Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose-polymerase-mediated apoptosis under high-glucose stimulation

Acta Biochimica et Biophysica Sinica

Volumn 43, Issue 9, 2011, Pages 703-711

  Qin, Xiuhong ^a   Zhang, Zhenzhen ^b   Xu, Haitao ^a   Wu, Yazhen ^a  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^b SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

Author keywords

apoptosis; diabetes; NF B; Notch signaling; retina

Indexed keywords

ANDROSTANE DERIVATIVE; CASPASE 3; GLUCOSE; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; CELL CULTURE; CELL STRAIN HEK293; CONFOCAL MICROSCOPY; DIABETIC RETINOPATHY; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; PATHOLOGY; RETINA; RNA INTERFERENCE; WESTERN BLOTTING;

ANDROSTADIENES; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIAL CELLS; GLUCOSE; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PHOSPHATIDYLINOSITOL 3-KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, NOTCH1; RETINA; RNA INTERFERENCE;

MUS;

EID: 80052189154     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmr069     Document Type: Article

References (37)

1. Infeld DA and O'Shea JG. Diabetic retinopathy. Postgrad Med J 1998, 74: 129-133. (Pubitemid 28132392)
2. Frank RN. Diabetic retinopathy. N Engl J Med 2004, 350: 48-58. (Pubitemid 38032183)
3. Sheetz MJ and King GL. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 2002, 288: 2579-2588. (Pubitemid 35386893)
4. Caldwell RB, Bartoli M, Behzadian MA, El-Remessy AE, Al-Shabrawey M, Platt DH and Caldwell RW. Vascular endothelial growth factor and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives. Diabetes Metab Res Rev 2003, 9: 442-455. (Pubitemid 37536961)
5. Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J and Adamis AP, et al. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: Role of oxidants and protein kinase-C activation. Diabetes 2003, 52: 829-837. (Pubitemid 36323593)
6. Zheng L, Szabo C and Kern TS. Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. Diabetes 2004, 53: 2960-2967. (Pubitemid 39425922)
7. Obrosova IG, Pacher P, Szabó C, Zsengeller Z, Hirooka H, Stevens MJ and Yorek MA. Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADPribose) polymerase activation in tissue sites for diabetes complications. Diabetes 2005, 54: 234-242. (Pubitemid 40105118)
8. Chen S, Khan ZA, Cukiernik M and Chakrabarti S. Differential activation of NF-kappa B and AP-1 in increased fibronectinsynthesis in target organs of diabetic complications. Am J Physiol Endocrinol Metab 2003, 284: E1089-E1097. (Pubitemid 36617453)
9. Garcia Soriano F, Virág L, Jagtap P, Szabó E, Mabley JG, Liaudet L and Marton A, et al. Diabetic endothelial dysfunction: The role of poly (ADP-ribose) polymerase activation. Nat Med 2001, 7: 108-113. (Pubitemid 32095649)
10. Vallabhapurapu S and Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009, 27: 693-733.
11. Karin M and Ben-Neriah Y. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol 2000, 18: 621-663. (Pubitemid 30365393)
12. Hayden MS and Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008, 132: 344-362.
13. Hassa PO, Buerki C, Lombardi C, Imhof R and Hottiger MO. Transcriptional coactivation of nuclear factor-kappaB dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1. J Biol Chem 2003, 278: 45145-45153. (Pubitemid 37432647)
14. Pacher P and Szabó C. Role of poly (ADP-Ribose) polymerase-1 activation in the pathogenesis of diabetic complications: Endothelial dysfunction, as a common underlying theme. Antioxid Redox Signal 2005, 7: 1568-1580. (Pubitemid 41767992)
15. Espinosa L, Santos S, Inglés-Esteve J, Muñoz-Canoves P and Bigas A. p65-NFkB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR. J Cell Sci 2002, 115: 1295-1303. (Pubitemid 34272493)
16. Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA and Hoffman T. T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells. J Exp Med 1996, 183: 2025-2032. (Pubitemid 26158895)
17. Romashkova JA and Makarov SS. NF-kappaB is a target of AKT in antiapoptotic PDGF signalling. Nature 1999, 401: 86-90.
18. Juryńczyk M and Selmaj K Notch: A new player in MS mechanisms. J Neuroimmunol 2010, 218: 3-11.
19. Liu ZL, Li Y, Kong QY, Zhan C, Wang Q, Chen XY and Sun Y, et al. Immunohistochemical profiling of Wnt, NF-jB, Stat3 and Notch signaling in human epidermal tumors. J Dermatol Sci 2008, 52: 133-136.
20. Nair P, Somasundaram K and Krishna S. Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. J Virol 2003, 77: 7106-7112. (Pubitemid 36666904)
21. Sade H, Krishna S and Sarin A. The anti-apoptotic effect of Notch-1 requires p56lckdependent, Akt/PKB-mediated signaling in T cells. J Biol Chem 2004, 279: 2937-2944. (Pubitemid 38114286)
22. Williams CK, Li JL, Murga M, Harris AL and Tosato G. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 2006, 107: 931-939. (Pubitemid 43156289)
23. Alexandre S, Rast C, Nguyen-Ba G, Poirier GG and Vasseur P. PARP degradation in apoptotic Syrian hamster embryo (SHE) cells compared to HL60 cell line. Biochimie 2000, 82: 1115-1122. (Pubitemid 32015728)
24. Zheng MH, Zhang ZF, Zhao XC, Ding YQ and Han H. The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis. J Genet Genomics 2010, 37: 573-582.
25. Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM and Murphy AJ. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA 2004, 101: 15949-15954. (Pubitemid 39507907)
26. Benedito R and Duarte A. Expression of DLL4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns 2005, 5: 750-755. (Pubitemid 40945859)
27. Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD and Wiegand SJ. Delta-like ligand 4 (DLL4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci USA 2007, 104: 3219-3224. (Pubitemid 46364140)
28. Krebs LT, Xue Y, Norton CR, Shutter JR, Maguire M, Sundberg JP and Gallahan D, et al. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev 2000, 14: 1343-1352. (Pubitemid 30397078)
29. Limbourg FP, Takeshita K, Radtke F, Bronson RT, Chin MT and Liao JK. Essential role of endothelial Notch1 in angiogenesis. Circulation 2005, 111: 1826-1832. (Pubitemid 40525149)
30. Krebs LT, Shutter JR, Tanigaki K, Honjo T, Stark KL and Gridley T. Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev 2004, 18: 2469-2473. (Pubitemid 39362888)
31. Muñoz-Chápuli R, Quesada AR and Angel Medina M. Angiogenesis and signal transduction in endothelial cells. Cell Mol Life Sci 2004, 61: 2224-2243. (Pubitemid 39280120)
32. Ciofani M and Zúniga-Pflücker JC. Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol 2005, 6: 881-888. (Pubitemid 43090442)
33. Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004, 15: 177-182. (Pubitemid 38251646)
34. Plas DR and Thompson CB. Akt-dependent transformation: There is more to growth than just surviving. Oncogene 2005, 24: 7435-7442. (Pubitemid 41637983)
35. Stiles B, Groszer M, Wang SY, Jiao J and Wu H. PTENless means more. Dev Biol 2004, 273: 175-184. (Pubitemid 39144393)
36. Datta SR, Dudek H, Tao X, Masters S, Fu HA, Gotoh Y and Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91: 231-241. (Pubitemid 27456390)
37. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E and Frisch S, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282: 1318-1321. (Pubitemid 28524494)