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Volumn 1, Issue 1, 2010, Pages 45-52

The inhibitory effects of berry-derived flavonoids against neurodegenerative processes

Author keywords

Brain; flavonoids; neuroinflammation; neurotoxins; Parkinson disease

Indexed keywords


EID: 80052719379     PISSN: 18785093     EISSN: 18785123     Source Type: Journal    
DOI: 10.3233/BR-2010-005     Document Type: Article
Times cited : (38)

References (40)
  • 4
    • 49549112269 scopus 로고    scopus 로고
    • Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes
    • P.K. Bahia, M. Rattray and R.J.Williams, Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes, Journal of Neurochemistry 106 (2008), 2194-2204
    • (2008) Journal of Neurochemistry , vol.106 , pp. 2194-2204
    • Bahia, P.K.1    Rattray, M.2    Williams, R.J.3
  • 5
    • 1042298763 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/cytokinestimulated microglia
    • C.J. Chen, S.L. Raung, S.L. Liao and S.Y. Chen, Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/cytokinestimulated microglia, Biochemical Pharmacology 67 (2004), 957-965
    • (2004) Biochemical Pharmacology , vol.67 , pp. 957-965
    • Chen, C.J.1    Raung, S.L.2    Liao, S.L.3    Chen, S.Y.4
  • 6
    • 26444594915 scopus 로고    scopus 로고
    • Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia
    • J.C. Chen, F.M. Ho, C. Pei-Dawn Lee, C.P. Chen, K.C. Jeng, H.B. Hsu, S.T. Lee, W. Wen Tung and W.W. Lin, Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia, European Journal of Pharmacology 521 (2005), 9-20
    • (2005) European Journal of Pharmacology , vol.521 , pp. 9-20
    • Chen, J.C.1    Ho, F.M.2    Pei-Dawn Lee, C.3    Chen, C.P.4    Jeng, K.C.5    Hsu, H.B.6    Lee, S.T.7    Wen Tung, W.8    Lin, W.W.9
  • 8
    • 0036233802 scopus 로고    scopus 로고
    • Fruit polyphenolics and brain aging: Nutritional interventions targeting age-related neuronal and behavioral deficits
    • R.L. Galli, B. Shukitt-Hale, K.A.Youdim and J.A. Joseph, Fruit polyphenolics and brain aging: Nutritional interventions targeting age-related neuronal and behavioral deficits, Annals of the New York Academy of Science 959 (2002), 128-132 (Pubitemid 34457558)
    • (2002) Annals of the New York Academy of Sciences , vol.959 , pp. 128-132
    • Galli, R.L.1    Shukitt-Hale, B.2    Youdim, K.A.3    Joseph, J.A.4
  • 9
    • 18844374851 scopus 로고    scopus 로고
    • Neuroinflammatory processes in Parkinson's disease
    • DOI 10.1016/j.parkreldis.2004.10.013, PII S1353802005000362
    • E.C. Hirsch, S. Hunot and A. Hartmann, Neuroinflammatory processes in Parkinson's disease, Parkinsonism and Related Disorders 11(Suppl. 1) (2005), S9-S15 (Pubitemid 40693572)
    • (2005) Parkinsonism and Related Disorders , vol.11 , Issue.SUPPL. 1
    • Hirsch, E.C.1    Hunot, S.2    Hartmann, A.3
  • 10
    • 20444387289 scopus 로고    scopus 로고
    • (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest
    • DOI 10.1254/jphs.FPJ04053X
    • Q. Huang, L.J. Wu, S. Tashiro, H.Y. Gao, S. Onodera and T. Ikejima, (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest, Journal of Pharmacological Sciences 98 (2005), 16-24 (Pubitemid 40806123)
    • (2005) Journal of Pharmacological Sciences , vol.98 , Issue.1 , pp. 16-24
    • Huang, Q.1    Wu, L.-J.2    Tashiro, S.-I.3    Gao, H.-Y.4    Onodera, S.5    Ikejima, T.6
  • 11
    • 67649329442 scopus 로고    scopus 로고
    • Oxidative stress and Parkinson's disease
    • P. Jenner, Oxidative stress and Parkinson's disease, Handbook of Clinical Neurology 83 (2007), 507-520
    • (2007) Handbook of Clinical Neurology , vol.83 , pp. 507-520
    • Jenner, P.1
  • 12
    • 0033568849 scopus 로고    scopus 로고
    • Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
    • J.A. Joseph, B. Shukitt-Hale, N.A. Denisova, D. Bielinski, A. Martin, J.J. McEwen and P.C. Bickford, Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation, Journal of Neuroscience 19 (1999), 8114-8121 (Pubitemid 30225807)
