The serotonin 5-HT2A receptor agonist TCB-2: A behavioral and neurophysiological analysis

Psychopharmacology

Volumn 212, Issue 1, 2010, Pages 13-23

  Fox, Meredith A ^a   French, Helen T ^a   Laporte, Justin L ^a   Blackler, Adele R ^a   Murphy, Dennis L ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

5 HT2A receptors; Anxiety; Corticosterone; DOI; Feeding; Head twitch response; Hypothermia; MDL 11,939; Serotonin transporter knockout mice; TCB 2

Indexed keywords

(4 BROMO 3,6 DIMETHOXYBENZOCYCLOBUTEN 1 YL)METHYLAMINE HYDROBROMIDE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; ARACHIDONIC ACID; CORTICOSTERONE; GLEMANSERIN; PHOSPHATIDYLINOSITIDE; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG STRUCTURE; FOOD DEPRIVATION; FOOD INTAKE; HEAD TWITCH; HYPOTHERMIA; KNOCKOUT MOUSE; LOCOMOTION; MALE; MOUSE; NEUROPHYSIOLOGY; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; ARACHIDONIC ACID; BEHAVIOR, ANIMAL; BICYCLO COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAD MOVEMENTS; HYPOTHERMIA; MALE; METHYLAMINES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOLS; SEROTONIN 5-HT2 RECEPTOR AGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN RECEPTOR AGONISTS;

EID: 77955769870     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-009-1694-1     Document Type: Article

References (44)

