Evaluation of in vivo liver genotoxic potential of Wy-14, 643 and piperonyl butoxide in rats subjected to two-week repeated oral administration

Archives of Toxicology

Volumn 84, Issue 6, 2010, Pages 493-500

  Suzuki, Terumasa ^a   Jin, Meilan ^b   Dewa, Yasuaki ^a   Ichimura, Ryohei ^a   Shimada, Yuko ^a   Mizukami, Sayaka ^a   Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Comet assay; Genotoxicity; Piperonyl butoxide; Wy 14, 643

Indexed keywords

CELL NUCLEUS DNA; GENE PRODUCT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PIPERONYL BUTOXIDE; PIRINIXIC ACID; PROTEIN APEX1; PROTEIN MLH1; UNCLASSIFIED DRUG; XRCC5 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; GENOTOXICITY; IN VIVO STUDY; LIVER; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; UPREGULATION;

ADMINISTRATION, ORAL; ANIMALS; COMET ASSAY; DNA; DNA DAMAGE; DNA REPAIR; HEPATECTOMY; LIVER; MALE; MUTAGENS; OXIDATIVE STRESS; PEROXISOMES; PESTICIDE SYNERGISTS; PIPERONYL BUTOXIDE; PPAR ALPHA; PYRIMIDINES; RATS; RATS, INBRED F344;

RATTUS; RODENTIA;

EID: 77953023029     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0516-x     Document Type: Article

References (37)

