Pyrithione-zinc prevents UVB-induced epidermal hyperplasia by inducing HIF-1α

Korean Journal of Physiology and Pharmacology

Volumn 14, Issue 2, 2010, Pages 91-97

  Cho, Young Suk ^a   Lee, Kyung Hoon ^b   Park, Jong Wan ^c  

^a Chungbuk National University College of Medicine   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

Hyperplasia; Hypoxia inducible factor 1 ; Pyrithione zinc; Skin; Ultraviolet

Indexed keywords

BAFILOMYCIN A1; BAICALEIN; EPIGALLOCATECHIN GALLATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN P21; PYRITHIONE ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CELL CULTURE; CELL HYPERPLASIA; CELL NUCLEUS; CONTROLLED STUDY; CREAM; DOWN REGULATION; DRUG EFFICACY; EPIDERMIS; EPIDERMIS HYPERPLASIA; HUMAN; HUMAN CELL; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PHOTOAGING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RADIATION EXPOSURE; SKIN CANCER; SKIN DISEASE; SKINFOLD; ULTRAVIOLET B RADIATION; UPREGULATION;

EID: 77952629131     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2010.14.2.91     Document Type: Article

References (25)

1. Melnikova VO, Ananthaswamy HN. Cellular and molecular events leading to the development of skin cancer. Mutat Res. 2005;571:91-106.
2. Marrot L, Meunier JR. Skin DNA photodamage and its biological consequences. J Am Acad Dermatol. 2008;58:S139-S148. (Pubitemid 351503640)
3. Ouhtit A, Muller HK, Davis DW, Ullrich SE, McConkey D, Ananthaswamy HN. Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol. 2000;156:201-207. (Pubitemid 30644453)
4. Lee JK, Kim JH, Nam KT, Lee SH. Molecular events associated with apoptosis and proliferation induced by ultraviolet-B radiation in the skin of hairless mice. J Dermatol Sci. 2003;32:171-179.
5. El-Abaseri TB, Putta S, Hansen LA. Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis. 2006;27:225-231. (Pubitemid 43159873)
6. Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem. 1995;270:1230-1237.
7. 2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 1998;12:149-162. (Pubitemid 28060446)
8. Koshiji M, Kageyama Y, Pete EA, Harikawa I, Barrett JC, Huang LE. HIF-1α induces cell cycle arrest by functionally counteracting Myc. EMBO J. 2004;23:1949-1956. (Pubitemid 38902073)
9. Cho YS, Bae JM, Chun YS, Chung JH, Jeon YK, Kim IS, Kim MS, Park JW. HIF-1α controls keratinocyte proliferation by up-regulating p21(WAF1/Cip1). Biochim Biophys Acta. 2008;1783:323-333.
10. Cho YS, Kim CH, Park JW. Involvement of HIF-1α in UVB-induced epidermal hyperplasia. Mol Cells. 2009;28:537-543.
11. Chun YS, Choi E, Kim GT, Lee MJ, Lee MJ, Lee SE, Kim MS, Park JW. Zinc induces the accumulation of hypoxia-inducible factor (HIF)-1α, but inhibits the nuclear translocation of HIF-1β, causing HIF-1 inactivation. Biochem Biophys Res Commun. 2000;268:652-656. (Pubitemid 30119677)
12. Lim JH, Park JW, Kim MS, Park SK, Johnson RS, Chun YS. Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1α. Mol Pharmacol. 2006;70:1856-1865.
13. Cho H, Lee HY, Ahn DR, Kim SY, Kim S, Lee KB, Lee YM, Park H, Yang EG. Baicalein induces functional hypoxia-inducible factor-1α and angiogenesis. Mol Pharmacol. 2008;74:70-81. (Pubitemid 351872160)
14. Weinreb O, Amit T, Youdim MB. A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate. Free Radic Biol Med. 2007;43:546-556.
15. Park SE, Park JW, Cho YS, Ryu JH, Pakk JS, Chun YS. HIF-1α promotes survival of prostate cells at a high zinc environment. Prostate. 2007;67:1514-1523.
16. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A. 1998;95:7987-7992. (Pubitemid 28326053)
17. Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol. 2004;5:343-354.
18. Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002;22:7004-7014.
19. Lang KJ, Kappel A, Goodall GJ. Hypoxia-inducible factor- 1α mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell. 2002;13:1792-1801.
20. Arsham AM, Plas DR, Thompson CB, Simon MC. Phosphatidylinositol 3-kLnase/Akt signaling is neither required for hypoxic stabilization of HIF-1α nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem. 2002;277:15162-15170.
21. Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway. J Biol Chem. 2002;277:29936-29944.
22. Luo W, Zhang J, Chang R, Hu H, Pandey A, Semenza GL. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but Not HIF-2α. J Biol Chem. 2010;285:3651-3663.
23. Pierard-Franchimont C, Goffin V, Decroix J, Pierard GE. A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Skin Pharmacol Appl Skin Physiol. 2002;15:434-441.
24. Bailey P, Arrowsmith C, Darling K, Dexter J, Eklund J, Lane A, Little C, Murray B, Scott A, Williams A, Wilson D. A doubleblind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity. Int J Cosmet Sci. 2003;25:183-188.
25. Guthery E, Seal LA, Anderson EL. Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects. Am J Infect Control. 2005;33:15-22.