메뉴 건너뛰기




Volumn 33, Issue 4, 2011, Pages 586-593

Immunomodulation of experimental allergic encephalomyelitis by cinnamon metabolite sodium benzoate

Author keywords

Adaptive immunity; EAE; Glial activation; Innate immunity; Neuroinflammation; Signal transduction; Sodium benzoate

Indexed keywords

BENZOIC ACID; PROTEIN P21;

EID: 80052454489     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2011.561861     Document Type: Review
Times cited : (37)

References (51)
  • 2
    • 17644444933 scopus 로고    scopus 로고
    • Inflammation and degeneration in multiple sclerosis
    • DOI 10.1007/s10072-003-0170-7
    • Brück, W., Stadelmann, C. Inflammation and degeneration in multiple sclerosis. Neurol Sci 2003, 24 Suppl 5, S265-S267. (Pubitemid 37493197)
    • (2003) Neurological Sciences , vol.24 , Issue.SUPPL. 5
    • Bruck, W.1    Stadelmann, C.2
  • 4
    • 0028840828 scopus 로고
    • Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease
    • Swanborg, R.H. Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clin Immunol Immunopathol 1995, 77, 4-13.
    • (1995) Clin. Immunol. Immunopathol. , vol.77 , pp. 4-13
    • Swanborg, R.H.1
  • 5
    • 0023902649 scopus 로고
    • Myelin proteolipid proteininduced experimental allergic encephalomyelitis variations of disease expression in different strains of mice
    • Tuohy, V.K., Sobel, R.A., Lees, M.B. Myelin proteolipid proteininduced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice. J Immunol 1988, 140, 1868-1873.
    • (1988) J. Immunol. , vol.140 , pp. 1868-1873
    • Tuohy, V.K.1    Sobel, R.A.2    Lees, M.B.3
  • 6
    • 77954563637 scopus 로고    scopus 로고
    • Neuroimmune pharmacological control of EAE
    • Pahan, K. Neuroimmune pharmacological control of EAE. J Neuroimmune Pharmacol 2010, 5, 165-167.
    • (2010) J. Neuroimmune. Pharmacol. , vol.5 , pp. 165-167
    • Pahan, K.1
  • 7
    • 77954563075 scopus 로고    scopus 로고
    • Studies in the modulation of experimental autoimmune encephalomyelitis
    • Libbey, J.E., Tsunoda, I., Fujinami, R.S. Studies in the modulation of experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol 2010, 5, 168-175.
    • (2010) J. Neuroimmune. Pharmacol. , vol.5 , pp. 168-175
    • Libbey, J.E.1    Tsunoda, I.2    Fujinami, R.S.3
  • 9
    • 33745631754 scopus 로고    scopus 로고
    • Antigen presentation in autoimmunity and CNS inflammation: How T lymphocytes recognize the brain
    • DOI 10.1007/s00109-006-0065-1
    • Becher, B., Bechmann, I., Greter, M. Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain. J Mol Med 2006, 84, 532-543. (Pubitemid 43992845)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.7 , pp. 532-543
    • Becher, B.1    Bechmann, I.2    Greter, M.3
  • 10
    • 0021171742 scopus 로고
    • Lack of tumorigenicity of sodium benzoate in mice
    • DOI 10.1016/0272-0590(84)90208-2
    • Toth, B. Lack of tumorigenicity of sodium benzoate in mice. Fundam Appl Toxicol 1984, 4, 494-496. (Pubitemid 14010959)
    • (1984) Fundamental and Applied Toxicology , vol.4 , Issue.3 , pp. 494-496
    • Toth, B.1
  • 12
    • 0026048410 scopus 로고
    • Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans
    • Kubota, K., Ishizaki, T. Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans. Eur J Clin Pharmacol 1991, 41, 363-368.
    • (1991) Eur. J. Clin. Pharmacol. , vol.41 , pp. 363-368
    • Kubota, K.1    Ishizaki, T.2
  • 13
    • 0035125896 scopus 로고    scopus 로고
    • Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L. but not in cell cultures of Centaurium erythraea RAFN
    • DOI 10.1007/s004250000394
    • Abd El-Mawla, A.M., Schmidt, W., Beerhues, L. Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L. but not in cell cultures of Centaurium erythraea RAFN. Planta 2001, 212, 288-293. (Pubitemid 32139886)
    • (2001) Planta , vol.212 , Issue.2 , pp. 288-293
    • El-Mawla, A.M.A.A.1    Schmidt, W.2    Beerhues, L.3
  • 14
    • 78649761056 scopus 로고    scopus 로고
    • Sphingolipids in multiple sclerosis
    • Jana, A., Pahan, K. Sphingolipids in multiple sclerosis. Neuromolecular Med 2010, 12, 351-361.
    • (2010) Neuromolecular. Med. , vol.12 , pp. 351-361
    • Jana, A.1    Pahan, K.2
  • 15
    • 77954563548 scopus 로고    scopus 로고
    • Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    • El-behi, M., Rostami, A., Ciric, B. Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol 2010, 5, 189-197.
    • (2010) J. Neuroimmune. Pharmacol. , vol.5 , pp. 189-197
    • El-behi, M.1    Rostami, A.2    Ciric, B.3
  • 16
    • 80755170378 scopus 로고    scopus 로고
    • Gammadelta T cells and multiple sclerosis: Friends foes or both
    • Dec
    • Chen, Z., Freedman, M.S. Gammadelta T cells and multiple sclerosis: Friends, foes, or both? Autoimmun Rev 2010 Dec 30.
    • (2010) Autoimmun. Rev. , vol.30
    • Chen, Z.1    Freedman, M.S.2
  • 17
    • 34748917549 scopus 로고    scopus 로고
    • Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-α
    • DOI 10.1124/mol.106.033787
    • Dasgupta, S., Roy, A., Jana, M., Hartley, D.M., Pahan, K. Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha. Mol Pharmacol 2007, 72, 934-946. (Pubitemid 47481416)
    • (2007) Molecular Pharmacology , vol.72 , Issue.4 , pp. 934-946
    • Dasgupta, S.1    Roy, A.2    Jana, M.3    Hartley, D.M.4    Pahan, K.5
  • 18
    • 34250809522 scopus 로고    scopus 로고
    • Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis
    • Brahmachari, S., Pahan, K. Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis. J Immunol 2007, 179, 275-283. (Pubitemid 46986543)
    • (2007) Journal of Immunology , vol.179 , Issue.1 , pp. 275-283
    • Brahmachari, S.1    Pahan, K.2
  • 19
    • 77954152480 scopus 로고    scopus 로고
    • Sodium benzoate a metabolite of cinnamon and a food additive reduces microglial and astroglial inflammatory responses
    • Brahmachari, S., Jana, A., Pahan, K. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. J Immunol 2009, 183, 5917-5927.
    • (2009) J. Immunol. , vol.183 , pp. 5917-5927
    • Brahmachari, S.1    Jana, A.2    Pahan, K.3
  • 20
    • 8544265317 scopus 로고    scopus 로고
    • Forkhead-box transcription factors and their role in the immune system
    • DOI 10.1038/nri1488
    • Coffer, P.J., Burgering, B.M. Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 2004, 4, 889-89 (Pubitemid 39490764)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.11 , pp. 889-899
    • Coffer, P.J.1    Burgering, B.M.T.2
  • 23
    • 77949906856 scopus 로고    scopus 로고
    • Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide
    • Brahmachari, S., Pahan, K. Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide. J Immunol 2010, 184, 1799-1809.
    • (2010) J. Immunol. , vol.184 , pp. 1799-1809
    • Brahmachari, S.1    Pahan, K.2
  • 24
    • 68149160901 scopus 로고    scopus 로고
    • Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide
    • Brahmachari, S., Pahan, K. Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. J Immunol 2009, 183, 2045-2058.
    • (2009) J. Immunol. , vol.183 , pp. 2045-2058
    • Brahmachari, S.1    Pahan, K.2
  • 25
    • 67349213676 scopus 로고    scopus 로고
    • A molecular trio in relapse and remission in multiple sclerosis
    • Steinman, L. A molecular trio in relapse and remission in multiple sclerosis. Nat Rev Immunol 2009, 9, 440-447.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 440-447
    • Steinman, L.1
  • 26
    • 77953366081 scopus 로고    scopus 로고
    • Gender-specific expression of beta1 integrin of VLA-4 in myelin basic protein-primed T cells: Implications for gender bias in multiple sclerosis
    • Brahmachari, S., Pahan, K. Gender-specific expression of beta1 integrin of VLA-4 in myelin basic protein-primed T cells: implications for gender bias in multiple sclerosis. J Immunol 2010, 184, 6103-6113.
    • (2010) J. Immunol. , vol.184 , pp. 6103-6113
    • Brahmachari, S.1    Pahan, K.2
  • 27
    • 0038605118 scopus 로고    scopus 로고
    • Role of very-late antigen-4 (VLA-4) in myelin basic protein-primed T cell contact-induced expression of proinflammatory cytokines in microglial cells
    • DOI 10.1074/jbc.M301789200
    • Dasgupta, S., Jana, M., Liu, X., Pahan, K. Role of very-late antigen-4 (VLA-4) in myelin basic protein-primed T cell contact-induced expression of proinflammatory cytokines in microglial cells. J Biol Chem 2003, 278, 22424-22431. (Pubitemid 36830294)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.25 , pp. 22424-22431
    • Dasgupta, S.1    Jana, M.2    Liu, X.3    Pahan, K.4
  • 28
