Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies

Biochemistry

Volumn 50, Issue 36, 2011, Pages 7765-7773

  Bates, Darcy J P ^a,c   Smitherman, Pamela K ^a   Townsend, Alan J ^a   King, S Bruce ^b   Morrow, Charles S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST UNIVERSITY   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDUCT FORMATION; CELLULAR RESPONSE; CONCENTRATION-DEPENDENT; DIRECT ACTIVATION; ELECTROPHILIC ACTIVATION; IN-VIVO; INHIBITORY PROTEINS; LINOLEIC; MCF-7 BREAST CANCER CELLS; NA CONCENTRATION; NANOMOLAR CONCENTRATION; NATURALLY OCCURRING; SIGNALING PATHWAYS; TRANSCRIPTIONAL PROGRAM;

ISOMERS; LINOLEIC ACID; NITROGEN OXIDES; SIGNALING; TRANSCRIPTION;

CHEMICAL ACTIVATION;

ELECTROPHILE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LINOLEIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; NITROALKENE FATTY ACID; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN MCF 7; ENZYME INDUCTION; FATTY ACID SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ALKENES; CELL LINE, TUMOR; HUMANS; LINOLEIC ACIDS; MAP KINASE KINASE 4; NF-E2-RELATED FACTOR 2; OLEIC ACIDS; PPAR GAMMA; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 80052488518     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2005784     Document Type: Article

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