-
1
-
-
28344447734
-
Osteosarcoma: Basic science and clinical implications
-
Hayden JB, Hoang BH. Osteosarcoma: Basic science and clinical implications. Orthop. Clin. North. Am. 37(1), 1-7 (2006).
-
(2006)
Orthop. Clin. North. Am.
, vol.37
, Issue.1
, pp. 1-7
-
-
Hayden, J.B.1
Hoang, B.H.2
-
2
-
-
0022656434
-
The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity
-
Link MP, Goorin AM, Miser AW et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N. Engl. J. Med. 314(25), 1600-1606 (1986).
-
(1986)
N. Engl. J. Med.
, vol.314
, Issue.25
, pp. 1600-1606
-
-
Link, M.P.1
Goorin, A.M.2
Miser, A.W.3
-
3
-
-
70649090109
-
Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways
-
Cleton-Jansen A-M, Anninga JK, Briaire-De Bruijn IH et al. Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. Br. J. Cancer 101(11), 1909-1918 (2009).
-
(2009)
Br. J. Cancer
, vol.101
, Issue.11
, pp. 1909-1918
-
-
Cleton-Jansen, A-.M.1
Anninga, J.K.2
Briaire-De Bruijn, I.H.3
-
4
-
-
18244377210
-
Wnt/b-catenin pathway
-
Moon RT. Wnt/b-catenin pathway. Sci. STKE 2005(271), (2005).
-
(2005)
Sci. STKE
, vol.2005
, pp. 271
-
-
Moon, R.T.1
-
5
-
-
49049103833
-
Wnt signaling and cancer development: Therapeutic implication
-
Paul S, Dey A. Wnt signaling and cancer development: Therapeutic implication. Neoplasma 55(3), 165-176 (2008).
-
(2008)
Neoplasma
, vol.55
, Issue.3
, pp. 165-176
-
-
Paul, S.1
Dey, A.2
-
6
-
-
33847199795
-
Wnt signaling and human diseases: What are the therapeutic implications?
-
Luo J, Chen J, Deng Z-L et al. Wnt signaling and human diseases: What are the therapeutic implications? Lab. Invest 87(2), 97-103 (2007).
-
(2007)
Lab. Invest
, vol.87
, Issue.2
, pp. 97-103
-
-
Luo, J.1
Chen, J.2
Deng, Z.-.L.3
-
7
-
-
33751530490
-
Mining the Wnt pathway for cancer therapeutics
-
Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat. Rev. Drug. Discov. 5(12), 997-1014 (2006).
-
(2006)
Nat. Rev. Drug. Discov.
, vol.5
, Issue.12
, pp. 997-1014
-
-
Barker, N.1
Clevers, H.2
-
8
-
-
18044386744
-
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
-
Gong Y, Slee RB, Fukai N et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107(4), 513-523 (2001).
-
(2001)
Cell
, vol.107
, Issue.4
, pp. 513-523
-
-
Gong, Y.1
Slee, R.B.2
Fukai, N.3
-
9
-
-
0037092049
-
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
-
Kato M, Patel MS, Levasseur R et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157(2), 303-314 (2002).
-
(2002)
J. Cell Biol.
, vol.157
, Issue.2
, pp. 303-314
-
-
Kato, M.1
Patel, M.S.2
Levasseur, R.3
-
10
-
-
10744224854
-
High bone mass in mice expressing a mutant LRP5 gene
-
Babij P, Zhao W, Small C et al. High bone mass in mice expressing a mutant LRP5 gene. J. Bone Miner Res. 18(6), 960-974 (2003).
-
(2003)
J. Bone Miner Res.
, vol.18
, Issue.6
, pp. 960-974
-
-
Babij, P.1
Zhao, W.2
Small, C.3
-
11
-
-
34249978979
-
The Wnt signaling pathway and bone metabolism
-
Johnson ML, Kamel MA. The Wnt signaling pathway and bone metabolism. Curr. Opin. Rheumatol. 19(4), 376-382 (2007).
-
(2007)
Curr. Opin. Rheumatol.
