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Volumn 27, Issue 20, 2009, Pages 2712-2722

Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production-Flow cytometry and mathematical modeling

Author keywords

Apoptosis; Flow cytometry; Influenza vaccine production; Mathematical modeling; MDCK; Puerto Rico; Virus host cell interaction; Wisconsin

Indexed keywords

INFLUENZA VACCINE; VIRUS HEMAGGLUTININ;

EID: 64449088759     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.02.027     Document Type: Article
Times cited : (73)

References (56)
  • 1
    • 0035858122 scopus 로고    scopus 로고
    • Comparison of large-scale mammalian cell culture systems with egg culture for the production of influenza virus A vaccine strains
    • Tree J.A., Richardson C., Fooks A.R., Clegg J.C., and Looby D. Comparison of large-scale mammalian cell culture systems with egg culture for the production of influenza virus A vaccine strains. Vaccine 19 25-26 (2001) 3444-3450
    • (2001) Vaccine , vol.19 , Issue.25-26 , pp. 3444-3450
    • Tree, J.A.1    Richardson, C.2    Fooks, A.R.3    Clegg, J.C.4    Looby, D.5
  • 2
    • 0037403081 scopus 로고    scopus 로고
    • Novel generations of influenza vaccines
    • Kemble G., and Greenberg H. Novel generations of influenza vaccines. Vaccine 21 16 (2003) 1789-1795
    • (2003) Vaccine , vol.21 , Issue.16 , pp. 1789-1795
    • Kemble, G.1    Greenberg, H.2
  • 4
    • 0032078697 scopus 로고    scopus 로고
    • Development of a mammalian cell (Vero) derived candidate influenza virus vaccine
    • Kistner O., Barrett P.N., Mundt W., Reiter M., Schober-Bendixen S., and Dorner F. Development of a mammalian cell (Vero) derived candidate influenza virus vaccine. Vaccine 16 9-10 (1998) 960-968
    • (1998) Vaccine , vol.16 , Issue.9-10 , pp. 960-968
    • Kistner, O.1    Barrett, P.N.2    Mundt, W.3    Reiter, M.4    Schober-Bendixen, S.5    Dorner, F.6
  • 5
    • 2442437845 scopus 로고    scopus 로고
    • Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture
    • Genzel Y., Behrendt I., Koenig S., Sann H., and Reichl U. Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture. Vaccine 22 June (17-18) (2004) 2202-2208
    • (2004) Vaccine , vol.22 , Issue.June 17-18 , pp. 2202-2208
    • Genzel, Y.1    Behrendt, I.2    Koenig, S.3    Sann, H.4    Reichl, U.5
  • 6
    • 0035925715 scopus 로고    scopus 로고
    • The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines
    • Pau M.G., Ophorst C., Koldijk M.H., Schouten G., Mehtali M., and Uytdehaag F. The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines. Vaccine 19 17-19 (2001) 2716-2721
    • (2001) Vaccine , vol.19 , Issue.17-19 , pp. 2716-2721
    • Pau, M.G.1    Ophorst, C.2    Koldijk, M.H.3    Schouten, G.4    Mehtali, M.5    Uytdehaag, F.6
  • 7
    • 77954657368 scopus 로고    scopus 로고
    • Immortalized avian cell lines for virus production
    • Germany; 2005 [30.11.2004
    • Sandig V, Jordan I, inventors. Immortalized avian cell lines for virus production. Germany; 2005 [30.11.2004].
    • Sandig, V.1    Jordan, I.2    inventors3
  • 8
    • 0029945540 scopus 로고    scopus 로고
    • African Green Monkey Kidney (Vero) cells provide an alternative host cell system for influenza A and B viruses
    • Govorkova. African Green Monkey Kidney (Vero) cells provide an alternative host cell system for influenza A and B viruses. J Virol 1996, 5519-24.
