-
1
-
-
0043003388
-
The discovery of activated protein C resistance
-
Dahlbäck B: The discovery of activated protein C resistance. J Thromb Haemost 2003, 1:3-9. An historical account of the APC resistance issue from the privileged viewpoint of the protagonist.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 3-9
-
-
Dahlbäck, B.1
-
2
-
-
0036124011
-
Factor V and thrombotic disease: Description of a janus-faced protein
-
Nicolaes GA, Dahlbäck B: Factor V and thrombotic disease: description of a janus-faced protein. Arterioscler Thromb Vasc Biol 2002, 22:530-538.
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 530-538
-
-
Nicolaes, G.A.1
Dahlbäck, B.2
-
3
-
-
0027446268
-
Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C
-
Dahlbäck B, Carlsson M, Svensson PJ: Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 1993, 90:1004-1008.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 1004-1008
-
-
Dahlbäck, B.1
Carlsson, M.2
Svensson, P.J.3
-
4
-
-
0028098218
-
Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V
-
Dahlbäck B, Hildebrand B: Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Natl Acad Sci U S A 1994, 91:1396-1400.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 1396-1400
-
-
Dahlbäck, B.1
Hildebrand, B.2
-
5
-
-
0028314865
-
Mutation in blood coagulation factor V associated with resistance to activated protein C
-
Bertina RM, Koeleman BP, Koster T, et al.: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994, 369:64-67.
-
(1994)
Nature
, vol.369
, pp. 64-67
-
-
Bertina, R.M.1
Koeleman, B.P.2
Koster, T.3
-
6
-
-
0028291210
-
Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis
-
Zöller B, Dahlbäck B: Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet 1994, 343:1536-1538.
-
(1994)
Lancet
, vol.343
, pp. 1536-1538
-
-
Zöller, B.1
Dahlbäck, B.2
-
7
-
-
0028290275
-
Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa
-
Shen L, Dahlbäck B: Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa. J Biol Chem 1994, 269:18735-18738.
-
(1994)
J Biol Chem
, vol.269
, pp. 18735-18738
-
-
Shen, L.1
Dahlbäck, B.2
-
9
-
-
0029117033
-
A chromogenic assay for activated protein C resistance
-
Váradi K, Moritz B, Lang H, et al.: A chromogenic assay for activated protein C resistance. Br J Haematol 1995, 90:884-891.
-
(1995)
Br J Haematol
, vol.90
, pp. 884-891
-
-
Váradi, K.1
Moritz, B.2
Lang, H.3
-
10
-
-
0033561431
-
Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V
-
Thorelli E, Kaufman RJ, Dahlbäck B: Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V. Blood 1999, 93:2552-2558.
-
(1999)
Blood
, vol.93
, pp. 2552-2558
-
-
Thorelli, E.1
Kaufman, R.J.2
Dahlbäck, B.3
-
11
-
-
0029133654
-
Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C
-
Nicolaes GA, Tans G, Thomassen MC, et al.: Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995, 270:21158-21166.
-
(1995)
J Biol Chem
, vol.270
, pp. 21158-21166
-
-
Nicolaes, G.A.1
Tans, G.2
Thomassen, M.C.3
-
12
-
-
0028939318
-
Characterization of the molecular defect in factor VR506Q
-
Kalafatis M, Bertina RM, Rand MD, et al.: Characterization of the molecular defect in factor VR506Q. J Biol Chem 1995, 270:4053-4057.
-
(1995)
J Biol Chem
, vol.270
, pp. 4053-4057
-
-
Kalafatis, M.1
Bertina, R.M.2
Rand, M.D.3
-
13
-
-
0028810678
-
Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C
-
Rosing J, Hoekema L, Nicolaes GA, et al.: Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995, 270:27852-27858.
-
(1995)
J Biol Chem
, vol.270
, pp. 27852-27858
-
-
Rosing, J.1
Hoekema, L.2
Nicolaes, G.A.3
-
14
-
-
0029048665
-
Activated protein C resistance: Molecular mechanisms based on studies using purified Gln506-factor V
-
Heeb MJ, Kojima Y, Greengard JS, et al.: Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V. Blood 1995, 85:3405-3411.