, vol.19
, Issue.4
, pp. 376-382
-
-
Johnson, M.L.1
Kamel, M.A.2
-
13
-
-
0036888309
-
Cytoplasmic and/or nuclear accumulation of the b-catenin protein is a frequent event in human osteosarcoma
-
Haydon RC, Deyrup A, Ishikawa A et al. Cytoplasmic and/or nuclear accumulation of the b-catenin protein is a frequent event in human osteosarcoma. Int. J. Cancer 102(4), 338-342 (2002).
-
(2002)
Int. J. Cancer
, vol.102
, Issue.4
, pp. 338-342
-
-
Haydon, R.C.1
Deyrup, A.2
Ishikawa, A.3
-
14
-
-
70349101267
-
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling
-
Enomoto M, Hayakawa S, Itsukushima S et al. Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. Oncogene 28(36), 3197-3208 (2009).
-
(2009)
Oncogene
, vol.28
, Issue.36
, pp. 3197-3208
-
-
Enomoto, M.1
Hayakawa, S.2
Itsukushima, S.3
-
15
-
-
0742287878
-
Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma
-
Shows that aberrant activation of Wnt signaling in osteosarcoma is associated with worse prognosis
-
Hoang BH, Kubo T, Healey JH et al. Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. Int. J. Cancer 109(1), 106-111 (2004). Shows that aberrant activation of Wnt signaling in osteosarcoma is associated with worse prognosis.
-
(2004)
Int. J. Cancer
, vol.109
, Issue.1
, pp. 106-111
-
-
Hoang, B.H.1
Kubo, T.2
Healey, J.H.3
-
16
-
-
33845581657
-
Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma
-
Demonstrates that Wnt inhibitor Frzb/sFRP3 exhibits decreased expression in osteosarcoma samples
-
Mandal D, Srivastava A, Mahlum E et al. Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma. Gene 386(1-2), 131-138 (2007). Demonstrates that Wnt inhibitor Frzb/sFRP3 exhibits decreased expression in osteosarcoma samples.
-
(2007)
Gene
, vol.386
, Issue.1-2
, pp. 131-138
-
-
Mandal, D.1
Srivastava, A.2
Mahlum, E.3
-
17
-
-
65249167488
-
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
-
Kansara M, Tsang M, Kodjabachian L et al. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J. Clin. Invest. 119(4), 837-851 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, Issue.4
, pp. 837-851
-
-
Kansara, M.1
Tsang, M.2
Kodjabachian, L.3
-
18
-
-
73649132981
-
Inactive Wnt/b-catenin pathway in conventional high-grade osteosarcoma
-
Cai Y, Mohseny AB, Karperien M, Hogendoorn PC, Zhou G, Cleton-Jansen AM. Inactive Wnt/b-catenin pathway in conventional high-grade osteosarcoma. J. Pathol. 220(1), 24-33 (2010).
-
(2010)
J. Pathol.
, vol.220
, Issue.1
, pp. 24-33
-
-
Cai, Y.1
Mohseny, A.B.2
Karperien, M.3
Hogendoorn, P.C.4
Zhou, G.5
Cleton-Jansen, A..M.6
-
19
-
-
36049042525
-
Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
-
Matushansky I, Hernando E, Socci ND et al. Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J. Clin. Invest.117(11), 3248-3257 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, Issue.11
, pp. 3248-3257
-
-
Matushansky, I.1
Hernando, E.2
Socci, N.D.3
-
20
-
-
31444455766
-
Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines
-
Lin YC, You L, Xu Z et al. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochem. Biophys. Res. Commun. 341(2), 635-640 (2006).
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.341
, Issue.2
, pp. 635-640
-
-
Lin, Y.C.1
You, L.2
Xu, Z.3
-
21
-
-
3142679453
-
Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer
-
Mazieres J, He B, You L et al. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res. 64(14), 4717-4720 (2004).
-
(2004)
Cancer Res.
, vol.64
, Issue.14
, pp. 4717-4720
-
-
Mazieres, J.1
He, B.2
You, L.3
-
22
-
-
33644912283
-
Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma
-
Batra S, Shi Y, Kuchenbecker KM et al. Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem. Biophys. Res. Commun. 342(4), 1228-1232 (2006).
