Chronically saturating levels of endogenous glycine disrupt glutamatergic neurotransmission and enhance synaptogenesis in the CA1 region of mouse hippocampus

Synapse

Volumn 65, Issue 11, 2011, Pages 1181-1195

  Bakkar, Wafae ^a,b   Ma, Chun Lei ^c   Pabba, Mohan ^a,b   Khacho, Pamela ^a,b   Zhang, Yong Li ^a   Muller, Emilie ^a   Martina, Marzia ^d   Bergeron, Richard ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c BINZHOU MEDICAL UNIVERSITY   (China)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Glutamate; Glycine encephalopathy; Ifenprodil; MEPSC; NMDA receptor; Whole cell patch clamp

Indexed keywords

GLYCINE; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POSTSYNAPTIC DENSITY PROTEIN 95; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 2; VESICULAR GLUTAMATE TRANSPORTER 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DENDRITE; HIPPOCAMPAL CA1 REGION; IC 50; IN VIVO STUDY; MEMBRANE POTENTIAL; MOUSE; NERVE EXCITABILITY; NEUROTRANSMISSION; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; STRATUM PYRAMIDALE; SYNAPSE; SYNAPTOGENESIS;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CA1 REGION, HIPPOCAMPAL; GLUTAMIC ACID; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURAL INHIBITION; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 80052357039     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20956     Document Type: Article

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