-
(1995)
Blood
, vol.85
, pp. 3405-3411
-
-
Heeb, M.J.1
Kojima, Y.2
Greengard, J.S.3
-
15
-
-
2542486395
-
Impaired APC-cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations
-
in press
-
Castoldi E, Brugge JM, Nicolaes GA, et al.: Impaired APC-cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations. Blood 2004, 103:in press. The role of the APC-cofactor activity of FV in APC resistance and in the regulation of thrombin generation in plasma is inferred from quantitative and functional FV defects: the first convincing evidence for the crucial pathophysiologic relevance of the anticoagulant activity of FV.
-
(2004)
Blood
, vol.103
-
-
Castoldi, E.1
Brugge, J.M.2
Nicolaes, G.A.3
-
16
-
-
0027986709
-
Homozygous factor V-deficient patients show resistance to activated protein C whereas heterozygotes do not
-
Simioni P, Girolami A: Homozygous factor V-deficient patients show resistance to activated protein C whereas heterozygotes do not. Blood Coagul Fibrinolysis 1994, 5:825-827.
-
(1994)
Blood Coagul Fibrinolysis
, vol.5
, pp. 825-827
-
-
Simioni, P.1
Girolami, A.2
-
17
-
-
0036624891
-
Isolation and characterization of an anti-factor V antibody causing activated protein C resistance from a patient with severe thrombotic manifestations
-
Kalafatis M, Simioni P, Tormene D, et al.: Isolation and characterization of an anti-factor V antibody causing activated protein C resistance from a patient with severe thrombotic manifestations. Blood 2002, 99:3985-3992.
-
(2002)
Blood
, vol.99
, pp. 3985-3992
-
-
Kalafatis, M.1
Simioni, P.2
Tormene, D.3
-
18
-
-
0028793802
-
Lowered APC-sensitivity ratio related to increased factor VIII-clotting activity
-
Henkens CM, Bom VJ, van der Meer J: Lowered APC-sensitivity ratio related to increased factor VIII-clotting activity. Thromb Haemost 1995, 74:1198-1199.
-
(1995)
Thromb Haemost
, vol.74
, pp. 1198-1199
-
-
Henkens, C.M.1
Bom, V.J.2
Van Der Meer, J.3
-
19
-
-
0030453523
-
The influence of factor VIII on measurement of activated protein C resistance
-
Laffan MA, Manning R: The influence of factor VIII on measurement of activated protein C resistance. Blood Coagul Fibrinolysis 1996, 7:761-765.
-
(1996)
Blood Coagul Fibrinolysis
, vol.7
, pp. 761-765
-
-
Laffan, M.A.1
Manning, R.2
-
20
-
-
0031888019
-
Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: Implications for the APC resistance test
-
Amano K, Michnick DA, Moussalli M, et al.: Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test. Thromb Haemost 1998, 79:557-563.
-
(1998)
Thromb Haemost
, vol.79
, pp. 557-563
-
-
Amano, K.1
Michnick, D.A.2
Moussalli, M.3
-
21
-
-
0029085314
-
Thrombin generation in plasma: Its assessment via the endogenous thrombin potential
-
Hemker HC, Béguin S: Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemost 1995, 74:134-138.
-
(1995)
Thromb Haemost
, vol.74
, pp. 134-138
-
-
Hemker, H.C.1
Béguin, S.2
-
22
-
-
0029872862
-
"Pseudo homozygous" activated protein C resistance due to double heterozygous factor V defects (factor V Leiden mutation and type I quantitative factor V defect) associated with thrombosis: Report of two cases belonging to two unrelated kindreds
-
Simioni P, Scudeller A, Radossi P, et al.: "Pseudo homozygous" activated protein C resistance due to double heterozygous factor V defects (factor V Leiden mutation and type I quantitative factor V defect) associated with thrombosis: report of two cases belonging to two unrelated kindreds. Thromb Haemost 1996, 75:422-426.
-
(1996)
Thromb Haemost
, vol.75
, pp. 422-426
-
-
Simioni, P.1
Scudeller, A.2
Radossi, P.3
-
23
-
-
0031757205
-
Molecular bases of pseudo-homozygous APC resistance: The compound heterozygosity for FV R506Q and a FV null mutation results in the exclusive presence of FV Leiden molecules in plasma
-
Castoldi E, Kalafatis M, Lunghi B, et al.: Molecular bases of pseudo-homozygous APC resistance: the compound heterozygosity for FV R506Q and a FV null mutation results in the exclusive presence of FV Leiden molecules in plasma. Thromb Haemost 1998, 80:403-406.
