Folate analysis in foods by UPLC-MS/MS: Development and validation of a novel, high throughput quantitative assay; Folate levels determined in Australian fortified breads

Analytical and Bioanalytical Chemistry

Volumn 401, Issue 3, 2011, Pages 1035-1042

  Chandra Hioe, Maria V ^a   Bucknall, Martin P ^a   Arcot, Jayashree ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

5 MTHF; Bread; Folic acid; Fortification; HPLC MS; MS MS; Quantitation; UPLC

Indexed keywords

5-MTHF; BREAD; FOLIC ACIDS; FORTIFICATION; HPLC-MS; MS/MS; QUANTITATION; UPLC;

AMINO ACIDS; EXTRACTION; FILTRATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

FOOD PRODUCTS;

5 METHYLTETRAHYDROFOLIC ACID; 5-METHYLTETRAHYDROFOLATE; FOLIC ACID; TETRAHYDROFOLIC ACID DERIVATIVE;

ANIMAL; ARTICLE; AUSTRALIA; BIOASSAY; BREAD; CHEMICAL ANALYSIS; DIET SUPPLEMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; METHODOLOGY; RAT; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; TIME; VALIDATION STUDY;

ANIMALS; AUSTRALIA; BIOLOGICAL ASSAY; BREAD; CHEMISTRY TECHNIQUES, ANALYTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FOLIC ACID; FOOD, FORTIFIED; LIMIT OF DETECTION; RATS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TETRAHYDROFOLATES; TIME FACTORS;

MANIHOT ESCULENTA; RATTUS; TRITICUM AESTIVUM;

EID: 80052569498     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5156-3     Document Type: Article

References (36)