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.342
, Issue.4
, pp. 1228-1232
-
-
Batra, S.1
Shi, Y.2
Kuchenbecker, K.M.3
-
23
-
-
33745634864
-
Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer
-
Ai L, Tao Q, Zhong S et al. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis 27(7), 1341-1348 (2006).
-
(2006)
Carcinogenesis
, vol.27
, Issue.7
, pp. 1341-1348
-
-
Ai, L.1
Tao, Q.2
Zhong, S.3
-
24
-
-
32944481037
-
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray
-
Yamashita S, Tsujino Y, Moriguchi K, Tatematsu M, Ushijima T. Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 97(1), 64-71 (2006).
-
(2006)
Cancer Sci.
, vol.97
, Issue.1
, pp. 64-71
-
-
Yamashita, S.1
Tsujino, Y.2
Moriguchi, K.3
Tatematsu, M.4
Ushijima, T.5
-
25
-
-
77949667984
-
Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma
-
Rubin EM, Guo Y, Tu K, Xie J, Zi X, Hoang BH. Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol. Cancer Ther. 9(3), 731-741 (2010).
-
(2010)
Mol. Cancer Ther.
, vol.9
, Issue.3
, pp. 731-741
-
-
Rubin, E.M.1
Guo, Y.2
Tu, K.3
Xie, J.4
Zi, X.5
Hoang, B.H.6
-
26
-
-
44849108031
-
Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling
-
Guo Y, Xie J, Rubin E et al. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 68(9), 3350-3360 (2008).
-
(2008)
Cancer Res.
, vol.68
, Issue.9
, pp. 3350-3360
-
-
Guo, Y.1
Xie, J.2
Rubin, E.3
-
27
-
-
34347254641
-
The soluble Wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo
-
Verified the therapeutic potential for Wnt pathway inhibitors
-
DeAlmeida VI, Miao L, Ernst JA, Koeppen H, Polakis P, Rubinfeld B. The soluble Wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res. 67(11), 5371-5379 (2007). Verified the therapeutic potential for Wnt pathway inhibitors.
-
(2007)
Cancer Res.
, vol.67
, Issue.11
, pp. 5371-5379
-
-
DeAlmeida, V.I.1
Miao, L.2
Ernst, J.A.3
Koeppen, H.4
Polakis, P.5
Rubinfeld, B.6
-
28
-
-
0035663742
-
Adenomatous polyposis coli (APC) b-catenin and cadherin are expressed in human bone and cartilage
-
Monaghan H, Bubb VJ, Sirimujalin R, Millward-Sadler SJ, Salter DM. Adenomatous polyposis coli (APC), b-catenin, and cadherin are expressed in human bone and cartilage. Histopathology 39(6), 611-619 (2001).
-
(2001)
Histopathology
, vol.39
, Issue.6
, pp. 611-619
-
-
Monaghan, H.1
Bubb, V.J.2
Sirimujalin, R.3
Millward-Sadler, S.J.4
Salter, D.M.5
-
29
-
-
9244240664
-
Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-b-catenin pathway
-
Hoang BH, Kubo T, Healey JH et al. Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-b-catenin pathway. Cancer Res. 64(8), 2734-2739 (2004).
-
(2004)
Cancer Res.
, vol.64
, Issue.8
, pp. 2734-2739
-
-
Hoang, B.H.1
Kubo, T.2
Healey, J.H.3
-
30
-
-
0033516577
-
Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling
-
Fedi P, Bafico A, Nieto Soria A et al. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J. Biol. Chem. 274(27), 19465-19472 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.27
, pp. 19465-19472
-
-
Fedi, P.1
Bafico, A.2
Nieto Soria, A.3
-
31
-
-
34447279476
-
Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells
-
Guo Y, Zi X, Koontz Z et al. Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. J. Orthop. Res. 25(7), 964-971 (2007).
-
(2007)
J. Orthop. Res.
, vol.25
, Issue.7
, pp. 964-971
-
-
Guo, Y.1
Zi, X.2
Koontz, Z.3
-
32
-
-
50649124475
-
Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model
-
Verified the therapeutic signifiance of Wnt inhibitors in osteosarcoma
-
Guo Y, Rubin EM, Xie J, Zi X, Hoang BH. Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model. Clin. Orthop. Relat. Res. 466(9), 2039-2045 (2008). Verified the therapeutic signifiance of Wnt inhibitors in osteosarcoma.
