The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function

Biochemical Pharmacology

Volumn 82, Issue 8, 2011, Pages 904-914

  Araud, Tanguy ^d   Graw, Sharon ^b   Berger, Ralph ^b   Lee, Michael ^b   Neveu, Estele ^a   Bertrand, Daniel ^a   Leonard, Sherry ^b,c  

^a HiQScreen   (Switzerland)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

CHRFAM7A; CHRNA7; Nicotinic receptor; Schizophrenia

Indexed keywords

1 (5 CHLORO 2,4 DIMETHOXY PHENYL) 3 (5 METHYL ISOXAZOL 3 YL)UREA; ALPHA BUNGAROTOXIN I 125; BUNGAROTOXIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BINDING AFFINITY; BINDING SITE; CELL LINE; CHRFAM7A GENE; CONFERENCE PAPER; CONTROLLED STUDY; EVOKED RESPONSE; FEMALE; GENE; GENE DELETION; GENE DUPLICATION; GENE EXPRESSION; GENE MUTATION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA TRANSLATION; SCHIZOPHRENIA; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANIMALS; BUNGAROTOXINS; CELL LINE, TUMOR; CLONING, MOLECULAR; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; GENES, DUPLICATE; GENETIC LINKAGE; HUMANS; ISOXAZOLES; LIGANDS; MULTIGENE FAMILY; OOCYTES; PATCH-CLAMP TECHNIQUES; PHENYLUREA COMPOUNDS; PROTEIN BINDING; RECEPTORS, NICOTINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SCHIZOPHRENIA; SMOKING; TRANSFECTION; XENOPUS LAEVIS;

EID: 80052026366     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.06.018     Document Type: Conference Paper

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