Validation of the safety of MDCK cells as a substrate for the production of a cell-derived influenza vaccine

Biologicals

Volumn 38, Issue 5, 2010, Pages 544-551

  Onions, David ^a   Egan, William ^b   Jarrett, Ruth ^c   Novicki, Deborah ^d   Gregersen, Jens Peter ^d  

^a BioReliance Corporation   (United States)

^b PharmaNet Consulting   (United States)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d NOVARTIS VACCINES AND DIAGNOSTICS   (United States)

Author keywords

Influenza vaccine; MDCK cell; Oncogenicity; Tumorigenicity

Indexed keywords

INFLUENZA VACCINE; PROPIOLACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; CELL LYSATE; CELL SEPARATION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; DNA TUMOR VIRUS; DRUG SAFETY; GROWTH RATE; HAMSTER; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETROVIRUS; RISK ASSESSMENT; TRANSMISSION ELECTRON MICROSCOPY; VACCINE PRODUCTION; VALIDATION PROCESS; VIRION; VIROGENESIS; VIRUS DETECTION; VIRUS INACTIVATION;

ALGORITHMS; ANIMALS; ANIMALS, NEWBORN; CELL EXTRACTS; CELL FRACTIONATION; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; CRICETINAE; DNA; DOGS; FEMALE; HUMANS; INFLUENZA VACCINES; KIDNEY; MALE; MICE; MICE, NUDE; RATS; VIRUS ACTIVATION;

MUS; ORTHOMYXOVIRIDAE;

EID: 77956231719     PISSN: 10451056     EISSN: 10958320     Source Type: Journal    
DOI: 10.1016/j.biologicals.2010.04.003     Document Type: Article

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