메뉴 건너뛰기




Volumn 215, Issue 3, 2011, Pages 581-593

Pharmacological and behavioral characterization of the 5-HT2A receptor in C57BL/6N mice

Author keywords

5 HT2A receptor; 5 HT2C receptor; Affinity; Cortex; Frontal cortex; Mouse; Pharmacological profile; Rat; Receptor density; Receptor regulation

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; GLEMANSERIN; KETANSERIN; MESULERGINE; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SODIUM CHLORIDE; TRITIUM; 4-IODO-2,5-DIMETHOXYPHENYLISOPROPYLAMINE; ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL; AMPHETAMINE DERIVATIVE; LIGAND; PIPERIDINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

EID: 80052306107     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2207-6     Document Type: Article
Times cited : (31)

References (75)
  • 1
    • 0032868038 scopus 로고    scopus 로고
    • Serotonin and hallucinogens
    • DOI 10.1016/S0893-133X(98)00135-3, PII S0893133X98001353
    • Aghajanian GK, Marek GJ (1999) Serotonin and hallucinogens. Neuropsychopharmacology 21(2 Suppl): 16S-23S (Pubitemid 29396466)
    • (1999) Neuropsychopharmacology , vol.21 , Issue.2 SUPPL.
    • Aghajanian, G.K.1    Marek, G.J.2
  • 2
    • 0034644787 scopus 로고    scopus 로고
    • Antagonist binding at 5-HT(2A) and 5-HT (2C) receptors in the rabbit: High correlation with the profile for the human receptors
    • Aloyo VJ, Harvey JA (2000) Antagonist binding at 5-HT(2A) and 5-HT (2C) receptors in the rabbit: high correlation with the profile for the human receptors. Eur J Pharmacol 406(2): 163-169
    • (2000) Eur J Pharmacol , vol.406 , Issue.2 , pp. 163-169
    • Aloyo, V.J.1    Harvey, J.A.2
  • 4
    • 59949102887 scopus 로고    scopus 로고
    • Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors
    • Aloyo VJ, Berg KA, Spampinato U, Clarke WP, Harvey JA (2009) Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors. Pharmacol Ther 121(2): 160-173
    • (2009) Pharmacol Ther , vol.121 , Issue.2 , pp. 160-173
    • Aloyo, V.J.1    Berg, K.A.2    Spampinato, U.3    Clarke, W.P.4    Harvey, J.A.5
  • 5
    • 0033837453 scopus 로고    scopus 로고
    • Regulation of 5-HT(2A) receptor mRNA levels and binding sites in rat frontal cortex by the agonist DOI and the antagonist mianserin
    • DOI 10.1016/S0028-3908(00)00026-5, PII S0028390800000265
    • Anji A, Kumari M, Sullivan Hanley NR, Bryan GL, Hensler JG (2000) Regulation of 5-HT(2A) receptor mRNA levels and binding sites in rat frontal cortex by the agonist DOI and the antagonist mianserin. Neuropharmacology 39(11): 1996-2005 (Pubitemid 30645623)
    • (2000) Neuropharmacology , vol.39 , Issue.11 , pp. 1996-2005
    • Anji, A.1    Kumari, M.2    Sullivan Hanley, N.R.3    Bryan, G.L.4    Hensler, J.G.5
  • 6
    • 0020567145 scopus 로고
    • 2 serotonin receptors
    • Battaglia G, Shannon M, Borgundvaag B, Titeler M (1983) pHdependent modulation of agonist interactions with [3H]-ketanserin-labelled S2 serotonin receptors. Life Sci 33 (20): 2011-2016 (Pubitemid 13021863)
    • (1983) Life Sciences , vol.33 , Issue.20 , pp. 2011-2016
    • Battaglia, G.1    Shannon, M.2    Borgundvaag, B.3    Titeler, M.4
  • 7
    • 0021740384 scopus 로고
    • 2 serotonin receptors
    • DOI 10.1111/j.1471-4159.1984.tb05375.x
    • Battaglia G, Shannon M, Titeler M (1984) Guanyl nucleotide and divalent cation regulation of cortical S2 serotonin receptors. J Neurochem 43(5): 1213-1219 (Pubitemid 15206964)
