Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity

Journal of Biological Chemistry

Volumn 286, Issue 35, 2011, Pages 30344-30351

  Sadighi Akha, Amir A ^a   Harper, James M ^a   Salmon, Adam B ^a,d   Schroeder, Bethany A ^a,e   Tyra, Heather M ^c   Rutkowski, D Thomas ^c   Miller, Richard A ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASAL LEVELS; CAENORHABDITIS ELEGANS; CASPASE-3; DATA SUPPORT; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENOTYPIC DIFFERENCES; LETHAL EFFECTS; MOUSE MODELS; PROAPOPTOTIC SIGNALS; TARGET GENES; THAPSIGARGINS; UNFOLDED PROTEIN RESPONSE;

CELL DEATH; FIBROBLASTS; GENES; MAMMALS; PHOSPHORYLATION; SIGNALING;

CELL CULTURE;

CASPASE 12; CASPASE 3; CASPASE 7; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PROTEIN P72; STRESS ACTIVATED PROTEIN KINASE; THAPSIGARGIN; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARMET GENE; ARTICLE; CONTROLLED STUDY; EDEM1 GENE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ERDJ3 GENE; FEMALE; FIBROBLAST; GENE; IRE1ALPHA GENE; LONGEVITY; MALE; MOUSE; NONHUMAN; P58IPK GENE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SEC61A1 GENE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; LONGEVITY; MALE; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; MUTATION; PHOSPHORYLATION; PITUITARY GLAND; PROTEIN DENATURATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

CAENORHABDITIS ELEGANS; MUS;

EID: 80052201287     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.220541     Document Type: Article

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