-
(2008)
Clin. Orthop. Relat. Res.
, vol.466
, Issue.9
, pp. 2039-2045
-
-
Guo, Y.1
Rubin, E.M.2
Xie, J.3
Zi, X.4
Hoang, B.H.5
-
33
-
-
70349932747
-
Towards an integrated view of Wnt signaling in development
-
van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development. Development (Cambridge, England) 136(19), 3205-3214 (2009).
-
(2009)
Development (Cambridge, England)
, vol.136
, Issue.19
, pp. 3205-3214
-
-
Van Amerongen, R.1
Nusse, R.2
-
34
-
-
33646241997
-
Purified Wnt5a protein activates or inhibits b-catenin-TCF signaling depending on receptor context
-
Mikels AJ, Nusse R. Purified Wnt5a protein activates or inhibits b-catenin-TCF signaling depending on receptor context. PLoS Biol. 4(4), e115 (2006).
-
(2006)
PLoS Biol.
, vol.4
, Issue.4
-
-
Mikels, A.J.1
Nusse, R.2
-
35
-
-
10744219743
-
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway
-
Oishi I, Suzuki H, Onishi N et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8(7), 645-654 (2003).
-
(2003)
Genes Cells
, vol.8
, Issue.7
, pp. 645-654
-
-
Oishi, I.1
Suzuki, H.2
Onishi, N.3
-
36
-
-
67449103899
-
Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma
-
Morioka K, Tanikawa C, Ochi K et al. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci. 100(7), 1227-1233 (2009).
-
(2009)
Cancer Sci.
, vol.100
, Issue.7
, pp. 1227-1233
-
-
Morioka, K.1
Tanikawa, C.2
Ochi, K.3
-
37
-
-
0037109028
-
Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray
-
Nagayama S, Katagiri T, Tsunoda T et al. Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res. 62(20), 5859-5866 (2002).
-
(2002)
Cancer Res.
, vol.62
, Issue.20
, pp. 5859-5866
-
-
Nagayama, S.1
Katagiri, T.2
Tsunoda, T.3
-
38
-
-
28844448329
-
Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas
-
Nagayama S, Fukukawa C, Katagiri T et al. Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas. Oncogene 24(41), 6201-6212 (2005).
-
(2005)
Oncogene
, vol.24
, Issue.41
, pp. 6201-6212
-
-
Nagayama, S.1
Fukukawa, C.2
Katagiri, T.3
-
39
-
-
61349183717
-
Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma
-
Fukukawa C, Nagayama S, Tsunoda T, Toguchida J, Nakamura Y, Katagiri T. Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. Oncogene 28(8), 1110-1120 (2009).
-
(2009)
Oncogene
, vol.28
, Issue.8
, pp. 1110-1120
-
-
Fukukawa, C.1
Nagayama, S.2
Tsunoda, T.3
Toguchida, J.4
Nakamura, Y.5
Katagiri, T.6
-
40
-
-
0038380439
-
Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma
-
Coltella N, Manara MC, Cerisano V et al. Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma. FASEB J. 17(9), 1162-1164 (2003).
-
(2003)
FASEB J.
, vol.17
, Issue.9
, pp. 1162-1164
-
-
Coltella, N.1
Manara, M.C.2
Cerisano, V.3
-
41
-
-
0037105707
-
Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer
-
Boon EM, van der Neut R, van de Wetering M, Clevers H, Pals ST. Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. Cancer Res. 62(18), 5126-5128 (2002).
-
(2002)
Cancer Res.
, vol.62
, Issue.18
, pp. 5126-5128
-
-
Boon, E.M.1
Van Der Neut, R.2
Van De Wetering, M.3
Clevers, H.4
Pals, S.T.5
-
42
-
-
33646390939
-
MET overexpression turns human primary osteoblasts into osteosarcomas
-
Patané S, Avnet S, Coltella N et al. MET overexpression turns human primary osteoblasts into osteosarcomas. Cancer Res. 66(9), 4750-4757 (2006).