    • (1984) Journal of Neurochemistry , vol.43 , Issue.5 , pp. 1213-1219
    • Battaglia, G.1    Shannon, M.2    Titeler, M.3
  • 8
    • 50349100815 scopus 로고    scopus 로고
    • Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression
    • Berg KA, Harvey JA, Spampinato U, Clarke WP (2008) Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression. Prog Brain Res 172: 287-305
    • (2008) Prog Brain Res , vol.172 , pp. 287-305
    • Berg, K.A.1    Harvey, J.A.2    Spampinato, U.3    Clarke, W.P.4
  • 10
    • 0029064303 scopus 로고
    • The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: Comparison with 5-HT2A and 5-HT2C receptors
    • Bonhaus DW, Bach C, DeSouza A, Salazar FH, Matsuoka BD, Zuppan P, Chan HW, Eglen RM (1995) The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br J Pharmacol 115(4): 622-628
    • (1995) Br J Pharmacol , vol.115 , Issue.4 , pp. 622-628
    • Bonhaus, D.W.1    Bach, C.2    Desouza, A.3    Salazar, F.H.4    Matsuoka, B.D.5    Zuppan, P.6    Chan, H.W.7    Eglen, R.M.8
  • 11
    • 35548957905 scopus 로고    scopus 로고
    • 2A receptor
    • DOI 10.1124/mol.107.039255
    • Braden MR, Nichols DE (2007) Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor. Mol Pharmacol 72(5): 1200-1209 (Pubitemid 350012594)
    • (2007) Molecular Pharmacology , vol.72 , Issue.5 , pp. 1200-1209
    • Braden, M.R.1    Nichols, D.E.2
  • 12
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 14
    • 0027431521 scopus 로고
    • 2 receptor down-regulation
    • DOI 10.1016/0014-2999(93)90670-D
    • Chaouloff F, Baudrie V, Coupry I (1993) Behavioural and biochemical evidence that glucocorticoids are not involved in DOI-elicited 5-HT2 receptor down-regulation. Eur J Pharmacol 249(1): 117-120 (Pubitemid 23326918)
    • (1993) European Journal of Pharmacology , vol.249 , Issue.1 , pp. 117-120
    • Chaouloff, F.1    Baudrie, V.2    Coupry, I.3
  • 15
    • 0030776330 scopus 로고    scopus 로고
    • Repeated DOI and SR 46349B treatments do not affect elevated plus-maze anxiety despite opposite effects on cortical 5-HT(2A) receptors
    • DOI 10.1016/S0014-2999(97)01197-7, PII S0014299997011977
    • Chaouloff F, Kulikov A, Mormède P (1997) Repeated DOI and SR 46349B treatments do not affect elevated plus-maze anxiety despite opposite effects on cortical 5-HT2A receptors. Eur J Pharmacol 334(1): 25-29 (Pubitemid 27417804)
    • (1997) European Journal of Pharmacology , vol.334 , Issue.1 , pp. 25-29
    • Chaouloff, F.1    Kulikov, A.2    Mormede, P.3
  • 16
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
    • Cheng Y, Prusoff WH (1973) Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 22(23): 3099-3108
    • (1973) Biochem Pharmacol , vol.22 , Issue.23 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 17
    • 0024987703 scopus 로고
    • 2 receptor-induced head-twitch behaviour in mice
    • DOI 10.1016/0014-2999(90)94066-7
    • Darmani NA, Martin BR, Glennon RA (1990) Withdrawal from chronic treatment with (+/-)-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice. Eur J Pharmacol 186(1): 115-118 (Pubitemid 20277552)
    • (1990) European Journal of Pharmacology , vol.186 , Issue.1 , pp. 115-118
    • Darmani, N.A.1    Martin, B.R.2    Glennon, R.A.3
  • 18