    • (1999) Journal of Neuroscience , vol.19 , Issue.18 , pp. 8114-8121
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Bielinski, D.4    Martin, A.5    McEwen, J.J.6    Bickford, P.C.7
  • 14
    • 1642553221 scopus 로고    scopus 로고
    • Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia
    • H. Lee, Y.O. Kim, H. Kim, S.Y. Kim, H.S. Noh, S.S. Kang, G.J. Cho, W.S. Choi and K. Suk, Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia, FASEB Journal 17 (2003), 1943-1944
    • (2003) FASEB Journal , vol.17 , pp. 1943-1944
    • Lee, H.1    Kim, Y.O.2    Kim, H.3    Kim, S.Y.4    Noh, H.S.5    Kang, S.S.6    Cho, G.J.7    Choi, W.S.8    Suk, K.9
  • 15
    • 7244242682 scopus 로고    scopus 로고
    • Minocycline inhibits apoptotic cell death via attenuation of TNF-α expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures
    • DOI 10.1111/j.1471-4159.2004.02780.x
    • S.M. Lee, T.Y. Yune, S.J. Kim, Y.C. Kim, Y.J. Oh, G.J. Markelonis and T.H. Oh, Minocycline inhibits apoptotic cell death via attenuation of TNF-Alpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures, Journal of Neurochemistry 91 (2004), 568-578 (Pubitemid 39431152)
    • (2004) Journal of Neurochemistry , vol.91 , Issue.3 , pp. 568-578
    • Lee, S.M.1    Yune, T.Y.2    Kim, S.J.3    Kim, Y.C.4    Oh, Y.J.5    Markelonis, G.J.6    Oh, T.H.7
  • 16
    • 0034851553 scopus 로고    scopus 로고
    • Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
    • DOI 10.1046/j.1471-4159.2001.00490.x
    • Y. Levites, O. Weinreb, G. Maor, M.B. Youdim and S. Mandel, Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration, Journal of Neurochemistry 78 (2001), 1073-1082 (Pubitemid 32823156)
    • (2001) Journal of Neurochemistry , vol.78 , Issue.5 , pp. 1073-1082
    • Levites, Y.1    Weinreb, O.2    Maor, G.3    Youdim, M.B.H.4    Mandel, S.5
  • 17
    • 10644230076 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury
    • DOI 10.1002/jnr.20315
    • R. Li,Y.G. Huang, D. Fang andW.D. Le, (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury, Journal of Neuroscience Research 78 (2004), 723-731 (Pubitemid 39657589)
    • (2004) Journal of Neuroscience Research , vol.78 , Issue.5 , pp. 723-731
    • Li, R.1    Huang, Y.-G.2    Fang, D.3    Le, W.-D.4
  • 18
    • 33749255399 scopus 로고    scopus 로고
    • A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives
    • DOI 10.1080/10715760600672509, PII W1255U116263V742, Polyphenols and Health
    • P. Maher, A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives, Free Radical Research 40 (2006), 1105-1111 (Pubitemid 44480551)
    • (2006) Free Radical Research , vol.40 , Issue.10 , pp. 1105-1111
    • Maher, P.1
  • 19
    • 33748702290 scopus 로고    scopus 로고
    • Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    • DOI 10.1523/JNEUROSCI.1504-06.2006
    • M.K. McCoy, T.N. Martinez, K.A. Ruhn, D.E. Szymkowski, C.G. Smith, B.R. Botterman, K.E. Tansey and M.G. Tansey, Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease, Journal of Neuroscience 26 (2006), 9365-9375 (Pubitemid 44396849)
    • (2006) Journal of Neuroscience , vol.26 , Issue.37 , pp. 9365-9375
    • McCoy, M.K.1    Martinez, T.N.2    Ruhn, K.A.3    Szymkowski, D.E.4    Smith, C.G.5    Botterman, B.R.6    Tansey, K.E.7    Tansey, M.G.8
  • 20
    • 33745660070 scopus 로고    scopus 로고
    • 5-S-Cysteinyl-dopamine effect on the human dopaminergic neuroblastoma cell line SH-SY5Y
    • DOI 10.1016/j.neuint.2006.01.023, PII S0197018606000829
    • L. Mosca, E. Lendaro, M. d'Erme, S. Marcellini, S. Moretti and M.A. Rosei, 5-S-Cysteinyl-dopamine effect on the human dopaminergic neuroblastoma cell line SH-SY5Y, Neurochemistry International 49 (2006), 262-269 (Pubitemid 43975191)
    • (2006) Neurochemistry International , vol.49 , Issue.3 , pp. 262-269
    • Mosca, L.1    Lendaro, E.2    D'Erme, M.3    Marcellini, S.4    Moretti, S.5    Rosei, M.A.6
  • 21
