Evaluation of in vivo genotoxic potential of fenofibrate in rats subjected to two-week repeated oral administration

Archives of Toxicology

Volumn 85, Issue 8, 2011, Pages 1003-1011

  Tawfeeq, Mohammad Monir ^a,b   Suzuki, Terumasa ^a   Shimamoto, Keisuke ^a   Hayashi, Hitomi ^a   Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b KABUL UNIVERSITY   (Afghanistan)

Author keywords

Comet assay; Fenofibrate; Genotoxicity; Initiation assay; Rat

Indexed keywords

FENOFIBRATE; GLUTATHIONE TRANSFERASE; REACTIVE OXYGEN METABOLITE;

8 OXOGUANINE DNA GLYCOSYLASE GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APURINIC APYRIMIDINIC ENDONUCLEASE 1 GENE; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE ACTIVITY; GENE EXPRESSION; GENOTOXICITY; GROWTH ARREST AND DNA DAMAGE INDUCIBLE 45 ALPHA GENE; IN VIVO STUDY; LIVER RESECTION; LIVER WEIGHT; MALE; MUTL HOMOLOG 1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; TAIL LENGTH; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS; TUMOR GENE; WEIGHT GAIN;

2-ACETYLAMINOFLUORENE; ADMINISTRATION, ORAL; ANIMALS; CARBON TETRACHLORIDE; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; FENOFIBRATE; GENE EXPRESSION REGULATION; HEPATECTOMY; HYPOLIPIDEMIC AGENTS; LIVER; MALE; PPAR ALPHA; RATS; RATS, INBRED F344;

RATTUS; RODENTIA;

EID: 80052734205     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-010-0628-3     Document Type: Article

References (40)

