Nanocarriers: A tool to overcome biological barriers in siRNA delivery

Expert Opinion on Biological Therapy

Volumn 11, Issue 10, 2011, Pages 1327-1339

  Kumari, Avnesh ^a   Kumar, Vineet ^a   Yadav, Sudesh Kumar ^a  

^a CSIR INSTITUTE OF HIMALAYAN BIORESOURCE TECHNOLOGY   (India)

Author keywords

Conjugation; Encapsulation; Nanocarriers; SiRNA

Indexed keywords

CARBON NANOTUBE; COPOLYMER; DENDRIMER; DOXORUBICIN; NANOCARRIER; NANOPARTICLE; QUANTUM DOT; SMALL INTERFERING RNA; SOLID LIPID NANOPARTICLE;

DRUG BINDING; DRUG CONJUGATION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; IN VIVO STUDY; NANOENCAPSULATION; REVIEW;

ANIMALS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GENE TRANSFER TECHNIQUES; HUMANS; NANOPARTICLES; RNA, SMALL INTERFERING;

EID: 80052481485     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2011.587801     Document Type: Review

References (77)

1. Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 2003;11:457-67 (Pubitemid 36648591)
2. Huang C, Li M, Chen C, Yao Q. Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications. Expert Opin Ther Targets 2008;12:637-45 (Pubitemid 351699481)
3. Cheng K, Mahato RI. siRNA delivery and targeting. Mol Pharm 2009;6:649-50
4. Jeong JH, Kim SW, Park TG. Molecular design of functional polymers for gene therapy. Prog Polym Sci 2007;32:1239-74 (Pubitemid 47513188)
5. Behlke MA. Progress towards in vivo use of siRNAs. Mol Ther 2006;13:644-70
6. Wang XL, Xu R, Wu X, et al. Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice. Mol Pharm 2009;6:738-46
7. Aagaard L, Rossi JJ. RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev 2007;59:75-86 (Pubitemid 46770900)
8. Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature 2003;422:37-44 (Pubitemid 36323287)
9. Panyam J, Zhou WZ, Prabha S, et al. Rapid endo-lysosomal escape of poly (DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery. Faseb J 2002;16:1217-26 (Pubitemid 34815409)
10. Vasir JK, Reddy MK, Labhasetwar VD. Nanosystems in drug targeting: opportunities and challenges. Current Nanoscience 2005;1:47-64
11. Chakraborty C. Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing. Curr Drug Targets 2007;8:469-82 (Pubitemid 46381297)
12. Wilson JA, Richardson CD. Future promise of siRNA and other nucleic acid based therapeutics for the treatment of chronic HCV. Infect Disord Drug Targets 2006;6:43-56 (Pubitemid 43796635)
13. Storvold GL, Andersen TI, Perou CM, et al. siRNA: a potential tool for future breast cancer therapy? Crit Rev Oncog 2006;12:127-50 (Pubitemid 44492226)
14. Khaled A, Guo S, Li F, Guo P. Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology. Nano Lett 2005;5:1797-08 (Pubitemid 41396168)
15. Blackburn WH, Dickerson EB, Smith MH, et al. Peptide-functionalized nanogels for targeted siRNA delivery. Bioconjug Chem 2009;20:960-8
16. Sinha R, Kim GJ, Nie S, Shin DM. Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 2006;5:1909-17 (Pubitemid 44336561)
17. Ikeda Y, Taira K. Ligand-targeted delivery of therapeutic siRNA. Pharm Res 2006;23:1631-40 (Pubitemid 44200525)
18. Davis ME. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Mol Pharm 2009;6:659-68
19. Zhang S, Zhao B, Jiang H, et al. Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release 2007;123:1-10 (Pubitemid 47444388)
20. Neu M, Fischer D, Kissel T. Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. J Gene Med 2005;7:992-1009 (Pubitemid 41195062)
21. Gao K, Huang L. Nonviral methods for siRNA delivery. Mol Pharm 2009;6:651-8
22. Gary DJ, Puri N, Won YY. Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery. J Control Release 2007;121:64-73 (Pubitemid 47126065)
23. Dash PR, Read ML, Barrett LB, et al. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery. Gene Ther 1999;6:643-50 (Pubitemid 29192673)