-
(2006)
Cancer Res.
, vol.66
, Issue.9
, pp. 4750-4757
-
-
Patané, S.1
Avnet, S.2
Coltella, N.3
-
43
-
-
23844510061
-
Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer
-
Yeon CH, Pegram MD. Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer. Invest. New Drugs 23(5), 391-409 (2005).
-
(2005)
Invest. New Drugs
, vol.23
, Issue.5
, pp. 391-409
-
-
Yeon, C.H.1
Pegram, M.D.2
-
44
-
-
27944456879
-
Investigating the potential of bevacizumab in other indications: Metastatic renal cell, non-small cell lung, pancreatic and breast cancer
-
de Gramont A, Van Cutsem E. Investigating the potential of bevacizumab in other indications: Metastatic renal cell, non-small cell lung, pancreatic and breast cancer. Oncology, 69(Suppl. 3), 46-56 (2005).
-
(2005)
Oncology
, vol.69
, Issue.SUPPL. 3
, pp. 46-56
-
-
De Gramont, A.1
Van Cutsem, E.2
-
45
-
-
18744384721
-
Small molecules with EGFR-TK inhibitor activity
-
Albanell J, Gascon P. Small molecules with EGFR-TK inhibitor activity. Curr. Drug Targets 6(3), 259-274 (2005).
-
(2005)
Curr. Drug Targets
, vol.6
, Issue.3
, pp. 259-274
-
-
Albanell, J.1
Gascon, P.2
-
46
-
-
77950552463
-
Targeting the HGF/Met signalling pathway in cancer
-
Established Met signaling as an important mediator in osteosarcoma
-
Cecchi F, Rabe DC, Bottaro DP. Targeting the HGF/Met signalling pathway in cancer. Eur. J. Cancer 46(7), 1260-1270 (2010). Established Met signaling as an important mediator in osteosarcoma.
-
(2010)
Eur. J. Cancer
, vol.46
, Issue.7
, pp. 1260-1270
-
-
Cecchi, F.1
Rabe, D.C.2
Bottaro, D.P.3
-
47
-
-
64849093206
-
A novel small molecule Met inhibitor, PF2362376, exhibits biological activity against osteosarcoma
-
Liao AT, McCleese J, Kamerling S, Christensen J, London CA. A novel small molecule Met inhibitor, PF2362376, exhibits biological activity against osteosarcoma. Vet. Comp. Oncol. 5(3), 177-196 (2007).
-
(2007)
Vet. Comp. Oncol.
, vol.5
, Issue.3
, pp. 177-196
-
-
Liao, A.T.1
McCleese, J.2
Kamerling, S.3
Christensen, J.4
London, C.A.5
-
48
-
-
70350108239
-
The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines
-
McCleese JK, Bear MD, Fossey SL et al. The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines. Int. J. Cancer 125(12), 2792-2801 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, Issue.12
, pp. 2792-2801
-
-
McCleese, J.K.1
Bear, M.D.2
Fossey, S.L.3
-
49
-
-
58149374839
-
Stemming cancer: Functional genomics of cancer stem cells in solid tumors
-
Regenbrecht CR, Lehrach H, Adjaye J. Stemming cancer: Functional genomics of cancer stem cells in solid tumors. Stem. Cell Rev. 4(4), 319-328 (2008).
-
(2008)
Stem. Cell Rev.
, vol.4
, Issue.4
, pp. 319-328
-
-
Regenbrecht, C.R.1
Lehrach, H.2
Adjaye, J.3
-
50
-
-
33644825465
-
Stem-like cells in bone sarcomas: Implications for tumorigenesis
-
Gibbs CP, Kukekov VG, Reith JD et al. Stem-like cells in bone sarcomas: Implications for tumorigenesis. Neoplasia 7(11), 967-976 (2005).
-
(2005)
Neoplasia
, vol.7
, Issue.11
, pp. 967-976
-
-
Gibbs, C.P.1
Kukekov, V.G.2
Reith, J.D.3
-
51
-
-
78649580167
-
Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity
-
Wang L, Park P, Zhang H, La Marca F, Lin C-Y. Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. Int. J. Cancer 128(2), 294-303 (2010).