1. PI Eacho TC Lanier CA Brodhecker 1991 Hepatocellular DNA synthesis in rats given peroxisome proliferating reagent: comparison of WY-14, 643 to clofibric acid, nafenopin and Ly171883 in rats Carcinogenesis 12 1557 1561 1893515 10.1093/carcin/12.9.1557 1:CAS:528:DyaK3MXlvFOkt7c%3D
2. DW Fairbairn PL Oliv KL O' Neill 1995 The comet assays: a comprehensive review Mutat Res 339 37 59 7877644 1:CAS:528:DyaK2MXktlChsro%3D
3. FP Guengerich DC Liebler 1985 Enzymatic activation of chemicals to toxic metabolites Crit Rev Toxicol 14 259 307 3926381 10.3109/10408448509037460 1:CAS:528:DyaL2MXkvF2ktbo%3D (Pubitemid 15062287)
4. R Hasegawa T Yoshida Y Mizoguchi M Futakuchi DJ Kim L Cui N Ito 1994 Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital Cancer Lett 83 89 95 8062238 10.1016/0304-3835(94)90303-4 1:CAS:528:DyaK2cXlvFGmtbg%3D (Pubitemid 24253522)
5. R Hess W Staubli W Riess 1965 Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat Nature 208 856 858 5870099 10.1038/208856a0 1:CAS:528:DyaF28XjtVWluw%3D%3D
6. A Hirata T Tsukamoto H Sakai S Takasu H Ban T Imai Y Totsuka R Nishigaki K Wakabayashi T Yanai T Masegi M Tatematsu 2008 Carcinogenic risk of heterocyclic amines in combination- assessment with a liver initiation model Food Chem Toxicol 46 2003 2009 18331778 10.1016/j.fct.2008.01.040 1:CAS:528:DC%2BD1cXlvVShsrk%3D
7. M Jin Y Dewa M Kawai J Nishimura Y Saegusa S Matsumoto T Harada M Shibutani K Mitsumori 2009 Induction of liver preneoplastic foci in F344 rats subjected to 28-day oral administration of diheptyl phthalate and its in vivo genotoxic potential Toxicology 264 16 25 19643158 10.1016/j.tox.2009.07.006 1:CAS:528:DC%2BD1MXhtV2lt7zO
8. H Kasai 1997 Analysis of a form of oxidative DNA damage, 8-hydrox-2-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis Mutat Res 387 147 163 9439711 10.1016/S1383-5742(97)00035-5 1:CAS:528:DyaK2sXnvVSrs74%3D (Pubitemid 28009270)
9. JE Klaunig LM Kamendulis 2004 The role of oxidative stress in carcinogenesis Annu Rev Pharmacol Toxicol 44 239 267 14744246 10.1146/annurev.pharmtox.44.101802.121851 1:CAS:528:DC%2BD2cXhvVCktL8%3D (Pubitemid 38263841)
10. P Lefebvre G Chinetti JC Fruchart B Staels 2006 Sorting out the role of PPAR alpha in energy metabolism and vascular homeostasis J Clin Invest 116 571 580 16511589 10.1172/JCI27989 1:CAS:528:DC%2BD28XitlGkt74%3D (Pubitemid 43326861)
11. DS Marsman RC Cattley JG Conway JA Popp 1988 Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl) phthalate and {4-chloro-6-(2, 3-xylidino)-2-pyrimidinylthio}acetic acid (Wy-14, 643) in rats Cancer Res 48 6739 6744 3180084 1:CAS:528:DyaL1MXhvFKqsw%3D%3D (Pubitemid 19012198)
12. M Moto Y Sasaki M Okamura M Fujita Y Kashida N Machida K Mitsumori 2003 Absence of in vivo genotoxicity and liver initiation activity of dicyclanil J Toxicol Sci 28 173 179 12974609 10.2131/jts.28.173 1:CAS:528: DC%2BD3sXptVCmuro%3D (Pubitemid 37129066)
13. M Moto T Umemura M Okamura M Muguruma T Ito M Jin Y Kashida K Mitsumori 2006 Possible involvement of oxidative stress in dicyclanil-induced hepatocarcinogenesis in mice Arch Toxicol 80 694 702 16550380 10.1007/s00204-006-0086-0 1:CAS:528:DC%2BD28XpsFWmsr4%3D (Pubitemid 44394530)
14. M Muguruma A Unami M Kanki Y Kuroiwa J Nishimura Y Dewa T Umemura Y Oishi K Mitsumori 2007 Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats Toxicology 236 61 75 17498859 10.1016/j.tox.2007.03.025 1:CAS:528:DC%2BD2sXlvVyit7s%3D (Pubitemid 46777069)
15. T Nishikawa H Wanibuchi M Ogawa A Kinoshita K Morimura T Hiroi Y Funae H Kishida D Nakae S Fukushima 2002 Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism Int J Cancer 100 136 139 12115560 10.1002/ijc.10471 1:CAS:528:DC%2BD38XkvFygu7w%3D (Pubitemid 34666185)
16. J Nishimura Y Dewa T Okamura M Mugumura M Jin Y Saegusa T Umemura K Mitsumori 2008 Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats Arch Toxicol 82 641 654 18253720 10.1007/s00204-007-0278-2 1:CAS:528:DC%2BD1cXhtFOisr3N
17. JM Peters C Cheung FJ Gonzalez 2005 Peroxisome proliferator-activated receptor- alpha and liver cancer: where do we stand? J Mol Med 83 774 785 15976920 10.1007/s00109-005-0678-9 1:CAS:528:DC%2BD2MXhtVOhurzE (Pubitemid 41407861)
18. HJ Prochaska P Talalay 1988 Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver Cancer Res 48 4776 4782 3409219 1:CAS:528:DyaL1cXls1ejtr0%3D
19. S Puntarulo AI Cederbaum 1998 Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes Free Radic Biol Med 24 1324 1330 9626590 10.1016/S0891-5849(97)00463-2 1:CAS:528: DyaK1cXjsFWht7Y%3D (Pubitemid 28246749)
20. MS Rao JK Reddy 1987 Peroxisome proliferation and hepatocarcinogenesis Carcinogenesis 8 631 636 3555880 10.1093/carcin/8.5.631 1:CAS:528: DyaL2sXmtlSmtbo%3D (Pubitemid 17122522)