1. MRC Vitamin Study Research Group 1991 Prevention of neural tube defects: results of the Medical Research Council Vitamin Study Lancet 1 1027 1031
2. AE Czeizel I Dudas 1992 Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation N Engl J Med 327 26 1832 1835 10.1056/NEJM199212243272602 1:STN:280:DyaK3s%2FnvVyisw%3D%3D (Pubitemid 23003073)
3. TJ Mathews MA Honein JD Erickson 2002 Spina bifida and anencephaly prevalence-United States, 1991-2001 Morb Mortal Wkly Rep 51 13 9 11 1:STN:280:DC%2BD38vpt1Cquw%3D%3D
4. P De Wals F Tairou MI Van Allen SH Uh RB Lowry B Sibbald JA Evans MC Van Den Hof P Zimmer M Crowley B Fernandez NS Lee T Niyonsenga 2007 Reduction in neural-tube defects after folic acid fortification in Canada N Engl J Med 357 2 135 142 10.1056/NEJMoa067103 (Pubitemid 47057731)
5. GP Oakley Jr 2009 The scientific basis for eliminating folic acid-preventable spina bifida: a modern miracle from epidemiology Ann Epidemiol 19 4 226 230 10.1016/j.annepidem.2009.01.016 10.1016/j.annepidem.2009.01.016
6. P Stokes K Webb 1999 Analysis of some folate monoglutamates by high-performance liquid chromatography-mass spectrometry. I J Chromatogr A 864 1 59 67 10.1016/S0021-9673(99)00992-9 10.1016/S0021-9673(99)00992-9 1:CAS:528:DyaK1MXns1Sns7o%3D
7. A Freisleben P Schieberle M Rychlik 2002 Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays J Agric Food Chem 50 17 4760 4768 10.1021/jf025571k 1:CAS:528: DC%2BD38XlsVCgsL8%3D (Pubitemid 34856142)
8. A Freisleben P Schieberle M Rychlik 2003 Specific and sensitive quantification of folate vitamers in foods by stable isotope dilution assays using high-performance liquid chromatography-tandem mass spectrometry Anal Bioanal Chem 376 2 149 156 1:CAS:528:DC%2BD3sXjs1Kns70%3D (Pubitemid 40878046)
9. A Freisleben P Schieberle M Rychlik 2003 Comparison of folate quantification in foods by high-performance liquid chromatography-fluorescence detection to that by stable isotope dilution assays using high-performance liquid chromatography-tandem mass spectrometry Anal Biochem 315 2 247 255 10.1016/S0003-2697(03)00029-0 1:CAS:528:DC%2BD3sXis12gs7o%3D (Pubitemid 36407498)
10. RJ Pawlosky VP Flanagan CM Pfeiffer 2001 Determination of 5-methyltetrahydrofolic acid in human serum by stable-isotope dilution high-performance liquid chromatography-mass spectrometry Anal Biochem 298 2 299 305 10.1006/abio.2001.5394 1:CAS:528:DC%2BD3MXotFGjtrY%3D (Pubitemid 33105246)
11. RJ Pawlosky VP Flanagan 2001 A quantitative stable-isotope LC-MS method for the determination of folic acid in fortified foods J Agric Food Chem 49 3 1282 1286 10.1021/jf001172i 1:CAS:528:DC%2BD3MXhtFygu78%3D (Pubitemid 32884949)
12. RJ Pawlosky VP Flanagan RF Doherty 2003 A mass spectrometric validated high-performance liquid chromatography procedure for the determination of folates in foods J Agric Food Chem 51 13 3726 3730 10.1021/jf034017n 1:CAS:528:DC%2BD3sXjvVahtbg%3D
13. RJ Pawlosky E Hertrampf VP Flanagan PM Thomas 2003 Mass spectral determinations of the folic acid content of fortified breads from Chile J Food Compos Anal 16 3 281 286 10.1016/S0889-1575(03)00033-4 1:CAS:528: DC%2BD3sXkt1Gksr8%3D (Pubitemid 36747901)
14. A Leporati D Catellani M Suman R Andreoli P Manini WMA Niessen 2005 Application of a liquid chromatography tandem mass spectrometry method to the analysis of water-soluble vitamins in Italian pasta Anal Chim Acta 531 1 87 95 10.1016/j.aca.2004.10.006 1:CAS:528:DC%2BD2MXhs1ahsbo%3D (Pubitemid 40255176)
15. JDM Patring JA Jastrebova 2007 Application of liquid chromatography- electrospray ionisation mass spectrometry for determination of dietary folates: Effects of buffer nature and mobile phase composition on sensitivity and selectivity J Chromatogr A 1143 1-2 72 82 10.1016/j.chroma.2006.12.079 1:CAS:528:DC%2BD2sXhs1Chtr0%3D (Pubitemid 46209100)
16. RM Kok DEC Smith JR Dainty JT Van Den Akker PM Finglas YM Smulders, et al. 2004 5-Methyltetrahydrofolic acid and folic acid measured in plasma with liquid chromatography tandem mass spectrometry: applications to folate absorption and metabolism Anal Biochem 326 2 129 138 10.1016/j.ab.2003.12.003 1:CAS:528:DC%2BD2cXhslegtL0%3D (Pubitemid 38293375)
