Factor VIIa binding to endothelial cell protein C receptor

Thrombosis Research

Volumn 122, Issue SUPPL.1, 2008, Pages

  Rao, L Vijaya Mohan ^a   Pendurthi, Usha R ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

Endothelial cell protein C receptor; Endothelium; Factor VIIa

Indexed keywords

BLOOD CLOTTING FACTOR 7A; ENDOTHELIAL CELL PROTEIN C RECEPTOR; RECEPTOR;

ENDOTHELIUM CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW;

ANTICOAGULANTS; BLOOD COAGULATION FACTORS; CELLS, CULTURED; COAGULANTS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FACTOR VIIA; HUMANS; PROTEIN C; RECEPTORS, CELL SURFACE; UMBILICAL VEINS;

EID: 48449097568     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(08)70009-4     Document Type: Review

References (18)

1. Rodgers G.M., Broze Jr. G.J., and Shuman M.A. The number of receptors for factor VII correlates with the ability of cultured cells to initiate coagulation. Blood 63 (1984) 434-438
2. Reuning U., Preissner K.T., and Muller-Berghaus G. Two independent binding sites on monolayers of human umbilical vein endothelial cells are responsible for interaction with coagulation factor VII and factor VIIa. Thromb Haemost 69 (1993) 197-204
3. Ghosh S., Pendurthi U.R., Esmon C.T., and Rao L.V. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem 282 (2007) 11849-11857
4. Regan L.M., Stearns-Kurosawa D.J., Kurosawa S., Mollica J., Fukudome K., and Esmon C.T. The endothelial cell protein C receptor. J Biol Chem 271 (1996) 17499-17503
5. Laszik Z., Mitro A., Taylor Jr. F.B., Ferrell G., and Esmon C.T. Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. Circulation 96 (1997) 3633-3640
6. Galligan L., Livingstone W., Volkov Y., Hokamp K., Murphy C., Lawler M., et al. Characterization of protein C receptor expression in monocytes. Br J Haematol 115 (2001) 408-414
7. Balazs A.B., Fabian A.J., Esmon C.T., and Mulligan R.C. Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. Blood 107 (2006) 2317-2321
8. Stearns-Kurosawa D.J., Kurosawa S., Mollica J.S., Ferrell G.L., and Esmon C.T. The endothelial cell protein C receptor augments protein C activation by the thrombin thrombomodulin complex. Proc Natl Acad Sci USA 93 (1996) 10212-10216
9. Esmon C.T. Structure and functions of the endothelial cell protein C receptor. Crit Care Med 32 (2004) S298-S301
10. Riewald M., Petrovan R.J., Donner A., Mueller B.M., and Ruf W. Activation of endothelial cell protease activated receptor 1 by protein C pathway. Science 296 (2002) 1880-1882
11. Joyce D.E., Gelbert L., Ciaccia A., Dehoff B., and Grinnell B.W. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 276 (2001) 11199-11203
12. Cheng T., Liu D., Griffin J.H., Fernandez J.A., Castellino F., Rosen E.D., et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 9 (2003) 338-342
13. Feistritzer C., and Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 105 (2005) 3178-3184
14. Fukudome K., and Esmon C.T. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 269 (1994) 26486-26491
15. Preston R.J., Ajzner E., Razzari C., Karageorgi S., Dua S., Dahlback B., et al. Multifunctional specificity of the protein C/activated protein C Gla domain. J Biol Chem 281 (2006) 28850-28857
16. Liaw P.C., Mather T., Oganesyan N., Ferrell G.L., and Esmon C.T. Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor. J Biol Chem 276 (2001) 8364-8370
17. Lopez-Sagaseta J., Montes R., Puy C., Diez N., Fukudome K., and Hermida J. Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity. J Thromb Haemost 5 (2007) 1817-1824
18. Bae J.S., Yang L., Manithody C., and Rezaie A.R. The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood 110 (2007) 3909-3916