    • 34548831411 scopus 로고    scopus 로고
    • 2A receptor-mediated behavior in the rabbit
    • DOI 10.1124/jpet.107.121707
    • Dave KD, Harvey JA, Aloyo VJ (2007) The time-course for up-and down-regulation of the cortical 5-hydroxytryptamine (5-HT)2A receptor density predicts 5-HT2A receptor-mediated behavior in the rabbit. J Pharmacol Exp Ther 323(1): 327-335 (Pubitemid 47443241)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.323 , Issue.1 , pp. 327-335
    • Dave, K.D.1    Harvey, J.A.2    Aloyo, V.J.3
  • 19
    • 0029804087 scopus 로고    scopus 로고
    • Similarities in the pharmacology of spontaneous and DOI-induced head-shakes suggest 5HT(2A) receptors are active under physiological conditions
    • DOI 10.1007/s002130050125
    • Dursun SM, Handley SL (1996) Similarities in the pharmacology of spontaneous and DOI-induced head-shakes suggest 5HT2A receptors are active under physiological conditions. Psychopharmacology (Berl) 128(2): 198-205 (Pubitemid 26383307)
    • (1996) Psychopharmacology , vol.128 , Issue.2 , pp. 198-205
    • Dursun, S.M.1    Handley, S.L.2
  • 20
    • 33744907721 scopus 로고    scopus 로고
    • Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder
    • DOI 10.1016/j.pnpbp.2005.11.005, PII S0278584605003490
    • El Mansari M, Blier P (2006) Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 30(3): 362-373 (Pubitemid 43841738)
    • (2006) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.30 , Issue.3 , pp. 362-373
    • El Mansari, M.1    Blier, P.2
  • 21
    • 0031894597 scopus 로고    scopus 로고
    • Effect of chronic m-CPP on locomotion, hypophagia, plasma corticosterone and 5-HT(2C) receptor levels in the rat
    • DOI 10.1038/sj.bjp.0701798
    • Fone KC, Austin RH, Topham IA, Kennett GA, Punhani T (1998) Effect of chronic m-CPP on locomotion, hypophagia, plasma corticosterone and 5-HT2C receptor levels in the rat. Br J Pharmacol 123(8): 1707-1715 (Pubitemid 28182055)
    • (1998) British Journal of Pharmacology , vol.123 , Issue.8 , pp. 1707-1715
    • Fone, K.C.F.1    Austin, R.H.2    Topham, I.A.3    Kennett, G.A.4    Punhani, T.5
  • 22
    • 77955769870 scopus 로고    scopus 로고
    • The serotonin 5-HT(2A) receptor agonist TCB-2: A behavioral and neurophysiological analysis
    • Fox MA, French HT, Laporte JL, Blackler AR, Murphy DL (2010) The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology 212(1): 13-23
    • (2010) Psychopharmacology , vol.212 , Issue.1 , pp. 13-23
    • Fox, M.A.1    French, H.T.2    Laporte, J.L.3    Blackler, A.R.4    Murphy, D.L.5
  • 25
    • 0021285237 scopus 로고
    • 2 receptor-mediated head-twitch behaviour following antidepressant treatment to mice
    • Goodwin GM, Green AR, Johnson P (1984) 5-HT2 receptor characteristics in frontal cortex and 5-HT2 receptor-mediated head-twitch behaviour following antidepressant treatment to mice. Br J Pharmacol 83(1): 235-242 (Pubitemid 14028836)
    • (1984) British Journal of Pharmacology , vol.83 , Issue.1 , pp. 235-242
    • Goodwin, G.M.1    Green, A.R.2    Johnson, P.3
  • 26
    • 0035891883 scopus 로고    scopus 로고
    • 2A receptors by agonists and antagonists
    • DOI 10.1016/S0361-9230(01)00623-2, PII S0361923001006232
    • Gray JA, Roth BL (2001) Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists. Brain Res Bull 56 (5): 441-451 (Pubitemid 34031779)
