-
1
-
-
0035696301
-
Functions of zinc in signaling, proliferation and differentiation of mammalian cells
-
DOI 10.1023/A:1012905406548
-
Beyersmann, D., and Haase, H. (2001) Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals 14, 331-341. (Pubitemid 34066636)
-
(2001)
BioMetals
, vol.14
, Issue.3-4
, pp. 331-341
-
-
Beyersmann, D.1
Haase, H.2
-
2
-
-
0025572588
-
A requirement for Zn2+ for the induction of thymidine kinase but not ornithine decarboxylase in 3T3 cells stimulated from quiescence
-
Chesters, J. K., Petrie, L., and Travis, A. J. (1990) A requirement for Zn2+ for the induction of thymidine kinase but not ornithine decarboxylase in 3T3 cells stimulated from quiescence. Biochem. J. 272, 525-527.
-
(1990)
Biochem. J.
, vol.272
, pp. 525-527
-
-
Chesters, J.K.1
Petrie, L.2
Travis, A.J.3
-
3
-
-
0024472714
-
Specificity and timing of the Zn2+ requirement for DNA synthesis by 3T3 cells
-
Chesters, J. K., Petrie, L., and Vint, H. (1989) Specificity and timing of the Zn2+ requirement for DNA synthesis by 3T3 cells. Exp. Cell. Res. 184, 499-508.
-
(1989)
Exp. Cell. Res.
, vol.184
, pp. 499-508
-
-
Chesters, J.K.1
Petrie, L.2
Vint, H.3
-
4
-
-
0027183546
-
Transition metals in control of gene expression
-
O'halloran, T. V. (1993) Transition metals in control of gene expression. Science 261, 715-725.
-
(1993)
Science
, vol.261
, pp. 715-725
-
-
O'Halloran, T.V.1
-
5
-
-
0028015805
-
Metal elements and gene expression
-
Cousins, R. J. (1994) Metal elements and gene expression. Annu. Rev. Nutr. 14, 449-469.
-
(1994)
Annu. Rev. Nutr.
, vol.14
, pp. 449-469
-
-
Cousins, R.J.1
-
6
-
-
59149085523
-
Mechanisms of mammalian zinc-regulated gene expression
-
Jackson, K. A., Valentine, R. A., Coneyworth, L. J., Mathers, J. C., and Ford, D. (2008) Mechanisms of mammalian zinc-regulated gene expression. Biochem. Soc. Trans. 36, 1262-1266.
-
(2008)
Biochem. Soc. Trans.
, vol.36
, pp. 1262-1266
-
-
Jackson, K.A.1
Valentine, R.A.2
Coneyworth, L.J.3
Mathers, J.C.4
Ford, D.5
-
7
-
-
0029866646
-
The galvanization of biology: A growing appreciation for the roles of zinc
-
Berg, J. M., and Shi, Y. (1996) The galvanization of biology: a growing appreciation for the roles of zinc. Science. 271, 1081-1085.
-
(1996)
Science
, vol.271
, pp. 1081-1085
-
-
Berg, J.M.1
Shi, Y.2
-
8
-
-
0028170444
-
2+: An endogenous modulator of ligand- And voltage-gated ion channels
-
DOI 10.1016/0028-3908(94)90152-X
-
Harrison, N. L., and Gibbons, S. J. (1994) Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology 33, 935-952. (Pubitemid 24290521)
-
(1994)
Neuropharmacology
, vol.33
, Issue.8
, pp. 935-952
-
-
Harrison, N.L.1
Gibbons, S.J.2
-
9
-
-
0026476480
-
Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells
-
Crapo, J. D., Oury, T., Rabouille, C., Slot, J. W., and Chang, L. Y. (1992) Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells. Proc. Natl. Acad. Sci. USA 89, 10405-10409.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 10405-10409
-
-
Crapo, J.D.1
Oury, T.2
Rabouille, C.3
Slot, J.W.4
Chang, L.Y.5
-
10
-
-
33745427600
-
Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation
-
Xu, J., Xu, Y., Nguyen, Q., Novikoff, P. M., and Czaja, M. J. (1996) Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation. Am. J. Physiol. 270, G60-G70.
