The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection

Clinical and Experimental Immunology

Volumn 153, Issue 3, 2008, Pages 420-428

  Chen, S M ^a   Cheng, D S ^a   Williams, B J ^a   Sherrill, T P ^a   Han, W ^a   Chont, M ^a   Saint Jean, L ^a   Christman, J W ^b   Sadikot, R T ^b   Yull, F E ^a   Blackwell, T S ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Chemokines; Immune regulation; Infections; Lung immunology; Transgenics

Indexed keywords

CHEMOATTRACTANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIUM COLONY; CONTROLLED STUDY; EPITHELIUM CELL; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; INNATE IMMUNITY; KERATINOCYTE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATORY EPITHELIUM; TRANSGENIC MOUSE;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL2; CHEMOKINES, CXC; CYTOKINES; DISEASE MODELS, ANIMAL; EPITHELIUM; KERATINOCYTES; LUNG; MICE; MICE, TRANSGENIC; NEUTROPHIL INFILTRATION; NF-KAPPA B; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 49649125598     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03707.x     Document Type: Article

References (38)

1. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005 171 : 388 416.
2. Rello J, Ollendorf DA, Oster G et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002 122 : 2115 21.
3. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med 2002 165 : 867 903.
4. Kollef MH. Prevention of hospital-associated pneumonia and ventilator-associated pneumonia. Crit Care Med 2004 32 : 1396 405.
5. Rello J, Diaz E. Pneumonia in the intensive care unit. Crit Care Med 2003 31 : 2544 51.
6. Martin TR, Frevert CW. Innate immunity in the lungs. Proc Am Thorac Soc 2005 2 : 403 11.
7. Abreu MT, Arditi M. Innate immunity and Toll-like receptors: clinical implications of basic science research. J Pediatr 2004 144 : 421 9.
8. Sadikot RT, Blackwell TS, Christman JW, Prince AS. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med 2005 171 : 1209 23.
9. Tseng J, Do J, Widdicombe JH, Machen TE. Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-alpha, and IL-1beta. Am J Physiol Cell Physiol 2006 290 : C678 90.
10. Zhang Z, Louboutin JP, Weiner DJ, Goldberg JB, Wilson JM. Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5. Infect Immun 2005 73 : 7151 60.
11. Greene CM, Carroll TP, Smith SG et al. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J Immunol 2005 174 : 1638 46.
12. Power MR, Peng Y, Maydanski E, Marshall JS, Lin TJ. The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J Biol Chem 2004 279 : 49315 22.
13. Rastogi D, Ratner AJ, Prince A. Host-bacterial interactions in the initiation of inflammation. Paediatr Respir Rev 2001 2 : 245 52.
14. Skerrett SJ, Liggitt HD, Hajjar AM, Wilson CB. Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol 2004 172 : 3377 81.
15. Mercurio F, Manning AM. Multiple signals converging on NF-kappaB. Curr Opin Cell Biol 1999 11 : 226 32.
16. Mercurio F, Manning AM. NF-kappaB as a primary regulator of the stress response. Oncogene 1999 18 : 6163 71.
17. Hajjar AM, Harowicz H, Liggitt HD, Fink PJ, Wilson CB, Skerrett SJ. An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia. Am J Respir Cell Mol Biol 2005 33 : 470 5.
18. Sadikot RT, Zeng H, Joo M et al. Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J Immunol 2006 176 : 4923 30.
19. Perl AK, Tichelaar JW, Whitsett JA. Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res 2002 11 : 21 9.
20. Cheng DS, Han W, Chen SM et al. Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. J Immunol 2007 178 : 6504 13.
21. Mercurio F, Zhu H, Murray BW et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 1997 278 : 860 6.
22. Sadikot RT, Han W, Everhart MB et al. Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. J Immunol 2003 170 : 1091 8.
23. Tichelaar JW, Lu W, Whitsett JA. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 2000 275 : 11858 64.
24. Abraham E, Carmody A, Shenkar R, Arcaroli J. Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 2000 279 : L1137 45.
25. Happel KI, Bagby GJ, Nelson S. Host defense and bacterial pneumonia. Semin Respir Crit Care Med 2004 25 : 43 52.
26. Poynter ME, Irvin CG, Janssen-Heininger YM. A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation. J Immunol 2003 170 : 6257 65.
27. Skerrett SJ, Liggitt HD, Hajjar AM, Ernst RK, Miller SI, Wilson CB. Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am J Physiol Lung Cell Mol Physiol 2004 287 : L143 52.
28. Tsai WC, Strieter RM, Mehrad B, Newstead MW, Zeng X, Standiford TJ. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect Immun 2000 68 : 4289 96.
29. Cheung DO, Halsey K, Speert DP. Role of pulmonary alveolar macrophages in defense of the lung against Pseudomonas aeruginosa. Infect Immun 2000 68 : 4585 92.
30. Kooguchi K, Hashimoto S, Kobayashi A et al. Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia. Infect Immun 1998 66 : 3164 9.
31. Hashimoto S, Pittet JF, Hong K et al. Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections. Am J Physiol 1996 270 : L819 28.
32. Zhang J, Wu XY, Yu FS. Inflammatory responses of corneal epithelial cells to Pseudomonas aeruginosa infection. Curr Eye Res 2005 30 : 527 34.
33. Kernacki KA, Barrett RP, Hobden JA, Hazlett LD. Macrophage inflammatory protein-2 is a mediator of polymorphonuclear neutrophil influx in ocular bacterial infection. J Immunol 2000 164 : 1037 45.
34. Mittal R, Chhibber S, Sharma S, Harjai K. Macrophage inflammatory protein-2, neutrophil recruitment and bacterial persistence in an experimental mouse model of urinary tract infection. Microbes Infect 2004 6 : 1326 32.
35. Chowdhury P, Sacks SH, Sheerin NS. Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection. Kidney Int 2004 66 : 1334 44.
36. Beutler B. Innate immunity: an overview. Mol Immunol 2004 40 : 845 59.
37. Diamond G, Legarda D, Ryan LK. The innate immune response of the respiratory epithelium. Immunol Rev 2000 173 : 27 38.
38. Bals R. Epithelial antimicrobial peptides in host defense against infection. Respir Res 2000 1 : 141 50.