Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

European Journal of Neuroscience

Volumn 29, Issue 6, 2009, Pages 1119-1130

  Guo, Huang ^a   Singh, Itender ^a   Wang, Yaoming ^a   Deane, Rashid ^a   Barrett, Theresa ^a   Fernández, José A ^b   Chow, Nienwen ^c   Griffin, John H ^b   Zlokovic, Berislav V ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c ZZ Biotech Research Laboratory   (United States)

Author keywords

Endothelial injury; Endothelial protein C receptor; Neuronal injury; Permanent ischemic injury; Protease activated receptor; Protein C mutant

Indexed keywords

3K3A ACTIVATED PROTEIN C; ACTIVATED PROTEIN C; CASPASE 3; CASPASE 9; DROTRECOGIN; ENDOTHELIAL PROTEIN C RECEPTOR; GLUCOSE; HEMOGLOBIN; N METHYL DEXTRO ASPARTIC ACID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; C57BL 6 MOUSE; CELL PROTECTION; CONTROLLED STUDY; CONVALESCENCE; DEGENERATIVE DISEASE; DRUG EFFICACY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; EXCITOTOXICITY; FEMALE; FUNCTIONAL ASSESSMENT; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEURAL STEM CELL; NEUROPROTECTION; NEWBORN; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; STROKE; TREATMENT DURATION; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; ANTIBODIES; ANTICOAGULANTS; APOPTOSIS; BRAIN; CASPASE 3; CASPASE 9; CELLS, CULTURED; EMBRYO, MAMMALIAN; ENDOTHELIAL CELLS; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; FEMALE; GLUCOSE; HEMOGLOBINS; HUMANS; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; PREGNANCY; PROTEIN C; RECEPTORS, PROTEINASE-ACTIVATED; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 61849178125     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2009.06664.x     Document Type: Article

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