-
(1996)
Am. J. Physiol.
, vol.270
-
-
Xu, J.1
Xu, Y.2
Nguyen, Q.3
Novikoff, P.M.4
Czaja, M.J.5
-
11
-
-
0006372708
-
Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals
-
DOI 10.1016/S0306-4522(98)00313-3, PII S0306452298003133
-
Kim, Y. H., Kim, E. Y., Gwag, B. J., Sohn, S., and Koh, J. Y. (1999) Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience 89, 175-182. (Pubitemid 29049037)
-
(1999)
Neuroscience
, vol.89
, Issue.1
, pp. 175-182
-
-
Kim, Y.-H.1
Kim, E.Y.2
Gwag, B.J.3
Sohn, S.4
Koh, J.-Y.5
-
12
-
-
0028906839
-
Role of intracellular free Ca(II) and Zn(II) in dexamethasone-induced apoptosis and dexamethasone resistance in human leukemic CEM cell lines
-
Adebodun, F., and Post, J. F. (1995) Role of intracellular free Ca(II) and Zn(II) in dexamethasone-induced apoptosis and dexamethasone resistance in human leukemic CEM cell lines. J. Cell. Physiol. 163, 80-86.
-
(1995)
J. Cell. Physiol.
, vol.163
, pp. 80-86
-
-
Adebodun, F.1
Post, J.F.2
-
13
-
-
0027501386
-
Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)
-
Zalewski, P. D., Forbes, I. J., and Betts, W. H. (1993) Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II). Biochem. J. 296, 403-408.
-
(1993)
Biochem. J.
, vol.296
, pp. 403-408
-
-
Zalewski, P.D.1
Forbes, I.J.2
Betts, W.H.3
-
14
-
-
0037986658
-
Iron chelators as antineoplastic agents: Current developments and promise of the PIH class of chelators
-
Lovejoy, D. B., and Richardson, D. R. (2003) Iron chelators as antineoplastic agents: current developments and promise of the PIH class of chelators. Curr. Med. Chem. 10, 1035-1049.
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 1035-1049
-
-
Lovejoy, D.B.1
Richardson, D.R.2
-
15
-
-
0033963879
-
Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study
-
Brewer, G. J., Dick, R. D., Grover, D. K., Leclaire, V., Tseng, M., Wicha, M., Pienta, K., Redman, B. G., Jahan, T., Sondak, V. K., Strawderman, M., Lecarpentier, G., and Merajver, S. D. (2000) Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study. Clin. Cancer. Res. 6, 1-10.
-
(2000)
Clin. Cancer. Res.
, vol.6
, pp. 1-10
-
-
Brewer, G.J.1
Dick, R.D.2
Grover, D.K.3
Leclaire, V.4
Tseng, M.5
Wicha, M.6
Pienta, K.7
Redman, B.G.8
Jahan, T.9
Sondak, V.K.10
Strawderman, M.11
Lecarpentier, G.12
Merajver, S.D.13
-
16
-
-
0037652214
-
Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer
-
Redman, B. G., Esper, P., Pan, Q., Dunn, R. L., Hussain, H. K., Chenevert, T., Brewer, G. J., and Merajver, S. D. (2003) Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer. Clin. Cancer. Res. 9, 1666-1672.
-
(2003)
Clin. Cancer. Res.
, vol.9
, pp. 1666-1672
-
-
Redman, B.G.1
Esper, P.2
Pan, Q.3
Dunn, R.L.4
Hussain, H.K.5
Chenevert, T.6
Brewer, G.J.7
Merajver, S.D.8
-
17
-
-
53249153476
-
Zinc-binding compounds induce cancer cell death via distinct modes of action
-
Ding, W. Q., Yu, H. J., and Lind, S. E. (2008) Zinc-binding compounds induce cancer cell death via distinct modes of action. Cancer. Lett. 271, 251-259.
