Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: Role of oxidants and protein kinase-C activation

Diabetes

Volumn 52, Issue 3, 2003, Pages 829-837

  Abiko, Toru ^a   Abiko, Atsuko ^a   Clermont, Allen C ^a   Shoelson, Brett ^a   Horio, Naoichi ^a   Takahashi, Junichi ^a   Adamis, Anthony P ^a   King, George L ^a,b   Bursell, Sven Erik ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

AOLF, acridine orange leukocyte fluorography; AT, appearance time; ET 1, endothelin 1; MCT, mean circulation time; PKC, protein kinase C; SLO, scanning laser ophthalmoscope; STZ, streptozotocin; VFA, video fluorescein angiography

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; OXIDIZING AGENT; PROTEIN KINASE C; RUBOXISTAURIN; THIOCTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DIABETIC RETINOPATHY; DRUG MECHANISM; ENDOTHELIUM LESION; HEMODYNAMICS; INSULIN RESISTANCE; LEUKOSTASIS; MALE; MONOCYTE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; RETINA BLOOD FLOW; RETINA CAPILLARY; SIGNAL TRANSDUCTION;

ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; BLOOD FLOW VELOCITY; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HEMODYNAMIC PROCESSES; HYDROGEN PEROXIDE; INDOLES; INSULIN RESISTANCE; LEUKOSTASIS; MALE; MALEIMIDES; MICROCIRCULATION; MICROSPHERES; OXIDANTS; OXIDATIVE STRESS; PROTEIN KINASE C; PROTEIN KINASES; RATS; RATS, LONG-EVANS; RATS, ZUCKER; RETINA; RETINAL VESSELS; THIOCTIC ACID;

EID: 0037341207     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.3.829     Document Type: Article

References (41)