    • (2001) Brain Research Bulletin , vol.56 , Issue.5 , pp. 441-451
    • Gray, J.A.1    Roth, B.L.2
  • 27
    • 84940137804 scopus 로고
    • Differential binding of ergot compounds to human versus rat 5-HT2 cortical receptors
    • Hagen JD, Pierce PA, Peroutka SJ (1994) Differential binding of ergot compounds to human versus rat 5-HT2 cortical receptors. Biol Signals 3(5): 223-229
    • (1994) Biol Signals , vol.3 , Issue.5 , pp. 223-229
    • Hagen, J.D.1    Pierce, P.A.2    Peroutka, S.J.3
  • 28
    • 0142089973 scopus 로고    scopus 로고
    • 2A receptor learning
    • DOI 10.1101/lm.60803
    • Harvey JA (2003) Role of the serotonin 5-HT(2A) receptor in learning. Learn Mem 10(5): 355-362 (Pubitemid 37266680)
    • (2003) Learning and Memory , vol.10 , Issue.5 , pp. 355-362
    • Harvey, J.A.1
  • 29
    • 23944486104 scopus 로고    scopus 로고
    • Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: Implications for Tourette's syndrome
    • DOI 10.1016/j.pbb.2005.06.010, PII S0091305705002157
    • Hayslett RL, Tizabi Y (2005) Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome. Pharmacol Biochem Behav 81 (4): 879-886 (Pubitemid 41187823)
    • (2005) Pharmacology Biochemistry and Behavior , vol.81 , Issue.4 , pp. 879-886
    • Hayslett, R.L.1    Tizabi, Y.2
  • 30
    • 0022349905 scopus 로고
    • 2 receptors
    • DOI 10.1016/0028-3908(85)90155-8
    • Heal DJ, Philpot J, Molyneux SG, Metz A (1985) Intracerebroventricular administration of 5, 7-dihydroxytryptamine to mice increases both head-twitch response and the number of cortical 5-HT2 receptors. Neuropharmacology 24(12): 1201-1205 (Pubitemid 16182645)
    • (1985) Neuropharmacology , vol.24 , Issue.12 , pp. 1201-1205
    • Heal, D.J.1    Philpot, J.2    Molyneux, S.G.3    Metz, A.4
  • 31
    • 0032210715 scopus 로고    scopus 로고
    • 2 receptor agonist or antagonist administration on serotonin-(1A) receptor sensitivity
    • DOI 10.1016/S0893-133X(98)00037-2, PII S0893133X98000372
    • Hensler JG, Truett KA (1998) Effect of chronic serotonin-2 receptor agonist or antagonist administration on serotonin-1A receptor sensitivity. Neuropsychopharmacology 19(5): 354-364 (Pubitemid 28451592)
    • (1998) Neuropsychopharmacology , vol.19 , Issue.5 , pp. 354-364
    • Hensler, J.G.1    Truett, K.A.2
  • 32
    • 0022340287 scopus 로고
    • 3H]ketanserin
    • DOI 10.1016/0014-2999(85)90658-2
    • Hoyer D, Engel G, Kalkman HO (1985) Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin. Eur J Pharmacol 118(1-2): 13-23 (Pubitemid 16189567)
    • (1985) European Journal of Pharmacology , vol.118 , Issue.1-2 , pp. 13-23
    • Hoyer, D.1    Engel, G.2    Kalkman, H.O.3
  • 33
    • 0022531874 scopus 로고
    • 2 recognition sites
    • DOI 10.1016/0006-8993(86)90903-0
    • Hoyer D, Pazos A, Probst A, Palacios JM (1986) Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites. Brain Res 376(1): 97-107 (Pubitemid 16046020)
    • (1986) Brain Research , vol.376 , Issue.1 , pp. 97-107
    • Hoyer, D.1    Pazos, A.2    Probst, A.3    Palacios, J.M.4
  • 34
    • 0027984917 scopus 로고
    • Differential effects of chronic antidepressant treatment on 5-HT(1C) receptor binding sites in Wistar rat brain
    • Hulihan-Giblin BA, Park YD, Aulakh CS (1994) Differential effects of chronic antidepressant treatment on 5-HT1C receptor binding sites in Wistar rat brain. Eur J Pharmacol 263(1-2): 213-216 (Pubitemid 24290275)