-
(2008)
Cancer. Lett.
, vol.271
, pp. 251-259
-
-
Ding, W.Q.1
Yu, H.J.2
Lind, S.E.3
-
18
-
-
0037628107
-
2+-induced cortical neuronal death
-
DOI 10.1016/S0028-3908(03)00171-0
-
Canzoniero, L. M., Manzerra, P., Sheline, C. T., and Choi, D. W. (2003) Membrane-permeant chelators can attenuate Zn2+-induced cortical neuronal death. Neuropharmacology 45, 420-428. (Pubitemid 36836138)
-
(2003)
Neuropharmacology
, vol.45
, Issue.3
, pp. 420-428
-
-
Canzoniero, L.M.T.1
Manzerra, P.2
Sheline, C.T.3
Choi, D.W.4
-
19
-
-
29244453628
-
Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines
-
Lecane, P. S., Karaman, M. W., Sirisawad, M., Naumovski, L., Miller, R. A., Hacia, J. G., and Magda, D. (2005) Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer. Res. 65, 11676-11688.
-
(2005)
Cancer. Res.
, vol.65
, pp. 11676-11688
-
-
Lecane, P.S.1
Karaman, M.W.2
Sirisawad, M.3
Naumovski, L.4
Miller, R.A.5
Hacia, J.G.6
Magda, D.7
-
20
-
-
0036740180
-
Pegylated zinc protoporphyrin: A water-soluble heme oxygenase inhibitor with tumor-targeting capacity
-
Sahoo, S. K., Sawa, T., Fang, J., Tanaka, S., Miyamoto, Y., Akaike, T., and Maeda, H. (2002) Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity. Bioconjug. Chem. 13, 1031-1038.
-
(2002)
Bioconjug. Chem.
, vol.13
, pp. 1031-1038
-
-
Sahoo, S.K.1
Sawa, T.2
Fang, J.3
Tanaka, S.4
Miyamoto, Y.5
Akaike, T.6
Maeda, H.7
-
21
-
-
0032908620
-
Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation
-
Kim, C. H., Kim, J. H., Hsu, C. Y., and Ahn, Y. S. (1999) Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation. FEBS. Lett. 449, 28-32.
-
(1999)
FEBS. Lett.
, vol.449
, pp. 28-32
-
-
Kim, C.H.1
Kim, J.H.2
Hsu, C.Y.3
Ahn, Y.S.4
-
22
-
-
0033574957
-
Pyrithione, a zinc ionophore, inhibits NF-kappaB activation
-
Kim, C. H., Kim, J. H., Moon, S. J., Chung, K. C., Hsu, C. Y., Seo, J. T., and Ahn, Y. S. (1999) Pyrithione, a zinc ionophore, inhibits NF-kappaB activation. Biochem. Biophys. Res. Commun. 259, 505-509.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.259
, pp. 505-509
-
-
Kim, C.H.1
Kim, J.H.2
Moon, S.J.3
Chung, K.C.4
Hsu, C.Y.5
Seo, J.T.6
Ahn, Y.S.7
-
23
-
-
48549102462
-
Synthesis and anticancer properties of watersoluble zinc ionophores
-
Magda, D., Lecane, P., Wang, Z., Hu, W., Thiemann, P., Ma, X., Dranchak, P. K., Wang, X., Lynch, V., Wei, W., Csokai, V., Hacia, J. G., and Sessler, J. L. (2008) Synthesis and anticancer properties of watersoluble zinc ionophores. Cancer. Res. 68, 5318-5325.
-
(2008)
Cancer. Res.