24. Davis ME, Zuckerman JE, Choi CHJ, et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010;464:1067-70
25. Vornlocher H-P. Antibody-directed cell-type-specific delivery of siRNA. Trends Mol Med 2006;12:1-3 (Pubitemid 43089648)
26. Elbakry A, Zaky A, Liebl R, et al. Layer-by-layer assembled gold nanoparticles for siRNA delivery. Nano Lett 2009;9:2059-64
27. Juliano R, Bauman J, Kang H, Ming X. Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol Pharm 2009;6:686-95
28. Kim SH, Jeong JH, Lee SH, et al. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J Control Release 2008;129:107-16
29. Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 2010;75:1-18
30. Baigude H, Rana TM. Delivery of therapeutic RNAi by nanovehicles. Chembiochem 2009;10:2449-54
31. Yezhelyev MV, Qi L, O'Regan RM, et al. Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging. J Am Chem Soc 2008;130:9006-12 (Pubitemid 352000838)
32. Buyens K, Demeester J, De Smedt SS, Sanders NN. Elucidating the encapsulation of short interfering RNA in PEGylated cationic liposomes. Langmuir 2009;25:4886-91
33. Jeong JH, Mok H, Oh YK, Park TG. siRNA conjugate delivery systems. Bioconjug Chem 2009;20:5-14
34. Kam NW, Liu Z, Dai H. Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J Am Chem Soc 2005;127:12492-3 (Pubitemid 41292159)
35. Derfus AM, Chen AA, Min DH, et al. Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem 2007;18:1391-6 (Pubitemid 47464045)
36. Hermanson GT. Heterobifunctional crosslinkers. In: Bioconjugate techniques, Illinois, USA: Elsevier; 2008
37. Giljohann DA, Seferos DS, Prigodich AE, et al. Gene regulation with polyvalent siRNA-nanoparticle conjugates. J Am Chem Soc 2009;131:2072-3
38. Medarova Z, Pham W, Farrar C, et al. In vivo imaging of siRNA delivery and silencing in tumors. Nat Med 2007;13:372-7 (Pubitemid 46376679)
39. Xia CF, Zhang Y, Zhang Y, et al. Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology. Pharm Res 2007;24:2309-16 (Pubitemid 350060723)
40. Wu D, Pardridge WM. Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system. J Pharmacol Exp Ther 1996;279:77-83 (Pubitemid 27166896)
41. Akhtar S, Benter IF. Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest 2007;117:3623-32 (Pubitemid 350224068)
42. Kim SH, Jeong JH, Lee SH, et al. LHRH receptor-mediated delivery of siRNA using polyelectrolyte complex micelles self-assembled from siRNA-PEG-LHRH conjugate and PEI. Bioconjug Chem 2008;19:2156-62
43. Daniel MC, Astruc D. Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 2004;104:293-346
44. Shukla R, Bansal V, Chaudhary M, et al. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 2005;21:10644-54 (Pubitemid 41692144)
45. Lee JS, Green JJ, Love KT, et al. Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett 2009;9:2402-6
46. Kim HR, Kim IK, Bae KH, et al. Cationic solid lipid nanoparticles reconstituted from low density lipoprotein components for delivery of siRNA. Mol Pharm 2008;5(4):622-31
47. Bouclier C, Moine L, Hillaireau H, et al. Physicochemical characteristics and preliminary in vivo biological evaluation of nanocapsules loaded with siRNA targeting estrogen receptor alpha. Biomacromolecules 2008;9:2881-90
48. Li SD, Huang L. Surface-modified LPD nanoparticles for tumor targeting. Ann N Y Acad Sci 2006;1082:1-8 (Pubitemid 44955442)
49. Xu Y, Szoka FC Jr. Mechanism of DNA release from cationic liposome/ DNA complexes used in cell transfection. Biochemistry 1996;35:5616-23 (Pubitemid 26143656)
50. Li SD, Huang L. Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Mol Pharm 2006;3:579-88 (Pubitemid 44639135)
51. Akerman ME, Chan WC, Laakkonen P, et al. Nanocrystal targeting in vivo. Proc Natl Acad Sci USA 2002;99:12617-21
