Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 8, 2011, Pages 5144-5152

  Kalariya, Nilesh M ^a,b   Reddy, Aramati B M ^a   Ansari, Naseem H ^a   VanKuijk, Frederik J G M ^a   Ramana, Kota V ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b University of Texas Medical Branch School of Nursing   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; RANTES; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLOOXYGENASE 2; ENDOTOXIN; ENDOTOXIN, ESCHERICHIA COLI; LIPOPOLYSACCHARIDE;

ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CELL INFILTRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UVEITIS; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CILIARY BODY; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FLUORESCENCE MICROSCOPY; LEWIS RAT; METABOLISM; TREATMENT OUTCOME;

ANIMALS; AQUEOUS HUMOR; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CILIARY BODY; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; ENDOTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; HUMANS; LIPOPOLYSACCHARIDES; MALE; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; PYRUVATES; RATS; RATS, INBRED LEW; REACTIVE OXYGEN SPECIES; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS;

EID: 80052311925     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-7047     Document Type: Article

References (52)

1. Holleman MAF. Notice sur l'action de l'eau oxygénée sur les acétoniques et sur le dicétones. Recl Trav Chim Pays-bas Belg. 1904;23:169-171.
2. Ervens B, Gligorovski S, Herrmann H. Temperature dependent rate constants for hydroxyl radical reactions with organic compounds in aqueous solutions. Phys Chem Chem Phys. 2003;5: 1811-1824.
3. Varma SD, Hegde KR. Lens thiol depletion by peroxynitrite. Protective effect of pyruvate. Mol Cell Biochem. 2007;298:199-204.
4. Kao KK, Fink MP. The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds. Biochem Pharmacol. 2010;80:151-159.
5. Yang R, Gallo DJ, Baust JJ, et al. Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2002;283:G212-G222.
6. Venkataraman R, Kellum JA, Song M, Fink MP. Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock. Shock. 2002;18:507-512.
7. Ulloa L, Ochani M, Yang H, et al. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A. 2002;99:12351-12356.
8. Johansson AS, Johansson-Haque K, Okret S, Palmblad J. Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway. Br J Pharmacol. 2008;154:1318-1326.
9. Dong W, Cai B, Pena G, et al. Ethyl pyruvate prevents inflammatory responses and organ damage during porcine hemorrhage. Shock. 2010;34:205-213.
10. Cai B, Chen F, Lin X, et al. Anti-inflammatory adjuvant in resuscitation fluids improves survival in hemorrhage. Crit Care Med. 2009;37:860-868.
11. Davé SH, Tilstra JS, Matsuoka K, et al. Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J Leukoc Biol. 2009;86:633-643.
12. Yang YZ, Ling Y, Yin T, et al. Delayed ethyl pyruvate therapy attenuates experimental acute pancreatitis via reduced serum high mobility group box 1 levels in rats. World J Gastroenterol. 2008;14:4546-4550.
13. Hamada N, Maeyama T, Kawaguchi T, et al. The role of high mobility group box 1 in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2008;39:440-447.
14. Varma SD, Devamanoharan PS, Ali AH. Prevention of intracellular oxidative stress to lens by pyruvate and its ester. Free Radic Res. 1998;28:131-135.
15. Varma SD, Devamanoharan PS, Rutzen AR, Ali AH, Henein M. Attenuation of galactose-induced cataract by pyruvate. Free Radic Res. 1999;30:253-263.
16. Devamanoharan PS, Henein M, Ali AH, Varma SD. Attenuation of sugar cataract by ethyl pyruvate. Mol Cell Biochem. 1999;200: 103-109.
17. Nussenblatt RB. The natural history of uveitis. Int Ophthalmol. 1990;14:303-308.
18. Joussen AM, Poulaki V, Le ML, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004; 18:1450-1452.
19. Ambati J, Anand A, Fernandez S, et al. An animal model of age-related macular degeneration in senescent Ccl-2-or Ccr-2-deficient mice. Nat Med. 2003;9:1390-1397.
20. Smith JA, Mackensen F, Sen HN, et al. Epidemiology and course of disease in childhood uveitis. Ophthalmology. 2009;116:1544-1551.
21. Read RW. Uveitis: advances in understanding of pathogenesis. Curr Rheumatol Rep. 2006;8:260-266.
22. Izumi-Nagai K, Nagai N, Ozawa Y, et al. Interleukin-6 receptormediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol. 2007;170:2149-2158.
23. Koizumi K, Poulaki V, Doehmen S, et al. Contribution of TNFalpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo. Invest Ophthalmol Vis Sci. 2003;44:2184-2191.
