Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

Journal of Leukocyte Biology

Volumn 90, Issue 3, 2011, Pages 551-562

  Jantsch, Jonathan ^a   Wiese, Melanie ^a   Schödel, Johannes ^a,b   Castiglione, Kirstin ^a   Gläsner, Joachim ^a   Kolbe, Sophie ^a   Mole, David ^b   Schleicher, Ulrike ^a   Eckardt, Kai Uwe ^a   Hensel, Michael ^c   Lang, Roland ^a   Bogdan, Christian ^a   Schnare, Markus ^d   Willam, Carsten ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OSNABRÜCK   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

CpG; Dendritic cells; HIF; LPS; MYD88; NOS2; Poly I:C; PTGS2; TRIF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION REGULATION; HYPOXIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANOXIA; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DENDRITIC CELLS; GENE EXPRESSION PROFILING; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 80052364757     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1210683     Document Type: Article

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