    • 36148955067 scopus 로고    scopus 로고
    • Myelin basic protein-primed T cells induce neurotrophins in glial cells via α5β3 integrin
    • DOI 10.1074/jbc.M702899200
    • Roy, A., Liu, X., Pahan, K. Myelin basic protein-primed T cells induce neurotrophins in glial cells via alphavbeta3 [corrected] integrin. J Biol Chem 2007, 282, 32222-32232. (Pubitemid 350106469)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.44 , pp. 32222-32232
    • Roy, A.1    Liu, X.2    Pahan, K.3
  • 29
    • 0030970058 scopus 로고    scopus 로고
    • Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
    • DOI 10.1007/s001090050101
    • Benveniste, E.N. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 1997, 75, 165-173. (Pubitemid 27132679)
    • (1997) Journal of Molecular Medicine , vol.75 , Issue.3 , pp. 165-173
    • Benveniste, E.N.1
  • 30
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • DOI 10.1016/S0092-8674(00)81107-1
    • Steinman, L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 1996, 85, 299-302. (Pubitemid 26160700)
    • (1996) Cell , vol.85 , Issue.3 , pp. 299-302
    • Steinman, L.1
  • 31
    • 33745807628 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase gene in glial cells
    • DOI 10.1089/ars.2006.8.929
    • Saha, R.N., Pahan, K. Regulation of inducible nitric oxide synthase gene in glial cells. Antioxid Redox Signal 2006, 8, 929-947. (Pubitemid 44036510)
    • (2006) Antioxidants and Redox Signaling , vol.8 , Issue.5-6 , pp. 929-947
    • Saha, R.N.1    Pahan, K.2
  • 32
    • 0031438501 scopus 로고    scopus 로고
    • Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages
    • Pahan, K., Sheikh, F.G., Namboodiri, A.M., Singh, I. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. J Clin Invest 1997, 100, 2671-2679. (Pubitemid 28007534)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.11 , pp. 2671-2679
    • Pahan, K.1    Sheikh, F.G.2    Namboodiri, M.S.3    Singh, I.4
  • 33
    • 0034025512 scopus 로고    scopus 로고
    • Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-κB in primary astrocytes
    • DOI 10.1046/j.1471-4159.2000.0742288.x
    • Pahan, K., Liu, X., McKinney, M.J., Wood, C., Sheikh, F.G., Raymond, J.R. Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-kappaB in primary astrocytes. J Neurochem 2000, 74, 2288-2295. (Pubitemid 30314203)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.6 , pp. 2288-2295
    • Pahan, K.1    Liu, X.2    McKinney, M.J.3    Wood, C.4    Sheikh, F.G.5    Raymond, J.R.6
  • 34
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-kappaB in inflammation
    • Ghosh, S., Hayden, M.S. New regulators of NF-kappaB in inflammation. Nat Rev Immunol 2008, 8, 837-848.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2
  • 35
    • 0027343619 scopus 로고
    • The origin and nature of ramified and amoeboid microglia: A historical review and current concepts
    • Ling, E.A., Wong, W.C. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 1993, 7, 9-18.
    • (1993) Glia , vol.7 , pp. 9-18
    • Ling, E.A.1    Wong, W.C.2
  • 36
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • DOI 10.1146/annurev.neuro.22.1.219
    • González-Scarano, F., Baltuch, G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 1999, 22, 219-240. (Pubitemid 29144887)
    • (1999) Annual Review of Neuroscience , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 37
    • 33744960217 scopus 로고    scopus 로고
    • Up-regulation of microglial CD11b expression by nitric oxide
    • DOI 10.1074/jbc.M600236200
    • Roy, A., Fung, Y.K., Liu, X., Pahan, K. Up-regulation of microglial CD11b expression by nitric oxide. J Biol Chem 2006, 281, 14971-14980. (Pubitemid 43855201)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.21 , pp. 14971-14980
    • Roy, A.1    Fung, Y.K.2    Liu, X.3    Pahan, K.4
  • 38
    • 0034609968 scopus 로고    scopus 로고
    • T-cell function and migration two sides of the same coin
    • von Andrian, U.H., Mackay, C.R. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000, 343, 1020-1034.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1020-1034
    • Von Andrian, U.H.1    Mackay, C.R.2
  • 39
    • 85047682713 scopus 로고    scopus 로고
    • α4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
    • DOI 10.1172/JCI200112440