    • (1994) European Journal of Pharmacology , vol.263 , Issue.1-2 , pp. 213-216
    • Hulihan-Giblin, B.A.1    Park, Y.D.2    Aulakh, C.S.3
  • 35
    • 0028009827 scopus 로고
    • Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines
    • Johnson MP, Loncharich RJ, Baez M, Nelson DL (1994) Species variations in transmembrane region Vof the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines. Mol Pharmacol 45(2): 277-286 (Pubitemid 24063081)
    • (1994) Molecular Pharmacology , vol.45 , Issue.2 , pp. 277-286
    • Johnson, M.P.1    Loncharich, R.J.2    Baez, M.3    Nelson, D.L.4
  • 37
    • 0030665907 scopus 로고    scopus 로고
    • Mutations of transmembrane IV and V serines indicate that all tryptamines do not bind to the rat 5-HT(2A) receptor in the same manner
    • DOI 10.1016/S0169-328X(97)00115-0, PII S0169328X97001150
    • Johnson MP, Wainscott DB, Lucaites VL, Baez M, Nelson DL (1997) Mutations of transmembrane IV and V serines indicate that all tryptamines do not bind to the rat 5-HT2A receptor in the same manner. Brain Res Mol Brain Res 49(1-2): 1-6 (Pubitemid 27453108)
    • (1997) Molecular Brain Research , vol.49 , Issue.1-2 , pp. 1-6
    • Johnson, M.P.1    Wainscott, D.B.2    Lucaites, V.L.3    Baez, M.4    Nelson, D.L.5
  • 38
    • 0026634655 scopus 로고
    • Site-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-HT2 receptor from a human to a rat pharmacology
    • Kao HT, Adham N, Olsen MA, Weinshank RL, Branchek TA, Hartig PR (1992) Site-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-HT2 receptor from a human to a rat pharmacology. FEBS Lett 307(3): 324-328
    • (1992) FEBS Lett , vol.307 , Issue.3 , pp. 324-328
    • Kao, H.T.1    Adham, N.2    Olsen, M.A.3    Weinshank, R.L.4    Branchek, T.A.5    Hartig, P.R.6
  • 39
    • 0027065043 scopus 로고
    • 2 receptors
    • Leonhardt S, Gorospe E, Hoffman BJ, Teitler M (1992) Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Mol Pharmacol 42(2): 328-335 (Pubitemid 23026167)
    • (1992) Molecular Pharmacology , vol.42 , Issue.2 , pp. 328-335
    • Leonhardt, S.1    Gorospe, E.2    Hoffman, B.J.3    Teitler, M.4
  • 41
    • 0020004528 scopus 로고
    • 2 receptor binding sites. Binding properties, brain distribution, and functional role
    • Leysen JE, Niemegeers CJ, Van Nueten JM, Laduron PM (1982) [3H] Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role. Mol Pharmacol 21(2): 301-314 (Pubitemid 12139828)
    • (1982) Molecular Pharmacology , vol.21 , Issue.2 , pp. 301-314
    • Leysen, J.E.1    Niemegeers, C.J.E.2    Van Nueten, J.M.3    Laduron, P.M.4
  • 42
    • 0023818724 scopus 로고
    • 3H]ketanserin binding sites associated with nerve terminals in rat brain and with platelets; relation with release of biogenic amine mewtabolites induced by ketanserin- and tetrabenazine-like drugs
    • Leysen JE, Eens A, Gommeren W, van Gompel P, Wynants J, Janssen PA (1988) Identification of nonserotonergic [3H]ketanserin binding sites associated with nerve terminals in rat brain and with platelets; relation with release of biogenic amine metabolites induced by ketanserin-and tetrabenazine-like drugs. J Pharmacol Exp Ther 244(1): 310-321 (Pubitemid 18042398)
    • (1988) Journal of Pharmacology and Experimental Therapeutics , vol.244 , Issue.1 , pp. 310-321
