Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: Implications for enzyme function and drug development

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 14199-14208

  Schilling, Stephan ^a   Kohlmann, Stephanie ^b   Bäuscher, Christoph ^b   Sedlmeier, Reinhard ^b   Koch, Birgit ^a   Eichentopf, Rico ^a   Becker, Andreas ^b   Cynis, Holger ^a   Hoffmann, Torsten ^a   Berg, Sabine ^c   Freyse, Ernst Joachim ^c   Hörsten, Stephan Von ^d   Rossner, Steffen ^e   Graubner, Sigrid ^b   Demuth, Hans Ulrich ^a,b  

^a PROBIODRUG AG   (Germany)

^b Ingenium Pharmaceuticals GmbH   (Germany)

^c Institut fur Diabetes 'Gerhardt Katsch'   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT MICE; BLOOD GLUCOSE; CYCLASES; DIFFERENT EFFECTS; DIFFERENT MODES; DRUG DEVELOPMENT; ENDOCRINE FUNCTIONS; ENZYME FUNCTIONS; GLUCOSE TOLERANCE; GLUTAMINYL; GONADOTROPIN-RELEASING HORMONE; KNOCK OUTS; MOTOR FUNCTION; SUBSTRATE CONVERSION; THYROTROPIN-RELEASING HORMONES; WILD TYPES;

ANIMALS; BODY FLUIDS; BRAIN; ENDOCRINOLOGY; ENZYMES; GLUCOSE; HORMONES;

ENZYME ACTIVITY;

GLUCOSE; GLUTAMINYL CYCLASE; GONADORELIN; PYROGLUTAMIC ACID; TESTOSTERONE; THYROTROPIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; COGNITION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; FEMALE; FUNCTIONAL ASSESSMENT; GENE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GONADOTROPIN BLOOD LEVEL; HORMONE SYNTHESIS; HYPOGONADISM; HYPOTHALAMUS; HYPOTHYROIDISM; LIVER; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QCPT GENE; SPLEEN; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL;

AMINOACYLTRANSFERASES; ANIMALS; DRUG DESIGN; EMBRYONIC STEM CELLS; FEMALE; HYPOGONADISM; HYPOTHYROIDISM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PYRROLIDONECARBOXYLIC ACID; TESTOSTERONE; THYROTROPIN;

ANIMALIA; MUS;

EID: 79954572883     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.229385     Document Type: Article

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