    • Vajkoczy, P., Laschinger, M., Engelhardt, B. Alpha4-integrin- VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest 2001, 108, 557-565. (Pubitemid 32777735)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.4 , pp. 557-565
    • Vajkoczy, P.1    Laschinger, M.2    Engelhardt, B.3
  • 40
    • 0028283232 scopus 로고
    • Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    • Steffen, B.J., Butcher, E.C., Engelhardt, B. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am J Pathol 1994, 145, 189-201. (Pubitemid 24217497)
    • (1994) American Journal of Pathology , vol.145 , Issue.1 , pp. 189-201
    • Steffen, B.J.1    Butcher, E.C.2    Engelhardt, B.3
  • 41
    • 0027931125 scopus 로고
    • GFAP and astrogliosis
    • Eng, L.F., Ghirnikar, R.S. GFAP and astrogliosis. Brain Pathol 1994,4, 229-237. (Pubitemid 24261929)
    • (1994) Brain Pathology , vol.4 , Issue.3 , pp. 229-237
    • Eng, L.F.1    Ghirnikar, R.S.2
  • 42
    • 33744968899 scopus 로고    scopus 로고
    • Signals for the induction of nitric oxide synthase in astrocytes
    • DOI 10.1016/j.neuint.2006.04.007, PII S0197018606001653, Molecular Mechanisms of Neuroinflammation
    • Saha, R.N., Pahan, K. Signals for the induction of nitric oxide synthase in astrocytes. Neurochem Int 2006, 49, 154-163. (Pubitemid 43867073)
    • (2006) Neurochemistry International , vol.49 , Issue.2 , pp. 154-163
    • Saha, R.N.1    Pahan, K.2
  • 43
    • 38449119486 scopus 로고    scopus 로고
    • MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65
    • Saha, R.N., Jana, M., Pahan, K. MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol 2007, 179, 7101-7109.
    • (2007) J. Immunol. , vol.179 , pp. 7101-7109
    • Saha, R.N.1    Jana, M.2    Pahan, K.3
  • 44
    • 2542481651 scopus 로고    scopus 로고
    • Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2004.01.007, PII S0197458004001034
    • Nagele, R.G., Wegiel, J., Venkataraman, V., Imaki, H., Wang, K.C., Wegiel, J. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol Aging 2004, 25, 663-674. (Pubitemid 38686490)
    • (2004) Neurobiology of Aging , vol.25 , Issue.5 , pp. 663-674
    • Nagele, R.G.1    Wegiel, J.2    Venkataraman, V.3    Imaki, H.4    Wang, K.-C.5    Wegiel, J.6
  • 45
    • 33646947850 scopus 로고    scopus 로고
    • Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide
    • DOI 10.1523/JNEUROSCI.5480-05.2006
    • Brahmachari, S., Fung, Y.K., Pahan, K. Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide. J Neurosci 2006, 26, 4930-4939. (Pubitemid 44315335)
    • (2006) Journal of Neuroscience , vol.26 , Issue.18 , pp. 4930-4939
    • Brahmachari, S.1    Fung, Y.K.2    Pahan, K.3
  • 46
    • 58849160520 scopus 로고    scopus 로고
    • Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death
    • Jana, A., Hogan, E.L., Pahan, K. Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death. J Neurol Sci 2009, 278, 5-15.
    • (2009) J. Neurol. Sci. , vol.278 , pp. 5-15
    • Jana, A.1    Hogan, E.L.2    Pahan, K.3
  • 47
    • 0030944188 scopus 로고    scopus 로고
    • Current and investigational therapies used to alter the course of disease in multiple sclerosis
    • Miller, A. Current and investigational therapies used to alter the course of disease in multiple sclerosis. South Med J 1997, 90, 367-375. (Pubitemid 27176396)
    • (1997) Southern Medical Journal , vol.90 , Issue.4 , pp. 367-375
    • Miller, A.1
  • 49
    • 0035205756 scopus 로고    scopus 로고
    • Final report on the safety assessment of benzyl alcohol benzoic acid and sodium benzoate
    • Nair, B. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate. Int J Toxicol 2001, 20 Suppl 3, 23-50.
    • (2001) Int. J. Toxicol. , vol.20 , Issue.3 , pp. 23-50
    • Nair, B.1
  • 51
    • 1642424401 scopus 로고    scopus 로고
    • Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients
    • DOI 10.1016/j.ymgme.2003.11.017, PII S1096719204000186
    • Scaglia, F., Carter, S., O'Brien, W.E., Lee, B. Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients. Mol Genet Metab 2004, 81 Suppl 1, S79-S85. (Pubitemid 38402240)
    • (2004) Molecular Genetics and Metabolism , vol.81 , Issue.SUPPL.
    • Scaglia, F.1    Carter, S.2    O'Brien, W.E.3    Lee, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.