    • Leysen, J.E.1    Eens, A.2    Gommeren, W.3    Van Gompel, P.4    Wynants, J.5    Janssen, P.A.J.6
  • 43
    • 84989072183 scopus 로고
    • 5-HT2 receptors, roles and regulation
    • discussion 192-193
    • Leysen JE, Pauwels PJ (1990) 5-HT2 receptors, roles and regulation. Ann NY Acad Sci 600: 183-191, discussion 192-193
    • (1990) Ann NY Acad Sci , vol.600 , pp. 183-191
    • Leysen, J.E.1    Pauwels, P.J.2
  • 44
    • 0032217035 scopus 로고    scopus 로고
    • 3H]MDL100,907 labels 5-HT(2A) serotonin receptors selectively in primate brain
    • DOI 10.1016/S0028-3908(98)00102-6, PII S0028390898001026
    • López-Giménez JF, Vilaró MT, Palacios JM, Mengod G (1998) [3H] MDL 100, 907 labels 5-HT2A serotonin receptors selectively in primate brain. Neuropharmacology 37(9): 1147-1158 (Pubitemid 29027829)
    • (1998) Neuropharmacology , vol.37 , Issue.9 , pp. 1147-1158
    • Lopez-Gimenez, J.F.1    Vilaro, M.T.2    Palacios, J.M.3    Mengod, G.4
  • 45
    • 0036141126 scopus 로고    scopus 로고
    • Serotonin 5-HT (2C) receptor knockout mice: Autoradiographic analysis of multiple serotonin receptors
    • López-Giménez JF, Tecott LH, Palacios JM, Mengod G, Vilaró MT (2002) Serotonin 5-HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors. J Neurosci Res 67(1): 69-85
    • (2002) J Neurosci Res , vol.67 , Issue.1 , pp. 69-85
    • López-Giménez, J.F.1    Tecott, L.H.2    Palacios, J.M.3    Mengod, G.4    Vilaró, M.T.5
  • 46
    • 0023165026 scopus 로고
    • 2 receptors
    • Lyon RA, Davis KH, Titeler M (1987) 3H-DOB (4-bromo-2, 5-dimethoxyphenylisopropylamine) labels a guanyl nucleotidesensitive state of cortical 5-HT2 receptors. Mol Pharmacol 31 (2): 194-199 (Pubitemid 17038899)
    • (1987) Molecular Pharmacology , vol.31 , Issue.2 , pp. 194-199
    • Lyon, R.A.1    Davis, K.H.2    Titeler, M.3
  • 47
    • 0037311477 scopus 로고    scopus 로고
    • Synergistic action of 5-HT2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders
    • Marek GJ, Carpenter LL, McDougle CJ, Price LH (2003) Synergistic action of 5-HT2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders. Neuropsychopharmacology 28(2): 402-412
    • (2003) Neuropsychopharmacology , vol.28 , Issue.2 , pp. 402-412
    • Marek, G.J.1    Carpenter, L.L.2    McDougle, C.J.3    Price, L.H.4
  • 48
    • 0024474046 scopus 로고
    • 3H-ketanserin
    • McKenna DJ, Peroutka SJ (1989) Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2, 5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin. J Neurosci 9(10): 3482-3490 (Pubitemid 19260020)
    • (1989) Journal of Neuroscience , vol.9 , Issue.10 , pp. 3482-3490
    • McKenna, D.J.1    Peroutka, S.J.2
  • 50
    • 0024466603 scopus 로고
    • Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values
    • Meltzer HY, Matsubara S, Lee JC (1989) Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther 251(1): 238-246
    • (1989) J Pharmacol Exp Ther , vol.251 , Issue.1 , pp. 238-246
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.C.3
  • 51
    • 0022912484 scopus 로고
    • 2 receptor number
    • Metz A, Heal DJ (1986) In mice repeated administration of electroconvulsive shock or desmethylimipramine produces rapid alterations in 5-HT2-mediated head-twitch responses and cortical 5-HT2 receptor number. Eur J Pharmacol 126(1-2): 159-162 (Pubitemid 16014748)