    • (1996) J Virol , pp. 5519-5524
    • Govorkova1
  • 9
    • 0037402228 scopus 로고    scopus 로고
    • The annual production cycle for influenza vaccine
    • Gerdil C. The annual production cycle for influenza vaccine. Vaccine 21 May (16) (2003) 1776-1779
    • (2003) Vaccine , vol.21 , Issue.May 16 , pp. 1776-1779
    • Gerdil, C.1
  • 10
    • 0001178028 scopus 로고    scopus 로고
    • Orthomyxoviridae: the viruses and their replication
    • Knipe D.M., and Howley P.M. (Eds), Lippincott Williams & Wilkins
    • Lamb R.A., and Krug R.M. Orthomyxoviridae: the viruses and their replication. In: Knipe D.M., and Howley P.M. (Eds). Fields virology. 4th ed. (2001), Lippincott Williams & Wilkins
    • (2001) Fields virology. 4th ed.
    • Lamb, R.A.1    Krug, R.M.2
  • 12
    • 36048995373 scopus 로고    scopus 로고
    • Stochastic population balance modeling of influenza virus replication in vaccine production processes
    • Sidorenko Y., Schulze-Horsel J., Voigt A., Reichl U., and Kienle A. Stochastic population balance modeling of influenza virus replication in vaccine production processes. Chem Eng Sci 63 (2008) 157-169
    • (2008) Chem Eng Sci , vol.63 , pp. 157-169
    • Sidorenko, Y.1    Schulze-Horsel, J.2    Voigt, A.3    Reichl, U.4    Kienle, A.5
  • 13
    • 0037566473 scopus 로고    scopus 로고
    • A rapid method for immunotitration of influenza viruses using flow cytometry
    • Lonsdale R., Pau M.G., Oerlemans M., Ophorst C., Vooys A., Havenga M., et al. A rapid method for immunotitration of influenza viruses using flow cytometry. J Virol Methods 110 June (1) (2003) 67-71
    • (2003) J Virol Methods , vol.110 , Issue.June 1 , pp. 67-71
    • Lonsdale, R.1    Pau, M.G.2    Oerlemans, M.3    Ophorst, C.4    Vooys, A.5    Havenga, M.6
  • 14
    • 44649161769 scopus 로고    scopus 로고
    • Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine production
    • Schulze-Horsel J., Genzel Y., and Reichl U. Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine production. BMC Biotechnol 8 (2008) 45
    • (2008) BMC Biotechnol , vol.8 , pp. 45
    • Schulze-Horsel, J.1    Genzel, Y.2    Reichl, U.3
  • 16
    • 0015383455 scopus 로고
    • Apoptosis-basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr J.F.R., Wyllie A.H., and Currie A.R. Apoptosis-basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26 4 (1972) 239-257
    • (1972) Br J Cancer , vol.26 , Issue.4 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 17
    • 0042318707 scopus 로고    scopus 로고
    • Apoptosis-an introduction
    • Lawen A. Apoptosis-an introduction. Bioessays 25 Sep (9) (2003) 888-896
    • (2003) Bioessays , vol.25 , Issue.Sep 9 , pp. 888-896
    • Lawen, A.1
  • 19
    • 1642325279 scopus 로고    scopus 로고
    • Life and death in mammalian cell culture: strategies for apoptosis inhibition
    • Arden N., and Betenbaugh M.J. Life and death in mammalian cell culture: strategies for apoptosis inhibition. Trends Biotechnol 22 Apr (4) (2004) 174-180
    • (2004) Trends Biotechnol , vol.22 , Issue.Apr 4 , pp. 174-180
    • Arden, N.1    Betenbaugh, M.J.2
  • 20
    • 0032007559 scopus 로고    scopus 로고
    • Overcoming apoptosis: new methods for improving protein-expression systems
    • Mastrangelo A.J., and Betenbaugh M.J. Overcoming apoptosis: new methods for improving protein-expression systems. Trends Biotechnol 16 Feb (2) (1998) 88-95
    • (1998) Trends Biotechnol , vol.16 , Issue.Feb 2 , pp. 88-95
