The E3 ligase c-Cbl regulates dendritic cell activation

EMBO Reports

Volumn 12, Issue 9, 2011, Pages 971-979

  Chiou, Shin Heng ^a   Shahi, Payam ^a   Wagner, Ryan T ^b   Hu, Hongbo ^a   Lapteva, Natalia ^a   Seethammagari, Mamatha ^a   Sun, Shao Cong ^a   Levitt, Jonathan M ^a,c   Spencer, David M ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Department of Molecular and Cellular Biology ^*  (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

c Cbl; dendritic cell; E3 ubiquitin ligase; IL12p70; p105

Indexed keywords

CBL PROTEIN; DENDRITIC CELL VACCINE; HETERODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P40; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P105; PROTEIN P50; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CANCER IMMUNOTHERAPY; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EFFICACY; FEMALE; IMMUNOGENICITY; IMMUNOREGULATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; TUMOR VOLUME; WESTERN BLOTTING;

ANIMALS; ANTIGENS, NUCLEAR; CHROMOSOMAL PROTEINS, NON-HISTONE; DENDRITIC CELLS; FEMALE; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B P50 SUBUNIT; PROTO-ONCOGENE PROTEINS C-CBL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 80052288687     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2011.143     Document Type: Article

References (39)

1. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124: 783-801 (Pubitemid 43261452)
2. Baer M, Dillner A, Schwartz RC, Sedon C, Nedospasov S, Johnson PF (1998) Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50. Mol Cell Biol 18: 5678-5689 (Pubitemid 28450519)
3. Belich MP, Salmeron A, Johnston LH, Ley SC (1999) TPL-2 kinase regulates the proteolysis of the NF-kB-inhibitory protein NF-kB1 p105. Nature 397: 363-368
4. Beutler BA (2009) TLRs and innate immunity. Blood 113: 1399-1407
5. Bohuslav J, Kravchenko VV, Parry GC, Erlich JH, Gerondakis S, Mackman N, Ulevitch RJ (1998) Regulation of an essential innate immune response by the p50 subunit of NF-kB. J Clin Invest 102: 1645-1652 (Pubitemid 28516249)
6. Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH (2007) Negative regulation of toll-like receptor signaling by NF-kB p50 ubiquitination blockade. Science 317: 675-678 (Pubitemid 47229968)
7. Chang M, Jin W, Sun SC (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10: 1089-1095
8. Curtsinger JM, Schmidt CS, Mondino A, Lins DC, Kedl RM, Jenkins MK, Mescher MF (1999) Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol 162: 3256-3262 (Pubitemid 29313572)
9. Curtsinger JM, Lins DC, Mescher MF (2003) Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J Exp Med 197: 1141-1151 (Pubitemid 36570069)
10. Dai R, Phillips RA, Ahmed SA (2007) Despite inhibition of nuclear localization of NF-kB p65, c-Rel, and RelB, 17-b estradiol up-regulates NF-kB signaling in mouse splenocytes: the potential role of Bcl-3. J Immunol 179: 1776-1783
11. Dale BM, Traum D, Erdjument-Bromage H, Tempst P, Greenberg S (2009) Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding. J Immunol 182: 5654-5662
12. Donald R, Ballard DW, Hawiger J (1995) Proteolytic processing of NF-kB/I kB in human monocytes. ATP-dependent induction by pro-inflammatory mediators. J Biol Chem 270: 9-12
13. Dumitru CD et al (2000) TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103: 1071-1083 (Pubitemid 32040907)
14. Elsharkawy AM, Oakley F, Lin F, Packham G, Mann DA, Mann J (2010) The NF-kB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. J Hepatol 53: 519-527
15. Ghosh S, May MJ, Kopp EB (1998) NF-kB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260 (Pubitemid 28183365)
16. Grumont R, Hochrein H, O'Keeffe M, Gugasyan R, White C, Caminschi I, Cook W, Gerondakis S (2001) c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription. J Exp Med 194: 1021-1032
17. Hanks BA, Jiang J, Singh RA, Song W, Barry M, Huls MH, Slawin KM, Spencer DM (2005) Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo. Nat Med 11: 130-137 (Pubitemid 40321347)
18. Haring JS, Badovinac VP, Harty JT (2006) Inflaming the CD8+ T cell response. Immunity 25: 19-29
19. Huang F, Gu H (2008) Negative regulation of lymphocyte development and function by the Cbl family of proteins. Immunol Rev 224: 229-238
20. Hunter S, Burton EA, Wu SC, Anderson SM (1999) Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase. J Biol Chem 274: 2097-2106
21. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM (1992) Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176: 1693-1702
22. Ishikawa H, Claudio E, Dambach D, Raventos-Suarez C, Ryan C, Bravo R (1998) Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kB1) but expressing p50. J Exp Med 187: 985-996 (Pubitemid 28176399)
23. Kassenbrock CK, Anderson SM (2004) Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations. J Biol Chem 279: 28017-28027 (Pubitemid 38900072)
24. Ledebur HC, Parks TP (1995) Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kB site and p65 homodimers. J Biol Chem 270: 933-943
25. Liew FY, Xu D, Brint EK, O'Neill LA (2005) Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 5: 446-458 (Pubitemid 40835033)
26. Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, Romani N, Schuler G (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223: 77-92 (Pubitemid 29096240)
27. Meng F, Lowell CA (1998) A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J 17: 4391-4403 (Pubitemid 28362629)
28. Plaksin D, Baeuerle PA, Eisenbach L (1993) KBF1 (p50 NF-kB homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells. J Exp Med 177: 1651-1662 (Pubitemid 23146132)
29. Plevy SE, Gemberling JH, Hsu S, Dorner AJ, Smale ST (1997) Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol Cell Biol 17: 4572-4588 (Pubitemid 27318134)
30. Rathinam C, Thien CB, Langdon WY, Gu H, Flavell RA (2008) The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. Genes Dev 22: 992-997 (Pubitemid 351544238)
31. Schmidt MH, Dikic I (2005) The Cbl interactome and its functions. Nat Rev Mol Cell Biol 6: 907-918 (Pubitemid 41778710)
32. Shen L, Evel-Kabler K, Strube R, Chen SY (2004) Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nat Biotechnol 22: 1546-1553 (Pubitemid 40039457)
33. Song XT, Evel-Kabler K, Shen L, Rollins L, Huang XF, Chen SY (2008) A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression. Nat Med 14: 258-265 (Pubitemid 351347913)
34. Thien CB, Blystad FD, Zhan Y, Lew AM, Voigt V, Andoniou CE, Langdon WY (2005) Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J 24: 3807-3819 (Pubitemid 41581696)
35. Udalova IA, Richardson A, Denys A, Smith C, Ackerman H, Foxwell B, Kwiatkowski D (2000) Functional consequences of a polymorphism affecting NF-kB p50-p50 binding to the TNF promoter region. Mol Cell Biol 20: 9113-9119 (Pubitemid 32246100)
36. Waterfield MR, Zhang M, Norman LP, Sun SC (2003) NF-kB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol Cell 11: 685-694 (Pubitemid 36385122)
37. Wong BR, Besser D, Kim N, Arron JR, Vologodskaia M, Hanafusa H, Choi Y (1999) TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell 4: 1041-1049 (Pubitemid 30054909)
38. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S (2004) A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303: 1522-1526 (Pubitemid 38314423)
39. Zhang J, Salojin K, Gao JX, Cameron M, Geisler C, Delovitch TL (1998) TCR alpha beta chains associate with the plasma membrane independently of CD3 and TCR zeta chains in murine primary T cells. J Immunol 161: 2930-2937 (Pubitemid 28425716)