Developmental profile of the changing properties of NMDA receptors at cerebellar mossy fiber-granule cell synapses

Journal of Neuroscience

Volumn 20, Issue 16, 2000, Pages 5899-5905

  Cathala, Laurence ^a   Misra, Charu ^a   Cull Candy, Stuart ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cerebellum; Granule cells; NMDA receptors; NMDA subunit expression; NR2C subunit; Patch clamp; Synaptic transmission

Indexed keywords

IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; COLONY FORMATION; GENE DELETION; GRANULE CELL; MEMBRANE PERMEABILITY; MOSSY FIBER; NERVE CELL PLASTICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PATCH CLAMP; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION;

EID: 0034663159     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-16-05899.2000     Document Type: Article

References (46)

1. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats
2. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture
3. NMDA EPSCs at glutamatergic synapses in the spinal cord dorsal horn of the postnatal rat
4. Activity-dependent decrease in NMDA receptor responses during development of the visual cortex
5. Molecular characterisation of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule
6. A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors
7. NMDA receptor diversity in the cerebellum: Identification of subunits contributing to functional receptors
8. Different proportions of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor currents at the mossy fiber-granule cell synapse of developing rat cerebellum
9. Evidence for NMDA and mGlu receptor-dependent long-term potentiation of mossy fiber-granule cell transmission in rat cerebellum
10. The glutamate receptor ion channels
11. Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene
12. NMDA-receptor channel diversity in the developing cerebellum
13. Functional consequences of changes in NMDA receptor subunit expression during development
14. Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor
15. Physiological mechanisms underlying long-term potentiation
16. Differentiation of cerebellar mossy fiber synapses in the rat: A quantitative electron microscope study
17. Developmental regulation of NMDA mediated synaptic currents at a central synapse
18. Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture
19. Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit
20. Experience-dependent modification of synaptic plasticity in visual cortex
21. 2+ block in NMDA receptor channels
22. Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism
23. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
24. Long-term potentiation - A decade of progress?
25. 2+ of NMDA responses in spinal cord neurones
26. Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum
27. Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells
28. 2+ in rat central neurones
29. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
30. Magnesium gates glutamate-activated channels in mouse central neurones
31. High-affinity zinc inhibition of NMDA NR1-NR2A receptors
32. Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells
33. Rapid, expression-dependent expression of synaptic NMDA receptors in visual cortex in vivo
34. Enhanced NR2A subunit expression and decreased NMDA receptors decay time at the onset of ocular dominance plasticity in the ferret
35. Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons
36. Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ
37. Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites
38. Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons
39. Functional correlation of NMDA receptor epsilon subunit expression with the properties of single-channel and synaptic currents in the developing cerebellum
40. The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
41. Functional and pharmacological differences between recombinant NMDA receptors
42. Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord
43. NMDA receptor heterogeneity during postnatal development of the rat brain: Differential expression of the NR2A, NR2B, and NR2C subunit proteins
44. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
45. Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the epsilon 4 (NR2D) sub-unit
46. Single-channel activations and concentration jumps: Comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors