메뉴 건너뛰기




Volumn 11, Issue , 2011, Pages

Metabolic and Kinetic analyses of influenza production in perfusion HEK293 cell culture

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELL DEATH; COST EFFECTIVENESS; KINETICS; METABOLISM; PHYSIOLOGY; SUBSTRATES; VACCINES; VIRUSES;

EID: 80052145378     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-11-84     Document Type: Article
Times cited : (60)

References (50)
  • 1
    • 77956231719 scopus 로고    scopus 로고
    • Validation of the safety of MDCK cells as a substrate for the production of a cell-derived influenza vaccine
    • 10.1016/j.biologicals.2010.04.003, 20537553
    • Onions D, Egan W, Jarrett R, Novicki D, Gregersen J-P. Validation of the safety of MDCK cells as a substrate for the production of a cell-derived influenza vaccine. Biologicals 2010, 38(5):544-551. 10.1016/j.biologicals.2010.04.003, 20537553.
    • (2010) Biologicals , vol.38 , Issue.5 , pp. 544-551
    • Onions, D.1    Egan, W.2    Jarrett, R.3    Novicki, D.4    Gregersen, J.-P.5
  • 3
    • 65649125562 scopus 로고    scopus 로고
    • Vero cell platform in vaccine production: moving towards cell culture-based viral vaccines
    • 10.1586/erv.09.19, 19397417
    • Barrett PN, Mundt W, Kistner O, Howard MK. Vero cell platform in vaccine production: moving towards cell culture-based viral vaccines. Expert Review of Vaccines 2009, 8(5):607-618. 10.1586/erv.09.19, 19397417.
    • (2009) Expert Review of Vaccines , vol.8 , Issue.5 , pp. 607-618
    • Barrett, P.N.1    Mundt, W.2    Kistner, O.3    Howard, M.K.4
  • 4
    • 33645046102 scopus 로고    scopus 로고
    • Serum-free influenza virus production avoiding washing steps and medium exchange in large-scale microcarrier culture
    • 10.1016/j.vaccine.2006.01.019, 16472544
    • Genzel Y, Fischer M, Reichl U. Serum-free influenza virus production avoiding washing steps and medium exchange in large-scale microcarrier culture. Vaccine 2006, 24:3261-3272. 10.1016/j.vaccine.2006.01.019, 16472544.
    • (2006) Vaccine , vol.24 , pp. 3261-3272
    • Genzel, Y.1    Fischer, M.2    Reichl, U.3
  • 5
    • 73849115748 scopus 로고    scopus 로고
    • Continuous cell lines as a production system for influenza vaccines
    • 10.1586/erv.09.128, 19943763
    • Genzel Y, Reichl U. Continuous cell lines as a production system for influenza vaccines. Expert Review of Vaccines 2009, 8(12):1681-1692. 10.1586/erv.09.128, 19943763.
    • (2009) Expert Review of Vaccines , vol.8 , Issue.12 , pp. 1681-1692
    • Genzel, Y.1    Reichl, U.2
  • 6
    • 67449102487 scopus 로고    scopus 로고
    • Trivalent MDCK cell culture-derived influenza vaccine Optaflu® (Novartis Vaccines)
    • 10.1586/erv.09.31, 19485748
    • Doroshenko A, Halperin SA. Trivalent MDCK cell culture-derived influenza vaccine Optaflu® (Novartis Vaccines). Expert Review of Vaccines 2009, 8(6):679-688. 10.1586/erv.09.31, 19485748.
    • (2009) Expert Review of Vaccines , vol.8 , Issue.6 , pp. 679-688
    • Doroshenko, A.1    Halperin, S.A.2
  • 7
    • 2442437845 scopus 로고    scopus 로고
    • Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture
    • 10.1016/j.vaccine.2003.11.041, 15149778
    • Genzel Y, Behrendt I, Konig S, Sann H, Reichl U. Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture. Vaccine 2004, 22(17-18):2202-2208. 10.1016/j.vaccine.2003.11.041, 15149778.
    • (2004) Vaccine , vol.22 , Issue.17-18 , pp. 2202-2208
    • Genzel, Y.1    Behrendt, I.2    Konig, S.3    Sann, H.4    Reichl, U.5
  • 8
    • 77955656086 scopus 로고    scopus 로고
    • A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor
    • 10.1016/j.vaccine.2010.07.004, 20638458
    • Lohr V, Genzel Y, Behrendt I, Scharfenberg K, Reichl U. A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor. Vaccine 2010, 28(38):6256-6264. 10.1016/j.vaccine.2010.07.004, 20638458.
    • (2010) Vaccine , vol.28 , Issue.38 , pp. 6256-6264
    • Lohr, V.1    Genzel, Y.2    Behrendt, I.3    Scharfenberg, K.4    Reichl, U.5
  • 9
    • 67650430190 scopus 로고    scopus 로고
    • New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: Studies on growth, metabolism and virus propagation
    • 10.1016/j.vaccine.2009.05.083, 19531390
    • Lohr V, Rath A, Genzel Y, Jordan I, Sandig V, Reichl U. New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: Studies on growth, metabolism and virus propagation. Vaccine 2009, 27(36):4975-4982. 10.1016/j.vaccine.2009.05.083, 19531390.
    • (2009) Vaccine , vol.27 , Issue.36 , pp. 4975-4982
    • Lohr, V.1    Rath, A.2    Genzel, Y.3    Jordan, I.4    Sandig, V.5    Reichl, U.6
  • 10
    • 0035925715 scopus 로고    scopus 로고
    • The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines
    • 10.1016/S0264-410X(00)00508-9, 11257414
    • Pau M, Ophorst C, Koldijk M, Schouten G, Mehtali M, Uytdehaag F. The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines. Vaccine 2001, 19(17-19):2716-2721. 10.1016/S0264-410X(00)00508-9, 11257414.
    • (2001) Vaccine , vol.19 , Issue.17-19 , pp. 2716-2721
    • Pau, M.1    Ophorst, C.2    Koldijk, M.3    Schouten, G.4    Mehtali, M.5    Uytdehaag, F.6
  • 11
    • 80052866609 scopus 로고    scopus 로고
    • Avian cell lines derived from primordial germ cells useful for the production of substances of interest
    • Mehtali M. Avian cell lines derived from primordial germ cells useful for the production of substances of interest. 2007,
    • (2007)
    • Mehtali, M.1
  • 12
    • 77953133120 scopus 로고    scopus 로고
    • Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing
    • 10.1016/j.vaccine.2010.03.029, 20347632
    • Le Ru A, Jacob D, Transfiguracion J, Ansorge S, Henry O, Kamen AA. Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing. Vaccine 2010, 28(21):3661-3671. 10.1016/j.vaccine.2010.03.029, 20347632.
    • (2010) Vaccine , vol.28 , Issue.21 , pp. 3661-3671
    • Le Ru, A.1    Jacob, D.2    Transfiguracion, J.3    Ansorge, S.4    Henry, O.5    Kamen, A.A.6
  • 13
    • 0028696562 scopus 로고
    • Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells
    • 10.1007/BF00762389, 7765926
    • Garnier A, Côté J, Nadeau I, Kamen A, Massie B. Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells. Cytotechnology 1994, 15(1):145-155. 10.1007/BF00762389, 7765926.
    • (1994) Cytotechnology , vol.15 , Issue.1 , pp. 145-155
    • Garnier, A.1    Côté, J.2    Nadeau, I.3    Kamen, A.4    Massie, B.5
  • 14
    • 0037215640 scopus 로고    scopus 로고
    • Production of adenovirus vector for gene therapy
    • 10.1016/S0734-9750(02)00030-7, 14550017
    • Nadeau I, Kamen A. Production of adenovirus vector for gene therapy. Biotechnology Advances 2003, 20(7-8):475-489. 10.1016/S0734-9750(02)00030-7, 14550017.
    • (2003) Biotechnology Advances , vol.20 , Issue.7-8 , pp. 475-489
    • Nadeau, I.1    Kamen, A.2
  • 15
    • 0034281747 scopus 로고    scopus 로고
    • 293SF Metabolic Flux Analysis during Cell Growth and Infection with an Adenoviral Vector
    • 10.1021/bp000098l, 11027184
    • Nadeau I, Jacob D, Perrier M, Kamen A. 293SF Metabolic Flux Analysis during Cell Growth and Infection with an Adenoviral Vector. Biotechnology Progress 2000, 16(5):872-884. 10.1021/bp000098l, 11027184.
    • (2000) Biotechnology Progress , vol.16 , Issue.5 , pp. 872-884
    • Nadeau, I.1    Jacob, D.2    Perrier, M.3    Kamen, A.4
  • 16
    • 0037359270 scopus 로고    scopus 로고
    • Low-Glutamine Fed-Batch Cultures of 293-HEK Serum-Free Suspension Cells for Adenovirus Production
    • 10.1021/bp025638o, 12675594
    • Lee YY, Yap MGS, Hu WS, Wong KTK. Low-Glutamine Fed-Batch Cultures of 293-HEK Serum-Free Suspension Cells for Adenovirus Production. Biotechnology Progress 2003, 19(2):501-509. 10.1021/bp025638o, 12675594.
    • (2003) Biotechnology Progress , vol.19 , Issue.2 , pp. 501-509
    • Lee, Y.Y.1    Yap, M.G.S.2    Hu, W.S.3    Wong, K.T.K.4
  • 17
    • 2942618534 scopus 로고    scopus 로고
    • Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures
    • 10.1002/bit.20074, 15162452
    • Henry O, Dormond E, Perrier M, Kamen A. Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures. Biotechnology and Bioengineering 2004, 86(7):765-774. 10.1002/bit.20074, 15162452.
    • (2004) Biotechnology and Bioengineering , vol.86 , Issue.7 , pp. 765-774
    • Henry, O.1    Dormond, E.2    Perrier, M.3    Kamen, A.4
  • 18
    • 1642325279 scopus 로고    scopus 로고
    • Life and death in mammalian cell culture: strategies for apoptosis inhibition
    • 10.1016/j.tibtech.2004.02.004, 15038922
    • Arden N, Betenbaugh MJ. Life and death in mammalian cell culture: strategies for apoptosis inhibition. Trends in Biotechnology 2004, 22(4):174-180. 10.1016/j.tibtech.2004.02.004, 15038922.
    • (2004) Trends in Biotechnology , vol.22 , Issue.4 , pp. 174-180
    • Arden, N.1    Betenbaugh, M.J.2
  • 19
    • 0028765762 scopus 로고
    • Induction of apoptosis in nutrient-deprived cultures of hybridoma and myeloma cells
    • 10.1002/bit.260440916, 18623032
    • Mercille S, Massie B. Induction of apoptosis in nutrient-deprived cultures of hybridoma and myeloma cells. Biotechnology and Bioengineering 1994, 44(9):1140-1154. 10.1002/bit.260440916, 18623032.
    • (1994) Biotechnology and Bioengineering , vol.44 , Issue.9 , pp. 1140-1154
    • Mercille, S.1    Massie, B.2
  • 20
    • 34547122264 scopus 로고    scopus 로고
    • Links between metabolism and apoptosis in mammalian cells: Applications for anti-apoptosis engineering
    • 10.1016/j.ymben.2007.05.003, 17611135
    • Majors BS, Betenbaugh MJ, Chiang GG. Links between metabolism and apoptosis in mammalian cells: Applications for anti-apoptosis engineering. Metabolic Engineering 2007, 9(4):317-326. 10.1016/j.ymben.2007.05.003, 17611135.
    • (2007) Metabolic Engineering , vol.9 , Issue.4 , pp. 317-326
    • Majors, B.S.1    Betenbaugh, M.J.2    Chiang, G.G.3
  • 21
    • 79955939126 scopus 로고    scopus 로고
    • Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis
    • 10.1007/s00449-010-0468-9, 20848294
    • Henry O, Jolicoeur M, Kamen A. Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis. Bioprocess and Biosystems Engineering 2011, 34(3):263-273. 10.1007/s00449-010-0468-9, 20848294.
    • (2011) Bioprocess and Biosystems Engineering , vol.34 , Issue.3 , pp. 263-273
    • Henry, O.1    Jolicoeur, M.2    Kamen, A.3
  • 22
    • 0344563583 scopus 로고    scopus 로고
    • Adaptive Control at Low Glucose Concentration of HEK-293 Cell Serum-Free Cultures
    • 10.1021/bp990077v, 10441351
    • Siegwart P, Côté J, Male K, Luong JHT, Perrier M, Kamen A. Adaptive Control at Low Glucose Concentration of HEK-293 Cell Serum-Free Cultures. Biotechnology Progress 1999, 15(4):608-616. 10.1021/bp990077v, 10441351.
    • (1999) Biotechnology Progress , vol.15 , Issue.4 , pp. 608-616
    • Siegwart, P.1    Côté, J.2    Male, K.3    Luong, J.H.T.4    Perrier, M.5    Kamen, A.6
  • 23
    • 33845666692 scopus 로고    scopus 로고
    • Transcriptional profiling of batch and fed-batch protein-free 293-HEK cultures
    • 10.1016/j.ymben.2006.08.006, 17097906
    • Lee YY, Wong KTK, Nissom PM, Wong DCF, Yap MGS. Transcriptional profiling of batch and fed-batch protein-free 293-HEK cultures. Metabolic Engineering 2007, 9(1):52-67. 10.1016/j.ymben.2006.08.006, 17097906.
    • (2007) Metabolic Engineering , vol.9 , Issue.1 , pp. 52-67
    • Lee, Y.Y.1    Wong, K.T.K.2    Nissom, P.M.3    Wong, D.C.F.4    Yap, M.G.S.5
  • 24
    • 0037021789 scopus 로고    scopus 로고
    • Low-protein medium affects the 293SF central metabolism during growth and infection with adenovirus
    • 10.1002/bit.10128, 11745177
    • Nadeau I, Gilbert PA, Jacob D, Perrier M, Kamen A. Low-protein medium affects the 293SF central metabolism during growth and infection with adenovirus. Biotechnology and Bioengineering 2002, 77(1):91-104. 10.1002/bit.10128, 11745177.
    • (2002) Biotechnology and Bioengineering , vol.77 , Issue.1 , pp. 91-104
    • Nadeau, I.1    Gilbert, P.A.2    Jacob, D.3    Perrier, M.4    Kamen, A.5
  • 25
    • 50049105414 scopus 로고    scopus 로고
    • Metabolic flux model for an anchorage-dependent MDCK cell line: Characteristic growth phases and minimum substrate consumption flux distribution
    • 10.1002/bit.21873, 18646224
    • Wahl A, Sidorenko Y, Dauner M, Genzel Y, Reichl U. Metabolic flux model for an anchorage-dependent MDCK cell line: Characteristic growth phases and minimum substrate consumption flux distribution. Biotechnology and Bioengineering 2008, 101(1):135-152. 10.1002/bit.21873, 18646224.
    • (2008) Biotechnology and Bioengineering , vol.101 , Issue.1 , pp. 135-152
    • Wahl, A.1    Sidorenko, Y.2    Dauner, M.3    Genzel, Y.4    Reichl, U.5
  • 26
    • 77956256133 scopus 로고    scopus 로고
    • Kinetic characterization of vero cell metabolism in a serum-free batch culture process
    • 10.1002/bit.22783, 20506276
    • Petiot E, Guedon E, Blanchard F, Gény C, Pinton H, Marc A. Kinetic characterization of vero cell metabolism in a serum-free batch culture process. Biotechnology and Bioengineering 2010, 107(1):143-153. 10.1002/bit.22783, 20506276.
    • (2010) Biotechnology and Bioengineering , vol.107 , Issue.1 , pp. 143-153
    • Petiot, E.1    Guedon, E.2    Blanchard, F.3    Gény, C.4    Pinton, H.5    Marc, A.6
  • 27
    • 0034237246 scopus 로고    scopus 로고
    • Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells
    • 10.1016/S0141-0229(00)00151-4, 10862901
    • Cruz HJ, Freitas CM, Alves PM, Moreira JL, Carrondo MJT. Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells. Enzyme and Microbial Technology 2000, 27(1-2):43-52. 10.1016/S0141-0229(00)00151-4, 10862901.
    • (2000) Enzyme and Microbial Technology , vol.27 , Issue.1-2 , pp. 43-52
    • Cruz, H.J.1    Freitas, C.M.2    Alves, P.M.3    Moreira, J.L.4    Carrondo, M.J.T.5
  • 28
    • 9444244378 scopus 로고    scopus 로고
    • Improvement of recombinant protein production with the human adenovirus/293S expression system using fed-batch strategies
    • Nadeau I, Garnier A, Côté J, Massie B, Chavarie C, Kamen A. Improvement of recombinant protein production with the human adenovirus/293S expression system using fed-batch strategies. Biotechnology and Bioengineering 1996, 51(6):613-623.
