Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations

Experimental Hematology

Volumn 33, Issue 4, 2005, Pages 469-479

  Robinson, Lisa J ^a   Xue, Jia ^a   Corey, Seth J ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLT3 LIGAND; MUTANT PROTEIN; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; BONE MARROW CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; GENE MUTATION; HUMAN; HUMAN CELL; LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 15244348388     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2005.01.004     Document Type: Article

References (46)

1. S.D. Lyman, and S.E. Jacobsen c-Kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities Blood 91 1998 1101 1134
2. D.L. Stirewalt, and J.P. Radich The role of FLT3 in haematopoietic malignancies Nat Rev Cancer 3 2003 650 665
3. D.G. Gilliland, and J.D. Griffin The roles of FLT3 in hematopoiesis and leukemia Blood 100 2002 1532 1542
4. H.J. McKenna Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells Curr Opin Hematol 8 2001 149 154
5. J.T. Reilly FLT3 and its role in the pathogenesis of acute myeloid leukemia Leuk Lymphoma 46 2003 1 7
6. M. Levis, and D. Small FLT3: ITDoes matter in leukemia Leukemia 17 2003 1738 1752
7. P.D. Kottaridis, R.E. Gale, and D.C. Linch Flt3 mutations and leukaemia Br J Haematol 122 2003 523 538
8. J. Jiang, J.G. Paez, and J.C. Lee Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML Blood 104 2004 1855 1858
9. S.A. Armstrong, M.E. Mabon, and L.B. Silverman FLT3 mutations in childhood acute lymphoblastic leukemia Blood 103 2004 3544 3546
10. R. Fenski, K. Flesch, and S. Serve Constitutive activation of FLT3 in acute myeloid leukemia and its consequences for the growth of 32D cells Br J Haematol 1010 2000 322 330
11. H. Kiyoi, M. Towatari, and S. Yokota Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product Leukemia 12 1998 1333 1337
12. Y. Yamamoto, H. Kiyoi, and Y. Nakano Activating mutation of D1035 within the activation loop of FLT3 in human hematologic malignancies Blood 97 2001 2434 2439
13. L.M. Kelly, Q. Liu, J.L. Kutok, I.R. Williams, C.L. Boulton, and D.G. Gilliland FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model Blood 99 2002 310 318
14. L.M. Kelly, J.L. Kutok, and I.R. Williams PML/RAR and FLT3-ITD induce an APL-like disease in a mouse model Proc Natl Acad Sci USA 99 2002 8283 8388
15. F. Hayakawa, M. Towatari, and H. Kiyoi Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL3-dependent cell lines Oncogene 19 2000 624 631
16. M. Mizuki, R. Fenski, and H. Halfter Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways Blood 96 2000 3907 3914
17. S.J. Corey, and S.M. Anderson Src-related tyrosine kinases in hematopoiesis Blood 93 1999 1 14
18. S.G. Rane, and E.P. Reddy JAKs, STATs, and Src kinases in hematopoiesis Oncogene 21 2002 3334 3358
19. Y. Li, R.M. Mohammad, A. Al-Katib, M.L. Varterasian, and B. Chen Bryostatin 1-induced monocytic differentiation in THP-1 human leukemia cells is associated with enhanced c-fyn tyrosine kinase and M-CSF receptors Leuk Res 21 1997 391 397
20. D. Linnekin, C.S. Deberry, and S. Mou Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells J Biol Chem 272 1997 27450 27455
21. T. Torigoe, R. O'Connor, D. Santoli, and J.C. Reed Interleukin-3 regulates the activity of the Lyn protein-tyrosine kinase in myeloid-committed leukemic cell lines Blood 80 1992 617 624
22. A.L. DeFranco, V.W.F. Chan, and C.A. Lowell Positive and negative roles of the tyrosine kinase Lyn in B cell function Semin Hematol 10 1998 299 307
23. I. Timokhina, H. Kissel, G. Stella, and P. Besmer Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation EMBO J 17 1998 6250 6262