-
(1998)
Thromb Haemost
, vol.80
, pp. 403-406
-
-
Castoldi, E.1
Kalafatis, M.2
Lunghi, B.3
-
24
-
-
2542469165
-
The factor V Leiden mutation results in the in vivo loss of a critical FV anticoagulant function
-
Westrick RJ, Sun H, Eitzman DT, et al.: The factor V Leiden mutation results in the in vivo loss of a critical FV anticoagulant function [abstract]. Blood 2002, 100:127a.
-
(2002)
Blood
, vol.100
-
-
Westrick, R.J.1
Sun, H.2
Eitzman, D.T.3
-
25
-
-
18244417756
-
Molecular recognition in the protein C anticoagulant pathway
-
Dahlbäck B, Villoutreix BO: Molecular recognition in the protein C anticoagulant pathway. J Thromb Haemost 2003, 1:1525-1534.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 1525-1534
-
-
Dahlbäck, B.1
Villoutreix, B.O.2
-
26
-
-
0029941850
-
Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V
-
Lu D, Kalafatis M, Mann KG, et al.: Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V. Blood 1996, 87:4708-4717.
-
(1996)
Blood
, vol.87
, pp. 4708-4717
-
-
Lu, D.1
Kalafatis, M.2
Mann, K.G.3
-
27
-
-
0032569021
-
The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V
-
Thorelli E, Kaufman RJ, Dahlbäck B: The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V. J Biol Chem 1998, 273:16140-16145.
-
(1998)
J Biol Chem
, vol.273
, pp. 16140-16145
-
-
Thorelli, E.1
Kaufman, R.J.2
Dahlbäck, B.3
-
28
-
-
0028110027
-
The mechanism of inactivation of human factor V and human factor Va by activated protein C
-
Kalafatis M, Rand MD, Mann KG: The mechanism of inactivation of human factor V and human factor Va by activated protein C. J Biol Chem 1994, 269:31869-31880.
-
(1994)
J Biol Chem
, vol.269
, pp. 31869-31880
-
-
Kalafatis, M.1
Rand, M.D.2
Mann, K.G.3
-
29
-
-
0027442867
-
Characterization of two forms of human factor Va with different cofactor activities
-
Rosing J, Bakker HM, Thomassen MC, et al.: Characterization of two forms of human factor Va with different cofactor activities. J Biol Chem 1993, 268:21130-21136.
-
(1993)
J Biol Chem
, vol.268
, pp. 21130-21136
-
-
Rosing, J.1
Bakker, H.M.2
Thomassen, M.C.3
-
31
-
-
0030860494
-
A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype
-
Bernardi F, Faioni EM, Castoldi E, et al.: A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype. Blood 1997, 90:1552-1557.
-
(1997)
Blood
, vol.90
, pp. 1552-1557
-
-
Bernardi, F.1
Faioni, E.M.2
Castoldi, E.3
-
32
-
-
0034058126
-
Mutations in the R2 FV gene affect the ratio between the two FV isoforms in plasma
-
Castoldi E, Rosing J, Girelli D, et al.: Mutations in the R2 FV gene affect the ratio between the two FV isoforms in plasma. Thromb Haemost 2000, 83:362-365.
-
(2000)
Thromb Haemost
, vol.83
, pp. 362-365
-
-
Castoldi, E.1
Rosing, J.2
Girelli, D.3
-
33
-
-
0035172615
-
Functional properties of factor V and factor Va encoded by the R2-gene
-
Hoekema L, Castoldi E, Tans G, et al.: Functional properties of factor V and factor Va encoded by the R2-gene. Thromb Haemost 2001, 85:75-81.
-
(2001)
Thromb Haemost
, vol.85
, pp. 75-81
-
-
Hoekema, L.1
Castoldi, E.2
Tans, G.3
-
34
-
-
9044228783
-
Detection of new polymorphic markers in the factor V gene: Association with factor V levels in plasma
-
Lunghi B, Iacoviello L, Gemmati D, et al.: Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma. Thromb Haemost 1996, 75:45-48.
-
(1996)
Thromb Haemost
, vol.75
, pp. 45-48
-
-
Lunghi, B.1
Iacoviello, L.2
Gemmati, D.3
-
35
-
-
0033059973
-
The factor V gene A4070G mutation and the risk of venous thrombosis
-
Alhenc-Gelas M, Nicaud V, Gandrille S, et al.: The factor V gene A4070G mutation and the risk of venous thrombosis. Thromb Haemost 1999, 81:193-197.