    • (1996) Biotechnology and Bioengineering , vol.51 , Issue.6 , pp. 613-623
    • Nadeau, I.1    Garnier, A.2    Côté, J.3    Massie, B.4    Chavarie, C.5    Kamen, A.6
  • 29
    • 0026196692 scopus 로고
    • Growth inhibition in animal cell culture
    • 10.1007/BF02922022, 1952924
    • Hassell T, Gleave S, Butler M. Growth inhibition in animal cell culture. Applied Biochemistry and Biotechnology 1991, 30(1):29-41. 10.1007/BF02922022, 1952924.
    • (1991) Applied Biochemistry and Biotechnology , vol.30 , Issue.1 , pp. 29-41
    • Hassell, T.1    Gleave, S.2    Butler, M.3
  • 30
    • 0026602112 scopus 로고
    • Influence of lactate, ammonia, and osmotic stress on adherent and suspension BHK cells
    • 10.1016/0141-0229(92)90029-N, 1367812
    • Wentz D, Schügerl K. Influence of lactate, ammonia, and osmotic stress on adherent and suspension BHK cells. Enzyme and Microbial Technology 1992, 14(1):68-75. 10.1016/0141-0229(92)90029-N, 1367812.
    • (1992) Enzyme and Microbial Technology , vol.14 , Issue.1 , pp. 68-75
    • Wentz, D.1    Schügerl, K.2
  • 31
    • 0034511786 scopus 로고    scopus 로고
    • Human 293 cell metabolism in low glutamine-supplied culture: Interpretation of metabolic changes through metabolic flux analysis
    • 10.1006/mben.2000.0152, 11120640
    • Nadeau I, Sabatié J, Koehl M, Perrier M, Kamen A. Human 293 cell metabolism in low glutamine-supplied culture: Interpretation of metabolic changes through metabolic flux analysis. Metabolic Engineering 2000, 2(4):277-292. 10.1006/mben.2000.0152, 11120640.
    • (2000) Metabolic Engineering , vol.2 , Issue.4 , pp. 277-292
    • Nadeau, I.1    Sabatié, J.2    Koehl, M.3    Perrier, M.4    Kamen, A.5
  • 32
    • 0026512475 scopus 로고
    • Continuous hybridoma suspension cultures with and without cell retention: kinetics of growth, metabolism and product formation
    • 10.1016/0168-1656(92)90130-2, 1367816
    • Schmid G, Wilke CR, Blanch HW. Continuous hybridoma suspension cultures with and without cell retention: kinetics of growth, metabolism and product formation. Journal of Biotechnology 1992, 22(1-2):31-40. 10.1016/0168-1656(92)90130-2, 1367816.
    • (1992) Journal of Biotechnology , vol.22 , Issue.1-2 , pp. 31-40
    • Schmid, G.1    Wilke, C.R.2    Blanch, H.W.3
  • 33
    • 0033975148 scopus 로고    scopus 로고
    • Pathways of glutamine metabolism in Spodoptera frugiperda (Sf9) insect cells: evidence for the presence of the nitrogen assimilation system, and a metabolic switch by 1H/15N NMR
    • 10.1016/S0168-1656(99)00231-X, 10702908
    • Drews M, Doverskog M, Öhman L, Chapman BE, Jacobsson U, Kuchel PW, Häggström L. Pathways of glutamine metabolism in Spodoptera frugiperda (Sf9) insect cells: evidence for the presence of the nitrogen assimilation system, and a metabolic switch by 1H/15N NMR. Journal of Biotechnology 2000, 78(1):23-37. 10.1016/S0168-1656(99)00231-X, 10702908.
    • (2000) Journal of Biotechnology , vol.78 , Issue.1 , pp. 23-37
    • Drews, M.1    Doverskog, M.2    Öhman, L.3    Chapman, B.E.4    Jacobsson, U.5    Kuchel, P.W.6    Häggström, L.7
  • 34
    • 64449088759 scopus 로고    scopus 로고
    • Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production -- Flow cytometry and mathematical modeling
    • 10.1016/j.vaccine.2009.02.027, 19428884
    • Schulze-Horsel J, Schulze M, Agalaridis G, Genzel Y, Reichl U. Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production -- Flow cytometry and mathematical modeling. Vaccine 2009, 27(20):2712-2722. 10.1016/j.vaccine.2009.02.027, 19428884.