    • 38949167692 scopus 로고    scopus 로고
    • Oxidative stress and neurotoxicity
    • DOI 10.1021/tx700210j
    • L.M. Sayre, G. Perry and M.A. Smith, Oxidative stress and neurotoxicity, Chemical Research in Toxicology 21 (2008), 172-188 (Pubitemid 351219718)
    • (2008) Chemical Research in Toxicology , vol.21 , Issue.1 , pp. 172-188
    • Sayre, L.M.1    Perry, G.2    Smith, M.A.3
  • 22
    • 34249788691 scopus 로고    scopus 로고
    • (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons
    • DOI 10.1111/j.1471-4159.2006.04434.x
    • H. Schroeter, P. Bahia, J.P. Spencer, O. Sheppard, M. Rattray, E. Cadenas, C. Rice-Evans and R.J. Williams, (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons, Journal of Neurochemistry 101 (2007), 1596-1606 (Pubitemid 46848841)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.6 , pp. 1596-1606
    • Schroeter, H.1    Bahia, P.2    Spencer, J.P.E.3    Sheppard, O.4    Rattray, M.5    Cadenas, E.6    Rice-Evans, C.7    Williams, R.J.8
  • 23
    • 0036753143 scopus 로고    scopus 로고
    • MAPK signaling in neurodegeneration: Influences of flavonoids and of nitric oxide
    • DOI 10.1016/S0197-4580(02)00075-1, PII S0197458002000751
    • H. Schroeter, C. Boyd, J.P. Spencer, R.J. Williams, E. Cadenas and C. Rice-Evans, MAPK signaling in neurodegeneration: Influences of flavonoids and of nitric oxide, Neurobioly of Aging 23 (2002), 861-880 (Pubitemid 35217712)
    • (2002) Neurobiology of Aging , vol.23 , Issue.5 , pp. 861-880
    • Schroeter, H.1    Boyd, C.2    Spencer, J.P.E.3    Williams, R.J.4    Cadenas, E.5    Rice-Evans, C.6
  • 24
    • 0031056511 scopus 로고    scopus 로고
    • Oxidation of dopamine in the presence of cysteine: Characterization of new toxic products
    • DOI 10.1021/tx960145c
    • X.M. Shen, F. Zhang and G. Dryhurst, Oxidation of dopamine in the presence of cysteine: Characterization of new toxic products, Chemical Research in Toxicology 10 (1997), 147-155 (Pubitemid 27091882)
    • (1997) Chemical Research in Toxicology , vol.10 , Issue.2 , pp. 147-155
    • Shen, X.-M.1    Zhang, F.2    Dryhurst, G.3
  • 25
    • 42149124306 scopus 로고    scopus 로고
    • Food for thought: The role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance
    • DOI 10.1017/S0029665108007088, PII S0029665108007088
    • J.P. Spencer, Food for thought: The role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance, Proceedings of the Nutrition Society 67 (2008), 238-252 (Pubitemid 351543406)
    • (2008) Proceedings of the Nutrition Society , vol.67 , Issue.2 , pp. 238-252
    • Spencer, J.P.E.1
  • 26
    • 0031722906 scopus 로고    scopus 로고
    • Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: Possible mechanisms of formation involving reactive oxygen species
    • J.P. Spencer, P. Jenner, S.E. Daniel, A.J. Lees, D.C. Marsden and B. Halliwell, Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: Possible mechanisms of formation involving reactive oxygen species, Journal of Neurochemistry 71 (1998), 2112-2122 (Pubitemid 28491568)
    • (1998) Journal of Neurochemistry , vol.71 , Issue.5 , pp. 2112-2122
    • Spencer, J.P.E.1    Jenner, P.2    Daniel, S.E.3    Lees, A.J.4    Marsden, D.C.5    Halliwell, B.6
  • 27
    • 70450221663 scopus 로고    scopus 로고
    • Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects
    • J.P. Spencer, D. Vauzour and C. Rendeiro, Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects, Archives of Biochemistry and Biophysics 492 (2009), 1-9.
    • (2009) Archives of Biochemistry and Biophysics , vol.492 , pp. 1-9
    • Spencer, J.P.1    Vauzour, D.2    Rendeiro, C.3
  • 28
    • 0036074531 scopus 로고    scopus 로고
    • 5-S-cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons
    • DOI 10.1046/j.1471-4159.2002.00808.x
    • J.P. Spencer, M. Whiteman, P. Jenner and B. Halliwell, 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons, Journal of Neurochemistry 81 (2002), 122-129 (Pubitemid 34808859)