, vol.68
, pp. 5318-5325
-
-
Magda, D.1
Lecane, P.2
Wang, Z.3
Hu, W.4
Thiemann, P.5
Ma, X.6
Dranchak, P.K.7
Wang, X.8
Lynch, V.9
Wei, W.10
Csokai, V.11
Hacia, J.G.12
Sessler, J.L.13
-
24
-
-
68049137454
-
Pyrithione and 8-hydroxyquinolines transport lead across erythrocyte membranes
-
Lind, S. E., Park, J. S., and Drexler, J. W. (2009) Pyrithione and 8-hydroxyquinolines transport lead across erythrocyte membranes. Transl. Res. 154, 153-159.
-
(2009)
Transl. Res.
, vol.154
, pp. 153-159
-
-
Lind, S.E.1
Park, J.S.2
Drexler, J.W.3
-
25
-
-
17144404213
-
Anticancer activity of the antibiotic clioquinol
-
Ding, W. Q., Liu, B., Vaught, J. L., Yamauchi, H., and Lind, S. E. (2005) Anticancer activity of the antibiotic clioquinol. Cancer. Res. 65, 3389-3395.
-
(2005)
Cancer. Res.
, vol.65
, pp. 3389-3395
-
-
Ding, W.Q.1
Liu, B.2
Vaught, J.L.3
Yamauchi, H.4
Lind, S.E.5
-
26
-
-
58249091525
-
Clioquinol targets zinc to lysosomes in human cancer cells
-
Yu, H., Zhou, Y., Lind, S. E., and Ding, W. Q. (2009) Clioquinol targets zinc to lysosomes in human cancer cells. Biochem. J. 417, 133-139.
-
(2009)
Biochem. J.
, vol.417
, pp. 133-139
-
-
Yu, H.1
Zhou, Y.2
Lind, S.E.3
Ding, W.Q.4
-
27
-
-
0037064006
-
Monensin mediates a rapid and selective transport of Pb(2+). Possible application of monensin for the treatment of Pb(2+) intoxication
-
Hamidinia, S. A., Shimelis, O. I., Tan, B., Erdahl, W. L., Chapman, C. J., Renkes, G. D., Taylor, R. W., and Pfeiffer, D. R. (2002) Monensin mediates a rapid and selective transport of Pb(2+). Possible application of monensin for the treatment of Pb(2+) intoxication. J. Biol. Chem. 277, 38111-38120.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 38111-38120
-
-
Hamidinia, S.A.1
Shimelis, O.I.2
Tan, B.3
Erdahl, W.L.4
Chapman, C.J.5
Renkes, G.D.6
Taylor, R.W.7
Pfeiffer, D.R.8
-
28
-
-
0021232940
-
Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus
-
Grafe, U., Schade, W., Roth, M., Radics, L., Incze, M., and Ujszaszy, K. (1984) Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus. J. Antibiot. (Tokyo). 37, 836-846.
-
(1984)
J. Antibiot. (Tokyo)
, vol.37
, pp. 836-846
-
-
Grafe, U.1
Schade, W.2
Roth, M.3
Radics, L.4
Incze, M.5
Ujszaszy, K.6
-
29
-
-
0021712916
-
The structure and absolute stereochemistry of zincophorin (antibiotic M144255): A monobasic carboxylic acid ionophore having a remarkable specificity for divalent cations
-
Brooks, H. A., Gardner, D., Poyser, J. P., and King, T. J. (1984) The structure and absolute stereochemistry of zincophorin (antibiotic M144255): a monobasic carboxylic acid ionophore having a remarkable specificity for divalent cations. J. Antibiot. (Tokyo). 37, 1501-1504.