    • Mastrangelo, A.J.1    Betenbaugh, M.J.2
  • 21
    • 34447303773 scopus 로고    scopus 로고
    • Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells
    • Figueroa B., Ailor E., Osborne D., Hardwick J.M., Reff M., and Betenbaugh M.J. Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells. Biotechnol Bioeng 97 July (4) (2007) 877-892
    • (2007) Biotechnol Bioeng , vol.97 , Issue.July 4 , pp. 877-892
    • Figueroa, B.1    Ailor, E.2    Osborne, D.3    Hardwick, J.M.4    Reff, M.5    Betenbaugh, M.J.6
  • 22
    • 0031901992 scopus 로고    scopus 로고
    • Apoptosis in cell culture
    • Al-Rubeai M., and Singh R.P. Apoptosis in cell culture. Curr Opin Biotechnol 9 Apr (2) (1998) 152-156
    • (1998) Curr Opin Biotechnol , vol.9 , Issue.Apr 2 , pp. 152-156
    • Al-Rubeai, M.1    Singh, R.P.2
  • 23
    • 13144294041 scopus 로고    scopus 로고
    • Rotavirus induces apoptosis in fully differentiated human intestinal Caco-2 cells
    • Chaibi C., Cotte-Laffitte J., Sandre C., Esclatine A., Servin A.L., Quero A.M., et al. Rotavirus induces apoptosis in fully differentiated human intestinal Caco-2 cells. Virology 332 Feb (2) (2005) 480-490
    • (2005) Virology , vol.332 , Issue.Feb 2 , pp. 480-490
    • Chaibi, C.1    Cotte-Laffitte, J.2    Sandre, C.3    Esclatine, A.4    Servin, A.L.5    Quero, A.M.6
  • 24
    • 0027382362 scopus 로고
    • Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells
    • Takizawa T., Matsukawa S., Higuchi Y., Nakamura S., Nakanishi Y., and Fukuda R. Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells. J Gen Virol 74 Nov (Pt 11) (1993) 2347-2355
    • (1993) J Gen Virol , vol.74 , Issue.Nov PART 11 , pp. 2347-2355
    • Takizawa, T.1    Matsukawa, S.2    Higuchi, Y.3    Nakamura, S.4    Nakanishi, Y.5    Fukuda, R.6
  • 25
    • 0037295292 scopus 로고    scopus 로고
    • Influenza-virus-induced signaling cascades: targets for antiviral therapy?
    • Ludwig S., Planz O., Pleschka S., and Wolff T. Influenza-virus-induced signaling cascades: targets for antiviral therapy?. Trends Mol Med 9 2 (2003) 46-52
    • (2003) Trends Mol Med , vol.9 , Issue.2 , pp. 46-52
    • Ludwig, S.1    Planz, O.2    Pleschka, S.3    Wolff, T.4
  • 26
    • 0032828271 scopus 로고    scopus 로고
    • A fatal relationship-influenza virus interactions with the host cell
    • Ludwig S., Pleschka S., and Wolff T. A fatal relationship-influenza virus interactions with the host cell. Viral Immunol 12 3 (1999) 175-196
    • (1999) Viral Immunol , vol.12 , Issue.3 , pp. 175-196
    • Ludwig, S.1    Pleschka, S.2    Wolff, T.3
  • 27
    • 0035043282 scopus 로고    scopus 로고
    • Global impact of influenza virus on cellular pathways is mediated by both replication-dependent and -independent events
    • Geiss G.K., An M.C., Bumgarner R.E., Hammersmark E., Cunningham D., and Katze M.G. Global impact of influenza virus on cellular pathways is mediated by both replication-dependent and -independent events. J Virol 75 May (9) (2001) 4321-4331
    • (2001) J Virol , vol.75 , Issue.May 9 , pp. 4321-4331
    • Geiss, G.K.1    An, M.C.2    Bumgarner, R.E.3    Hammersmark, E.4    Cunningham, D.5    Katze, M.G.6
  • 28
    • 0038521274 scopus 로고    scopus 로고
    • Caspase 3 activation is essential for efficient influenza virus propagation
    • Wurzer W.J., Planz O., Ehrhardt C., Giner M., Silberzahn T., Pleschka S., et al. Caspase 3 activation is essential for efficient influenza virus propagation. EMBO J 22 June (11) (2003) 2717-2728