24. B. O'Laughlin-Bunner, N. Radosevic, and M.L. Taylor Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells Blood 98 2001 343 350
25. V.C. Broudy, N.L. Lin, and W.C. Liles Signaling via Src family kinases is required for normal internalization of the receptor c-Kit Blood 94 1999 1979 1986
26. T. Jahn, P. Seipel, and S. Coutinho Analysing c-kit internalization using a functional c-kit-EGFP chimera containing fluorochrome within the extracellular domain Oncogene 21 2002 4508 4520
27. V. Roginskaya, S. Zuo, E. Caudell, G. Nambudiri, A.J. Kraker, and S.J. Corey Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth Leukemia 13 1999 855 861
28. M.B. Wilson, S.J. Schreiner, H.J. Choi, J. Kamens, and T.E. Smithgall Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis Oncogene 21 2002 8075 8088
29. N.J. Donato, J.Y. Wu, and J. Stapley BCR-ABL independence and LYN kinase overexpression in chronic myeloid leukemia cells selected for resistance to STI571 Blood 101 2003 690 698
30. D. Small, M. Levenstein, and E. Kim STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells Proc Natl Acad Sci USA 91 1994 459 463
31. M. Nakao, S. Yokota, and T. Iwai Internal tandem duplication of the flt3 gene found in acute myeloid leukemia Leukemia 10 1996 1911 1918
32. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
33. S. Zhang, and H.E. Broxmeyer p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells Biochem Biophys Res Commun 254 1999 440 445
34. M. Dosil, S. Wang, and I.R. Lemischka Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin-3-dependent hematopoietic cells Mol Cell Biol 13 1993 6572 6585
35. M. Levis, K.F. Tse, B.D. Smith, E. Garrett, and D. Small A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations Blood 98 2001 885 887
36. H. Quentmeier, J. Reinhardt, M. Zaborski, and H.G. Drexler FLT3 mutations in acute myeloid leukemia cell lines Leukemia 17 2003 120 124
37. S.D. Lyman, L. James, J. Zappone, P.R. Sleath, M.P. Beckmann, and T. Bird Characterization of the protein encoded by the Flt3 (Flk2) receptor-like tyrosine kinase gene Oncogene 8 1993 815 822
38. S. Rosenkranz, Y. Ikuno, and F.L. Leong Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression J Biol Chem 275 2000 9620 9627
39. J.H. Hanke, J.P. Gardner, and R.L. Dow Discovery of a novel, potent, and Src family-specific tyrosine kinase inhibitor J Biol Chem 271 1996 695 701
40. C.L. Yu, and S.J. Burakoff Involvement of proteosomes in regulating Jak-Stat pathways upon linterleukin-2 stimulation J Biol Chem 272 1997 14017 14020
41. R. Rottapel, C.W. Turck, and N. Casteran Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase Oncogene 9 1994 1755 1765
42. M.G. Hunter, and B.R. Avalos Deletion of a critical internalization domain in the G-CSFR in acute myelogenoud leukemia preceded by severe congenital neutropenia Blood 93 1999 440 446
43. A.C. Ward, Y.M. van Aesch, and I.P. Touw Defective internalization and sustained activation of truncated granulocyte colon-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia Blood 93 1999 447 458
44. M.A. Olayioye, I. Beuvink, R. Horsch, J.M. Daly, and N.E. Hynes ErbB receptor-induced activation of STAT transcription factor is mediated by src tyrosine kinases J Biol Chem 274 1999 17209 17218
45. A.B. Pawlowska, S. Hashino, H. McKenna, B.J. Weigel, P.A. Taylor, and B.R. Blazar In vitro tumor-pulsed or in vivo Flt3 ligand-generated dendritic cells provide protection against acute myelogenous leukemia in nontransplanted or syngeneic bone marrow-transplanted mice Blood 97 2001 1474 1482
46. A. Wang, S.E. Braun, G. Sonpavde, and K. Cornetta Anti-leukemic activity of Flt3 ligand in murine leukemia Cancer Res 60 2000 1895 1900