-
(1984)
J. Antibiot. (Tokyo)
, vol.37
, pp. 1501-1504
-
-
Brooks, H.A.1
Gardner, D.2
Poyser, J.P.3
King, T.J.4
-
30
-
-
0028072422
-
Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes
-
Bessho, R., Matsubara, K., Kubota, M., Kuwakado, K., Hirota, H., Wakazono, Y., Lin, Y. W., Okuda, A., Kawai, M., Nishikomori, R., and Heike, T. (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem. Pharmacol. 48, 1883-1889.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 1883-1889
-
-
Bessho, R.1
Matsubara, K.2
Kubota, M.3
Kuwakado, K.4
Hirota, H.5
Wakazono, Y.6
Lin, Y.W.7
Okuda, A.8
Kawai, M.9
Nishikomori, R.10
Heike, T.11
-
31
-
-
13344279414
-
Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells
-
Tsai, J. C., Jain, M., Hsieh, C. M., Lee, W. S., Yoshizumi, M., Patterson, C., Perrella, M. A., Cooke, C., Wang, H., Haber, E., Schlegel, R., and Lee, M. E. (1996) Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J. Biol. Chem. 271, 3667-3670.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 3667-3670
-
-
Tsai, J.C.1
Jain, M.2
Hsieh, C.M.3
Lee, W.S.4
Yoshizumi, M.5
Patterson, C.6
Perrella, M.A.7
Cooke, C.8
Wang, H.9
Haber, E.10
Schlegel, R.11
Lee, M.E.12
-
32
-
-
0030663670
-
Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPbeta
-
Chinery, R., Brockman, J. A., Peeler, M. O., Shyr, Y., Beauchamp, R. D., and Coffey, R. J. (1997) Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. Nat. Med. 3, 1233-1241.
-
(1997)
Nat. Med.
, vol.3
, pp. 1233-1241
-
-
Chinery, R.1
Brockman, J.A.2
Peeler, M.O.3
Shyr, Y.4
Beauchamp, R.D.5
Coffey, R.J.6
-
33
-
-
84901648175
-
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells
-
Daniel, K. G., Chen, D., Orlu, S., Cui, Q. C., Miller, F. R., and Dou, Q. P. (2005) Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells. Breast. Cancer. Res. 7, R897-R908.
-
(2005)
Breast. Cancer. Res.
, vol.7
-
-
Daniel, K.G.1
Chen, D.2
Orlu, S.3
Cui, Q.C.4
Miller, F.R.5
Dou, Q.P.6
-
34
-
-
0000852065
-
Pyrrolidine dithiocarbamate induces bovine cerebral endothelial cell death by increasing the intracellular zinc level
-
Kim, C. H., Kim, J. H., Xu, J., Hsu, C. Y., and Ahn, Y. S. (1999) Pyrrolidine dithiocarbamate induces bovine cerebral endothelial cell death by increasing the intracellular zinc level. J. Neurochem. 72, 1586-1592.
-
(1999)
J. Neurochem.
, vol.72
, pp. 1586-1592
-
-
Kim, C.H.1
Kim, J.H.2
Xu, J.3
Hsu, C.Y.4
Ahn, Y.S.5
-
35
-
-
0024348430
-
Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines
-
Blatt, J., Taylor, S. R., and Kontoghiorghes, G. J. (1989) Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines. Cancer. Res. 49, 2925-2927.
-
(1989)
Cancer. Res.
, vol.49
, pp. 2925-2927
-
-
Blatt, J.1
Taylor, S.R.2
Kontoghiorghes, G.J.3
-
36
-
-
0023009651
-
Cytotoxic effects of the lipophilic iron chelator omadine
-
Kontoghiorghes, G. J., Piga, A., and Hoffbrand, A. V. (1986) Cytotoxic effects of the lipophilic iron chelator omadine. FEBS. Lett. 204, 208-212.
-
(1986)
FEBS. Lett.
, vol.204
, pp. 208-212
-
-
Kontoghiorghes, G.J.1
Piga, A.2
Hoffbrand, A.V.3
-
37
-
-
0036886679
-
Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells
-
Kondoh, M., Tasaki, E., Araragi, S., Takiguchi, M., Higashimoto, M., Watanabe, Y., and Sato, M. (2002) Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells. Eur. J. Biochem. 269, 6204-6211.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 6204-6211
-
-
Kondoh, M.1
Tasaki, E.2
Araragi, S.3
Takiguchi, M.4
Higashimoto, M.5
Watanabe, Y.6
Sato, M.7
-
38
-
-
21144441227
-
Activation of caspase-3 in HL-60 cells treated with pyrithione and zinc
-
Kondoh, M., Tasaki, E., Takiguchi, M., Higashimoto, M., Watanabe, Y., and Sato, M. (2005) Activation of caspase-3 in HL-60 cells treated with pyrithione and zinc. Biol. Pharm. Bull. 28, 757-759.
