The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

EMBO Molecular Medicine

Volumn 3, Issue 9, 2011, Pages 545-558

  Cynis, Holger ^a   Hoffmann, Torsten ^a   Friedrich, Daniel ^a   Kehlen, Astrid ^a   Gans, Kathrin ^a   Kleinschmidt, Martin ^a   Rahfeld, Jens Ulrich ^a   Wolf, Raik ^a   Wermann, Michael ^a   Stephan, Anett ^a   Haegele, Monique ^a   Sedlmeier, Reinhard ^b   Graubner, Sigrid ^b   Jagla, Wolfgang ^b   Müller, Anke ^b   Eichentopf, Rico ^a   Heiser, Ulrich ^a   Seifert, Franziska ^c   Quax, Paul H A ^d   de Vries, Margreet R ^d   Hesse, Isabel ^e   Trautwein, Daniela ^e   Wollert, Ulrich ^e   Berg, Sabine ^f   Freyse, Ernst Joachim ^f   Schilling, Stephan ^a   Demuth, Hans Ulrich ^a,b   more..

^a PROBIODRUG AG   (Germany)

^b Ingenium Pharmaceuticals GmbH   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e St Barbara Hospital   (Germany)

^f Institut fur Diabetes 'Gerhardt Katsch'   (Germany)

Author keywords

CCL2; Drug development; Glutaminyl cyclases; Inflammation; Pyroglutamate

Indexed keywords

1 (1H BENZO[D]IMIDAZOL 5 YL) 5 (4 PROPOXYPHENYL)IMIDAZOLIDINE 2,4 DIONE; AMINOPEPTIDASE; ANTIBODY; ANTIINFLAMMATORY AGENT; APOLIPOPROTEIN E; BENZIMIDAZOLE; GLUTAMINYL CYCLASE; GLUTAMINYL CYCLASE INHIBITOR; GLUTAMINYL CYCLASE ISOENZYME QC; GLUTAMINYL CYCLASE ISOENZYME QC INHIBITOR; IMIDAZOLE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; ISOENZYME; MONOCYTE CHEMOTACTIC PROTEIN 1; POLYPEPTIDE; PQ 50; PQ 529; PYROGLUTAMIC ACID; THIOGLYCOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL INFILTRATION; CHEMOTAXIS; CHRONIC INFLAMMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; FEMALE; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; HUMAN TISSUE; INFLAMMATION; ISOENZYME ANALYSIS; MALE; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONITIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

AMINOACYLTRANSFERASES; ANIMALS; ATHEROSCLEROSIS; CELL LINE; CELL MOVEMENT; CHEMOKINE CCL2; FEMALE; GENE SILENCING; HUMANS; INFLAMMATION; ISOENZYMES; MICE; MICE, INBRED C57BL; MONOCYTES;

EID: 80052288497     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201100158     Document Type: Article

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