Similarities in the pharmacology of spontaneous and DOI-induced head-shakes suggest 5HT(2A) receptors are active under physiological conditions

Psychopharmacology

Volumn 128, Issue 2, 1996, Pages 198-205

  Dursun, S M ^a,b   Handley, S L ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

5HT(2A) receptors; antipsychotics; head shakes; Tourette's syndrome

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALPHA 1 ADRENERGIC RECEPTOR; CITALOPRAM; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; ECOPIPAM; HALOPERIDOL; KETANSERIN; NEUROLEPTIC AGENT; PIMOZIDE; PRAZOSIN; RACLOPRIDE; RITANSERIN; SEROTONIN 2A RECEPTOR; SULPIRIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; GILLES DE LA TOURETTE SYNDROME; HEAD TWITCH; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SCHIZOPHRENIA;

ADRENERGIC ALPHA-ANTAGONISTS; AMPHETAMINES; ANIMALS; BEHAVIOR, ANIMAL; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; RECEPTORS, BIOGENIC AMINE; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0029804087     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050125     Document Type: Article

References (44)

1. Arnt J, Hyttel J, Larsen JJ (1984) The citalopram/5-HTP-induced head-shake syndrome is correlated to 5-HT2 receptor affinity and also influenced by other transmitters. Acta Pharmacol Toxicol 55:363-372
2. Bedard P, Pycock CJ (1977) "Wet-dog" shake behaviour in the rat: a possible quantitative model of central 5-hydroxytryptamine activity. Neuropharmacology 16:663-670
3. 2 receptor antagonists in squirrel monkeys. J Pharmacol Exp Ther 258:910-917
4. Blackburn TP, Thornber CW, Pearce RJ, Cox B (1988) In vitro studies with ICI 169,369, a new chemically novel 5-HT antagonist. Eur J Pharmacol 150:247-256
5. Boulton CS, Handley SL (1973) Factors modifying the head-twitch response to 5-hydroxytryptophan. Psychopharmacology 31: 205-214
6. 1C receptor expressed in Xenopus oocytes by the benzazepines SCH23390 and SKF 38393. Br J Pharmacol 104:1038-1044
7. Brown J, Handley SL (1980) Effects on the pinna reflex of drugs acting at alpha-adrenoceptors J Pharm Pharmacol 32:436-437
8. 1C sites. Eur J Pharmacol 191: 93-96
9. Chipkin RE, Iorio LC, Coffin VL, McQuade RD, Berger JG, Barnett A (1988) Pharmacological profile of SCH39166: a dopamine D-1 selective benzonapthazepine with potential antipsychotic activity. J Pharmacol Exp Ther 247:1093-1102
10. Christensen AV, Arnt J, Hyttel J, Larsen J, Svendsen O (1984) Pharmacological effects of a specific dopamine D-1 antagonist SCH23390 in comparison with neuroleptics. Life Sci 34: 1529-1540
11. Corne SJ, Pickering RW (1967) A possible correlation between drug induced hallucinations in man and a behavioural response in mice. Psychopharmacology 11:65-78
12. Corne SJ, Pickering RW, Warner BT (1963) A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine. Br J Pharmacol 20:106-120
13. Glennon RA (1987) Central serotonin receptors as targets for drug research. J Med Chem 30:1-12
14. Green AR (1984) 5-HT mediated behaviour (animal studies). Neuropharmacology 23:1521-1528
15. Green AR, Heal DJ (1985) The effects of drugs on serotonin-mediated behavioural models. In: Green AR (ed) Neuropharmacology of serotonin. Oxford University Press, Oxford, pp 326-365
16. 2 antagonist pirenperone. Neuropharmacology 22:573-578
17. Handley SL, Brown J (1982) Effects on the 5-hydroxytryptamine induced head twitch of drugs with selective actions on alpha-1 and alpha-2 adrenoceptors. Neuropharmacology 21: 507-510