    • (2003) EMBO J , vol.22 , Issue.June 11 , pp. 2717-2728
    • Wurzer, W.J.1    Planz, O.2    Ehrhardt, C.3    Giner, M.4    Silberzahn, T.5    Pleschka, S.6
  • 30
    • 0035882169 scopus 로고    scopus 로고
    • The involvement of a stress-activated pathway in equine influenza virus-mediated apoptosis
    • Lin C., Zimmer S.G., Lu Z., Holland R.E., Dong Q., and Chambers T.M. The involvement of a stress-activated pathway in equine influenza virus-mediated apoptosis. Virology 287 Aug (1) (2001) 202-213
    • (2001) Virology , vol.287 , Issue.Aug 1 , pp. 202-213
    • Lin, C.1    Zimmer, S.G.2    Lu, Z.3    Holland, R.E.4    Dong, Q.5    Chambers, T.M.6
  • 31
    • 0033041585 scopus 로고    scopus 로고
    • Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death
    • Takizawa T., Tatematsu C., Ohashi K., and Nakanishi Y. Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death. Microbiol Immunol 43 3 (1999) 245-252
    • (1999) Microbiol Immunol , vol.43 , Issue.3 , pp. 245-252
    • Takizawa, T.1    Tatematsu, C.2    Ohashi, K.3    Nakanishi, Y.4
  • 32
    • 0032735123 scopus 로고    scopus 로고
    • Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cells
    • Zhirnov O.P., Konakova T.E., Garten W., and Klenk H.D. Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cells. J Virol 73 Dec (12) (1999) 10158-10163
    • (1999) J Virol , vol.73 , Issue.Dec 12 , pp. 10158-10163
    • Zhirnov, O.P.1    Konakova, T.E.2    Garten, W.3    Klenk, H.D.4
  • 33
    • 0033124625 scopus 로고    scopus 로고
    • Influenza virus overcomes apoptosis by rapid multiplication
    • Kurokawa M., Koyama A.H., Yasuoka S., and Adachi A. Influenza virus overcomes apoptosis by rapid multiplication. Int J Mol Med 3 5 (1999) 527-530
    • (1999) Int J Mol Med , vol.3 , Issue.5 , pp. 527-530
    • Kurokawa, M.1    Koyama, A.H.2    Yasuoka, S.3    Adachi, A.4
  • 34
    • 0030744941 scopus 로고    scopus 로고
    • Different progress of MDCK cell death after infection by two different influenza virus isolates
    • Hornickova Z. Different progress of MDCK cell death after infection by two different influenza virus isolates. Cell Biochem Funct 15 2 (1997) 87-93
    • (1997) Cell Biochem Funct , vol.15 , Issue.2 , pp. 87-93
    • Hornickova, Z.1
  • 35
    • 4444244396 scopus 로고    scopus 로고
    • Influenza circulating strains in Argentina exhibit differential induction of cytotoxicity and caspase-3 in vitro
    • Mersich S.E., Baumeister E.G., Riva D., Lewis A.P., Cadario M.E., Pontoriero A.V., et al. Influenza circulating strains in Argentina exhibit differential induction of cytotoxicity and caspase-3 in vitro. J Clin Virol 31 Oct (2) (2004) 134-139
    • (2004) J Clin Virol , vol.31 , Issue.Oct 2 , pp. 134-139
    • Mersich, S.E.1    Baumeister, E.G.2    Riva, D.3    Lewis, A.P.4    Cadario, M.E.5    Pontoriero, A.V.6
  • 36
    • 0037053092 scopus 로고    scopus 로고
    • Correlation between levels of apoptosis, levels of infection and haemagglutinin receptor binding interaction of various subtypes of influenza virus: does the viral neuraminidase have a role in these associations
    • Mohsin M.A., Morris S.J., Smith H., and Sweet C. Correlation between levels of apoptosis, levels of infection and haemagglutinin receptor binding interaction of various subtypes of influenza virus: does the viral neuraminidase have a role in these associations. Virus Res 85 2 (2002) 123-131
    • (2002) Virus Res , vol.85 , Issue.2 , pp. 123-131