52. Gao X, Cui Y, Levenson RM, et al. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004;22:969-76 (Pubitemid 39014473)
53. Derfus AM, Chan WCW, Bhatia SN. Intracellular delivery of quantumdots for live cell labeling and organelle tracking. Adv Mater 2004;16:961-6
54. Boussif O, Lezoualc'h F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995;92:7297-301
55. Sonawane ND, Szoka FC Jr, Verkman AS. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem 2003;278:44826-31 (Pubitemid 37377241)
56. Bianco A, Kostarelos K, Prato M. Opportunities and challenges of carbon-based nanomaterials for cancer therapy. Expert Opin Drug Deliv 2008;5:331-42 (Pubitemid 351454382)
57. Peer D, Karp JM, Hong S, et al. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007;2:751-60 (Pubitemid 350223348)
58. McCarroll J, Baigude H, Yang CS, Rana TM. Nanotubes functionalized with lipids and natural amino acid dendrimers: a new strategy to create nanomaterials for delivering systemic RNAi. Bioconjug Chem 2009;21:56-63
59. Herrero MA, Toma FM, Al-Jamal KT, et al. Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery. J Am Chem Soc 2009;131:9843-8
60. Liu Z, Winters M, Holodniy M, Dai H. siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. Angew Chem Int Ed Engl 2007;46:2023-7 (Pubitemid 46973660)
61. Liu Z, Tabakman S, Welsher K, Dai H. Carbon Nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery. Nano Res 2009;2:85-120
62. Stanton MG, Colletti SL. Medicinal chemistry of siRNA delivery. J Med Chem 2010;53:7887-901
63. Mendonca LS, Firmino F, Moreira JN, et al. Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloid leukemia treatment. Bioconjug Chem 2010;21:157-68
64. Gillies ER, Frechet JM. Dendrimers and dendritic polymers in drug delivery. Drug Discov Today 2005;10:35-43 (Pubitemid 40164817)
65. Patil ML, Zhang M, Betigeri S, et al. Surface-modified and internally cationic polyamidoamine dendrimers for efficient siRNA delivery. Bioconjug Chem 2008;19:1396-03 (Pubitemid 352032339)
66. Agrawal A, Min DH, Singh N, et al. Functional delivery of siRNA in mice using dendriworms. ACS Nano 2009;3:2495-504
67. Saad M, Garbuzenko OB, Minko T. Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer. Nanomedicine 2008;3:761-76
68. Chen Y, Bathula SR, Li J, Huang L. Multi-functional nanoparticles delivering siRNA and doxorubicin overcome drug resistance in cancer. J Biol Chem 2010;285:22639-50
69. Taratula O, Garbuzenko O, Savla R, et al. Multifunctional nanomedicine platform for cancer specific delivery of siRNA by superparamagnetic iron oxide nanoparticles-dendrimer complexes. Curr Drug Delivery 2011;8:59-69
70. Benoit DSW, Henry SM, Shubin AD, et al. pH-Responsive polymeric siRNA carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of Polo-like Kinase 1. Mol Pharm 2010;7:442-55
71. Huang HY, Kuo WT, Huang YY. Combining gene and chemo therapy using multifunctional polymeric micelles. World Acad Sci Eng Technol 2010;65:1142-5
72. Convertine AJ, Diab C, Prieve M, et al. pH-Responsive polymeric micelle carriers for siRNA drugs. Biomacromolecules 2010;11:2904-11
73. Musacchio T, Vaze O, D'Souza G, Torchilin VP. Effective Stabilization and delivery of siRNA: reversible siRNA-phospholipid conjugate in nanosized mixed polymeric micelles. Bioconjugate Chem 2010;21:1530-6
74. Fattal E, Barratt G. Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA. Br J Pharmacol 2009;157:179-94
75. Tokatlian T, Segura T. siRNA applications in nanomedicine. Nanomed Nanobiotechnol 2010;2:305-15
76. Bartlett DW, Davis ME. Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles. Biotechnol Bioeng 2008;99:975-85 (Pubitemid 351316639)
77. Xia T, Kovochich M, Liong M, et al. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 2009;3:3273-86