17. M Rychlik 2004 Revised folate content of foods determined by stable isotope dilution assays J Food Compos Anal 17 3-4 475 483 10.1016/j.jfca.2004. 03.017 1:CAS:528:DC%2BD2cXksVanurc%3D (Pubitemid 38796428)
18. J Patring M Wandel M Jägerstad W Frølich 2009 Folate content of Norwegian and Swedish flours and bread analysed by use of liquid chromatography-mass spectrometry J Food Compos Anal 22 7-8 649 656 10.1016/j.jfca.2009.02.007 1:CAS:528:DC%2BD1MXhtlGjt7%2FL
19. CM Pfeiffer LM Rogers JF Gregory III 1997 Determination of folate in cereal-grain food products using trienzyme extraction and combined affinity and reversed-phase liquid chromatography J Agric Food Chem 45 2 407 413 10.1021/jf960633q 1:CAS:528:DyaK2sXmvFGlsA%3D%3D (Pubitemid 127485943)
20. GF Zhang KE Maudens S Storozhenko KA Mortier D Van Der Straeten WE Lambert 2003 Determination of total folate in plant material by chemical conversion into para-aminobenzoic acid followed by high performance liquid chromatography combined with on-line postcolumn derivatization and fluorescence detection J Agric Food Chem 51 27 7872 7878 10.1021/jf034808p 1:CAS:528:DC%2BD3sXptlKjs7k%3D
21. Nielsen AC (2008) Special report on top brands
22. E Yazynina M Johansson M Jägerstad J Jastrebova 2008 Low folate content in gluten-free cereal products and their main ingredients Food Chem 111 1 236 242 10.1016/j.foodchem.2008.03.055 1:CAS:528:DC%2BD1cXmt1arurs%3D
23. Hibbert G (2006) Data analysis for chemistry. Oxford University Press, New York
24. ES Osseyi RL Wehling JA Albrecht 2001 HPLC determination of stability and distribution of added folic acid and some endogenous folates during breadmaking Cereal Chem 78 4 375 378 10.1094/CCHEM.2001.78.4.375 1:CAS:528: DC%2BD3MXlsVaqsLw%3D (Pubitemid 32643261)
25. E Gujska K Majewska 2005 Effect of baking process on added folic acid and endogenous folates stability in wheat and rye breads Plant Foods Hum Nutr 60 2 37 42 10.1007/s11130-005-5097-0 1:CAS:528:DC%2BD2MXmtVSntr0%3D (Pubitemid 40968358)
26. V Öhrvik H Öhrvik J Tallkvist C Witthöft 2010 Folates in bread: retention during bread-making and in vitro bioaccessibility Eur J Nutr 49 6 365 372 10.1007/s00394-010-0094-y
27. WA Anderson D Slaughter C Laffey C Lardner 2010 Reduction of folic acid during baking and implications for mandatory fortification of bread Int J Food Sci Technol 45 6 1104 1110 10.1111/j.1365-2621.2010.02226.x 1:CAS:528: DC%2BC3cXntlKhsb4%3D
28. JI Rader CM Weaver G Angyal 2000 Total folate in enriched cereal-grain products in the United States following fortification Food Chem 70 3 275 289 10.1016/S0308-8146(00)00116-3 1:CAS:528:DC%2BD3cXkslShsLo%3D (Pubitemid 30421102)
29. FSANZ (2006) Draft assessment report proposal P295 consideration of mandatory fortification with folic acid. FSANZ, Canberra
30. J Alaburda AP de Almeida L Shundo V Ruvieri M Sabino 2008 Determination of folic acid in fortified wheat flours J Food Compos Anal 21 4 336 342 10.1016/j.jfca.2007.12.002 1:CAS:528:DC%2BD1cXlslygtbk%3D
31. P Whittaker PR Tufaro JI Rader 2001 Iron and folate in fortified cereals J Am Coll Nutr 20 3 247 254 1:CAS:528:DC%2BD3MXlt1ylurc%3D (Pubitemid 32606172)
32. D Kea 2008 Nutritional value of bread J Cer Sci 48 243 257 10.1016/j.jcs.2008.01.003
33. YA Shakur C Rogenstein B Hartman-Craven V Tarasuk DL O'Connor 2009 How much folate is in canadian fortified products 10 years after mandated fortification? Can J Public Health 100 4 281 284
34. M Lucock 2000 Folic acid: nutritional biochemistry, molecular biology, and role in disease processes Mol Genet Metab 71 1-2 121 138 10.1006/mgme.2000.3027 1:CAS:528:DC%2BD3cXms1yjsLY%3D
35. PM Finglas CM Witthöft L Vahteristo AJA Wright S Southon FA Mellon, et al. 2002 Use of an oral/intravenous dual-label stable-isotope protocol to determine folic acid bioavailability from fortified cereal grain foods in women J Nutr 132 5 936 939 1:CAS:528:DC%2BD38XjvFSnsL0%3D (Pubitemid 34493556)
36. CM Pfeiffer Z Fazili L McCoy M Zhang EW Gunter 2004 Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and microbiologic assay Clin Chem 50 2 423 432 10.1373/clinchem.2003.026955 1:CAS:528:DC%2BD2cXhtFKktbs%3D (Pubitemid 38156385)