-
(2005)
Biol. Pharm. Bull.
, vol.28
, pp. 757-759
-
-
Kondoh, M.1
Tasaki, E.2
Takiguchi, M.3
Higashimoto, M.4
Watanabe, Y.5
Sato, M.6
-
39
-
-
18044397492
-
Zinc pyrithione induces apoptosis and increases expression of Bim
-
Mann, J. J., and Fraker, P. J. (2005) Zinc pyrithione induces apoptosis and increases expression of Bim. Apoptosis. 10, 369-379.
-
(2005)
Apoptosis
, vol.10
, pp. 369-379
-
-
Mann, J.J.1
Fraker, P.J.2
-
40
-
-
64149090846
-
The curious case of clioquinol
-
Cahoon, L. (2009) The curious case of clioquinol. Nat. Med. 15, 356-359.
-
(2009)
Nat. Med.
, vol.15
, pp. 356-359
-
-
Cahoon, L.1
-
41
-
-
18444399243
-
Treatment of Alzheimer's disease with clioquinol
-
Regland, B., Lehmann, W., Abedini, I., Blennow, K., Jonsson, M., Karlsson, I., Sjogren, M., Wallin, A., Xilinas, M., and Gottfries, C. G. (2001) Treatment of Alzheimer's disease with clioquinol. Dement. Geriatr. Cogn. Disord. 12, 408-414.
-
(2001)
Dement. Geriatr. Cogn. Disord.
, vol.12
, pp. 408-414
-
-
Regland, B.1
Lehmann, W.2
Abedini, I.3
Blennow, K.4
Jonsson, M.5
Karlsson, I.6
Sjogren, M.7
Wallin, A.8
Xilinas, M.9
Gottfries, C.G.10
-
42
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
Ritchie, C. W., Bush, A. I., Mackinnon, A., Macfarlane, S., Mastwyk, M., Macgregor, L., Kiers, L., Cherny, R., Li, Q. X., Tammer, A., Carrington, D., Mavros, C., Volitakis, I., Xilinas, M., Ames, D., Davis, S., Beyreuther, K., Tanzi, R. E., and Masters, C. L. (2003) Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch. Neurol. 60, 1685-1691.
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
Macfarlane, S.4
Mastwyk, M.5
Macgregor, L.6
Kiers, L.7
Cherny, R.8
Li, Q.X.9
Tammer, A.10
Carrington, D.11
Mavros, C.12
Volitakis, I.13
Xilinas, M.14
Ames, D.15
Davis, S.16
Beyreuther, K.17
Tanzi, R.E.18
Masters, C.L.19
-
43
-
-
4644256805
-
Differential sensitivity of cancer cells to docosahexaenoic acid-induced cytotoxicity: The potential importance of down-regulation of superoxide dismutase 1 expression
-
Ding, W. Q., Vaught, J. L., Yamauchi, H., and Lind, S. E. (2004) Differential sensitivity of cancer cells to docosahexaenoic acid-induced cytotoxicity: the potential importance of down-regulation of superoxide dismutase 1 expression. Mol. Cancer. Ther. 3, 1109-1117.
-
(2004)
Mol. Cancer. Ther.
, vol.3
, pp. 1109-1117
-
-
Ding, W.Q.1
Vaught, J.L.2
Yamauchi, H.3
Lind, S.E.4
-
44
-
-
33748302272
-
Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells
-
Ding, W. Q., Liu, B., Vaught, J. L., Palmiter, R. D., and Lind, S. E. (2006) Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells. Mol. Cancer. Ther. 5, 1864-1872.
