Examination of genetic linkage of chromosome 15 to schizophrenia in a large veterans affairs cooperative study sample

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 105, Issue 8, 2001, Pages 662-668

  Tsuang, Debby W ^a,b,c   Skol, Andrew D ^a,b,c,d   Faraone, Stephen V ^a,b,c,d,e,f   Bingham, Stephen ^a,b,c   Young, Keith A ^a,b   Prabhudesai, Sarita ^a,b   Haverstock, Susan L ^a,b,c,d,e,f   Mena, Felicitas ^a,b,c,d,e,f   Shrikumar Menon, A ^a,b,c,d   Bisset, Darren ^a,b,c,d,e,f   Pepple, John ^a,b,c   Sauter, Fred ^a,b,c,d,e,f   Baldwin, Charlene ^a,b   Weiss, David ^a,b   Collins, Joseph ^a,b,c   Boehnke, Michael ^a,b,c,d   Schellenberg, Gerard D ^a,b,c,d,e,f   Tsuang, Ming T ^a,b,c,d  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e MASSACHUSETTS MENTAL HEALTH CENTER   (United States)

^f HARVARD UNIVERSITY   (United States)

Author keywords

Chromosome 15; Genetics; Linkage; Nicotinic cholinergic receptor; Schizophrenia

Indexed keywords

NICOTINIC RECEPTOR;

ARTICLE; CHRNA7 GENE; CHROMOSOME 15Q; DATA ANALYSIS; ETHNIC GROUP; GENE; GENETIC LINKAGE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCHIZOIDISM; SCHIZOPHRENIA; SCORING SYSTEM; SOLDIER;

ADULT; CHROMOSOMES, HUMAN, PAIR 15; DNA; FAMILY HEALTH; FEMALE; GENOTYPE; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PEDIGREE; RECEPTORS, NICOTINIC; SCHIZOPHRENIA; VETERANS;

EID: 0035829968     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.1550     Document Type: Article

References (40)

1. Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics
2. 2+ release supports the relay mode of activity in thalamocortical cells
3. Poor P50 suppression among schizophrenic patients and their first-degree biological relatives
4. Genomic scan for genes predisposing to schizophrenia
5. No evidence for linkage between schizophrenia and markers at chromosome 15q13-14
6. Genome-wide scan for schizophrenia in the Finnish population: Evidence for a locus on chromosome 7q22
7. Diagnostic accuracy and confusability analyses: An application to the Diagnostic Interview for Genetic Studies
8. Genome scan of European-American schizophrenia pedigrees: Results of the NIMH Genetics Initiative and Millennium Consortium
9. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
10. Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha 7-nicotinic acetylcholine receptor subunit gene (CHRNA7)
11. Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)
12. Mutation analysis of the alpha7 nicotinic acetylcholine receptor gene and its partial duplication in schizophrenic patients
13. Nicotinic receptor desensitization and sensory gating deficits in schizophrenia
14. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes lq32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12,1-11.23
15. A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci
16. NIMH Genetics Initiative Millennium Schizophrenia Consortium: Linkage analysis of African-American pedigrees
17. Allele-sharing models. LOD scores and accurate linkage tests
18. Parametric and nonparametric linkage analysis: A unified multipoint approach
19. Nicotinic receptor function in schizophrenia
20. Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH Genetics Initiative
21. Smoking and schizophrenia: Abnormal nicotinic receptor expression
22. Genome scan of schizophrenia
23. Cholinergic gating of response to auditory stimuli in rat hippocampus
24. Genetic linkage in schizophrenia: Perspectives from genetic epidemiology
25. An international two-stage genome-wide search for schizophrenia susceptibility genes
26. Developmental and genetic influences on the P50 sensory gating phenotype
27. No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families
28. Diagnostic interview for genetic studies: Rationale, unique features, and training-NIMH Genetics Initiative
29. PedCheck: A program for identification of genotype incompatibilities in linkage analysis
30. Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes
31. Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families
32. Deficits in sensory gating in schizophrenic patients and their relatives: Evidence obtained with auditory evoked responses
33. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice
34. Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15
35. DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain
36. Expression of Meis and Pbx genes and their protein products in the developing telencephalon: Implications for regional differentiation
37. Schizophrenia: Genes and environment
38. The genetics of schizophrenia
39. Department of Veterans Affairs Cooperative Studies program genetic linkage study of schizophrenia
40. Codistribution of a sensory gating deficit and schizophrenia in multi-affected families