Synthesis, structural, and biological evaluation of bis- heteroarylmaleimides and bis-heterofused imides

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5291-5299

  Ferri, Nicola ^a   Radice, Tiziano ^a   Antonino, Manuela ^a   Beccalli, Egle Maria ^a   Tinelli, Stella ^b   Zunino, Franco ^b   Corsini, Alberto ^a   Pratesi, Graziella ^b   Ragg, Enzio M ^a   Gelmi, Maria Luisa ^a   Contini, Alessandro ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Biological activity; DNA intercalator; Microwave chemistry; Molecular dynamics; NMR spectroscopy

Indexed keywords

AMONAFIDE; ANTINEOPLASTIC AGENT; BIS HETEROARYLMALEIMIDE DERIVATIVE; BIS HETEROFUSED IMIDE DERIVATIVE; ELINAFIDE; MALEIMIDE DERIVATIVE; NEW DRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; IC 50; LUNG CARCINOMA; MOUSE; NONHUMAN; PHASE TRANSITION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SMOOTH MUSCLE FIBER; STRUCTURE ANALYSIS; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; AORTA; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; IMIDES; MALEIMIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 80052590924     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.016     Document Type: Article

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