The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4575-4582

  Hasinoff, Brian B ^a   Zhang, Rui ^a   Wu, Xing ^a   Guziec, Lynn J ^b   Guziec Jr , Frank S ^b   Marshall, Kyle ^b   Yalowich, Jack C ^c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b SOUTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bisanthrapyrazole; Bisintercalating; DNA binding; Topoisomerase II

Indexed keywords

7 CHLORO 2 [2 [(2 HYDROXYETHYL)METHYLAMINO]ETHYL]ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; DRUG DESIGN; DRUG DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR MODEL;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; ETHYLENEDIAMINES; HUMANS; INTERCALATING AGENTS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66449094136     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.072     Document Type: Article

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