21. MS Rao N Usuda V Subbarao JK Reddy 1987 Absence of gamma-glutamyl transpeptidase activity in neoplastic lesions induced in the liver of male F-344 rats by di-(2 -ethylhexyl)phthalate, a peroxisome proliferator Carcinogenesis 9 1347 1350 10.1093/carcin/8.9.1347 (Pubitemid 17135265)
22. MS Rao MR Nemali N Usuda DG Scarpelli T Makino HC Pitot JK Reddy 1988 Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators Cancer Res 48 4919 4925 2457433 1:CAS:528: DyaL1cXlsVOhs7g%3D
23. JK Reddy MS Rao 1989 Oxidative DNA damage caused by persistent peroxisome proliferation: it is role in hepatocarcinogenesis Mutat Res 214 63 68 2671702 1:CAS:528:DyaL1MXls1ykt7w%3D (Pubitemid 19220287)
24. JK Reddy DL Azarnoff CE Hignite 1980 Hypolipidaemic hepatic peroxisome proliferators from a novel class of chemical carcinogens Nature 283 397 398 6766207 10.1038/283397a0 1:CAS:528:DyaL3cXhslGnur4%3D (Pubitemid 10125816)
25. H Sakai T Tsukamoto M Yamamoto T Yanai T Masegi K Inada H Nakanishi M Tatematsu 2000 Summation of initiation activities of low doses of the non-hepatocarcinogen 1, 2-dimethylhydrazine in the liver after carbon tetrachloride administration Cancer Lett 148 59 63 10680593 10.1016/S0304- 3835(99)00306-7 1:CAS:528:DC%2BD3cXhtVemtQ%3D%3D (Pubitemid 30012129)
26. H Sakai T Tsukamoto M Yamamoto K Kobayashi H Yuasa T Imai T Yanai T Masegi M Tatematsu 2002 Distinction of carcinogens from mutagens by induction of liver cell foci in a model for detection of initiation activity Cancer Lett 188 33 38 12406545 10.1016/S0304-3835(02)00009-5 1:CAS:528:DC%2BD38Xot1Wqt7c%3D (Pubitemid 35292326)
27. M Sano A Hagiwara S Tamano R Hasegawa K Imaida N Ito T Shirai 1999 Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phathlate after diethylnitrosamine initiation J Toxicol Sci 24 177 186 10478332 1:STN:280:DyaK1MvgslOksg%3D%3D (Pubitemid 29436686)
28. YF Sasaki E Nishidate F Izumiyama N Matsusaka S Tsuda 1997 Detection of rodent liver carcinogen genotoxicity by the alkaline single-cell gel electrophoresis (comet)assay in multiple mouse organs (liver, lung, spleen, kidney and bone marrow) Mutat Res 391 201 214 9268046 1:CAS:528: DyaK2sXkt1Sru7c%3D (Pubitemid 27308703)
29. KW Seo KB Kim YJ Kim JY Choi KT Lee KS Choi 2004 Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats Food Chem Toxicol 42 107 114 14630134 10.1016/j.fct.2003.08.010 1:CAS:528:DC%2BD3sXptVentLs%3D (Pubitemid 37421330)
30. BS Shane DL Smith-Dunn L Ganesh ML Cunningham 1999 Mutagenicity of Wyeth 14, 643 in vivo in the liver of Big Blue transgenic mice Proc Am Assoc Cancer Res 39 241
31. BS Shane DL Smith-Dunn JG de Boer BW Glickman ML Cunningham 2000 Subchronic administration of phenobarbital alters the mutation spectrum of lacl in the livers of Big Blue transgenic mice Mutat Res 448 69 80 10751624 1:CAS:528:DC%2BD3cXit1aru7c%3D (Pubitemid 30177155)
32. T Shoda K Mitsumori H Onodera K Toyoda C Uneyama K Takada M Hirose 2000 Liver tumor-promoting effect of beta-naphthoflavone, a strong CYP 1A1/2 inducer, and the relationship between CYP 1A1/2 induction and Cx32 decrease in its hepatocarcinogenesis in the rat Toxicol Pathol 28 540 547 10930040 10.1177/019262330002800406 1:CAS:528:DC%2BD3cXlvFCrtLw%3D (Pubitemid 30622217)
33. VK Singh L Ganesh ML Cunningham BS Shane 2001 Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14, 643, at the lambdacll locus in Big Blue transgenic mice Biochem Pharmacol 62 685 692 11551513 10.1016/S0006-2952(01)00722-5 1:CAS:528:DC%2BD3MXms1Oksrs%3D (Pubitemid 32816985)
34. B Staels J Dallongeville J Auwex K Schoonjans E Leitersdorf JC Frchart 1998 Mechanism of action of fibrates on lipid and lipoprotein metabolism Circulation 98 2088 2093 9808609 1:CAS:528:DyaK1cXnsFCisr8%3D (Pubitemid 28512236)
35. T Suzuki M Jin Y Dewa R Ichimura Y Shimada S Mizukami M Shibutani K Mitsumori 2010 Evaluation of in vivo liver genotoxic potential of Wy-14, 643 and piperonyl butoxide in rats subjected to two-week repeated oral administration Arch Toxicol 84 493 500 20127075 10.1007/s00204-010-0516-x 1:CAS:528: DC%2BC3cXhtlersro%3D
36. H Tsuda G Lee E Farber 1980 Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens Cancer Res 40 1157 1164 6101993 1:CAS:528:DyaL3cXkt1Sntr4%3D (Pubitemid 10135825)
37. US Food and Drug Administration (2008) http://www.fda.gov/medwatch/ ; search word is triglide tablets
38. A Valavanidis T Vlachogianni C Fiotakis 2009 8-Hydroxy-2′- deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27 120 139 19412858 1:CAS:528:DC%2BD1MXlsVeqtrc%3D
39. CG Woods AM Burns BU Bradford PK Ross O Kosyk JA Swenberg ML Cunninqham I Rusyn 2007 WY-14, 643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase Toxicol Sci 98 366 374 17483499 10.1093/toxsci/kfm104 1:CAS:528:DC%2BD2sXosFGjtLs%3D (Pubitemid 47244809)
40. AV Yeldandi MS Rao JK Reedy 2000 Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis Mutat Res 448 159 177 10725470 1:CAS:528:DC%2BD3cXhvV2ksbk%3D (Pubitemid 30139452)