Adaptive control at low glucose concentration of HEK-293 cell serum-free cultures

Biotechnology Progress

Volumn 15, Issue 4, 1999, Pages 608-616

  Siegwart, Pascal ^a,b   Côté, Johanne ^a   Male, Keith ^a   Luong, John H T ^a   Perrier, Michel ^b   Kamen, Amine ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; BIOSENSOR; CELL METABOLISM; FED BATCH CULTURE; GLUCOSE METABOLISM; GLUTAMINE; LACTIC ACID;

ADAPTIVE CONTROL SYSTEMS; AMMONIA; BIOCONVERSION; CELLS; CHEMICAL VARIABLES CONTROL; GLUCOSE; GLUCOSE SENSORS; GROWTH KINETICS; MATHEMATICAL MODELS; METABOLISM; NONLINEAR CONTROL SYSTEMS;

ADAPTIVE NONLINEAR CONTROLLER; CELL SERUM FREE CULTURES; GLYCOLYSIS; OXIDATIVE PATHWAY CAPACITY;

BATCH CELL CULTURE;

EID: 0344563583     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp990077v     Document Type: Article

References (30)

1. Bastin, G.; Dochain, D. On-line estimation and adaptive control of bioreactors; Elsevier Science Publishers B. V.: Amsterdam, The Netherlands, 1990.
2. Côté, J.; Garnier, A.; Massie, B.; Kamen, A. Serum-free production of recombinant proteins and adenoviral vectors by 293SF-3F6 cells. Biotechnol. Bioeng. 1998, 59, 567-575.
3. Dairaku, K; Izumoto, E.; Morikawa, H.; Shioya, S.; Takamatsu, T. An advanced micro-computer coupled control system in a Baker's yeast fed-batch culture using a tubing method. J. Ferment. Technol. 1983, 61, 198-196.
4. Gaertner J. G.; Dhurjati, P. Fractional factorial study of hybridoma behavior. 2. Kinetics of nutrient uptake and waste production. Biotechnol. Prog. 1993, 9, 309-316.
5. Garnier, A.; Côté, J.; Nadeau, I.; Kamen, A.; Massie, B. Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells. Cytotechnology 1994, 15, 145-155.
6. Glacken, M. W.; Fleischaker, R. J.; Sinskey, A. J. Reduction of waste product excretion via nutrient control: possible strategies for maximizing product and cell yield on serum in cultures of mammalian cells. Biotechnol. Bioeng. 1986, 28, 1376-1389.
7. Hsia, T. System identification; Lexington Books, 1977.
8. Hu, W. S.; Aunins, J. Large scale mammalian cell culture. Curr. Opin. Biotechnol. 1997, 8, 148-153.
9. Jordan, M.; Köhne, C.; Wurm, F. Calcium-phosphate mediated DNA transfer into HEK-293 cells in suspension: control of physicochemical parameters allows transfection in stirred media. Cytotechnology 1998, 26, 39-47.
10. Kamen, A.; Tom, R.; Caron, A.; Chavarie, C.; Massie B.; Archambault, J. Culture of insect cells in a helical ribbon impeller bioreactor. Biotechnol. Bioeng. 1991, 38, 619-628.
11. Kamen A. A.; Bédard, C.; Tom, R.; Perret, S.; Jardin, B. Online monitoring of respiration in healthy and recombinant-baculovirus infected cell bioreactor cultures. Biotechnol. Bioeng. 1996, 50, 36-48.
12. Konstantinov, K. Monitoring and control of the physiological state of cell cultures. Biotechnol. Bioeng. 1996, 52, 271-289.
13. Konstantinov, K.; Zhou, W.; Golini F.; Hu, W. Expert systems in the control of animal cell culture processes: potentials, functions, and perspectives. Cytotechnology 1994, 14, 233-246.
14. Kovesdi, I.; Brough, D.; Bruder, J.; Wickham, T. Adenoviral vectors for gene transfer. Curr. Opin. Biotechnol. 1997, 8, 583-589.
15. Kurokawa, H.; Park, Y. S.; Lijima, S.; Kobayashi, T. Growth characteristics in fed-batch culture of hybridoma cells with control of glucose and glutamine concentrations. Biotechnol. Bioeng. 1994, 44, 95-103.
16. Male, K. B.; Gartu, O.; Kamen, A.; Luong, J. H. T. On line monitoring of glucose in mammalian cell culture using a flow injection analysis (FIA) mediated biosensor. Biotechnol. Bioeng. 1997, 55, 497-504.
17. Miller, W. M. A kinetic analysis of hybridoma growth and metabolism, Ph.D. Thesis. University of California, Berkeley, CA, 1987.
18. Nadeau, I.; Gamier, A.; Côté, J.; Massie, B.; Chavarie, C.; Kamen, A. Improvement of recombinant protein production with the human adenovirus/293S expression system using fed-batch strategies. Biotechnol. Bioeng. 1996, 51, 613-623.
19. Newland, M.; Greenfield P. F.; Reid, S. Hybridoma growth limitations: the roles of energy metabolism and ammonia production. Cytotechnology 1990, 3, 215-229.
20. Omasa, T.; Higashiyama, K; Shioya S.; Suga, K. Effects of lactate concentration on hybridoma culture in lactate-controlled fed-batch operation. Biotechnol. Bioeng. 1992, 39, 556-564.
21. Ozturk, S. S.; Thrift, J. C.; Blackie, J. D.; Naveh, D. Real-time monitoring and control of glucose and lactate concentrations in a mammalian cell perfusion reactor. Biotechnol. Bioeng. 1997, 53, 372-378.
22. Schneider, M.; Marison, I. W.; Stockar, U. The importance of ammonia in mammlian cell culture. J. Biotechnol. 1996, 46, 161-185.
23. Siegwart, P. Modélisation et controle adatatif de la croissance de cellules humaines HEK-293 en milieu sans serum. [Msc thesis]. Montréal (QC): Ecole Polytechnique de Montréal; 1998. Available from: University Microfilm International (UMI).
24. Sonnleitner, B.; Käppeli, O. Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: formulation and verification of a hypothesis. Biotechnol. Bioeng. 1985, 28, 927-937.
25. Voet, D.; Voet, J. G. Biochemistry, 2nd ed.; John Wiley, 1994.
26. Weatherburn, M. Phenol-hypochlorite reaction for determination of ammonia. Anal. Chem. 1967, 39, 971-974.
27. Xie, L.; Wang, D. I. C. Energy metabolism and ATP balance in animal cell cultivation using a stoichiometrically based reaction network. Biotechnol. Bioeng. 1996, 52, 591-601.
28. Xie, L.; Wang, D. I. C. Material balance studies on animal cell metabolism using a stoichiometrically based reaction network. Biotechnol. Bioeng. 1996, 52, 579-590.
29. Zeng A. P.; Deckwer, W. D. Mathematical modeling and analysis of glucose and glutamine utilization and regulation in cultures of continuous mammlian cells. Biotechnol. Bioeng. 1995, 47, 334-346.
30. Zhou W.; Hu W. S. Effect of insulin on a serum-free hybridoma culture. Biotechnol. Bioeng. 1995, 47, 181-185.