each affect RNA processing and the synthesis of a reporter protein. Mol. Gen. Genet. 247, 48-54.
64. Tzamarias, D., Roussou, I., and Thireos, G. (1989). Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation. Cell 57, 947-954.
65. Vallier, L.G., and Carlson, M. (1994). Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiae. Genetics 137, 49-54.
66. Vallier, L.G., Coons, D., Bisson, L.F., and Carlson, M. (1994). Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics 136, 1279-1285.
67. Wach, A., Brachat, A., Pöhlmann, R., and Philippsen, P. (1994). New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10, 1793-1808.
68. Wek, R.C., Cannon, J.F., Dever, T.E., and Hinnebusch, A.G. (1992). Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2α kinase GCN2. Mol. Cell. Biol. 12, 5700-5710.
69. Wilson, W.A., Hawley, S.A., and Hardie, D.G. (1996). Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio. Curr. Biol. 6, 1426-1434.