    • (2009) Vaccine , vol.27 , Issue.20 , pp. 2712-2722
    • Schulze-Horsel, J.1    Schulze, M.2    Agalaridis, G.3    Genzel, Y.4    Reichl, U.5
  • 35
    • 0034955802 scopus 로고    scopus 로고
    • Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression
    • 10.1016/S1359-6101(00)00026-5, 21892805
    • Julkunen I, Sareneva T, Pirhonen J, Ronni T, Melén K, Matikainen S. Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine & Growth Factor Reviews 2001, 12(2-3):171-180. 10.1016/S1359-6101(00)00026-5, 21892805.
    • (2001) Cytokine & Growth Factor Reviews , vol.12 , Issue.2-3 , pp. 171-180
    • Julkunen, I.1    Sareneva, T.2    Pirhonen, J.3    Ronni, T.4    Melén, K.5    Matikainen, S.6
  • 37
    • 33644825268 scopus 로고    scopus 로고
    • Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells
    • 10.1111/j.1462-5822.2005.00678.x, 16469051
    • Ludwig S, Pleschka S, Planz O, Wolff T. Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells. Cellular Microbiology 2006, 8(3):375-386. 10.1111/j.1462-5822.2005.00678.x, 16469051.
    • (2006) Cellular Microbiology , vol.8 , Issue.3 , pp. 375-386
    • Ludwig, S.1    Pleschka, S.2    Planz, O.3    Wolff, T.4
  • 38
    • 33746809465 scopus 로고    scopus 로고
    • Wave microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media
    • 10.1016/j.vaccine.2006.05.023, 16781022
    • Genzel Y, Olmer R, Schafer B, Reichl U. Wave microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media. Vaccine 2006, 24:6074-6087. 10.1016/j.vaccine.2006.05.023, 16781022.
    • (2006) Vaccine , vol.24 , pp. 6074-6087
    • Genzel, Y.1    Olmer, R.2    Schafer, B.3    Reichl, U.4
  • 39
    • 77952065243 scopus 로고    scopus 로고
    • Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling
    • 10.1186/1752-0509-4-61, 2890500, 20465796
    • Ritter J, Wahl A, Freund S, Genzel Y, Reichl U. Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC Systems Biology 2010, 4(1):61. 10.1186/1752-0509-4-61, 2890500, 20465796.
    • (2010) BMC Systems Biology , vol.4 , Issue.1 , pp. 61
    • Ritter, J.1    Wahl, A.2    Freund, S.3    Genzel, Y.4    Reichl, U.5
  • 40
    • 6344270264 scopus 로고    scopus 로고
    • Structured model of influenza virus replication in MDCK cells
    • Sidorenko Y, Reichl U. Structured model of influenza virus replication in MDCK cells. Biotech Bioeng 2004, 88(1):1-14.
    • (2004) Biotech Bioeng , vol.88 , Issue.1 , pp. 1-14
    • Sidorenko, Y.1    Reichl, U.2
  • 41
    • 36048995373 scopus 로고    scopus 로고
    • Stochastic population balance modeling of influenza virus replication in vaccine production processes
    • Sidorenko Y, Schulze-Horsel J, Voigt A, Reichl U, Kienle A. Stochastic population balance modeling of influenza virus replication in vaccine production processes. Chemical Engineering Science 2008, 63(1):157-169.
    • (2008) Chemical Engineering Science , vol.63 , Issue.1 , pp. 157-169
    • Sidorenko, Y.1    Schulze-Horsel, J.2    Voigt, A.3    Reichl, U.4    Kienle, A.5
  • 42
    • 0031866073 scopus 로고    scopus 로고
    • Comparison of RNA hybridization, hemagglutination assay, titration of infectious virus and immunofluorescence as methods for monitoring influenza virus replication in vitro
    • 10.1016/S0166-0934(98)00071-8, 9763129
    • Rimmelzwaan GF, Baars M, Claas ECJ, Osterhaus ADME. Comparison of RNA hybridization, hemagglutination assay, titration of infectious virus and immunofluorescence as methods for monitoring influenza virus replication in vitro. Journal of Virological Methods 1998, 74(1):57-66. 10.1016/S0166-0934(98)00071-8, 9763129.