    • (1986) European Journal of Pharmacology , vol.126 , Issue.1-2 , pp. 159-162
    • Metz, A.1    Heal, D.J.2
  • 52
    • 50649122969 scopus 로고    scopus 로고
    • The dorsal raphe nucleus and serotonin: Implications for neuroplasticity linked to major depression and Alzheimer's disease
    • Michelsen KA, Prickaerts J, Steinbusch HWM (2008) The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease. Prog Brain Res 172: 233-264
    • (2008) Prog Brain Res , vol.172 , pp. 233-264
    • Michelsen, K.A.1    Prickaerts, J.2    Hwm, S.3
  • 53
    • 0023233787 scopus 로고
    • Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist
    • Neale RF, Fallon SL, Boyar WC, Wasley JW, Martin LL, Stone GA, Glaeser BS, Sinton CM, Williams M (1987) Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur J Pharmacol 136(1): 1-9 (Pubitemid 17109585)
    • (1987) European Journal of Pharmacology , vol.136 , Issue.1 , pp. 1-9
    • Neale, R.F.1    Fallon, S.L.2    Boyar, W.C.3
  • 55
    • 0021748014 scopus 로고
    • Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: Evidence for species differences in brain serotonin-2 receptors
    • DOI 10.1016/0014-2999(84)90056-6
    • Pazos A, Hoyer D, Palacios JM (1984) Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: evidence for species differences in brain serotonin-2 receptors. Eur J Pharmacol 106(3): 531-538 (Pubitemid 15194102)
    • (1984) European Journal of Pharmacology , vol.106 , Issue.3 , pp. 531-538
    • Pazos, A.1    Hoyer, D.2    Palacios, J.M.3
  • 56
    • 0022401097 scopus 로고
    • Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors
    • DOI 10.1016/0006-8993(85)90857-1
    • Pazos A, Cortés R, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res 346(2): 231-249 (Pubitemid 16241112)
    • (1985) Brain Research , vol.346 , Issue.2 , pp. 231-249
    • Pazos, A.1    Cortes, R.2    Palacios, J.M.3
  • 58
    • 0019793815 scopus 로고
    • Two distinct central serotonin receptors with different physiological functions
    • Peroutka SJ, Lebovitz RM, Snyder SH (1981) Two distinct central serotonin receptors with different physiological functions. Science 212(4496): 827-829 (Pubitemid 11069388)
    • (1981) Science , vol.212 , Issue.4496 , pp. 827-829
    • Peroutka, S.J.1    Lebovitz, R.M.2    Snyder, S.H.3
  • 59
    • 0028176806 scopus 로고
    • Distribution of the serotonin 5-HT2 receptor family mRNAs: Comparison between 5-HT2A and 5-HT2C receptors
    • Pompeiano M, Palacios JM, Mengod G (1994) Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 23 (1-2): 163-178
    • (1994) Brain Res Mol Brain Res , vol.23 , Issue.1-2 , pp. 163-178
    • Pompeiano, M.1    Palacios, J.M.2    Mengod, G.3
  • 60
    • 0026598104 scopus 로고
    • Serotonin receptors in human neuroblastoma: A possible biologic tumor marker
    • Pranzatelli MR, Balletti J (1992) Serotonin receptors in human neuroblastoma: a possible biologic tumor marker. Exp Neurol 115(3): 423-427
    • (1992) Exp Neurol , vol.115 , Issue.3 , pp. 423-427
    • Pranzatelli, M.R.1    Balletti, J.2
  • 66
    • 0026638381 scopus 로고
    • Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors
    • Roth BL, Ciaranello RD, Meltzer HY (1992) Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors. J Pharmacol Exp Ther 260(3): 1361-1365
    • (1992) J Pharmacol Exp Ther , vol.260 , Issue.3 , pp. 1361-1365