-
(2010)
Int. J. Cancer
, vol.128
, Issue.2
, pp. 294-303
-
-
Wang, L.1
Park, P.2
Zhang, H.3
La Marca, F.4
Lin, C-.Y.5
-
52
-
-
54949122514
-
Detection and characterization of CD133+ cancer stem cells in human solid tumours
-
Tirino V, Desiderio V, d'Aquino R et al. Detection and characterization of CD133+ cancer stem cells in human solid tumours. PLoS One 3(10), e3469 (2008).
-
(2008)
PLoS One
, vol.3
, Issue.10
-
-
Tirino, V.1
Desiderio, V.2
D'Aquino, R.3
-
53
-
-
67651005780
-
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma
-
Verified a tumor-initiating cell population in osteosarcoma
-
Levings PP, McGarry SV, Currie TP et al. Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res. 69(14), 5648-5655 (2009). Verified a tumor-initiating cell population in osteosarcoma.
-
(2009)
Cancer Res.
, vol.69
, Issue.14
, pp. 5648-5655
-
-
Levings, P.P.1
McGarry, S.V.2
Currie, T.P.3
-
54
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh SK, Hawkins C, Clarke ID et al. Identification of human brain tumour initiating cells. Nature 432(7015), 396-401 (2004).
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
-
55
-
-
33846095137
-
Identification and expansion of human colon-cancer-initiating cells
-
Ricci-Vitiani L, Lombardi DG, Pilozzi E et al. Identification and expansion of human colon-cancer-initiating cells. Nature 445(7123), 111-115 (2007).
-
(2007)
Nature
, vol.445
, Issue.7123
, pp. 111-115
-
-
Ricci-Vitiani, L.1
Lombardi, D.G.2
Pilozzi, E.3
-
56
-
-
77954351665
-
Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance
-
Honoki K, Fujii H, Kubo A et al. Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. Oncol. Rep. 24(2), 501-505 (2010).
-
(2010)
Oncol. Rep.
, vol.24
, Issue.2
, pp. 501-505
-
-
Honoki, K.1
Fujii, H.2
Kubo, A.3
-
57
-
-
1242267927
-
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
-
Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10(1), 55-63 (2004).
-
(2004)
Nat. Med.
, vol.10
, Issue.1
, pp. 55-63
-
-
Sato, N.1
Meijer, L.2
Skaltsounis, L.3
Greengard, P.4
Brivanlou, A.H.5
-
58
-
-
28444438841
-
Defining the role of Wnt/b-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells
-
Dravid G, Ye Z, Hammond H et al. Defining the role of Wnt/b-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells 23(10), 1489-1501 (2005).
-
(2005)
Stem Cells
, vol.23
, Issue.10
, pp. 1489-1501
-
-
Dravid, G.1
Ye, Z.2
Hammond, H.3
-
59
-
-
77953715690
-
Targeting Wnt signaling: Can we safely eradicate cancer stem cells?
-
Takahashi-Yanaga F, Kahn M. Targeting Wnt signaling: Can we safely eradicate cancer stem cells? Clin Cancer Res. 16(12), 3153-3162 (2010).
-
(2010)
Clin Cancer Res.
, vol.16
, Issue.12
, pp. 3153-3162
-
-
Takahashi-Yanaga, F.1
Kahn, M.2
-
60
-
-
78449241791
-
PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: Chemoprevention by diclofenac
-
Kaur J, Sanyal SN. PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: Chemoprevention by diclofenac. Tumour Biol. 31(6), 623-631 (2010).
-
(2010)
Tumour Biol.
, vol.31
, Issue.6
, pp. 623-631
-
-
Kaur, J.1
Sanyal, S.N.2
-
61
-
-
0037421985
-
A randomized trial of aspirin to prevent colorectal adenomas
-
Baron JA, Cole BF, Sandler RS et al. A randomized trial of aspirin to prevent colorectal adenomas. N. Engl. J. Med. 348(10), 891-899 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, Issue.10
, pp. 891-899
-
-
Baron, J.A.1
Cole, B.F.2
Sandler, R.S.3
-
62
-
-
0036521678
-
Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention
-
Chan TA. Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention. Lancet Oncol. 3(3), 166-174 (2002).
-
(2002)
Lancet Oncol.
, vol.3
, Issue.3
, pp. 166-174
-
-
Chan, T.A.1
-
63
-
-
0037421984
-
A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
-
Sandler RS, Halabi S, Baron JA et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N. Engl. J. Med. 348(10), 883-890 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, Issue.10
, pp. 883-890
-
-
Sandler, R.S.1
Halabi, S.2
Baron, J.A.3
-
64
-
-
77957734800
-
Celecoxib inhibits b-catenin-dependent survival of the human osteosarcoma MG-63 cell line
-
Xia JJ, Pei LB, Zhuang JP et al. Celecoxib inhibits b-catenin-dependent survival of the human osteosarcoma MG-63 cell line. J. Int. Med. Res. 38(4), 1294-1304 (2010).
-
(2010)
J. Int. Med. Res.
, vol.38
, Issue.4
, pp. 1294-1304
-
-
Xia, J.J.1
Pei, L.B.2
Zhuang, J.P.3
-
65
-
-
74949129043
-
Enhanced anticancer activity of glutamate prodrugs of all-trans retinoic acid
-
Cui C, Zhang Y, Wang L, Liu H, Cui G. Enhanced anticancer activity of glutamate prodrugs of all-trans retinoic acid. J. Pharm. Pharmacol 61(10), 1353-1358 (2009).
-
(2009)
J. Pharm. Pharmacol
, vol.61
, Issue.10
, pp. 1353-1358
-
-
Cui, C.1
Zhang, Y.2
Wang, L.3
Liu, H.4
Cui, G.5
-
66
-
-
0347481364
-
Trans-repression of b-catenin activity by nuclear receptors
-
Shah S, Hecht A, Pestell R, Byers SW. Trans-repression of b-catenin activity by nuclear receptors. J. Biol. Chem. 278(48), 48137-48145 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.48
, pp. 48137-48145
-
-
Shah, S.1
Hecht, A.2
Pestell, R.3
Byers, S.W.4
-
67
-
-
12844274417
-
Quercetin, a potent inhibitor against b-catenin/Tcf signaling in SW480 colon cancer cells
-
Park CH, Chang JY, Hahm ER, Park S, Kim H-K, Yang CH. Quercetin, a potent inhibitor against b-catenin/Tcf signaling in SW480 colon cancer cells. Biochem. Biophys. Res. Commun. 328(1), 227-234 (2005).
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.328
, Issue.1
, pp. 227-234
-
-
Park, C.H.1
Chang, J.Y.2
Hahm, E.R.3
Park, S.4
Kim, H-.K.5
Yang, C.H.6
-
68
-
-
33744961079
-
Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1
-
Kim J, Zhang X, Rieger-Christ KM et al. Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1. J. Biol. Chem. 281(16), 10865-10875 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.16
, pp. 10865-10875
-
-
Kim, J.1
Zhang, X.2
Rieger-Christ, K.M.3
-
69
-
-
0037028207
-
B-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells
-
Jaiswal AS, Marlow BP, Gupta N, Narayan S. b-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21(55), 8414-8427 (2002).
-
(2002)
Oncogene
, vol.21
, Issue.55
, pp. 8414-8427
-
-
Jaiswal, A.S.1
Marlow, B.P.2
Gupta, N.3
Narayan, S.4
-
70
-
-
41549166240
-
Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia
-
Roccaro AM, Leleu X, Sacco A et al. Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia. Clin. Cancer Res. 14(6), 1849-1858 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.6
, pp. 1849-1858
-
-
Roccaro, A.M.1
Leleu, X.2
Sacco, A.3
-
71
-
-
77955559259
-
Targeting breast stem cells with the cancer preventive compounds curcumin and piperine
-
Demonstrates that cancer stem cells can be targeted through modulation of the Wnt pathway
-
Kakarala M, Brenner DE, Korkaya H et al. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res. Treat 122(3), 777-785 (2010). Demonstrates that cancer stem cells can be targeted through modulation of the Wnt pathway.