    • Mohsin, M.A.1    Morris, S.J.2    Smith, H.3    Sweet, C.4
  • 37
    • 33144469071 scopus 로고    scopus 로고
    • Modeling and estimation of replication fitness of human immunodeficiency virus type 1 in vitro experiments by using a growth competition assay
    • Wu H.L., Huang Y.X., Dykes C., Liu D.C., Ma J.M., Perelson A.S., et al. Modeling and estimation of replication fitness of human immunodeficiency virus type 1 in vitro experiments by using a growth competition assay. J Virol 80 March (5) (2006) 2380-2389
    • (2006) J Virol , vol.80 , Issue.March 5 , pp. 2380-2389
    • Wu, H.L.1    Huang, Y.X.2    Dykes, C.3    Liu, D.C.4    Ma, J.M.5    Perelson, A.S.6
  • 38
    • 48449093709 scopus 로고    scopus 로고
    • Modeling and estimation of kinetic parameters and replicative fitness of HIV-1 from flow-cytometry-based growth competition experiments
    • Miao H.Y., Dykes C., Demeter L.M., Cavenaugh J., Park S.Y., Perelson A.S., et al. Modeling and estimation of kinetic parameters and replicative fitness of HIV-1 from flow-cytometry-based growth competition experiments. Bull Math Biol 70 Aug (6) (2008) 1749-1771
    • (2008) Bull Math Biol , vol.70 , Issue.Aug 6 , pp. 1749-1771
    • Miao, H.Y.1    Dykes, C.2    Demeter, L.M.3    Cavenaugh, J.4    Park, S.Y.5    Perelson, A.S.6
  • 39
    • 3543124656 scopus 로고    scopus 로고
    • Multiplicity of human immunodeficiency virus infections in lymphoid tissue
    • Dixit N.M., and Perelson A.S. Multiplicity of human immunodeficiency virus infections in lymphoid tissue. J Virol 78 Aug (16) (2004) 8942-8945
    • (2004) J Virol , vol.78 , Issue.Aug 16 , pp. 8942-8945
    • Dixit, N.M.1    Perelson, A.S.2
  • 40
    • 20444393131 scopus 로고    scopus 로고
    • HIV dynamics with multiple infections of target cells
    • Dixit N.M., and Perelson A.S. HIV dynamics with multiple infections of target cells. Proc Natl Acad Sci U S A 102 June (23) (2005) 8198-8203
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.June 23 , pp. 8198-8203
    • Dixit, N.M.1    Perelson, A.S.2
  • 41
    • 40949093915 scopus 로고    scopus 로고
    • Stochastic population balance modeling of influenza virus replication in vaccine production processes. II. Detailed description of the replication mechanism
    • Sidorenko Y., Voigt A., Schulze-Horsel J., Reichl U., and Kienle A. Stochastic population balance modeling of influenza virus replication in vaccine production processes. II. Detailed description of the replication mechanism. Chem Eng Sci 63 Apr (8) (2008) 2299-2304
    • (2008) Chem Eng Sci , vol.63 , Issue.Apr 8 , pp. 2299-2304
    • Sidorenko, Y.1    Voigt, A.2    Schulze-Horsel, J.3    Reichl, U.4    Kienle, A.5
  • 43
    • 2442437845 scopus 로고    scopus 로고
    • Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture
    • Genzel Y., Behrendt I., König S., Sann H., and Reichl U. Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture. Vaccine 22 (2004) 2202-2208
    • (2004) Vaccine , vol.22 , pp. 2202-2208
    • Genzel, Y.1    Behrendt, I.2    König, S.3    Sann, H.4    Reichl, U.5
  • 44
    • 64449085877 scopus 로고    scopus 로고
    • Growth behaviour of number distributed adherent MDCK cells for optimization in large scale microcarrier cultures
    • submitted for publication
    • Bock A, Moehler L, Sann H, Schulze-Horsel J, Genzel Y, Reichl U. Growth behaviour of number distributed adherent MDCK cells for optimization in large scale microcarrier cultures, submitted for publication.
