Inhibition of leukocyte sticking and infiltration, but not rolling, by antibodies to ICAM-1 and LFA-1 in murine endotoxin-induced uveitis

Investigative Ophthalmology and Visual Science

Volumn 42, Issue 11, 2001, Pages 2563-2566

  Becker, M D ^a   Garman, K ^a   Whitcup, S M ^a   Planck, S R ^a   Rosenbaum, J T ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI ENDOTOXIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1 ANTIBODY; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNOMODULATION; INFLAMMATORY INFILTRATE; IRIS; LEUKOCYTE ADHERENCE INHIBITION; LEUKOCYTE MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UVEITIS;

ACUTE DISEASE; ANIMALS; ANTIBODIES, MONOCLONAL; CELL ADHESION; CHEMOTAXIS, LEUKOCYTE; ESCHERICHIA COLI; FEMALE; FLUOROPHOTOMETRY; INJECTIONS, INTRAPERITONEAL; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES; LIPOPOLYSACCHARIDES; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, INBRED BALB C; UVEITIS, ANTERIOR;

EID: 0034787987     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Endotoxin-induced uveitis in rats as a model for human disease
2. An evaluation of ocular inflammation following the injection of bacterial endotoxin into the rat foot pad
3. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
4. The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment
5. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
6. Role of P-selectin in endotoxin-induced uveitis
7. Monoclonal antibody against CD11b/CD18 inhibits endotoxin-induced uveitis
8. Role of ICAM-1 and LFA-1 in endotoxin-induced uveitis in mice
9. Efficacy of antibodies to adhesion molecules, CD11a or CD18, in rabbit models of uveitis
10. Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis
11. Blocking both E-selectin and P-selectin inhibits endotoxin-induced leukocyte infiltration into the eye
12. The effect of genetic deficiency of adhesion molecules on the course of endotoxin-induced uveitis
13. Digital video-imaging of leukocyte migration in the iris: Intravital microscopy in a physiological model during the onset of endotoxin-induced uveitis
14. Inhibition of mixed lymphocyte response by a rat monoclonal antibody to a novel murine lymphocyte activation antigen (MALA-2)
15. Reduction in the severity of graft-versus-host disease and increased survival in allogenic mice by treatment with monoclonal antibodies to cell adhesion antigens LFA-1 alpha and MALA-2
16. Monoclonal antibodies against ICAM-1 (CD54) and LFA-1 (CD11a/CD18) inhibit experimental autoimmune uveitis
17. Blocking ICAM-1 (CD54) and LFA-1 (CD11a) inhibits experimental allergic conjunctivitis
18. Regulation of ICAM-1 expression in mouse macrophages
19. Intercellular adhesion molecular 1 on monocytes mediates adhesion as well as trans-endothelial migration and can he downregulated using antisense oligonucleotides