-
(2010)
Breast Cancer Res. Treat
, vol.122
, Issue.3
, pp. 777-785
-
-
Kakarala, M.1
Brenner, D.E.2
Korkaya, H.3
-
72
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/b-catenin protein complex
-
Lepourcelet M, Chen Y-NP, France DS et al. Small-molecule antagonists of the oncogenic Tcf/b-catenin protein complex. Cancer Cell 5(1), 91-102 (2004).
-
(2004)
Cancer Cell
, vol.5
, Issue.1
, pp. 91-102
-
-
Lepourcelet, M.1
Chen, Y.-N.P.2
France, D.S.3
-
73
-
-
33744821869
-
Inhibition of protein-protein interactions: The discovery of druglike b-catenin inhibitors by combining virtual and biophysical screening
-
Trosset J-Y, Dalvit C, Knapp S et al. Inhibition of protein-protein interactions: The discovery of druglike b-catenin inhibitors by combining virtual and biophysical screening. Proteins 64(1), 60-67 (2006).
-
(2006)
Proteins
, vol.64
, Issue.1
, pp. 60-67
-
-
Trosset, J-.Y.1
Dalvit, C.2
Knapp, S.3
-
74
-
-
68549112883
-
2,4-diamino-quinazolines as inhibitors of b-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer
-
Chen Z, Venkatesan AM, Dehnhardt CM et al. 2,4-diamino-quinazolines as inhibitors of b-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer. Bioorg Med. Chem. Lett. 19(17), 4980-4983 (2009).
-
(2009)
Bioorg Med. Chem. Lett.
, vol.19
, Issue.17
, pp. 4980-4983
-
-
Chen, Z.1
Venkatesan, A.M.2
Dehnhardt, C.M.3
-
75
-
-
67650266967
-
Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled
-
Grandy D, Shan J, Zhang X et al. Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J. Biol. Chem. 284(24), 16256-16263 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.24
, pp. 16256-16263
-
-
Grandy, D.1
Shan, J.2
Zhang, X.3
-
76
-
-
28244496603
-
Identification of a specific inhibitor of the dishevelled PDZ domain
-
Shan J, Shi D-L, Wang J, Zheng J. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44(47), 15495-15503 (2005).
-
(2005)
Biochemistry
, vol.44
, Issue.47
, pp. 15495-15503
-
-
Shan, J.1
Shi, D-.L.2
Wang, J.3
Zheng, J.4
-
77
-
-
33846673934
-
An antagonist of dishevelled protein-protein interaction suppresses b-catenin-dependent tumor cell growth
-
Fujii N, You L, Xu Z et al. An antagonist of dishevelled protein-protein interaction suppresses b-catenin-dependent tumor cell growth. Cancer Res. 67(2), 573-579 (2007).
-
(2007)
Cancer Res.
, vol.67
, Issue.2
, pp. 573-579
-
-
Fujii, N.1
You, L.2
Xu, Z.3
-
78
-
-
4344587136
-
A small molecule inhibitor of b-catenin/CREB-binding protein transcription [corrected]
-
Emami KH, Nguyen C, Ma H et al. A small molecule inhibitor of b-catenin/CREB-binding protein transcription [corrected]. Proc. Natl Acad. Sci. USA 101(34), 12682-12687 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, Issue.34
, pp. 12682-12687
-
-
Emami, K.H.1
Nguyen, C.2
Ma, H.3
-
79
-
-
1642341682
-
A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
-
He B, You L, Uematsu K et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 6(1), 7-14 (2004).
-
(2004)
Neoplasia
, vol.6
, Issue.1
, pp. 7-14
-
-
He, B.1
You, L.2
Uematsu, K.3
-
80
-
-
33746040565
-
Canonical Wnt signaling: High-throughput RNAi widens the path
-
Brown AM. Canonical Wnt signaling: High-throughput RNAi widens the path. Genome Biol. 6(9), 231 (2005).
-
(2005)
Genome Biol.
, vol.6
, Issue.9
, pp. 231
-
-
Brown, A..M.1
|