    • (1998) Journal of Virological Methods , vol.74 , Issue.1 , pp. 57-66
    • Rimmelzwaan, G.F.1    Baars, M.2    Claas, E.C.J.3    Osterhaus, A.D.M.E.4
  • 43
    • 77952094583 scopus 로고    scopus 로고
    • Temperature sensitivity on growth and/or replication of H1N1, H1N2 and H3N2 influenza A viruses isolated from pigs and birds in mammalian cells
    • 10.1016/j.vetmic.2009.10.012, 19926410
    • Massin P, Kuntz-Simon G, Barbezange C, Deblanc C, Oger A, Marquet-Blouin E, Bougeard S, van der Werf S, Jestin V. Temperature sensitivity on growth and/or replication of H1N1, H1N2 and H3N2 influenza A viruses isolated from pigs and birds in mammalian cells. Veterinary Microbiology 2010, 142(3-4):232-241. 10.1016/j.vetmic.2009.10.012, 19926410.
    • (2010) Veterinary Microbiology , vol.142 , Issue.3-4 , pp. 232-241
    • Massin, P.1    Kuntz-Simon, G.2    Barbezange, C.3    Deblanc, C.4    Oger, A.5    Marquet-Blouin, E.6    Bougeard, S.7    van der Werf, S.8    Jestin, V.9
  • 44
    • 0022118573 scopus 로고
    • Stability of infectious influenza A viruses at low pH and at elevated temperature
    • 10.1016/0264-410X(85)90109-4, 4060851
    • Scholtissek C. Stability of infectious influenza A viruses at low pH and at elevated temperature. Vaccine 1985, 3(3):215-218. 10.1016/0264-410X(85)90109-4, 4060851.
    • (1985) Vaccine , vol.3 , Issue.3 , pp. 215-218
    • Scholtissek, C.1
  • 45
    • 70350048935 scopus 로고    scopus 로고
    • Use of MDCK cells for production of live attenuated influenza vaccine
    • 10.1016/j.vaccine.2009.06.024, 19559113
    • Liu J, Shi X, Schwartz R, Kemble G. Use of MDCK cells for production of live attenuated influenza vaccine. Vaccine 2009, 27(46):6460-6463. 10.1016/j.vaccine.2009.06.024, 19559113.
    • (2009) Vaccine , vol.27 , Issue.46 , pp. 6460-6463
    • Liu, J.1    Shi, X.2    Schwartz, R.3    Kemble, G.4
  • 46
    • 2642647059 scopus 로고    scopus 로고
    • Serum-free production of recombinant proteins and adenoviral vectors by 293SF-3F6 cells
    • 10.1002/(SICI)1097-0290(19980905)59:5<567::AID-BIT6>3.0.CO;2-8, 10099373
    • Côté J, Garnier A, Massie B, Kamen A. Serum-free production of recombinant proteins and adenoviral vectors by 293SF-3F6 cells. Biotechnology and Bioengineering 1998, 59(5):567-575. 10.1002/(SICI)1097-0290(19980905)59:5<567::AID-BIT6>3.0.CO;2-8, 10099373.
    • (1998) Biotechnology and Bioengineering , vol.59 , Issue.5 , pp. 567-575
    • Côté, J.1    Garnier, A.2    Massie, B.3    Kamen, A.4
  • 48
    • 41949093873 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatographic analysis of amino acids in protein hydrolysates using an automated pre-column derivatisation method
    • 10.1016/j.chroma.2007.11.052, 18070624
    • Boogers I, Plugge W, Stokkermans YQ, Duchateau ALL. Ultra-performance liquid chromatographic analysis of amino acids in protein hydrolysates using an automated pre-column derivatisation method. Journal of Chromatography A 2008, 1189(1-2):406-409. 10.1016/j.chroma.2007.11.052, 18070624.
    • (2008) Journal of Chromatography A , vol.1189 , Issue.1-2 , pp. 406-409
    • Boogers, I.1    Plugge, W.2    Stokkermans, Y.Q.3    Duchateau, A.L.L.4
  • 49
    • 38949155404 scopus 로고    scopus 로고
    • Vaccine Production, in Animal cell biotechnology: Methods and protocol R
    • Humana Press
    • Genzel Y, Reichl U. Vaccine Production, in Animal cell biotechnology: Methods and protocol R. Pörtner Editor 2007, 457-473. Humana Press.
    • (2007) Pörtner Editor , pp. 457-473
    • Genzel, Y.1    Reichl, U.2
  • 50
    • 34250971354 scopus 로고
    • Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche
    • Kärber G. Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Naunyn-Schmiedeberg's Archives of Pharmacology 1931, 162(4):480-483.
    • (1931) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.162 , Issue.4 , pp. 480-483
    • Kärber, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.