1. Beamand JA, Price RJ, Phillips JC, Butler WH, Jones GD, Osimitz TG, Gabriel KL, Preiss FJ, Lake BG (1996) Lack of effect of piperonyl butoxide on unscheduled DNA synthesis in precision-cut human liver slices. Mutat Res 371:273-282.
2. Deutsch WA, Kukreja A, Shane B, Hegde V (2001) Phenobarbital, oxazepam and Wyeth 14, 643 cause DNA damage as measured by the Comet assay. Mutagenesis 16:439-442.
3. Fairbairn DW, Olive PL, O'Neill KL (1995) The comet assay: a comprehensive review. Mutat Res 339:37-59.
4. Glauert HP, Reddy JK, Kennan WS, Sattler GL, Rao VS, Pitot HC (1984) Effect of hypolipidemic peroxisome proliferators on unscheduled DNA synthesis in cultured hepatocytes and on mutagenesis in Salmonella. Cancer Lett 24:147-156.
5. Hasegawa R, Yoshida T, Mizoguchi Y, Futakuchi M, Kim DJ, Cui L, Ito N (1994) Phenotypic alteration of hepatocellular foci in rats treated with cloWbrate and phenobarbital. Cancer Lett 83:89-95.
6. Hirata A, Tsukamoto T, Sakai H, Takasu S, Ban H, Imai T, Totsuka Y, Nishigaki R, Wakabayashi K, Yanai T, Masegi T, Tatematsu M (2008) Carcinogenic risk of heterocyclic amines in combination- assessment with a liver initiation model. Food Chem Toxicol 46:2003-2009.
7. Jin M, Dewa Y, Kawai M, Nishimura J, Saegusa Y, Matsumoto S, Harada T, Shibutani M, Mitsumori K (2009) Induction of liver preneoplastic foci in F344 rats subjected to 28-day oral administration of diheptyl phthalate and its in vivo genotoxic potential. Toxicology 264:16-25.
8. Kasai H (1997) Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res 387:147-163.
9. Klaunig JE, Kamendulis LM (2004) The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44:239-267.
10. Marsman DS, Cattley RC, Conway JG, Popp JA (1988) Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6- (2, 3-xylidino)- 2-pyrimidinylthio]acetic acid (Wy-14, 643) in rats. Cancer Res 48:6739-6744.
11. Moto M, Sasaki YF, Okamura M, Fujita M, Kashida Y, Machida N, Mitsumori K (2003) Absence of in vivo genotoxicity and liver initiation activity of dicyclanil. J Toxicol Sci 28:173-179.
12. Muguruma M, Unami A, Kanki M, Kuroiwa Y, Nishimura J, Dewa Y, Umemura T, Oishi Y, Mitsumori K (2007) Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats. Toxicology 236:61-75.
13. Muguruma M, Kawai M, Dewa Y, Nishimura J, Saegusa Y, Yasuno H, Jin M, Matsumoto S, Takabatake M, Arai K, Mitsumori K (2009) Threshold dose of piperonyl butoxide that induces reactive oxygen species-mediated hepatocarcinogenesis in rats. Arch Toxicol 83:183-193.
14. Nishikawa T, Wanibuchi H, Ogawa M, Kinoshita A, Morimura K, Hiroi T, Funae Y, Kishida H, Nakae D,, (2002) Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism. Int J Cancer 100:136-139.
15. Nishimura J, Dewa Y, Okamura T, Muguruma M, Jim M, Saegusa Y, Umemura T, Mitsumori K (2008) Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats. Arch Toxicol 82:641-654.
16. Peters JM, Cattley RC, Gonzalez FJ (1997) Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14, 643. Carcinogenesis 18:2029-2033.
17. Peters JM, Cheung C, Gonzalez FJ (2005) Peroxisome proliferatoractivated receptor-α and liver cancer: where do we stand? J Mol Med 83:774-785.
18. Pogribny IP, Tryndyak VP, Boureiko A, Melnyk S, Bagnyukova TV, Montgomery B, Rusyn I (2008) Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutat Res 644:17-23.
19. Puntarulo S, Cederbaum AI (1998) Production of reactive oxygen species by microsomes enriched in speciWc human cytochrome P450 enzymes. Free Radic Biol Med 24:1324-1330.
20. Rao MS, Reddy JK (1987) Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis 8:631-636.
21. Rao MS, Nemali MR, Usuda N, Scarpelli DG, Makino T, Pitot HC, Reddy JK (1988) Lack of expression of glutathione-S-transferase P, gamma-flutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators. Cancer Res 48:4919-4925.
22. Reddy JK, Rao MS (1989) Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis. Mutat Res 214:63-68.
23. Sakai H, Tsukamoto T, Yamamoto M, Yanai T, Masegi T, Inada K, Nakanishi H, Tatematsu M (2000) Summation of initiation activities of low doses of the non-hepatocarcinogen 1, 2-dimethylhydrazine in the liver after carbon tetrachloride administration. Cancer Lett 148:59-63.
24. Sakai H, Tsukamoto T, Yamamoto M, Kobayashi K, Yuasa H, Imai T, Yanai T, Masegi T, Tatematsu M (2002) Distinction of carcinogens from mutagens by induction of liver cell foci in a model for detection of initiation activity. Cancer Lett 188:33-38.
25. Sano M, Hagiwara A, Tamano S, Hasegawa R, Imaida K, Ito N, Shirai T (1999) Dose-dependent induction of carcinomas and Xutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl) phthalate after diethylnitrosamine initiation. J Toxicol Sci 24:177-186.
26. Sasaki Y, Ueno S, Miyamae Y, Ohta T, Tsuda S (1998) Detection of organ speciWc genotoxicity by alkaline single cell gel electrophoresis assay with mouse multiple organs. Environ Mutagen Res 20:51-62.
27. Seo KW, Kim KB, Kim YJ, Choi JY, Lee KT, Choi KS (2004) Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats. Food Chem Toxicol 42:107-114.
28. Shane BS, Smith-Dunn DL, Ganesh L, Cunningham ML (1999) Mutagenicity of Wyeth 14, 643 in vivo in the liver of Big Blue transgenic mice. Proc Am Assoc Cancer Res 39:241.
29. Shane BS, Smith-Dunn DL, deBoer JG, Glickman BW, Cunningham ML (2000) Subchronic administration of phenobarbital alters the mutation spectrum of lacI in the livers of Big Blue transgenic mice. Mutat Res 448:69-89.
30. Singh VK, Ganesh L, Cunningham ML, Shane BS (2001) Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14, 643, at the lambdacII locus in Big Blue transgenic mice. Biochem Pharmacol 62:685-692.
31. Takahashi O, Oishi S, Fujitani T, Tanaka T, Yoneyama M (1994) Chronic toxicity studies of piperonyl butoxide in F344 rats: induction of hepatocellular carcinoma. Fundam Appl Toxicol 22:293-303.
32. Tsuda H, Lee G, Farber E (1980) Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res 40:1157-1164.
33. Valavanidis A, Vlachogianni T, Fiotakis C (2009) 8-hydroxy-2' -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health Part C Environ Carcinog Ecotoxicol Rev 27:120-139.
34. Wiklund SJ, Agurell E (2003) Aspects of design and statistical analysis in the Comet assay. Mutagenesis 18:167-175.
35. Williams GM, Maruyama H, Tanaka T (1987) Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl) phthalate in rat liver carcinogenesis. Carcinogenesis 8:875-880.
36. Woods CG, Burns AM, Bradford BU, Ross PK, Kosyk O, Swenberg JA, Cunninqham ML, Rusyn I (2007) WY-14, 643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. Toxicol Sci 98:366-374.
37. Zahradka P (2007) Cardiovascular actions of the peroxisome proliferator-activated receptor-alpha (PPA Ralpha) agonist Wy14, 643. Cardiovasc Drug Rev 25:99-122.