24. Shiratori K, Ohgami K, Ilieva IB, Koyama Y, Yoshida K, Ohno S. Inhibition of endotoxin-induced uveitis and potentiation of cyclooxygenase-2 protein expression by alpha-melanocyte-stimulating hormone. Invest Ophthalmol Vis Sci. 2004;45:159-164.
25. Bellot JL, Palmero M, Garcia-Cabanes C, Espi R, Hariton C, Orts A. Additive effect of nitric oxide and prostaglandin-E2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit. Inflamm Res. 1996;45:203-208.
26. Mo JS, Matsukawa A, Ohkawara S, Yoshinaga M. Role and regulation of IL-8 and MCP-1 in LPS-induced uveitis in rabbits. Exp Eye Res. 1999;68:333-340.
27. Kurihara T, Ozawa Y, Shinoda K, et al. Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation. Invest Ophthalmol Vis Sci. 2006;47:5545-5552.
28. Nagai N, Oike Y, Noda K, et al. Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor. Invest Ophthalmol Vis Sci. 2005;46:2925-2931.
29. Nagai N, Izumi-Nagai K, Oike Y, et al. Suppression of diabetesinduced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway. Invest Ophthalmol Vis Sci. 2007;48:4342-4350.
30. Becker MD, Garman K, Whitcup SM, Planck SR, Rosenbaum JT. Inhibition of leukocyte sticking and infiltration, but not rolling, by antibodies to ICAM-1 and LFA-1 in murine endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 2001;42:2563-2566.
31. Yadav UCS, Kalariya NM, Ramana KV. Emerging role of antioxidants in the protection of uveitis complications. Curr Med Chem. 2011;18:931-942.
32. Kalariya NM, Shoeb M, Reddy AB, Zhang M, van Kuijk FJ, Ramana KV. Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone. Invest Ophthalmol Vis Sci. 2010;51:5105-5113.
33. Sims CA, Wattanasirichaigoon S, Menconi MJ, Ajami AM, Fink MP. Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Crit Care Med. 2001;29:1513-1518.
34. Huang LF, Yao YM, Zhang LT, Dong N, Yu Y, Sheng ZY. The effect of high mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats. Shock. 2009;31:322-329.
35. Harvey SA, Guerriero E, Charukamnoetkanok N, Piluek J, Schuman JS, Sundarraj N. Responses of cultured human keratocytes and myofibroblasts to ethyl pyruvate: a microarray analysis of gene expression. Invest Ophthalmol Vis Sci. 2010;51:2917-2927.
36. Varma SD, Hegde KR, Kovtun S. Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate. Ophthalmologica. 2006;220:52-57.
37. Hegde KR, Kovtun S, Varma SD. Intraocular penetration of pyruvate following its topical administration in mice. Mol Cell Biochem. 2010;338:87-90.
38. Han Y, Englert JA, Yang R, Delude RL, Fink MP. Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. J Pharmacol Exp Ther. 2005;312:1097-1105.
39. Song M, Kellum JA, Kaldas H, Fink MP. Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells. J Pharmacol Exp Ther. 2004;308:307-316.
40. Genovese T, Esposito E, Mazzon E, et al. Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury. Shock. 2009;32: 217-227.
41. Duygulu F, Evereklioglu C, Calis M, Borlu M, Cekmen M, Ascioglu O. Synovial nitric oxide concentrations are increased and correlated with serum levels in patients with active Behçet's disease: a pilot study. Clin Rheumatol. 2005;24:324-330.
42. Mandai M, Yoshimura N, Yoshida M, Iwaki M, Honda Y. The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine. Invest Ophthalmol Vis Sci. 1994;35:3673-3680.
43. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A. 1993;90:7240-7244.
44. Coca-Prados M, Escribano J, Ortego J. Differential gene expression in the human ciliary epithelium. Prog Retin Eye Res. 1999;18: 403-429.
45. Santos Lacomba M, Marcos Martin C, Gallardo Galera JM, et al. Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis. Ophthalmic Res. 2001;33:251-255.
46. Yadav UC, Srivastava SK, Ramana KV. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2007;48:4634-4642.
47. Yadav UC, Subramanyam S, Ramana KV. Prevention of endotoxininduced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci. 2009;50:2276-2282.
48. Franks WA, Limb GA, Stanford MR, et al. Cytokines in human intraocular inflammation. Curr Eye Res. 1992;11:187-191.
49. Tugal-Tutkun I, Mudun A, Urgancioglu M, et al. Efficacy of infliximab in the treatment of uveitis that is resistant to treatment with the combination of azathioprine, cyclosporine, and corticosteroids in Behçet's disease: an open-label trial. Arthritis Rheum. 2005;52:2478-2484.
50. Surh YJ, Chun KS, Cha HH, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NFkappa B activation. Mutat Res. 2001;480-481:243-268.
51. Alexander G, Carlsen H, Blomhoff R. Strong in vivo activation of NF-kappaB in mouse lenses by classic stressors. Invest Ophthalmol Vis Sci. 2003;44:2683-2688.
52. 2-mediated oxidative stress activates NF-kappa B in lens epithelial cells. Free Radic Biol Med. 2001;31:651-658.