1. CS Aulakh P Mazzola-Pomietto BA Hulihan-Giblin DL Murphy 1995 Lack of cross-tolerance for hypophagia induced by DOI versus m-CPP suggests separate mediation by 5-HT2A and 5-HT2C receptors, respectively Neuropsychopharmacology 13 1 8 10.1038/sj.npp.1380270 1:CAS:528:DyaK2MXns1Kksbo%3D 8526967
2. M Basselin MA Fox L Chang JM Bell D Greenstein M Chen DL Murphy SI Rapoport 2009 Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice Neuropsychopharmacology 34 1695 1709 10.1038/npp.2008.227 1:CAS:528: DC%2BD1MXls12qu70%3D 19145225
3. D Bengel DL Murphy AM Andrews CH Wichems D Feltner A Heils R Mossner H Westphal KP Lesch 1998 Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice Mol Pharmacol 53 649 655 1:CAS:528:DyaK1cXislCgtL0%3D 9547354
4. DJ Bill M Knight EA Forster A Fletcher 1991 Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia Br J Pharmacol 103 1857 1864 1:CAS:528:DyaK3MXltVGqsbo%3D 1833017
5. CW Chang E Poteet JA Schetz ZH Gumus H Weinstein 2009 Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation Neuropharmacology 56 Suppl 1 213 225 10.1016/j.neuropharm. 2008.07.049 1:CAS:528:DC%2BD1MXhsVKitQ%3D%3D 18762202
6. C Faure O Mnie-Filali H Scarna G Debonnel N Haddjeri 2006 Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT Neurosci Lett 404 122 126 10.1016/j.neulet.2006.05.023 1:CAS:528:DC%2BD28XntFSitrk%3D 16759802 (Pubitemid 44041780)
7. MA Fox CL Jensen HT French AR Stein SJ Huang TJ Tolliver DL Murphy 2008 Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice Psychopharmacology (Berl) 201 203 218 10.1007/s00213-008-1268-7 1:CAS:528:DC%2BD1cXhtlyjtL%2FO
8. MA Geyer FX Vollenweider 2008 Serotonin research: contributions to understanding psychoses Trends Pharmacol Sci 29 445 453 10.1016/j.tips.2008.06. 006 1:CAS:528:DC%2BD1cXhtVKnurrN 19086254
9. J Gonzalez-Maeso T Yuen BJ Ebersole E Wurmbach A Lira M Zhou N Weisstaub R Hen JA Gingrich SC Sealfon 2003 Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex J Neurosci 23 8836 8843 1:CAS:528:DC%2BD3sXotFOntbo%3D 14523084
10. J Gonzalez-Maeso NV Weisstaub M Zhou P Chan L Ivic R Ang A Lira M Bradley-Moore Y Ge Q Zhou SC Sealfon JA Gingrich 2007 Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior Neuron 53 439 452 10.1016/j.neuron.2007.01.008 1:CAS:528: DC%2BD2sXitVekuro%3D 17270739 (Pubitemid 46161267)
11. GM Goodwin RJ De Souza AR Green 1985 The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). A model of presynaptic 5-HT1 function Neuropharmacology 24 1187 1194 10.1016/0028-3908(85)90153-4 1:CAS:528:DyaL28XotF2huw%3D%3D 2869435 (Pubitemid 16182643)
12. MR Guscott E Egan GP Cook JA Stanton MS Beer TW Rosahl S Hartmann J Kulagowski G McAllister KC Fone PH Hutson 2003 The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor Neuropharmacology 44 1031 1037 10.1016/S0028-3908(03)00117-5 1:CAS:528:DC%2BD3sXjvFeksLk%3D 12763096 (Pubitemid 36570427)
13. PB Hedlund PE Danielson EA Thomas K Slanina MJ Carson JG Sutcliffe 2003 No hypothermic response to serotonin in 5-HT7 receptor knockout mice Proc Natl Acad Sci U S A 100 1375 1380 10.1073/pnas.0337340100 1:CAS:528: DC%2BD3sXhtF2gu7g%3D 12529502 (Pubitemid 36184009)
14. LK Heisler N Pronchuk K Nonogaki L Zhou J Raber L Tung GS Yeo S O'Rahilly WF Colmers JK Elmquist LH Tecott 2007 Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation J Neurosci 27 6956 6964 10.1523/JNEUROSCI.2584-06.2007 1:CAS:528: DC%2BD2sXnsVyjt74%3D 17596444 (Pubitemid 47015900)
15. SK Hemrick-Luecke DC Evans 2002 Comparison of the potency of MDL 100, 907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis Neuropharmacology 42 162 169 10.1016/S0028-3908(01)00166-6 1:CAS:528:DC%2BD38Xms1aitQ%3D%3D 11804612 (Pubitemid 34137019)
16. LE Hollister MF Macnicol HK Gillespie 1969 An hallucinogenic amphetamine analog (DOM) in man Psychopharmacologia 14 62 73 10.1007/BF00401535 1:CAS:528:DyaF1MXms1Oguw%3D%3D 5351858
17. XZ Hu RH Lipsky G Zhu LA Akhtar J Taubman BD Greenberg K Xu PD Arnold MA Richter JL Kennedy DL Murphy D Goldman 2006 Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder Am J Hum Genet 78 815 826 10.1086/503850 1:CAS:528:DC%2BD28Xkt1Ggsro%3D 16642437
18. KA Jennings WJ Sheward AJ Harmar T Sharp 2008 Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function Neuropharmacology 54 776 783 10.1016/j.neuropharm.2007.12.001 1:CAS:528:DC%2BD1cXjs1Slurw%3D 18241894
19. CM Krall JB Richards RA Rabin JC Winter 2008 Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice Pharmacol Biochem Behav 88 349 357 10.1016/j.pbb.2007.09.006 1:CAS:528:DC%2BD2sXhtlCru7jM 17935763 (Pubitemid 350116261)
20. KP Lesch D Bengel A Heils SZ Sabol BD Greenberg S Petri J Benjamin CR Muller DH Hamer DL Murphy 1996 Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1527 1531 10.1126/science.274.5292.1527 1:CAS:528:DyaK28Xnt1ansL8%3D 8929413 (Pubitemid 26403928)
21. Q Li CH Wichems L Ma LD Van de Kar F Garcia DL Murphy 2003 Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice J Neurochem 84 1256 1265 10.1046/j.1471-4159.2003. 01607.x 1:CAS:528:DC%2BD3sXisVaqu78%3D 12614326 (Pubitemid 36343592)
22. P Mazzola-Pomietto CS Aulakh KM Wozniak JL Hill DL Murphy 1995 Evidence that 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia in rats is mediated by stimulation of 5-HT2A receptors Psychopharmacology (Berl) 117 193 199 10.1007/BF02245187 1:CAS:528:DyaK2MXjsl2kur8%3D