    • (2002) Journal of Neurochemistry , vol.81 , Issue.1 , pp. 122-129
    • Spencer, J.P.E.1    Whiteman, M.2    Jenner, P.3    Halliwell, B.4
  • 29
    • 15244350494 scopus 로고    scopus 로고
    • Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor α-induced neurotoxicity in concert with microglial-derived Fas ligand
    • DOI 10.1523/JNEUROSCI.4456-04.2005
    • D.L. Taylor, F. Jones, E.S. Kubota and J.M. Pocock, Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand, Journal of Neuroscience 25 (2005), 2952-2964 (Pubitemid 40389253)
    • (2005) Journal of Neuroscience , vol.25 , Issue.11 , pp. 2952-2964
    • Taylor, D.L.1    Jones, F.2    Kubota, E.S.3    Pocock, J.M.4
  • 33
    • 48049106637 scopus 로고    scopus 로고
    • Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson's disease and protection by polyphenols
    • D. Vauzour, G. Ravaioli, K. Vafeiadou, A. Rodriguez-Mateos, C. Angeloni and J.P. Spencer, Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson's disease and protection by polyphenols, Archives of Biochemistry and Biophysics 476 (2008), 145-151
    • (2008) Archives of Biochemistry and Biophysics , vol.476 , pp. 145-151
    • Vauzour, D.1    Ravaioli, G.2    Vafeiadou, K.3    Rodriguez-Mateos, A.4    Angeloni, C.5    Spencer, J.P.6
  • 34
    • 35448949428 scopus 로고    scopus 로고
    • Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
    • DOI 10.1111/j.1471-4159.2007.04841.x
    • D. Vauzour, K. Vafeiadou, C. Rice-Evans, R.J. Williams and J.P. Spencer, Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-Apoptotic effects of flavanones in cortical neurons, Journal of Neurochemistry 103 (2007), 1355-1367 (Pubitemid 47631805)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.4 , pp. 1355-1367
    • Vauzour, D.1    Vafeiadou, K.2    Rice-Evans, C.3    Williams, R.J.4    Spencer, J.P.E.5
  • 36
    • 34548250927 scopus 로고    scopus 로고
    • Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols
    • DOI 10.1016/j.bbrc.2007.07.153, PII S0006291X07016518
    • D. Vauzour, K. Vafeiadou and J.P. Spencer, Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols, Biochemical and Biophysical Research Communications 362 (2007), 340-346 (Pubitemid 47332414)
    • (2007) Biochemical and Biophysical Research Communications , vol.362 , Issue.2 , pp. 340-346
    • Vauzour, D.1    Vafeiadou, K.2    Spencer, J.P.E.3
  • 37
    • 14944340012 scopus 로고    scopus 로고
    • Genistein protects dopaminergic neurons by inhibiting microglial activation
    • DOI 10.1097/00001756-200502280-00013
    • X. Wang, S. Chen, G. Ma, M. Ye and G. Lu, Genistein protects dopaminergic neurons by inhibiting microglial activation, Neuroreport 16 (2005), 267-270 (Pubitemid 40364588)
    • (2005) NeuroReport , vol.16 , Issue.3 , pp. 267-270
    • Wang, X.1    Chen, S.2    Ma, G.3    Ye, M.4    Lu, G.5
  • 38
    • 4444226105 scopus 로고    scopus 로고
    • Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
    • DOI 10.1016/j.jnutbio.2004.05.002, PII S0955286304001184
    • O. Weinreb, S. Mandel, T. Amit and M.B. Youdim, Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases, Journal of Nutritional Biochemistry 15 (2004), 506-516 (Pubitemid 39209392)
    • (2004) Journal of Nutritional Biochemistry , vol.15 , Issue.9 , pp. 506-516
    • Weinreb, O.1    Mandel, S.2    Amit, T.3    Youdim, M.B.H.4
  • 39
  • 40
    • 1242338756 scopus 로고    scopus 로고
    • Flavonoid permeability across an in situ model of the blood-brain barrier
    • DOI 10.1016/j.freeradbiomed.2003.11.023
    • K.A. Youdim, M.Z. Qaiser, D.J. Begley, C.A. Rice-Evans and N.J. Abbott, Flavonoid permeability across an in situ model of the blood-brain barrier, Free Radical Biology and Medicine 36 (2004), 592-604 (Pubitemid 38230176)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.5 , pp. 592-604
    • Youdim, K.A.1    Qaiser, M.Z.2    Begley, D.J.3    Rice-Evans, C.A.4    Abbott, N.J.5


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