1. Aiello LP, Cahill M, Wong JS: Systemic considerations in the management of diabetic retinopathy. Am J Ophthalmol 132:760-776, 2001
2. Kohner EM, Patel V, Rassam SM: Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes 44:603-607, 1995
3. Bursell SE, Clermont AC, Aiello LP, Aiello LM, Schlossman DK, Feener EP, Laffel L, King GL: High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care 22:1245-1251, 1999
4. Miyamoto K, Ogura Y: Pathogenetic potential of leukocytes in diabetic retinopathy. Semin Ophthalmol 14:233-239, 1999
5. Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC, Aiello LP, Ogura Y, Adamis AP: Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellar adhesion molecule-1 inhibition. Proc Natl Acad Sci U S A 96:10836-10841, 1999
6. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes-mellitus. N Engl J Med 329:977-986, 1993
7. U.K. Prospective Diabetes Study Group: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837-853, 1998
8. Takagi G, Bursell SE, Lin YW, Takagi H, Duh E, Jiang Z, Clermont AC, King GL: Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1. Invest Ophthalmol Vis Sci 37:2504-2518, 1996
9. Peruno G, Chaturvedi N, Talmud PJ, Cotroneo P, Manto A, Nannipieri M, Luong LA, Fuller JH: Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinepril in IDDM. Diabetes 47:1507-1511, 1998
10. Evans T, Deng DX, Chen S, Chakrabarti S: Endothelin receptor blockade prevents augmented extracellular matrix component mRNA expression and capillary basement membrane thickening in the retina of diabetic and galactose-fed rats. Diabetes 49:662-666, 2000
11. Booth G, Stalker TJ, Lefer AM, Scalia R: Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes 51:1556-1564, 2002
12. Beckman JA, Goldfine AB, Gordon MB, Garrett LA, Creager MA: Inhibition of protein kinase C beta prevents impaired endothelium-dependant vasodilation caused by hyperglycemia in humans. Circ Res 90:107-111, 2002
13. Baron AD: Insulin resistance and vascular function. J Diabetes Complications 16:92-102, 2002
14. Way KJ, Katai N, King GL: Protein kinase C and the development of diabetic vascular complications. Diabet Med 15:945-959, 2001
15. Resnick HE, Howard BV: Diabetes and cardiovascular disease. Annu Rev Med 53:245-267, 2002
16. Way KJ, Katai N, King GL: Protein kinase C and the development of diabetic vascular complications. Diabet Med 18:945-959, 2001
17. Resnick HE, Howard BV: Diabetes and cardiovascular disease. Annu Rev Med 53:245-267, 2002
18. Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820, 2001
19. Frank RN: Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors. Am J Opthalmol 133:693-698, 2002
20. Clermont AC, Brittis M, Shiba T, McGovern T, King GL, Bursell SE: Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps. Invest Opthalmol Vis Sci 35:981-990, 1994
21. Miyamoto K, Hiroshiba N, Tsujikawa A, Ogura Y: In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci 39:2190-2194, 1998
22. Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL: Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes 43:1372-1377, 1994
23. Packer L, Kraemer K, Rimbach G: Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17:888-895, 2001
24. Kagokawa H, Clermont AC, Bursell SE: Differential effect of vitamin E and lipoic acid in retinal blood flow in diabetic rats (Abstract). Diabetes 48 (Suppl. 1):153A, 1999
25. Nourooz-Zadeh J, Tajaddini-Sarmadi J, Wolff SP: Measurement of plasma hydro peroxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Anal Biochem 220:403-409, 1994
26. Unger RH, Orci L: Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J 15:312-321, 2001
27. Frei B: On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med 222:196-204, 1999
28. Kunisaki M, Bursell SE, Clermont AC, Ishii H, Ballas LM, Jirousek MR, Umeda F, Nawata H, King GL: Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol 269:E239-E246, 1995
29. Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont AC, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL: Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272:728-731, 1996
30. Lo SK, Janakidevi K, Lai L, Malik AB: Hydrogen peroxide-induced increase in endothelial adhesiveness is dependent on ICAM-1 activation. Am J Physiol 264:L406-L412, 1993
31. Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP: Retinal vascular endothelial growth factor induces intercellular adhesion molecular-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol 160:501-509, 2002
32. Matsumoto K, Sera Y, Nakamura H, Ueki Y, Miyake S: Serum concentrations of soluble adhesion molecules are related to degree of hyperglycemia and insulin resistance in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 55:131-138, 2002
33. Chen NG, Holmes M, Reaven GM: Relationship between insulin resistance, soluble adhesion molecules, and mononuclear cell binding in healthy volunteers. J Clin Endocrinol Metab 84:3485-3489, 1999
34. Bluher M, Unger R, Rassoul F, Richter V, Paschke R: Relation between glycaemic control, hyperinsulinaemia, and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or type II diabetes. Diabetologia 45:210-216, 2002
35. Licata G, Scaglione R, Dominguez LJ: Early markers of cardiovascular damage in obese subjects. Nutr Metab Cardiovasc Dis 9:78-86, 1999
36. Paques M, Boval B, Richard S, Tadayori R, Massin P, Mundler O, Gaugric A, Vicaut E: Evaluation of fluorescein-labeled autologous leukocytes for examination of retinal circulation in humans. Curr Eye Res 21:560-565, 2000
37. Bergman RN, Mittelman SD: Central role of the adipocyte in insulin resistance. J Basic Clin Physiol Pharmacol 9:205-221, 1998
38. Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Inamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H: High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49:1939-1945, 2000
39. van Dam PS, van Asbeck BS, Van Oirschot JF, Biessels GJ, Haners FP, Marx JJ: Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state. Eur J Clin Invest 31:417-424, 2001
40. Gorlach A, Brandes RP, Nguyen K, Amidi M, Dehghani F, Busse R: A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res 87:26-32, 2000
41. Kowluru RA: Diabetes-induced elevations in retinal oxidative stress, protein kinase C and nitric oxide are interrelated. Acta Diabetol 38:179-185, 2001