23. TH McLean JC Parrish MR Braden D Marona-Lewicka A Gallardo-Godoy DE Nichols 2006 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists J Med Chem 49 5794 5803 10.1021/jm060656o 1:CAS:528: DC%2BD28XosVCitbo%3D 16970404 (Pubitemid 44423716)
24. Y Morishima T Shibano 1995 Evidence that 5-HT2A receptors are not involved in 5-HT-mediated thermoregulation in mice Pharmacol Biochem Behav 52 755 758 10.1016/0091-3057(95)00172-S 1:CAS:528:DyaK2MXpsVGrtrc%3D 8587916 (Pubitemid 3005261)
25. PR Moya KA Berg MA Gutierrez-Hernandez P Saez-Briones M Reyes-Parada BK Cassels WP Clarke 2007 Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors J Pharmacol Exp Ther 321 1054 1061 10.1124/jpet.106.117507 1:CAS:528:DC%2BD2sXmsFeqs7w%3D 17337633 (Pubitemid 46762692)
26. DE Nichols 2004 Hallucinogens Pharmacol Ther 101 131 181 10.1016/j.pharmthera.2003.11.002 1:CAS:528:DC%2BD2cXptFCmsg%3D%3D 14761703 (Pubitemid 38167565)
27. N Praschak-Rieder J Kennedy AA Wilson D Hussey A Boovariwala M Willeit N Ginovart S Tharmalingam M Masellis S Houle JH Meyer 2007 Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study Biol Psychiatry 62 327 331 10.1016/j.biopsych.2006.09.022 1:CAS:528:DC%2BD2sXos1Sitb8%3D 17210141 (Pubitemid 47444277)
28. Y Qu N Villacreses DL Murphy SI Rapoport 2005 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter Psychopharmacology (Berl) 180 12 20 10.1007/s00213-005-2231-5 1:CAS:528:DC%2BD2MXksVGjtr8%3D (Pubitemid 40897066)
29. A Rioux V Fabre KP Lesch R Moessner DL Murphy L Lanfumey M Hamon MP Martres 1999 Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter Neurosci Lett 262 113 116 10.1016/S0304-3940(99)00049-X 1:CAS:528:DyaK1MXhs1Onurw%3D 10203244 (Pubitemid 29130301)
30. P Salmi S Ahlenius 1998 Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanisms Pharmacol Toxicol 82 122 127 10.1111/j.1600-0773.1998.tb01410.x 1:CAS:528:DyaK1cXhsF2lsbw%3D 9553989
31. LE Schechter KJ Simansky 1988 1-(2, 5-Dimethoxy-4-iodophenyl)-2- aminopropane (DOI) exerts an anorexic action that is blocked by 5-HT2 antagonists in rats Psychopharmacology (Berl) 94 342 346 10.1007/BF00174687 1:CAS:528:DyaL1cXhs1Wqsbk%3D
32. CL Schmid KM Raehal LM Bohn 2008 Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo Proc Natl Acad Sci U S A 105 1079 1084 10.1073/pnas.0708862105 1:CAS:528: DC%2BD1cXht1Gis7g%3D 18195357 (Pubitemid 351282084)
33. SH Snyder LA Faillace H Weingartner 1968 DOM (STP), a new hallucinogenic drug, and DOET: effects in normal subjects Am J Psychiatry 125 113 120 1:STN:280:DyaF1czmtFKksQ%3D%3D 4385937
34. LH Tecott LM Sun SF Akana AM Strack DH Lowenstein MF Dallman D Julius 1995 Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors Nature 374 542 546 10.1038/374542a0 1:CAS:528:DyaK2MXkvVKqtr4%3D 7700379
35. JD Urban WP Clarke M von Zastrow DE Nichols B Kobilka H Weinstein JA Javitch BL Roth A Christopoulos PM Sexton KJ Miller M Spedding RB Mailman 2007 Functional selectivity and classical concepts of quantitative pharmacology J Pharmacol Exp Ther 320 1 13 10.1124/jpet.106.104463 1:CAS:528: DC%2BD2sXjsFersw%3D%3D 16803859 (Pubitemid 46025713)
36. LD Van de Kar A Javed Y Zhang F Serres DK Raap TS Gray 2001 5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells J Neurosci 21 3572 3579 11331386
37. SP Vickers CT Dourish GA Kennett 2001 Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors Neuropharmacology 41 200 209 10.1016/S0028-3908(01)00063-6 1:CAS:528: DC%2BD3MXlslersr8%3D 11489456 (Pubitemid 32728091)
38. H Weingartner SH Snyder LA Faillace 1971 DOM (STP), a new hallucinogenic drug: specific perceptual changes J Clin Pharmacol New Drugs 11 103 111 10.1177/009127007101100205 1:CAS:528:DyaE3MXpsl2rsw%3D%3D 5206471
39. NV Weisstaub M Zhou A Lira E Lambe J Gonzalez-Maeso JP Hornung E Sibille M Underwood S Itohara WT Dauer MS Ansorge E Morelli JJ Mann M Toth G Aghajanian SC Sealfon R Hen JA Gingrich 2006 Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice Science 313 536 540 10.1126/science.1123432 1:CAS:528:DC%2BD28Xnt1Knt7Y%3D 16873667 (Pubitemid 44148461)
40. JR Wendland PR Moya MR Kruse RF Ren-Patterson CL Jensen KR Timpano DL Murphy 2008 A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder Hum Mol Genet 17 717 723 10.1093/hmg/ddm343 1:CAS:528:DC%2BD1cXitVenu78%3D 18055562 (Pubitemid 351292260)
41. DL Willins HY Meltzer 1997 Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats J Pharmacol Exp Ther 282 699 706 1:CAS:528:DyaK2sXltlSntLw%3D 9262333
42. J Yamada Y Sugimoto K Horisaka 1995 Serotonin2 (5-HT2) receptor agonist 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice Biol Pharm Bull 18 1580 1583 1:CAS:528:DyaK2MXps1Glt74%3D 8593484
43. B Yu J Becnel M Zerfaoui R Rohatgi AH Boulares CD Nichols 2008 Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency J Pharmacol Exp Ther 327 316 323 10.1124/jpet.108.143461 1:CAS:528:DC%2BD1cXhtlWns7zE 18708586
44. Y Zhang KJ Damjanoska GA Carrasco B Dudas DN D'Souza J Tetzlaff F Garcia NR Hanley K Scripathirathan BR Petersen TS Gray G Battaglia NA Muma LD Van de Kar 2002 Evidence that 5-HT2A receptors in the hypothalamic paraventricular nucleus mediate neuroendocrine responses to (-)DOI J Neurosci 22 9635 9642 1:CAS:528:DC%2BD3sXmsVGmtb4%3D 12417689