-
(2006)
Mol. Cancer. Ther.
, vol.5
, pp. 1864-1872
-
-
Ding, W.Q.1
Liu, B.2
Vaught, J.L.3
Palmiter, R.D.4
Lind, S.E.5
-
45
-
-
63149185866
-
PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells
-
Tuller, E. R., Brook, A. L., Yu, H. J., Lou, J. R., Benbrook, D. M., and Ding, W. Q. (2009) PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Biochem. Pharmacol. 77, 1480-1486.
-
(2009)
Biochem. Pharmacol.
, vol.77
, pp. 1480-1486
-
-
Tuller, E.R.1
Brook, A.L.2
Yu, H.J.3
Lou, J.R.4
Benbrook, D.M.5
Ding, W.Q.6
-
46
-
-
33847746963
-
Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts
-
Chen, D., Cui, Q. C., Yang, H., Barrea, R. A., Sarkar, F. H., Sheng, S., Yan, B., Reddy, G. P., and Dou, Q. P. (2007) Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts. Cancer. Res. 67, 1636-1644.
-
(2007)
Cancer. Res.
, vol.67
, pp. 1636-1644
-
-
Chen, D.1
Cui, Q.C.2
Yang, H.3
Barrea, R.A.4
Sarkar, F.H.5
Sheng, S.6
Yan, B.7
Reddy, G.P.8
Dou, Q.P.9
-
47
-
-
62549083952
-
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma
-
Mao, X., Li, X., Sprangers, R., Wang, X., Venugopal, A., Wood, T., Zhang, Y., Kuntz, D. A., Coe, E., Trudel, S., Rose, D., Batey, R. A., Kay, L. E., and Schimmer, A. D. (2009) Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma. Leukemia. 23, 585-590.
-
(2009)
Leukemia
, vol.23
, pp. 585-590
-
-
Mao, X.1
Li, X.2
Sprangers, R.3
Wang, X.4
Venugopal, A.5
Wood, T.6
Zhang, Y.7
Kuntz, D.A.8
Coe, E.9
Trudel, S.10
Rose, D.11
Batey, R.A.12
Kay, L.E.13
Schimmer, A.D.14
-
48
-
-
46149107512
-
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
-
Adlard, P. A., Cherny, R. A., Finkelstein, D. I., Gautier, E., Robb, E., Cortes, M., Volitakis, I., Liu, X., Smith, J. P., Perez, K., Laughton, K., Li, Q. X., Charman, S. A., Nicolazzo, J. A., Wilkins, S., Deleva, K., Lynch, T., Kok, G., Ritchie, C. W., Tanzi, R. E., Cappai, R., Masters, C. L., Barnham, K. J., and Bush, A. I. (2008) Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 59, 43-55.
-
(2008)
Neuron
, vol.59
, pp. 43-55
-
-
Adlard, P.A.1
Cherny, R.A.2
Finkelstein, D.I.3
Gautier, E.4
Robb, E.5
Cortes, M.6
Volitakis, I.7
Liu, X.8
Smith, J.P.9
Perez, K.10
Laughton, K.11
Li, Q.X.12
Charman, S.A.13
Nicolazzo, J.A.14
Wilkins, S.15
Deleva, K.16
Lynch, T.17
Kok, G.18
Ritchie, C.W.19
Tanzi, R.E.20
Cappai, R.21
Masters, C.L.22
Barnham, K.J.23
Bush, A.I.24
more..
