Induction of liver preneoplastic foci in F344 rats subjected to 28-day oral administration of diheptyl phthalate and its in vivo genotoxic potential

Toxicology

Volumn 264, Issue 1-2, 2009, Pages 16-25

  Jin, Meilan ^a,b   Dewa, Yasuaki ^a,c   Kawai, Masaomi ^a,c   Nishimura, Jihei ^a,c   Saegusa, Yukie ^a,c   Kemmochi, Sayaka ^a,c   Harada, Tomoaki ^a   Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

Diheptyl phthalate; Genotoxicity; Phthalate esters

Indexed keywords

DNA; GLUTATHIONE TRANSFERASE; PHTHALIC ACID DIHEPTYL ESTER; PHTHALIC ACID ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; FISCHER 344 RAT; GENOTOXICITY; IN VIVO STUDY; LIVER CANCER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRECANCER; PRIORITY JOURNAL; RAT; UNINDEXED SEQUENCE;

ANIMALS; COMET ASSAY; GLUTATHIONE TRANSFERASE; HEPATECTOMY; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER; LIVER NEOPLASMS; MALE; MUTAGENICITY TESTS; MUTAGENS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PHTHALIC ACIDS; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

RATTUS;

EID: 69449092606     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.07.006     Document Type: Article

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