    • Bock, A.1    Moehler, L.2    Sann, H.3    Schulze-Horsel, J.4    Genzel, Y.5    Reichl, U.6
  • 45
    • 41949085484 scopus 로고    scopus 로고
    • Monitoring influenza virus content in vaccine production: precise assays for the quantitation of hemagglutination and neuraminidase activity
    • Kalbfuss B., Knoechlein A., Kroeber T., and Reichl U. Monitoring influenza virus content in vaccine production: precise assays for the quantitation of hemagglutination and neuraminidase activity. Biologicals 36 3 (2008) 145-161
    • (2008) Biologicals , vol.36 , Issue.3 , pp. 145-161
    • Kalbfuss, B.1    Knoechlein, A.2    Kroeber, T.3    Reichl, U.4
  • 48
    • 33645046102 scopus 로고    scopus 로고
    • Serum-free influenza virus production avoiding washing steps and medium exchange in large-scale microcarrier culture
    • Genzel Y., Fischer M., and Reichl U. Serum-free influenza virus production avoiding washing steps and medium exchange in large-scale microcarrier culture. Vaccine 24 Apr (16) (2006) 3261-3272
    • (2006) Vaccine , vol.24 , Issue.Apr 16 , pp. 3261-3272
    • Genzel, Y.1    Fischer, M.2    Reichl, U.3
  • 49
    • 0014271050 scopus 로고
    • Replication and plaque assay of influenza virus in an established line of canine kidney cells
    • Gaush C.R., and Smith T.F. Replication and plaque assay of influenza virus in an established line of canine kidney cells. Appl Microbiol 16 Apr (4) (1968) 588-594
    • (1968) Appl Microbiol , vol.16 , Issue.Apr 4 , pp. 588-594
    • Gaush, C.R.1    Smith, T.F.2
  • 50
    • 0029861191 scopus 로고    scopus 로고
    • Influenza virus neuraminidase activates latent transforming growth factor beta
    • Schultz-Cherry S., and Hinshaw V.S. Influenza virus neuraminidase activates latent transforming growth factor beta. J Virol 70 Dec (12) (1996) 8624-8629
    • (1996) J Virol , vol.70 , Issue.Dec 12 , pp. 8624-8629
    • Schultz-Cherry, S.1    Hinshaw, V.S.2
  • 51
    • 33644825268 scopus 로고    scopus 로고
    • Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells
    • Ludwig S., Pleschka S., Planz O., and Wolff T. Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells. Cell Microbiol 8 Mar (3) (2006) 375-386
    • (2006) Cell Microbiol , vol.8 , Issue.Mar 3 , pp. 375-386
    • Ludwig, S.1    Pleschka, S.2    Planz, O.3    Wolff, T.4
  • 52
    • 0035960736 scopus 로고    scopus 로고
    • An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism
    • Rosenblatt J., Raff M.C., and Cramer L.P. An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr Biol 11 Nov (23) (2001) 1847-1857
    • (2001) Curr Biol , vol.11 , Issue.Nov 23 , pp. 1847-1857
    • Rosenblatt, J.1    Raff, M.C.2    Cramer, L.P.3
  • 53
    • 17444405938 scopus 로고    scopus 로고
    • Mathematical model of influenza A virus production in large-scale microcarrier culture
    • Möhler L., Flockerzi D., Sann H., and Reichl U. Mathematical model of influenza A virus production in large-scale microcarrier culture. Biotechnol Bioeng 90 1 (2005) 46-58
    • (2005) Biotechnol Bioeng , vol.90 , Issue.1 , pp. 46-58
    • Möhler, L.1    Flockerzi, D.2    Sann, H.3    Reichl, U.4
  • 54
    • 40149089096 scopus 로고    scopus 로고
    • Clonogenic assay of type a influenza viruses reveals noninfectious cell-killing (apoptosis-inducing) particles
    • Ngunjiri J.M., Sekellick M.J., and Marcus P.I. Clonogenic assay of type a influenza viruses reveals noninfectious cell-killing (apoptosis-inducing) particles. J Virol 82 Mar (6) (2008) 2673-2680
    • (2008) J Virol , vol.82 , Issue.Mar 6 , pp. 2673-2680
    • Ngunjiri, J.M.1    Sekellick, M.J.2    Marcus, P.I.3
  • 55
    • 0142000477 scopus 로고    scopus 로고
    • Differential evolution-A simple and efficient heuristic for global optimization over continuous spaces
    • Storn R., and Price K. Differential evolution-A simple and efficient heuristic for global optimization over continuous spaces. J Global Optim 11 Dec (4) (1997) 341-359
    • (1997) J Global Optim , vol.11 , Issue.Dec 4 , pp. 341-359
    • Storn, R.1    Price, K.2
  • 56
    • 0035090232 scopus 로고    scopus 로고
    • Apoptosis induced by hypertonicity in Madin Darley canine kidney cells: protective effect of betaine
    • Horio M., Ito A., Matsuoka Y., Moriyama T., Orita Y., Takenaka M., et al. Apoptosis induced by hypertonicity in Madin Darley canine kidney cells: protective effect of betaine. Nephrol Dial Transplant 16 3 (2001) 483-490
    • (2001) Nephrol Dial Transplant , vol.16 , Issue.3 , pp. 483-490
    • Horio, M.1    Ito, A.2    Matsuoka, Y.3    Moriyama, T.4    Orita, Y.5    Takenaka, M.6


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