Breaking the cell cycle of HSCs by p57 and friends

Cell Stem Cell

Volumn 9, Issue 3, 2011, Pages 187-192

  Tesio, Melania ^a   Trumpp, Andreas ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Heidelberg Institute for Stem Cell Technology and Experimental Medicine HI STEM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D; HEAT SHOCK COGNATE PROTEIN 70; PROTEIN P57; TRANSCRIPTION FACTOR;

CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL FUNCTION; CELL NUCLEUS; CELL RENEWAL; GENE MUTATION; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SOMATIC CELL;

ADULT STEM CELLS; ANIMALS; CELL AGING; CELL SURVIVAL; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASE INHIBITOR P57; HEMATOPOIETIC STEM CELLS; HSC70 HEAT-SHOCK PROTEINS;

EID: 80052276418     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2011.08.005     Document Type: Review

References (30)

1. A. Besson, R.K. Assoian, and J.M. Roberts Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors? Nat. Rev. Cancer 4 2004 948 955 (Pubitemid 39626218)
2. T. Cheng, N. Rodrigues, D. Dombkowski, S. Stier, and D.T. Scadden Stem cell repopulation efficiency but not pool size is governed by p27(kip1) Nat. Med. 6 2000 1235 1240
3. A.R. Choudhury, Z. Ju, M.W. Djojosubroto, A. Schienke, A. Lechel, S. Schaetzlein, H. Jiang, A. Stepczynska, C. Wang, and J. Buer Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation Nat. Genet. 39 2007 99 105 (Pubitemid 46026508)
4. A. Ehninger, and A. Trumpp The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in J. Exp. Med. 208 2011 421 428
5. W.S. el-Deiry, J.W. Harper, P.M. O'Connor, V.E. Velculescu, C.E. Canman, J. Jackman, J.A. Pietenpol, M. Burrell, D.E. Hill, and Y. Wang WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis Cancer Res. 54 1994 1169 1174 (Pubitemid 24108052)
6. M.A. Essers, S. Offner, W.E. Blanco-Bose, Z. Waibler, U. Kalinke, M.A. Duchosal, and A. Trumpp IFNalpha activates dormant haematopoietic stem cells in vivo Nature 458 2009 904 908
7. K. Ito, A. Hirao, F. Arai, S. Matsuoka, K. Takubo, I. Hamaguchi, K. Nomiyama, K. Hosokawa, K. Sakurada, and N. Nakagata Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells Nature 431 2004 997 1002 (Pubitemid 39434422)
8. V. Janzen, R. Forkert, H.E. Fleming, Y. Saito, M.T. Waring, D.M. Dombkowski, T. Cheng, R.A. DePinho, N.E. Sharpless, and D.T. Scadden Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a Nature 443 2006 421 426 (Pubitemid 44477274)
9. E.S. José-Enériz, J. Román-Gómez, L. Cordeu, E. Ballestar, L. Gárate, E.J. Andreu, I. Isidro, E. Guruceaga, A. Jiménez-Velasco, and A. Heiniger BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia Br. J. Haematol. 142 2008 571 582 (Pubitemid 352020204)
10. K.Y. King, M.T. Baldridge, D.C. Weksberg, S.M. Chambers, G.L. Lukov, S. Wu, N.C. Boles, S.Y. Jung, J. Qin, and D. Liu Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling Blood 118 2011 1525 1533
11. A. Matsumoto, S. Takeishi, T. Kanie, E. Susaki, I. Onoyama, Y. Tateishi, K. Nakayama, and K.I. Nakayama p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells Cell Stem Cell 9 2011 262 271 this issue
12. J.L. McKenzie, O.I. Gan, M. Doedens, J.C. Wang, and J.E. Dick Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment Nat. Immunol. 7 2006 1225 1233 (Pubitemid 44594319)
13. K.W. Orford, and D.T. Scadden Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation Nat. Rev. Genet. 9 2008 115 128
14. E. Passegué, A.J. Wagers, S. Giuriato, W.C. Anderson, and I.L. Weissman Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates J. Exp. Med. 202 2005 1599 1611 (Pubitemid 41746605)
15. I.S. Pateras, K. Apostolopoulou, K. Niforou, A. Kotsinas, and V.G. Gorgoulis p57KIP2: "Kip"ing the cell under control Mol. Cancer Res. 7 2009 1902 1919
16. C.J. Sherr, and J.M. Roberts CDK inhibitors: positive and negative regulators of G1-phase progression Genes Dev. 13 1999 1501 1512 (Pubitemid 29297917)
17. L. Stepanova, and B.P. Sorrentino A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress Blood 106 2005 827 832 (Pubitemid 41076421)
18. H. Takizawa, R.R. Regoes, C.S. Boddupalli, S. Bonhoeffer, and M.G. Manz Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation J. Exp. Med. 208 2011 273 284
19. R. van Os, L.M. Kamminga, A. Ausema, L.V. Bystrykh, D.P. Draijer, K. van Pelt, B. Dontje, and G. de Haan A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning Stem Cells 25 2007 836 843 (Pubitemid 46572579)
20. A. Viale, F. De Franco, A. Orleth, V. Cambiaghi, V. Giuliani, D. Bossi, C. Ronchini, S. Ronzoni, I. Muradore, and S. Monestiroli Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells Nature 457 2009 51 56
21. C.R. Walkley, M.L. Fero, W.M. Chien, L.E. Purton, and G.A. McArthur Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells Nat. Cell Biol. 7 2005 172 178 (Pubitemid 40268132)
22. A. Wilson, E. Laurenti, G. Oser, R.C. van der Wath, W. Blanco-Bose, M. Jaworski, S. Offner, C.F. Dunant, L. Eshkind, and E. Bockamp Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair Cell 135 2008 1118 1129
23. A. Wilson, E. Laurenti, and A. Trumpp Balancing dormant and self-renewing hematopoietic stem cells Curr. Opin. Genet. Dev. 19 2009 461 468
24. S. Yamazaki, A. Iwama, S. Takayanagi, Y. Morita, K. Eto, H. Ema, and H. Nakauchi Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells EMBO J. 25 2006 3515 3523 (Pubitemid 44264862)
25. S. Yamazaki, A. Iwama, S. Takayanagi, K. Eto, H. Ema, and H. Nakauchi TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation Blood 113 2009 1250 1256
26. H. Yoshihara, F. Arai, K. Hosokawa, T. Hagiwara, K. Takubo, Y. Nakamura, Y. Gomei, H. Iwasaki, S. Matsuoka, and K. Miyamoto Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche Cell Stem Cell 1 2007 685 697 (Pubitemid 350215333)
27. H. Yu, Y. Yuan, H. Shen, and T. Cheng Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite manners Blood 107 2006 1200 1206 (Pubitemid 43156324)
28. Y. Yuan, H. Shen, D.S. Franklin, D.T. Scadden, and T. Cheng In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C Nat. Cell Biol. 6 2004 436 442 (Pubitemid 38607504)
29. P. Zhang, N.J. Liégeois, C. Wong, M. Finegold, H. Hou, J.C. Thompson, A. Silverman, J.W. Harper, R.A. DePinho, and S.J. Elledge Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome Nature 387 1997 151 158 (Pubitemid 27209424)
30. P. Zou, F. Arai, H. Yoshihara, I. Tai, K. Hosokawa, Y. Matsumoto, K. Shinmyozu, F. Tsukahara, Y. Maru, and K. Nakayama p57Kip2 and p27Kip1 Cooperate to Maintain Hematopoietic Stem Cell Quiescence through Interactions with Hsc70 Cell Stem Cell 9 2011 247 261 this issue