    • Roth, B.L.1    Ciaranello, R.D.2    Meltzer, H.Y.3
  • 67
  • 68
    • 0020637328 scopus 로고
    • 2-receptors in human brain
    • DOI 10.1016/0006-8993(83)90729-1
    • Schotte A, Maloteaux JM, Laduron PM (1983) Characterization and regional distribution of serotonin S2-receptors in human brain. Brain Res 276(2): 231-235 (Pubitemid 13009710)
    • (1983) Brain Research , vol.276 , Issue.2 , pp. 231-235
    • Schotte, A.1    Maloteaux, J.M.2    Laduron, P.M.3
  • 69
    • 0028987495 scopus 로고
    • (1-(2, 5-dimethoxy-4 iodophenyl -2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: Modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists
    • Schreiber R, Brocco M, Audinot V, Gobert A, Veiga S, Millan MJ (1995) (1-(2, 5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. J Pharmacol Exp Ther 273 (1): 101-112
    • (1995) J Pharmacol Exp Ther , vol.273 , Issue.1 , pp. 101-112
    • Schreiber, R.1    Brocco, M.2    Audinot, V.3    Gobert, A.4    Veiga, S.5    Millan, M.J.6
  • 70
    • 0033014541 scopus 로고    scopus 로고
    • Mechanism of tolerance development to 2,5-dimethoxy-4-iodoamphetamine in rats: Down-regulation of the 5-HT(2A), but not 5-HT(2C), receptor
    • DOI 10.1007/s002130051000
    • Smith RL, Barrett RJ, Sanders-Bush E (1999) Mechanism of tolerance development to 2, 5-dimethoxy-4-iodoamphetamine in rats: down-regulation of the 5-HT2A, but not 5-HT2C, receptor. Psychopharmacology (Berl) 144(3): 248-254 (Pubitemid 29307276)
    • (1999) Psychopharmacology , vol.144 , Issue.3 , pp. 248-254
    • Smith, R.L.1    Barrett, R.J.2    Sanders-Bush, E.3
  • 71
    • 50349086146 scopus 로고    scopus 로고
    • Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome
    • Steeves TDL, Fox SH (2008) Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome. Prog Brain Res 172: 495-513
    • (2008) Prog Brain Res , vol.172 , pp. 495-513
    • Tdl, S.1    Fox, S.H.2
  • 72
    • 0037453204 scopus 로고    scopus 로고
    • 2C receptors and their atypical regulation properties
    • DOI 10.1016/S0024-3205(03)00141-3
    • Van Oekelen D, Luyten WHML, Leysen JE (2003) 5-HT2A and 5-HT2C receptors and their atypical regulation properties. Life Sci 72(22): 2429-2449 (Pubitemid 36321816)
    • (2003) Life Sciences , vol.72 , Issue.22 , pp. 2429-2449
    • Van Oekelen, D.1    Luyten, W.H.M.L.2    Leysen, J.E.3
  • 73
    • 0030087741 scopus 로고    scopus 로고
    • Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: Evidence for species differences
    • Wainscott DB, Lucaites VL, Kursar JD, Baez M, Nelson DL (1996) Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences. J Pharmacol Exp Ther 276 (2): 720-727
    • (1996) J Pharmacol Exp Ther , vol.276 , Issue.2 , pp. 720-727
    • Wainscott, D.B.1    Lucaites, V.L.2    Kursar, J.D.3    Baez, M.4    Nelson, D.L.5
  • 75
    • 0038784461 scopus 로고    scopus 로고
    • A genetic screen for mouse mutations with defects in serotonin responsiveness
    • DOI 10.1016/S0169-328X(03)00205-5
    • Weiss KC, Kim DY, Pawson CT, Cordes SP (2003) A genetic screen for mouse mutations with defects in serotonin responsiveness. Brain Res Mol Brain Res 115(2): 162-172 (Pubitemid 36859866)
    • (2003) Molecular Brain Research , vol.115 , Issue.2 , pp. 162-172
    • Weiss, K.C.1    Kim, D.Y.2    Pawson, C.T.3    Cordes, S.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.