Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: Identification of MCP-2(6-76) as a natural chemokine inhibitor

Journal of Immunology

Volumn 160, Issue 8, 1998, Pages 4034-4041

  Proost, Paul ^a   Struyf, Sofie ^a   Couvreur, Mikaël ^a   Lenaerts, Jean Pierre ^a   Conings, René ^a   Menten, Patricia ^a   Verhaert, Peter ^b   Wuyts, Anja ^a   Van Damme, Jo ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM ION; CHEMOKINE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; PROTEIN INHIBITOR; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CALCIUM MOBILIZATION; CHEMOTAXIS; DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; MASS SPECTROMETRY; MONONUCLEAR CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CHEMOKINE CCL2; CHEMOKINES; CHEMOTAXIS, LEUKOCYTE; HUMANS; MICE; MONOCYTE CHEMOATTRACTANT PROTEINS; MONOCYTES; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CHEMOKINE;

EID: 0032522660     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Baggiolini, M., B. Dewald, and B. Moser. 1994. Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines. Adv. Immunol. 55:97.
2. Taub, D. D., and J. J. Oppenheim. 1994. Chemokines, inflammation and the immune system. Ther. Immunol. 1:229.
3. Proost, P., A. Wuyts, and J. Van Damme. 1996. The role of chemokines in inflammation. Int. J. Clin. Lab. Res. 26:211.
4. Walz, A., B. Dewald, V. von Tscharner, and M. Baggiolini. 1989. Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue activating peptide III and platelet factor 4 on human neutrophils. J. Exp. Med. 170:1745.
5. Van Damme, J., J. Van Beeumen, R. Conings, B. Decock, and A. Billiau. 1989. Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of β-thromboglobulin. Eur. J. Biochem. 181:337.
6. Hébert, C. A., F. W. Luscinskas, J.-M. Kiely, E. A. Luis, W. C. Darbonne, G. L. Bennett, C. C. Liu, M. S. Obin, M. A. Gimbrone, Jr., and J. B. Baker. 1990. Endothelial and leukocyte forms of IL-8: conversion by thrombin and interactions with neutrophils. J. Immunol. 145:3033.
7. Nourshargh, S., J. A. Perkins, H. J. Showell, K. Matsushima, T. J. Williams, and P. D. Collins. 1992. A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8. J. Immunol. 148:106.
8. 2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities. J. Biol. Chem. 266:23128.
9. Proost, P., A. Wuyts, R. Conings, J.-P. Lenaerts, A. Billiau, G. Opdenakker, and J. Van Damme. 1993. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. Biochemistry 32:10170.
10. Arenzana-Seisdedos, F., J.-L. Virelizier, D. Rousset, I. Clark-Lewis, P. Loetscher, B. Moser, and M. Baggiolini. 1996. HIV blocked by chemokine antagonist. Nature 383:400.
11. Proudfoot, A. E., C. A. Power, A. J. Hoogewerf, M. O. Montjovent, F. Borlat, R. E. Offord, and T. N. Wells. 1996. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist. J. Biol. Chem. 271:2599.
12. Simmons, G., P. R. Clapham, L. Picard, R. E. Offord, M. M. Rosenkilde, T. W. Schwartz, R. Buser, T. N. C. Wells, and A. E. I. Proudfoot. 1997. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 276:276.
13. + T cells. Science 270:1811.
14. 2-terminal residues. J. Exp. Med. 181:631.
15. Opdenakker, G., P. M. Rudd, M. Wormald, R. A. Dwek, and J. Van Damme. 1995. Cells regulate the activities of cytokines by glycosylation. FASEB J. 9:453.
16. Rollins, B. J., P. Stier, T. Ernst, and G. G. Wong. 1989. The human homolog of the JE gene encodes a monocyte secretory protein. Mol. Cell. Biol. 9:4687.
17. Rollins, B. J., and M. E. Sunday. 1991. Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. Mol. Cell. Biol. 11:3125.
18. Rollins, B. J., E. D. Morrison, and C. D. Stiles. 1988. Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc. Natl. Acad. Sci. USA 85:3738.
19. Jiang, Y., A. J. Valente, M. J. Williamson, L. Zhang, and D. T. Graves. 1990. Post-translational modification of a monocyte-specific chemoattractant synthesized by glioma, osteosarcoma, and vascular smooth muscle cells. J. Biol. Chem. 265:18318.
20. Van Damme, J., P. Proost, J.-P. Lenaerts, and G. Opdenakker. 1992. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. J. Exp. Med. 176:59.
21. Van Damme, J., B. Decock, J.-P. Lenaerts, R. Conings, R. Bertini, A. Mantovani, and A. Billiau. 1989. Identification by sequence analysis of chemotactic factors for monocytes produced by normal and transformed cells stimulated with virus, double-stranded RNA or cytokine. Eur. J. Immunol. 19:2367.