-
(1999)
Thromb Haemost
, vol.81
, pp. 193-197
-
-
Alhenc-Gelas, M.1
Nicaud, V.2
Gandrille, S.3
-
36
-
-
0034127421
-
The HR2 haplotype of factor V: Effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis
-
de Visser MC, Guasch JF, Kamphuisen PW, et al.: The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis. Thromb Haemost 2000, 83:577-582.
-
(2000)
Thromb Haemost
, vol.83
, pp. 577-582
-
-
De Visser, M.C.1
Guasch, J.F.2
Kamphuisen, P.W.3
-
37
-
-
0032520041
-
Factor V Cambridge: A new mutation (Arg306→Thr) associated with resistance to activated protein C
-
Williamson D, Brown K, Luddington R, et al.: Factor V Cambridge: a new mutation (Arg306→Thr) associated with resistance to activated protein C. Blood 1998, 91:1140-1144.
-
(1998)
Blood
, vol.91
, pp. 1140-1144
-
-
Williamson, D.1
Brown, K.2
Luddington, R.3
-
38
-
-
0032520034
-
A novel mutation of Arg306 of factor V gene in Hong Kong Chinese
-
Chan WP, Lee CK, Kwong YL, et al.: A novel mutation of Arg306 of factor V gene in Hong Kong Chinese. Blood 1998, 91:1135-1139.
-
(1998)
Blood
, vol.91
, pp. 1135-1139
-
-
Chan, W.P.1
Lee, C.K.2
Kwong, Y.L.3
-
39
-
-
0037100417
-
Functional characterization of recombinant FV Hong Kong and FV Cambridge
-
Norstrøm E, Thorelli E, Dahlbäck B: Functional characterization of recombinant FV Hong Kong and FV Cambridge. Blood 2002, 100:524-530.
-
(2002)
Blood
, vol.100
, pp. 524-530
-
-
Norstrøm, E.1
Thorelli, E.2
Dahlbäck, B.3
-
40
-
-
0036526619
-
The activated protein C (APC)-resistant phenotype of APC cleavage site mutants of recombinant factor V in a reconstituted plasma model
-
van der Neut Kolfschoten M, Dirven RJ, Tans G: et al.: The activated protein C (APC)-resistant phenotype of APC cleavage site mutants of recombinant factor V in a reconstituted plasma model. Blood Coagul Fibrinolysis 2002, 13:207-215.
-
(2002)
Blood Coagul Fibrinolysis
, vol.13
, pp. 207-215
-
-
Van Der Neut Kolfschoten, M.1
Dirven, R.J.2
Tans, G.3
-
41
-
-
1942425200
-
Functional characterization of Factor V-Ile359Thr: A novel mutation associated with thrombosis
-
Steen M, Norstrøm EA, Tholander AL, et al.: Functional characterization of Factor V-Ile359Thr: a novel mutation associated with thrombosis. Blood 2004, 103:3381-3387.
-
(2004)
Blood
, vol.103
, pp. 3381-3387
-
-
Steen, M.1
Norstrøm, E.A.2
Tholander, A.L.3
-
42
-
-
0033557951
-
A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis
-
de Visser MC, Rosendaal FR, Bertina RM: A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis. Blood 1999, 93:1271-1276.
-
(1999)
Blood
, vol.93
, pp. 1271-1276
-
-
De Visser, M.C.1
Rosendaal, F.R.2
Bertina, R.M.3
-
43
-
-
0033693676
-
Phenotyping the clotting system
-
Hemker HC, Béguin S: Phenotyping the clotting system. Thromb Haemost 2000, 84:747-751.
-
(2000)
Thromb Haemost
, vol.84
, pp. 747-751
-
-
Hemker, H.C.1
Béguin, S.2
-
44
-
-
0026708655
-
Characterization of the interaction between the A2 subunit and A1/A3-C1-C2 dimer in human factor VIIIa
-
Fay PJ, Smudzin TM: Characterization of the interaction between the A2 subunit and A1/A3-C1-C2 dimer in human factor VIIIa. J Biol Chem 1992, 267:13246-13250.
-
(1992)
J Biol Chem
, vol.267
, pp. 13246-13250
-
-
Fay, P.J.1
Smudzin, T.M.2
|