18. Handley SL, Dursun SM (1992) Serotonin and Tourette's Syndrome: movements such as head-shakes and wet-dog-shakes may model human tics. Adv Biosci 85:235-253
19. Handley SL, Singh L (1986) Neurotransmitters and shaking behaviour more than a "gut-bath" for the brain ? Trends Pharmacol Sci 7:324-328
20. Hartig PR (1989) Molecular biology of 5-HT receptors. Trends Pharmacol Sci 10:64-69
21. 2 mediated head-twitch responses in mice: possible implications for the actions of antidepressant drugs. Psychopharmacology 89: 414-420
22. Heaton JCP, Handley SL (1989) Comparison of DOI-induced scratching and head-twitch behaviours: differential action of 8-OH-DPAT. Br J Pharmacol 98:687P
23. 1C receptors. Trends Pharmacol Sci 9:89-94
24. 1 recognition sites. J Recept Res 8:59-91
25. Hoyer D, Schoeffter P (1991) 5-HT receptors: subtypes and second messengers. J Recept Res 11:197-214
26. Johnson AM (1991) The comparative pharmacological properties of selective serotonin re-uptake inhibitors in animals In: Feighner JP, Boyer WF (eds) Selective serotonin re-uptake inhibitors. Perspectives in Psychiatry vol. 1. Wiley, Chichester, pp 37-70
27. 3H-raclopride. Biochem Pharmacol 34: 2251-2259
28. 2 receptors, roles and regulation. Ann New York Acad Sci 600:183-193
29. 2 receptor binding sites. Mol Pharmacol 21:301-314
30. Maj J, Baran L, Bigajska K, Rogoz A, Skuza G (1978) The influence of neuroleptics on the behavioural effects of 5-hydroxytryptophan. Pol J Pharmacol Pharm 20:431-440
31. Matthews WD, Smith CD (1980) Pharmacological profile of a model for central serotonin receptor activation. Life Sci 26: 1397-1403
32. McCreadie RG, Thara R, Kamath S, Padmavathy R, Latha S, Mathrubootham N, Menon MS (1996) Abnormal involuntary movements in never-medicated Indian patients with schizophrenia. Br J Psychiatry 168:221-226
33. Meltzer HY, Matsubara S, Lee JC (1989) Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1 and serotonin-2 pKi values. J Pharmacol Exp Ther 251: 238-246
34. 3H-Prazosin binds specifically to "alpha-1" adrenoceptors in rat brain. Naunyn-Schmiedeberg's Arch Pharmacol 312:23-26
35. Norussis MJ (1992) SPSS for Windows Release 5: professional statistics user's guide. SPSS, Chicago
36. Ogren SO, Hall H, Kohler C, Magnusson O, Sjostrand S (1986) The selective dopamine D: receptor antagonist raclopride discriminates between dopamine-mediated motor functions. Psychopharmacology 90:287-294
37. Robertson MM (1989) The Gilles de la Tourette's syndrome: the current status. Br J Psychiatry 154:147-169
38. Roth BL, Meltzer HY (1995) The role of serotonin in schizophrenia. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 1215-1227
39. 1C receptors. J Pharmacol Exp Ther 260: 1361-1365
40. 1. Nature 350: 614-619
41. 1C receptors in porcine choroid plexus. Life Sci 49:1505-1511
42. Waddington JL, O'Callaghan E, Buckley P, Madigan C, Redmond O, Stack JP, Kinsella A, Larkin C, Ennis JT (1995) Tardive dyskinesia in Schizophrenia. Relationship to minor physical abnormalities, frontal Robe dysfunction and cerebral structure on magnetic resonance imaging. Br J Psychiatry 167: 41-44
43. 1 dopamine receptor antagonist: binding characteristics and localization. Exp Neurol 111:145-151
44. Wei ET (1981) Pharmacological aspects of shaking behaviour produced by TRH, AG-3-5 and morphine withdrawal. Fed Proc 40:1491-1496