22. Proost, P., P. Van Leuven, A. Wuyts, R. Ebberink, G. Opdenakker, and J. Van Damme. 1995. Chemical synthesis, purification and folding of the human monocyte chemotactic proteins MCP-2 and MCP-3 into biologically active chemokines. Cytokine 7:97.
23. Proost, P., A. Wuyts, R. Conings, J.-P. Lenaerts, W. Put, and J. Van Damme. 1996. Purification and identification of natural chemokines. Methods: Companion Methods Enzymol. 10:82.
24. Piszkiewicz, D., M. Landon, and E. L. Smith. 1970. Anomalous cleavage of aspartyl-proline peptide bonds during amino acid sequence determinations. Biochem. Biophys. Res. Commun. 40:1173.
25. Wuyts, A., N. Van Osselear, A. Haelens, I. Samson, P. Herdewijn, A. Ben-Baruch, J. J. Oppenheim, P. Proost, and J. Van Damme. 1997. Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. Biochemistry 36:2716.
26. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440.
27. Sozzani, S., D. Zhou, M. Locati, M. Rieppi, P. Proost, M. Magazin, N. Vita, J. Van Damme, and A. Mantovani. 1994. Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3: similarities and differences with MCP-1. J. Immunol. 152:3615.
28. Yamagami, S., H. Tanaka, and N. Endo. 1997. Monocyte chemoattractant protein-2 can exert its effects through the MCP-1 receptor (CC CKR2B). FEBS Lett. 400:329.
29. Gong, X., W. Gong, D. B. Kuhns, A. Ben-Baruch, O. M. Z. Howard, and J. M. Wang. 1997. Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors. J. Biol. Chem. 272:11682.
30. Heath, H., S. Qin, P. Rao, L. Wu, G. LaRosa, N. Kassam, P. D. Ponath, and C. R. Mackay. 1997. Chemokine receptor usage by human eosinophils: the importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J. Clin. Invest. 99:178.
31. Schröder, J.-M., H. Gregory, J. Young, and E. Christophers. 1992. Neutrophil-activating proteins in psoriasis. J. Invest. Dermatol. 98:241.
32. Masure, S., L. Paemen, P. Proost, J. Van Damme, and G. Opdenakker. 1995. Expression of a human mutant monocyte chemotactic protein 3 in Pichia pastoris and characterization as an MCP-3 receptor antagonist. J. Interferon Cytokine Res. 15:955.
33. Liu, Z.-G., A. Haelens, A. Wuyts, S. Struyf, X.-W. Pang, P. Proost, W.-F. Chen, and J. Van Damme. 1996. Isolation of a lymphocyte chemotactic factor produced by the murine thymic epithelial cell line MTEC1: identification as a 30 kDa glycosylated form of MCP-1. Eur. Cytokine Netw. 7:381.
34. Jiang, Y., L. A. Tabak, A. J. Valente, and D. T. Graves. 1991. Initial characterization of the carbohydrate structure of MCP-1. Biochem. Biophys. Res. Commun. 178:1400.
35. Ishii, K., S. Yamagami, H. Tanaka, M. Motoki, Y. Suwa, and N. Endo. 1995. Full active baculovirus-expressed human monocyte chemoattractant protein 1 with the intact N-terminus. Biochem. Biophys. Res. Commun. 206:955.
36. 2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant. J. Exp. Med. 183:681.
37. Uguccioni, M., M. D'Apuzzo, M. Loetscher, B. Dewald, and M. Baggiolini. 1995. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1α and MIP-1β on human monocytes. Eur. J. Immunol. 25:64.
38. Franci, C., L. M. Wong, J. Van Damme, P. Proost, and I. F. Charo. 1995. Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor. J. Immunol. 154:6511.
39. Neer, E. J. 1995. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80:249.
40. Arai, H., and I. F. Charo. 1996. Differential regulation of G-protein-mediated signaling by chemokine receptors. J. Biol. Chem. 271:21814.
41. Bossink, A. W. J., L. Paemen, P. M. Jansen, C. E. Hack, L. G. Thijs, and J. Van Damme. 1995. Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. Blood 86:3841.
42. Chensue, S. W., K. S. Warmington, J. H. Ruth, P. S. Sanghi, P. Lincoln, and S. L. Kunkel. 1996. Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J. Immunol. 157:4602.
43. Rutledge, B. J., H. Rayburn, R. Rosenberg, R. J. North, R. P. Gladue, C. L. Corless, and B. J. Rollins. 1995. High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. J. Immunol. 155:4838.
44. Gong, J.-H., L. G. Ratkay, J. D. Waterfield, and I. Clark-Lewis. 1997. An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J. Exp. Med. 186:131.
45. Boshoff, C., Y. Endo, P. D. Collins, Y. Takeuchi, J. D. Reeves, V. L. Schweickart, M. A. Siani, T. Sasaki, T. J. Williams, P. W. Gray, P. S. Moore, Y. Chang, and R. A. Weiss. 1997. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 278:290.
46. Kledal, T. N., M. M. Rosenkilde, F. Coulin, G. Simmons, A. H. Johnsen, S. Alouani, C. A. Power, H. R. Lüttichau, J. Gerstoft, P. R. Clapham, I. Clark-Lewis, T. N. C. Wells, and T. W. Schwartz. 1997. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 277:1656.