-
49
-
-
66249101637
-
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+
-
Andersson, D. A., Gentry, C., Moss, S., and Bevan, S. (2009) Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc. Natl. Acad. Sci. USA 106, 8374-8379.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 8374-8379
-
-
Andersson, D.A.1
Gentry, C.2
Moss, S.3
Bevan, S.4
-
50
-
-
33745860362
-
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity
-
White, A. R., Du, T., Laughton, K. M., Volitakis, I., Sharples, R. A., Xilinas, M. E., Hoke, D. E., Holsinger, R. M., Evin, G., Cherny, R. A., Hill, A. F., Barnham, K. J., Li, Q. X., Bush, A. I., and Masters, C. L. (2006) Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. J. Biol. Chem. 281, 17670-17680.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 17670-17680
-
-
White, A.R.1
Du, T.2
Laughton, K.M.3
Volitakis, I.4
Sharples, R.A.5
Xilinas, M.E.6
Hoke, D.E.7
Holsinger, R.M.8
Evin, G.9
Cherny, R.A.10
Hill, A.F.11
Barnham, K.J.12
Li, Q.X.13
Bush, A.I.14
Masters, C.L.15
-
51
-
-
34547425301
-
Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates
-
Lee, E. J., Lee, J. Y., Seo, S. R., and Chung, K. C. (2007) Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates. Mol. Cell. Neurosci. 35, 585-595.
-
(2007)
Mol. Cell. Neurosci.
, vol.35
, pp. 585-595
-
-
Lee, E.J.1
Lee, J.Y.2
Seo, S.R.3
Chung, K.C.4
-
52
-
-
2442464889
-
Apoptosis defects and chemotherapy resistance: Molecular interaction maps and networks
-
Pommier, Y., Sordet, O., Antony, S., Hayward, R. L., and Kohn, K. W. (2004) Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 23, 2934-2949.
-
(2004)
Oncogene
, vol.23
, pp. 2934-2949
-
-
Pommier, Y.1
Sordet, O.2
Antony, S.3
Hayward, R.L.4
Kohn, K.W.5
-
53
-
-
37349020313
-
Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages
-
Du, T., Filiz, G., Caragounis, A., Crouch, P. J., and White, A. R. (2008) Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages. J. Pharmacol. Exp. Ther. 324, 360-367.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.324
, pp. 360-367
-
-
Du, T.1
Filiz, G.2
Caragounis, A.3
Crouch, P.J.4
White, A.R.5
-
54
-
-
48949098573
-
Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebo-controlled trial
-
Lannfelt, L., Blennow, K., Zetterberg, H., Batsman, S., Ames, D., Harrison, J., Masters, C. L., Targum, S., Bush, A. I., Murdoch, R., Wilson, J., and Ritchie, C. W. (2008) Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet. Neurol. 7, 779-786.
-
(2008)
Lancet. Neurol.
, vol.7
, pp. 779-786
-
-
Lannfelt, L.1
Blennow, K.2
Zetterberg, H.3
Batsman, S.4
Ames, D.5
Harrison, J.6
Masters, C.L.7
Targum, S.8
Bush, A.I.9
Murdoch, R.10
Wilson, J.11
Ritchie, C.W.12
-
55
-
-
0036050582
-
Disulfiram induces apoptosis in human melanoma cells: A redox-related process
-
Cen, D., Gonzalez, R. I., Buckmeier, J. A., Kahlon, R. S., Tohidian, N. B., and Meyskens, F. L. (2002) Disulfiram induces apoptosis in human melanoma cells: a redox-related process. Mol. Cancer. Ther. 1, 197-204.
-
(2002)
Mol. Cancer. Ther.
, vol.1
, pp. 197-204
-
-
Cen, D.1
Gonzalez, R.I.2
Buckmeier, J.A.3
Kahlon, R.S.4
Tohidian, N.B.5
Meyskens, F.L.6
-
56
-
-
0142148099
-
Inhibition of invasion and angiogenesis by zinc-chelating agent disulfiram
-
Shian, S. G., Kao, Y. R., Wu, F. Y., and Wu, C. W. (2003) Inhibition of invasion and angiogenesis by zinc-chelating agent disulfiram. Mol. Pharmacol. 64, 1076-1084.
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 1076-1084
-
-
Shian, S.G.1
Kao, Y.R.2
Wu, F.Y.3
Wu, C.W.4
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