Pyroglutamyl peptidase type I from Trypanosoma brucei: A new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts

Biochemical Journal

Volumn 394, Issue 3, 2006, Pages 635-645

  Morty, Rory E ^a   Bulau, Patrick ^a   Pellé, Roger ^b   Wilki, Sherwin ^c   Abe, Koji ^d  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

^b INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE   (Kenya)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d DAIICHI SANKYO CO   (Japan)

Author keywords

African trypanosome; Aminopeptidase; Gonadotropin releasing hormone (GnRH); Hypothyroidism; Pyroglutamyl peptidase (PGP) type I; Thyrotrophin releasing hormone (TRH)

Indexed keywords

BLOOD; HYDROLYSIS; ORGANIC ACIDS; PH EFFECTS; POLYPEPTIDES;

AFRICAN TRYPANOSOME; AMINOPEPTIDASE; GONADOTROPIN-RELEASING HORMONE (GNRH); HYPOTHYROIDISM; PYROGLUTAMYL PEPTIDASE (PGP) TYPE I; THYROTROPHIN-RELEASING HORMONE (TRH);

ENZYMES;

5 OXOPROLYL PEPTIDASE; ANTITRYPANOSOMAL AGENT; GONADORELIN; PEPTIDE HYDROLASE INHIBITOR; PROTIRELIN; PYROGLUTAMIC ACID; PYROGLUTAMYL DIAZOMETHYL KETONE; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; BLOOD PH; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; LIFE CYCLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; ENZYME STABILITY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GONADOTROPIN-RELEASING HORMONE; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; PHYLOGENY; PYROGLUTAMYL-PEPTIDASE I; RATS; SEQUENCE HOMOLOGY, AMINO ACID; THYROTROPIN-RELEASING HORMONE; TRYPANOSOMA BRUCEI BRUCEI; VIRULENCE FACTORS;

ANIMALIA; PROTOZOA; RODENTIA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI;

EID: 33644995282     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051593     Document Type: Article

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